STRINGSTRING
lgl-1 lgl-1 unc-78 unc-78 unc-94 unc-94 C07A9.5 C07A9.5 C07B5.4 C07B5.4 wsp-1 wsp-1 nab-1 nab-1 C50C3.2 C50C3.2 pkc-3 pkc-3 ifb-2 ifb-2 cyk-1 cyk-1 ani-1 ani-1 ani-3 ani-3 atn-1 atn-1 act-5 act-5 unc-70 unc-70 spc-1 spc-1 ani-2 ani-2 aipl-1 aipl-1 dbn-1 dbn-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lgl-1LLGL domain-containing protein. (941 aa)
unc-78Actin-interacting protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Regulator of actin organization in myofibrils. (611 aa)
unc-94Tropomodulin; Acts as the pointed end capping protein which maintains the length and dynamics of the actin filament. Blocks the elongation and depolymerization of the actin filaments at the pointed end (By similarity); Belongs to the tropomodulin family. (401 aa)
C07A9.5Uncharacterized calcium-binding protein C07A9.5. (358 aa)
C07B5.4PH domain-containing protein. (515 aa)
wsp-1WASP (Actin cytoskeleton modulator) homolog. (781 aa)
nab-1NeurABin. (721 aa)
C50C3.2Uncharacterized protein C50C3.2; Belongs to the spectrin family. (2236 aa)
pkc-3Protein kinase C-like 3; Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury. (597 aa)
ifb-2Intermediate filament protein ifb-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413. (577 aa)
cyk-1CYtoKinesis defect. (1437 aa)
ani-1Anillin-like protein 1; Required for contractile events in embryos that occur prior to mitosis, such as cortical ruffling and pseudocleavage. Promotes membrane ruffling by organizing cortical patches of septins and myosin II. Not generally required for cytokinesis in mitotic cells. Required for the asymmetric cleavage events that extrude the two polar bodies during oocyte meiosis. Not required for meiotic contractile ring assembly, initiation or closure but is required for the transformation of the contractile ring from a disk above the spindle to a tube around the spindle midzone. Pro [...] (1159 aa)
ani-3Anillin-like protein 3. (709 aa)
atn-1AcTiniN. (920 aa)
act-5ACTin. (375 aa)
unc-70Spectrin beta chain; Belongs to the spectrin family. (2326 aa)
spc-1SPeCtrin. (2432 aa)
ani-2Anillin-like protein 2; Required to maintain the structure of the rachis, the central cytoplasmic core of the syncytial adult gonad. Failure to maintain the rachis leads to premature dissociation of oocytes and thereby impedes oogenesis. (1009 aa)
aipl-1WD_REPEATS_REGION domain-containing protein. (600 aa)
dbn-1Drebrin-like protein. (643 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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