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| | F26E4.3 | Uncharacterized peptidase C1-like protein F26E4.3. (452 aa) |
| | hse-5 | D-glucuronyl C5-epimerase; Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acids (By similarity). Plays a role in the early migration of AQR and PQR neurons, which descend from the Q neuroblasts ; Belongs to the D-glucuronyl C5-epimerase family. (616 aa) |
| | B0393.5 | Uncharacterized protein. (1183 aa) |
| | adt-1 | A disintegrin and metalloproteinase with thrombospondin motifs adt-1; Plays a role in ray morphogenesis in the male tail, probably by remodeling the extracellular matrix (ECM) in the cuticle. (1461 aa) |
| | C03H12.1 | Uncharacterized protein. (731 aa) |
| | tol-1 | TIR domain-containing protein. (1221 aa) |
| | bli-1 | Cuticle collagen bli-1; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. This collagen is required for proper strut formation within the unique medial layer of the adult cuticle. (948 aa) |
| | skpo-2 | ShK domain and PerOxidase domain containing protein. (729 aa) |
| | C16E9.1 | Uncharacterized protein. (565 aa) |
| | C18H7.1 | VWFA domain-containing protein. (425 aa) |
| | zmp-3 | Matrix metalloproteinase-C; Metalloproteinase. (579 aa) |
| | col-178 | Col_cuticle_N domain-containing protein. (283 aa) |
| | col-179 | Col_cuticle_N domain-containing protein. (283 aa) |
| | cle-1 | CoLlagen with Endostatin domain. (1175 aa) |
| | mig-6 | Papilin; Involved in pharynx morphogenesis probably by remodeling the basement membrane. [Isoform b]: Plays a role in post embryonic distal cell tip migration. Essential extracellular matrix (ECM) protein required for hypodermal enclosure in the embryo. (2167 aa) |
| | lon-2 | LONg; Belongs to the glypican family. (508 aa) |
| | ost-1 | SPARC; Has a high affinity for collagen. Affects nematode body morphology and mobility. Essential for C.elegans development and muscle function. The cysteine-rich region could have protease inhibitory activity or may provide the framework for a protein binding module. Probable role in skeletal morphogenesis; Belongs to the SPARC family. (264 aa) |
| | col-14 | Cuticle collagen 14; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (345 aa) |
| | cut-1 | Cuticlin-1; Component of the cuticles. It forms a ribbon approximately 2 microns wide running along the lateral lines underneath the alae. Contributes to the formation of extracellular envelopes protecting the organism from the environment. (424 aa) |
| | C49C8.5 | Fibrinogen C-terminal domain-containing protein. (451 aa) |
| | lam-2 | Laminin-like protein lam-2; During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. (1633 aa) |
| | ensh-1 | Fibrinogen C-terminal domain-containing protein. (465 aa) |
| | col-158 | Col_cuticle_N domain-containing protein. (336 aa) |
| | mec-5 | MEC-5. (327 aa) |
| | zmp-1 | Matrix metalloproteinase-A; Metalloprotease which, together with cadherin cdh-3 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development probably by promoting the degradation of the basement membrane separating the gonad from the vulva epithelium. (521 aa) |
| | let-2 | Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. (1759 aa) |
| | adt-2 | A disintegrin and metalloproteinase with thrombospondin motifs adt-2; Regulates body size probably independently of the TGF beta- like dbl-1 pathway. However, may regulate some dbl-1-mediated transcription. Plays a role in cuticle collagen fibril organization. Required for embryonic development. (1020 aa) |
| | spon-1 | SPONdin (Extracellular matrix glycoprotein) family. (819 aa) |
| | mig-18 | Abnormal cell migration protein 18; Required for the directional control of distal tip cell migration during gonadogenesis, probably by recruiting fibulin fbl-1 to the gonad basement membrane. (228 aa) |
| | col-128 | COLlagen. (427 aa) |
| | him-4 | EGF-like domain-containing protein. (5213 aa) |
| | col-153 | Col_cuticle_N domain-containing protein. (337 aa) |
| | sqt-3 | Cuticle collagen 1; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (301 aa) |
| | gon-1 | A disintegrin and metalloproteinase with thrombospondin motifs gon-1; Secreted metalloprotease required for distal tip cell (DTC) migration along the body wall basement membranes, a key step that promotes gonad morphogenesis. Probably acts by remodeling the basement membrane during cell migration. Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons, probably by controlling collagen IV emb-9 degradation, a component of the synapse basement membrane. Also involved in the organization of adult muscle morphology. Has [...] (2165 aa) |
| | F26E4.7 | Uncharacterized protein. (677 aa) |
| | dpy-5 | Cuticle collagen dpy-5; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (284 aa) |
| | col-99 | Putative cuticle collagen 99; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity). (735 aa) |
| | dpy-13 | Cuticle collagen dpy-13; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-13 affects the body shape. (302 aa) |
| | cpz-1 | Cathepsin Z-1; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Probably, required for the degradation of the old cuticle. Belongs to the peptidase C1 family. (306 aa) |
| | col-83 | Col_cuticle_N domain-containing protein. (346 aa) |
| | unc-6 | Netrin unc-6; Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation [...] (612 aa) |
| | agr-1 | AGRin (Synaptic protein) homolog family member. (1473 aa) |
| | elks-1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. (836 aa) |
| | dpy-7 | Cuticle collagen dpy-7; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-7 affects the body shape. (318 aa) |
| | cut-2 | Cuticlin-2; Component of the insoluble part of the cuticles. (215 aa) |
