STRINGSTRING
tsg-101 tsg-101 ego-2 ego-2 vps-2 vps-2 vps-25 vps-25 vps-24 vps-24 T24B8.2 T24B8.2 T23G11.7 T23G11.7 R12C12.5 R12C12.5 sand-1 sand-1 vps-60 vps-60 did-2 did-2 vps-36 vps-36 vps-32.1 vps-32.1 stam-1 stam-1 C30B5.2 C30B5.2 vps-22 vps-22 vps-20 vps-20 vps-28 vps-28 Y74C10AL.2 Y74C10AL.2 C01A2.4 C01A2.4 mvb-12 mvb-12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tsg-101Tumor Susceptibility Gene homolog. (425 aa)
ego-2BRO1 domain-containing protein. (1494 aa)
vps-2Related to yeast Vacuolar Protein Sorting factor. (237 aa)
vps-25Related to yeast Vacuolar Protein Sorting factor. (183 aa)
vps-24Related to yeast Vacuolar Protein Sorting factor. (208 aa)
T24B8.2Charged Multivesicular Body Protein homolog. (411 aa)
T23G11.7Uncharacterized protein. (361 aa)
R12C12.5Uncharacterized protein. (236 aa)
sand-1SAND endocytosis protein family. (459 aa)
vps-60Related to yeast Vacuolar Protein Sorting factor. (217 aa)
did-2Doa4-Independent Degradation, homologous to yeast Did2. (205 aa)
vps-36GLUE N-terminal domain-containing protein. (383 aa)
vps-32.1Related to yeast Vacuolar Protein Sorting factor. (221 aa)
stam-1Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. (457 aa)
C30B5.2Vacuolar protein sorting-associated protein 55 homolog; Involved in endosomal protein transport. (132 aa)
vps-22Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (269 aa)
vps-20Related to yeast Vacuolar Protein Sorting factor. (208 aa)
vps-28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family. (210 aa)
Y74C10AL.2Uncharacterized protein. (157 aa)
C01A2.4Uncharacterized protein. (207 aa)
mvb-12MVB (Yeast MultiVesicular Body sorting factor) related. (277 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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