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| | rgef-1 | Rap Guanine nucleotide Exchange Factor homolog. (654 aa) |
| | rga-9 | Rho-GAP domain-containing protein. (478 aa) |
| | rbg-3 | Rab-GAP TBC domain-containing protein. (585 aa) |
| | chin-1 | CHImaeriN (Rac-GTPase-activating protein) homolog. (421 aa) |
| | tag-52 | Putative protein tag-52. (665 aa) |
| | ced-5 | CED-5. (1781 aa) |
| | aex-3 | MAP kinase-activating death domain protein; Plays a novel and significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of rab-3 and cab-1 to the GTP-bound active forms. Regulator of presynaptic activity that interacts with rab-3 to regulate synaptic vesicle release. Is also a regulator of the cab-1 synaptic transmission pathway. Probably by converting rab-3 to its GTP-bound active form, plays a role [...] (1409 aa) |
| | rei-1 | Guanine nucleotide exchange factor rei-1; Guanine nucleotide exchange factor for Rab GTPase Rab-11.1. Spatially and temporally regulates the distribution of Rab-11.1 to target membranes during embryogenesis. Plays a role in cytokinesis, probably by targeting rab-11.1 to the cleavage furrows. (244 aa) |
| | tbc-6 | Growth hormone-regulated TBC protein 6. (330 aa) |
| | pac-1 | GTPase-activating protein pac-1; GTPase-activating protein for members of the Rho subfamily including Rac1, RhoA and cdc42 and other Ras-related subfamilies including let-60. Mediates radial (inner-outer) polarity and gastrulation by excluding par-6 from contacted cell surfaces; acts by inactivating cdc42 at inner cell surfaces which limits active cdc42 to outer cell surfaces devoid of cell-cell contacts, where cdc42 can bind and recruit par-6. Required for blastomere polarization. (1718 aa) |
| | rgs-1 | Regulator of G-protein signaling rgs-1; Inhibits G protein signaling in nervous system, interacting preferentially with the G(O) subfamily member goa-1. In vitro, protein acts as a GTPase activator of goa-1. Rgs-1 and rgs-2 redundantly adjust signaling when worms are fed to allow rapid induction of egg-laying behavior. (247 aa) |
| | unc-89 | Muscle M-line assembly protein unc-89; Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments. The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role. Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles. By binding mel-26, a substrate adapter of t [...] (8081 aa) |
| | mcp-1 | GDP-D-glucose phosphorylase 1; Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. Belongs to the GDPGP1 family. (482 aa) |
| | tiam-1 | DH domain-containing protein. (889 aa) |
| | cgef-1 | DH domain-containing protein. (1055 aa) |
| | eif-2Bgamma | Probable translation initiation factor eIF-2B subunit gamma; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B gamma/epsilon subunits family. (404 aa) |
| | eat-16 | Uncharacterized protein. (473 aa) |
| | gbf-1 | SEC7 domain-containing protein. (1975 aa) |
| | ran-3 | Regulator of chromosome condensation; Key component of the Ran GTPase system, which comprises ran- 1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Promotes the exchange of Ran-bound GDP by GTP and regulates the onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1 (ran-3)/RAN (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. (569 aa) |
| | tag-77 | Uncharacterized protein. (1006 aa) |
| | ran-2 | Ran GTPase-activating protein 2; GTPase system comprising ran-1, ran-2 and ran-3 is essential in nucleocytoplasmic trafficking. Ran-2 is a GTPase activator for the nuclear RAS-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Required for correct chromosome alignment and segregation on the metaphase plate. (960 aa) |
| | tbc-19 | TBC (Tre-2/Bub2/Cdc16) domain family. (1333 aa) |
| | tbc-7 | Rab-GAP TBC domain-containing protein. (696 aa) |
| | exc-5 | Uncharacterized protein. (861 aa) |
| | tbck-1 | TBC Kinase homolog. (841 aa) |
| | vav-1 | Protein vav-1; Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase. Has a critical roles in the generation of rhythmic behaviors: feeding, defecation and ovulation by dynamically regulating the concentration of intracellular calcium. Plays a role in male tail tip morphogenesis. (1007 aa) |
| | C37C3.2 | Eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). (436 aa) |
| | gpr-2 | G-protein regulator 2; In the 1-cell embryo, probably together with gpr-1, controls nuclear rotation and spindle elongation during mitosis. Complex of gpr-1 and gpr-2, in association with lin- 5, activates G-protein signaling to affect mitotic spindle force. Polarity determinants (par genes) may regulate lin- 5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement. (525 aa) |
