STRINGSTRING
Y45F3A.9 Y45F3A.9 mett-10 mett-10 nsun-5 nsun-5 Y45F3A.8 Y45F3A.8 eef-1B.2 eef-1B.2 nsun-4 nsun-4 Y39A1A.14 Y39A1A.14 C04H5.1 C04H5.1 C06E1.9 C06E1.9 nol-2 nol-2 tfbm-1 tfbm-1 C27F2.4 C27F2.4 C38D4.9 C38D4.9 E02H1.1 E02H1.1 F33A8.4 F33A8.4 F45G2.9 F45G2.9 H06I04.3 H06I04.3 fib-1 fib-1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Y45F3A.9SpoU_sub_bind domain-containing protein. (294 aa)
mett-10U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that mediates N6-methylation of adenine of U6 small nuclear RNA (U6 snRNA) (By similarity). Involved in mRNA splicing (By similarity). Required for gamete production, inhibiting germ cell proliferative fate and ensuring germ cell meiotic development. Also promotes progression of the mitotic cell cycle in those germ cells that continue to proliferate. Plays a role in the development of the vulva, somatic gonad and embryo. Belongs to the methyltransferase superfamily. METTL16/RlmF family. (479 aa)
nsun-5SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (439 aa)
Y45F3A.8Uncharacterized protein. (404 aa)
eef-1B.2Probable elongation factor 1-beta/1-delta 2; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. (440 aa)
nsun-4SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (465 aa)
Y39A1A.14Ribosomal RNA small subunit methyltransferase nep-1; S-adenosyl-L-methionine-dependent pseudouridine N(1)- methyltransferase that methylates a pseudouridine in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3- carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre- ribosomes; Belongs to the class IV-like SAM-binding methyltransferase superfami [...] (231 aa)
C04H5.1Multifunctional methyltransferase subunit TRM112-like protein; Acts as an activator of both RNA and protein methyltransferases. (125 aa)
C06E1.9Uncharacterized protein C06E1.9. (643 aa)
nol-2SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (664 aa)
tfbm-1Dimethyladenosine transferase 1, mitochondrial; Probable S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA. Stimulates transcription independently of the methyltransferase activity (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily. (367 aa)
C27F2.4Uncharacterized protein. (283 aa)
C38D4.9MTS domain-containing protein. (214 aa)
E02H1.1Probable dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. (308 aa)
F33A8.4Uncharacterized protein. (467 aa)
F45G2.9rRNA methyltransferase 2, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 808 (Um808) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. (214 aa)
H06I04.3Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits. (833 aa)
fib-1rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (By similarity). Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl- L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (By similarity). Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Also acts as a protein [...] (352 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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