STRINGSTRING
F47G9.4 F47G9.4 F44E5.4 F44E5.4 hsp-4 hsp-4 F42A6.6 F42A6.6 dnj-12 dnj-12 hsp-12.3 hsp-12.3 dnj-11 dnj-11 fkb-6 fkb-6 unc-45 unc-45 hsp-1 hsp-1 dnj-10 dnj-10 F11F1.1 F11F1.1 pcrg-1 pcrg-1 hsp-6 hsp-6 rpap-3 rpap-3 ttc-4 ttc-4 hsp-3 hsp-3 hsp-12.2 hsp-12.2 hsp-70 hsp-70 clk-2 clk-2 ahsa-1 ahsa-1 dnj-1 dnj-1 daf-41 daf-41 dnj-26 dnj-26 pph-5 pph-5 Y22D7AL.9 Y22D7AL.9 cdc-37 cdc-37 dnj-23 dnj-23 skn-1 skn-1 hip-1 hip-1 chn-1 chn-1 dnj-19 dnj-19 sti-1 sti-1 ebax-1 ebax-1 K07E8.6 K07E8.6 unc-23 unc-23 stc-1 stc-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F47G9.4Probable RING finger protein 207 homolog. (822 aa)
F44E5.4Uncharacterized protein; Belongs to the heat shock protein 70 family. (645 aa)
hsp-4Endoplasmic reticulum chaperone BiP homolog; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Required for ER dynamics during the first embryonic cell divisions. Specifically, controls ER transition into sheet-like structures at the onset of mitosis, possibly by regulating homotypic membrane fusion. Belongs to the heat shock protein 70 family. (657 aa)
F42A6.6DUF775 domain-containing protein. (219 aa)
dnj-12DNaJ domain (Prokaryotic heat shock protein). (402 aa)
hsp-12.3SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (109 aa)
dnj-11DNaJ domain (Prokaryotic heat shock protein). (589 aa)
fkb-6Peptidylprolyl isomerase. (431 aa)
unc-45TPR_REGION domain-containing protein. (961 aa)
hsp-1Heat shock 70 kDa protein A. (640 aa)
dnj-10DnaJ homolog dnj-10. (456 aa)
F11F1.1DUF148 domain-containing protein; Belongs to the heat shock protein 70 family. (607 aa)
pcrg-1Parkin Co-Regulated Gene (PACRG) homolog. (294 aa)
hsp-6Heat shock 70 kDa protein F, mitochondrial; Belongs to the heat shock protein 70 family. (657 aa)
rpap-3RPAP3_C domain-containing protein. (297 aa)
ttc-4TeTratriCopeptide repeat domain protein related. (419 aa)
hsp-3Heat shock 70 kDa protein C; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. (661 aa)
hsp-12.2Heat shock protein Hsp-12.2; Belongs to the small heat shock protein (HSP20) family. (110 aa)
hsp-70Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa)
clk-2Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family. (877 aa)
ahsa-1Aha1_N domain-containing protein. (342 aa)
dnj-1DnaJ homolog subfamily B member 1; Acts as a co-chaperone with Hsp70 required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity). Acts by determining Hsp70's ATPase and polypeptide-binding activities (By similarity). Can also act as a chaperone that promotes maturation of potassium channel unc-103 by stabilizing nascent channel subunits and assembling them into tetramers ; Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily. (401 aa)
daf-41Co-chaperone protein daf-41; Co-chaperone for hsp90/daf-21. Involved in regulation of longevity, larval entry and exit from the dauer stage of development and response to environmental cues, such as oxidative stress, in a temperature-dependent manner. Role in daf-16 and hsf-1 inhibition at elevated temperatures. Belongs to the p23/wos2 family. (175 aa)
dnj-26J domain-containing protein. (365 aa)
pph-5Serine/threonine-protein phosphatase 5; Serine/threonine-protein phosphatase. Dephosphorylates cdc-37. Probably by dephosphorylating separase sep-1, may be involved in sep-1-mediated exocytosis of cortical granules during meiotic anaphase and mitotic cytokinesis. (496 aa)
Y22D7AL.9TPR_REGION domain-containing protein. (836 aa)
cdc-37Probable Hsp90 co-chaperone cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (By similarity). Inhibits daf-21/Hsp90 ATPase activity ; Belongs to the CDC37 family. (403 aa)
dnj-23J domain-containing protein. (242 aa)
skn-1Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa)
hip-1TPR_REGION domain-containing protein. (422 aa)
chn-1C-term of Hsp70-iNteracting protein (CHIP family). (266 aa)
dnj-19DNaJ domain (Prokaryotic heat shock protein). (439 aa)
sti-1Stress-induced-phosphoprotein 1; Plays a role in gonad development. Up-regulates longevity and thermotolerance. Binds daf-21/hsp90 and inhibits its ATPase activity. (320 aa)
ebax-1SWIM-type domain-containing protein. (1717 aa)
K07E8.6CDC37_M domain-containing protein. (339 aa)
unc-23BAG domain-containing protein. (458 aa)
stc-1STCH (Truncated HSP) family. (450 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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