| | tbc-8 | Rab-GAP TBC domain-containing protein. (913 aa) |
| | rin-1 | VPS9 domain-containing protein. (1890 aa) |
| | lst-6 | Lateral Signaling Target. (1487 aa) |
| | C56G7.3 | ELMO domain-containing protein C56G7.3. (322 aa) |
| | eif-2Bepsilon | W2 domain-containing protein. (666 aa) |
| | hgap-2 | Heterodimeric GTPase Activating Protein subunit. (1750 aa) |
| | tbc-14 | Rab-GAP TBC domain-containing protein. (630 aa) |
| | rabn-5 | FYVE-type domain-containing protein. (414 aa) |
| | glo-4 | X-linked retinitis pigmentosa GTPase regulator homolog; Could be a guanine-nucleotide releasing factor for glo-1. May play a role in gut granule biogenesis. Regulates axon termination in PLM and ALM neurons. (1386 aa) |
| | F07F6.4 | Uncharacterized protein F07F6.4; GTPase-activating protein for the ADP ribosylation factor family. (529 aa) |
| | pes-7 | Patterned Expression Site. (1391 aa) |
| | srgp-1 | Rho-GAP domain-containing protein. (1059 aa) |
| | rhgf-1 | RHo Guanine nucleotide exchange Factor. (1340 aa) |
| | git-1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. (670 aa) |
| | tbcd-1 | Tubulin-specific chaperone D; Tubulin-folding protein; involved in the first step of the tubulin folding pathway (By similarity). Plays a role in microtubule polymerization ; Belongs to the TBCD family. (1232 aa) |
| | rgs-2 | Regulator of G-protein signaling rgs-2; Weakly inhibits G protein signaling in nervous system, interacting preferentially with the G(O) subfamily member goa-1. In vitro, it acts as a GTPase activator of goa-1. Rgs-1 and rgs-2 redundantly adjust signaling when worms are fed to allow rapid induction of egg-laying behavior. Modulates chemotaxis responses by regulating negatively the sensitivity to quinine in ASH sensory neurons. (181 aa) |
| | alfa-1 | ALS/FTD Associated gene homolog. (734 aa) |
| | rbg-1 | Rab3 GTPase-activating protein catalytic subunit; Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity). (915 aa) |
| | gpr-1 | G-protein regulator 1; In the 1-cell embryo, probably together with gpr-2, controls nuclear rotation and spindle elongation during mitosis. Complex of gpr-1 and gpr-2, in association with lin- 5, activates G-protein signaling to affect mitotic spindle force. Polarity determinants (par genes) may regulate lin- 5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement. (525 aa) |
| | flcn-1 | UDENN FLCN/SMCR8-type domain-containing protein. (707 aa) |
| | F22G12.5 | DHR-2 domain-containing protein; Belongs to the DOCK family. (2338 aa) |
| | rgl-1 | Ral GDS-Like. (880 aa) |
| | egl-10 | Regulator of G-protein signaling egl-10; Involved in egg-laying and locomotion. May regulate G protein goa-1 signaling. (639 aa) |
| | plc-1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. plc-1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity (By similarity). By activating IP3 receptor itr-1-mediated intracellular Ca(2+) release via the production of IP3, regulates ovulation by controlling contraction and/or dilation of the di [...] (1898 aa) |
| | ags-3 | Activator of G protein Signalling. (579 aa) |
| | tbc-3 | Rab-GAP TBC domain-containing protein. (495 aa) |
| | uig-1 | PH domain-containing protein. (972 aa) |
| | syd-1 | Rho GTPase-activating protein syd-1; Probable GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Regulates the localization and assembly of presynaptic components during presynaptic development and is required for specifying the identity of axons during initial polarity acquisition. In these roles it is thought to act cell autonomously downstream of syg-1 and syg-2 and upstream of syd-2, possibly as a positive regulator of the latter. Required for the control of movement, egg-laying and the correct localization of elks-1. (987 aa) |
| | tbc-11 | Rab-GAP TBC domain-containing protein. (934 aa) |
| | tbc-18 | TBC (Tre-2/Bub2/Cdc16) domain family. (826 aa) |
| | tbc-13 | Rab-GAP TBC domain-containing protein. (459 aa) |
| | gei-1 | START domain-containing protein. (1510 aa) |
| | rme-4 | UDENN domain-containing protein. (661 aa) |
| | F46H5.4 | Uncharacterized protein; Belongs to the DOCK family. (2018 aa) |
| | rhi-1 | Probable rho GDP-dissociation inhibitor; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. (191 aa) |
| | rrc-1 | GTPase-activating protein rrc-1; Functions as a GTPase-activating protein (GAP) for ced- 10/rac-1 and CDC42. (759 aa) |
| | tbc-16 | Rab-GAP TBC domain-containing protein. (725 aa) |