| | nid-1 | NIDogen (Basement membrane protein). (1584 aa) |
| | fbl-1 | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. Plays a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Important for certain developmental processes and contributes to the supramolecular organization of ECM architecture, in particular to those of basement membranes. [Isoform c]: Involved in the assembly of the flexible hemicentin-containing tracks found joining the pharynx and body-wall- muscle basement membranes; Belongs to the fibulin family. (751 aa) |
| | mig-17 | Metalloprotease mig-17; Metalloprotease. Acts in the basement membrane to control directional migration of distal tip cells (DTCs) along the body wall basement membranes, a key step that promotes gonad morphogenesis. Regulates DTC migration probably by recruiting fibulin fbl-1, type IV collagen let-2 and nidogen nid-1 to the gonad basement membrane thereby promoting the remodeling of the basement membrane. During larval development and probably upstream of basement membrane proteins fbl-1, let-2 and nid-1, regulates pharynx length, probably by regulating pharyngeal cell length. Does no [...] (509 aa) |
| | col-105 | Col_cuticle_N domain-containing protein. (290 aa) |
| | gpn-1 | GlyPicaN; Belongs to the glypican family. (543 aa) |
| | zmp-2 | Matrix metalloproteinase-B; Metalloprotease involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Plays a role in thermotolerance probably by preventing the accumulation of oxidized lipoproteins and cholesterol. (519 aa) |
| | dpy-14 | Col_cuticle_N domain-containing protein. (322 aa) |
| | zmp-5 | ZnMc domain-containing protein. (405 aa) |
| | lron-7 | LRRCT domain-containing protein. (586 aa) |
| | emb-9 | Collagen alpha-1(IV) chain; Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons. May play a role in axon regeneration in embryos following injury in D-type motor neurons. (1759 aa) |
| | lect-2 | Peptidase_M23 domain-containing protein. (335 aa) |
| | timp-1 | NTR domain-containing protein. (154 aa) |
| | cri-2 | Putative metalloproteinase inhibitor tag-225; Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Belongs to the protease inhibitor I35 (TIMP) family. (158 aa) |
| | epi-1 | Laminin-like protein epi-1; During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. (3715 aa) |
| | pxn-2 | PeroXidasiN (Drosophila peroxidase) homolog. (1328 aa) |
| | col-84 | Col_cuticle_N domain-containing protein. (333 aa) |
| | col-76 | Col_cuticle_N domain-containing protein. (499 aa) |
| | cut-6 | CUTiclin. (572 aa) |
| | col-135 | COLlagen. (660 aa) |
| | suro-1 | Putative carboxypeptidase suro-1; May play a role in processing or organization of cuticle collagen proteins, including rol-6 and col-19. (664 aa) |
| | rol-6 | Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa) |
| | T01D3.6 | Uncharacterized protein. (927 aa) |
| | T04F3.2 | Sparc (SPARC) related MOdular Calcium binding protein homolog. (260 aa) |
| | qua-1 | Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development. (1169 aa) |
| | pxf-1 | Rap guanine nucleotide exchange factor; Acts as a guanine nucleotide exchange factor for small G protein GTPases like rap-1 and rap-2. Required in the hypodermis, especially in the seam cells, for proper formation of the cuticle. Belongs to the RAPGEF2 family. (1470 aa) |
| | T15B7.1 | Uncharacterized protein. (372 aa) |
| | adt-3 | Peptidase M12B domain-containing protein. (940 aa) |
| | zmp-6 | ZnMc domain-containing protein. (279 aa) |
| | sma-10 | Leucine-rich repeats and immunoglobulin-like domains protein sma-10; Binds to the TGF-beta receptors sma-6 and daf-4, and enhances TGF-beta signaling activity in vitro. Has a role in regulation of body size. (881 aa) |
| | lam-3 | LAMinin related. See also lmb. (3102 aa) |
| | lron-8 | LRRCT domain-containing protein. (341 aa) |
| | lam-1 | LAMinin related. See also lmb. (1790 aa) |
| | col-78 | COLlagen. (278 aa) |
| | col-123 | Col_cuticle_N domain-containing protein. (358 aa) |
| | zmp-4 | ZnMc domain-containing protein. (472 aa) |
| | lec-1 | 32 kDa beta-galactoside-binding lectin; Binds galactose. (285 aa) |
| | col-87 | COLlagen. (548 aa) |
| | col-96 | Col_cuticle_N domain-containing protein. (289 aa) |
| | dpy-4 | Col_cuticle_N domain-containing protein. (289 aa) |
| | col-115 | COLlagen. (393 aa) |
| | Y43C5A.2 | Fibrinogen C-terminal domain-containing protein. (452 aa) |
| | col-71 | Col_cuticle_N domain-containing protein. (371 aa) |
| | Y50D7A.13 | ZnMc domain-containing protein. (194 aa) |
| | tln-1 | Talin. (2553 aa) |
| | unc-52 | Basement membrane proteoglycan; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable structural role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in body wall muscles and myoepithelial sheath cells. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. Involved in ovulation. (3375 aa) |
| | pat-3 | Integrin beta pat-3; Integrin alpha ina-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable). Plays a role in cell migration, morphogenesis and probably in cell-cell interactions. During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M line [...] (809 aa) |
| | cdh-3 | Cadherin-3; Cell adhesion protein involved in the control of epithelial morphogenesis. Together with metalloproteinase zmp-1 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development. (3361 aa) |
| | col-19 | Cuticle collagen 19; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (289 aa) |
| | lon-3 | Cuticle collagen lon-3; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Dose-dependent regulator of body length and shape. (324 aa) |
| | pxn-1 | Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. (1285 aa) |