| | rme-6 | Receptor-mediated endocytosis protein 6; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis. Acts by regulating the activation of rab-5 by exchanging bound GDP for free GTP at clathrin coated pits. (1093 aa) |
| | F53A10.2 | Rap-GAP domain-containing protein. (811 aa) |
| | F53H1.3 | UDENN domain-containing protein. (554 aa) |
| | F54C9.11 | Uncharacterized protein. (367 aa) |
| | eef-1B.1 | Probable elongation factor 1-beta/1-delta 1; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP; Belongs to the EF-1-beta/EF-1-delta family. (213 aa) |
| | unc-73 | Guanine nucleotide exchange factor UNC-73A. (2488 aa) |
| | hum-7 | Heavy chain, Unconventional Myosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1880 aa) |
| | rgs-7 | Regulator of G-protein signaling rgs-7; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunit egl-30 (G-alpha(q)), thereby driving it into its inactive GDP-bound form. May organize egl-30 into a stable multiprotein signaling complex, and thereby persistently inhibit egl-30 when triggered by calcium or phospholipids. (819 aa) |
| | lgl-1 | LLGL domain-containing protein. (941 aa) |
| | sam-4 | Uncharacterized protein. (240 aa) |
| | gbas-1 | G-protein alpha subunit activating protein gbas-1; Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates G-protein alpha subunit goa-1. (758 aa) |
| | frm-3 | FERM domain-containing protein. (1091 aa) |
| | rga-5 | Rho-GAP domain-containing protein. (1341 aa) |
| | sec-12 | WD_REPEATS_REGION domain-containing protein. (425 aa) |
| | K02B12.7 | Arf-GAP domain-containing protein. (423 aa) |
| | grp-1 | GTP exchange factor for ARFs 1; Promotes guanine-nucleotide exchange on ARF. Promotes the activation of ARF through replacement of GDP with GTP (By similarity). Plays a role in cell shedding during embryogenesis, probably by promoting the endocytosis of cell adhesion molecules. (393 aa) |
| | ephx-1 | EPHeXin (Eph-interacting GEF) homolog. (1159 aa) |
| | rpi-2 | Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. (341 aa) |
| | cyk-4 | CYtoKinesis defect. (681 aa) |
| | rga-3 | Rho-GAP domain-containing protein. (1085 aa) |
| | pix-1 | PIX (PAK (p21-activated kinase) Interacting eXchange factor) homolog. (646 aa) |
| | tom-1 | LLGL domain-containing protein. (1255 aa) |
| | bris-1 | SEC7 domain-containing protein. (640 aa) |
| | osg-1 | Rho guanine nucleotide exchange factor osg-1; Probable guanine nucleotide exchange factor which regulates the Rho GTPase rho-1. Functions in ASE sensory neurons where it promotes neuronal degeneration under conditions of oxidative stress. (1182 aa) |
| | R05G6.10 | Ras-GEF domain-containing protein. (547 aa) |
| | tbc-10 | Rab-GAP TBC domain-containing protein. (445 aa) |
| | R06F6.8 | Guanine nucleotide exchange factor subunit R06F6.8; Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi; Belongs to the RIC1 family. (1470 aa) |
| | tbc-12 | Rab-GAP TBC domain-containing protein. (614 aa) |
| | smcr-8 | Guanine nucleotide exchange protein smcr-8; Part of a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy; Belongs to the SMCR8 family. (511 aa) |
| | sma-1 | SMAll. (4166 aa) |
| | T04C9.1 | Uncharacterized protein. (881 aa) |
| | ced-9 | Apoptosis regulator ced-9; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway. (280 aa) |
| | T08A11.1 | DEP domain-containing protein. (1872 aa) |
| | rhgf-2 | DH domain-containing protein. (1149 aa) |
| | pxf-1 | Rap guanine nucleotide exchange factor; Acts as a guanine nucleotide exchange factor for small G protein GTPases like rap-1 and rap-2. Required in the hypodermis, especially in the seam cells, for proper formation of the cuticle. Belongs to the RAPGEF2 family. (1470 aa) |
| | rund-1 | RUN domain-containing protein. (549 aa) |
| | ect-2 | ECT2 (Mammalian Rho GEF) homolog. (932 aa) |
| | epac-1 | Rap guanine nucleotide exchange factor 1; Guanine nucleotide-releasing protein (By similarity). Together with GTPase drn-1, may regulate acetylcholine release at the neuromuscular junctions probably downstream of G-protein gsa-1 and adenylate cyclase acy-1. (1038 aa) |
| | rbg-2 | Rab3 GTPase-activating protein regulatory subunit; Probable regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase- activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity). (1307 aa) |
| | rlbp-1 | Rho-GAP domain-containing protein. (461 aa) |
| | gap-1 | Ras GTPase-activating protein gap-1; GTPase-activating protein, which inhibits the vulval induction by acting as a negative regulator for the member of the Ras family let-60. Probably decreases the signaling activity of Ras by stimulating its intrinsic GTPase activity, thereby lowering the levels of GTP-bound, active Ras. (629 aa) |
| | eat-17 | Rab-GAP TBC domain-containing protein. (888 aa) |
| | sipa-1 | Rap-GAP domain-containing protein. (997 aa) |
| | sos-1 | Son of sevenless homolog; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May regulate signaling pathways downstream of receptor tyrosine kinase, egl-15 and let-23. Required for larval and male spicule development, fluid homeostasis, vulva induction, spermatogenesis, and oogenesis by promoting meiosis prophase exit during oocyte maturation. Required for the delamination of G1 cell by promoting the loss of cell junctions and detachment from the excretory system during larval development. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nico [...] (1493 aa) |
| | rga-1 | Rho-GAP domain-containing protein. (444 aa) |
| | W09D10.1 | Arf-GAP domain-containing protein. (495 aa) |
| | W09G3.7 | Uncharacterized protein. (404 aa) |
| | Y105E8A.25 | DH domain-containing protein. (1619 aa) |
| | Y106G6G.2 | SEC7 domain-containing protein. (1655 aa) |
| | sec-23 | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (821 aa) |
| | cnt-1 | Arf-GAP with ANK repeat and PH domain-containing protein cnt-1; GTPase-activating protein for the ADP ribosylation factor family (Probable). Regulates endosome recycling downstream of rab-10 and upstream of arf-6. (826 aa) |
| | hgap-1 | Rap-GAP domain-containing protein. (1306 aa) |
| | Y34B4A.4 | Uncharacterized protein. (877 aa) |
| | rga-8 | Rho-GAP domain-containing protein. (709 aa) |
| | Y37A1B.17 | Uncharacterized protein. (1523 aa) |
| | cnt-2 | Arf-GAP with ANK repeat and PH domain-containing protein cnt-2; GTPase-activating protein for the ADP ribosylation factor family (Probable). During neurogenesis, involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell probably by controlling endocytosis. In oocytes, involved in vitellogenin vit-2 uptake by regulating receptor rme-2 endocytosis; Belongs to the centaurin gamma-like family. (1107 aa) |
| | rabx-5 | RAB eXchange factor. (517 aa) |
| | eef-1B.2 | Probable elongation factor 1-beta/1-delta 2; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. (440 aa) |
| | tbc-9 | Rab-GAP TBC domain-containing protein. (1247 aa) |
| | tbc-17 | Rab-GAP TBC domain-containing protein. (1073 aa) |
| | rga-2 | Rho GTPase Activating protein. (908 aa) |
| | tbc-20 | Rab-GAP TBC domain-containing protein. (411 aa) |
| | efa-6 | Exchange factor for Arf-6; Guanine nucleotide exchange factor for arf-6 (By similarity). Involved in response to injury in mechanosensory neurons. Inhibits axon regrowth via microtubule dynamics, possibly by inducing axonal microtubule catastrophes. Limits microtubule growth near the cellular cortex of early embryonic cells. (818 aa) |
| | gdi-1 | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (459 aa) |
| | mdt-9 | Putative guanine nucleotide exchange factor MSS4 homolog; Guanine-nucleotide-releasing protein that acts on members of the sec4/ypt1/rab subfamily. (147 aa) |
| | rep-1 | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (510 aa) |
| | ric-8 | Synembryn; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins independently of G-protein coupled receptors. Acts by exchanging bound GDP for free GTP. Able to facilitate synaptic transmission in the nervous system probably by activating G(q)-alpha (egl-30). Also able to activate the G(s)-alpha in synaptic signaling network. Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i)-alpha protein goa-1 and gpa-16 independently of G-protein couple [...] (566 aa) |
| | agef-1 | SEC7 domain-containing protein. (1594 aa) |
| | rga-4 | Rho-GAP domain-containing protein. (1135 aa) |
| | Y92H12BL.4 | Uncharacterized protein. (397 aa) |
| | Y92H12BM.1 | WW domain-containing protein. (228 aa) |
| | Y95B8A.12 | Pleckstrin homology and RHoGef (RhoGEF) domain containing. (628 aa) |
| | lmtr-2 | Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family. (124 aa) |
| | tbc-2 | TBC (Tre-2/Bub2/Cdc16) domain family. (908 aa) |
| | spv-1 | Spermathecal Physiology Variant. (966 aa) |
| | gap-2 | Ras GTPase-activating protein gap-2; GTPase-activating protein, which acts as a negative regulator for the member of the Ras family let-60. Probably decreases the signaling activity of Ras by stimulating its intrinsic GTPase activity, thereby lowering the levels of GTP-bound, active Ras. The different isoforms may play a distinct role in specific tissues. (1259 aa) |
| | ZK970.8 | Uncharacterized protein. (143 aa) |
