STRINGSTRING
Y47H10A.3 Y47H10A.3 rnh-1.2 rnh-1.2 upp-1 upp-1 panl-3 panl-3 fitm-2 fitm-2 ZK177.8 ZK177.8 rnh-1.1 rnh-1.1 ZK1127.13 ZK1127.13 ccr-4 ccr-4 hap-1 hap-1 ZC190.4 ZC190.4 Y92H12BL.5 Y92H12BL.5 ndx-8 ndx-8 ntl-11 ntl-11 exos-2 exos-2 smg-3 smg-3 smg-7 smg-7 exos-4.2 exos-4.2 wah-1 wah-1 ccf-1 ccf-1 ntl-3 ntl-3 dcap-1 dcap-1 smg-6 smg-6 smg-9 smg-9 rpb-7 rpb-7 smg-2 smg-2 xrn-2 xrn-2 Y48A6B.7 Y48A6B.7 Y47H10A.5 Y47H10A.5 Y47H10A.4 Y47H10A.4 crn-1 crn-1 ttc-37 ttc-37 tiar-2 tiar-2 Y44E3A.6 Y44E3A.6 xrn-1 xrn-1 ndx-3 ndx-3 ndx-4 ndx-4 smgl-2 smgl-2 cyn-13 cyn-13 dcs-1 dcs-1 W08E3.2 W08E3.2 mtr-4 mtr-4 puf-9 puf-9 W02F12.4 W02F12.4 smg-5 smg-5 eol-1 eol-1 rnh-2 rnh-2 prp-19 prp-19 T09F3.5 T09F3.5 T09F3.4 T09F3.4 eri-1 eri-1 pelo-1 pelo-1 pde-12 pde-12 pde-4 pde-4 R13A5.10 R13A5.10 nth-1 nth-1 mag-1 mag-1 pde-2 pde-2 rnp-4 rnp-4 mig-23 mig-23 edc-3 edc-3 rle-1 rle-1 M01G12.9 M01G12.9 M01G12.7 M01G12.7 M01G12.14 M01G12.14 dcr-1 dcr-1 K12D12.5 K12D12.5 K10C9.3 K10C9.3 parn-1 parn-1 uda-1 uda-1 dut-1 dut-1 crn-6 crn-6 smg-8 smg-8 ahcy-1 ahcy-1 exos-3 exos-3 rnh-1.0 rnh-1.0 let-711 let-711 eme-1 eme-1 dom-3 dom-3 dcap-2 dcap-2 cdd-2 cdd-2 disl-2 disl-2 smg-4 smg-4 tag-153 tag-153 patr-1 patr-1 rpb-4 rpb-4 lem-3 lem-3 exos-8 exos-8 lsm-1 lsm-1 ncbp-1 ncbp-1 exos-9 exos-9 mlcd-1 mlcd-1 F33D11.10 F33D11.10 panl-2 panl-2 exos-7 exos-7 drsh-1 drsh-1 F21D5.6 F21D5.6 hint-1 hint-1 smgl-1 smgl-1 puf-6 puf-6 ndx-9 ndx-9 tir-1 tir-1 tsn-1 tsn-1 F10E7.5 F10E7.5 crn-7 crn-7 F09E5.3 F09E5.3 apy-1 apy-1 F07H5.10 F07H5.10 F02A9.10-2 F02A9.10-2 skih-2 skih-2 crn-2 crn-2 smg-1 smg-1 cdd-1 cdd-1 C44B7.12 C44B7.12 mus-81 mus-81 cps-6 cps-6 C37H5.14 C37H5.14 ntp-1 ntp-1 ntl-9 ntl-9 hel-1 hel-1 dpyd-1 dpyd-1 tiar-1 tiar-1 crn-5 crn-5 crn-3 crn-3 lin-41 lin-41 C08F8.2 C08F8.2 nuc-1 nuc-1 C06G3.5 C06G3.5 ain-1 ain-1 dis-3 dis-3 rnh-1.3 rnh-1.3 BE0003N10.1 BE0003N10.1 exos-4.1 exos-4.1 ntl-2 ntl-2 ain-2 ain-2 crn-4 crn-4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Y47H10A.3Uncharacterized protein. (333 aa)
rnh-1.2RNase H domain-containing protein. (192 aa)
upp-1Uridine and thymidine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and thymidine to uracil and ribose-phosphate or thymine and deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (Probable). Required for normal lifespan ; Belongs to the PNP/UDP phosphorylase family. (295 aa)
panl-3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (632 aa)
fitm-2FIT family protein fitm-2. (283 aa)
ZK177.8Uncharacterized protein ZK177.8. (587 aa)
rnh-1.1RNase H domain-containing protein. (507 aa)
ZK1127.13Uncharacterized protein. (128 aa)
ccr-4Endo/exonuclease/phosphatase domain-containing protein. (677 aa)
hap-1Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (184 aa)
ZC190.4SAM domain-containing protein. (629 aa)
Y92H12BL.5Nudix hydrolase domain-containing protein; Belongs to the Nudix hydrolase family. (150 aa)
ndx-8Peroxisomal coenzyme A diphosphatase ndx-8; Coenzyme A diphosphatase which mediates the cleavage of CoA into 3',5'-ADP and 4'-phosphopantetheine; Belongs to the Nudix hydrolase family. (234 aa)
ntl-11NOT-Like (Yeast CCR4/NOT complex component). (640 aa)
exos-2EXOSome (Multiexonuclease complex) component. (303 aa)
smg-3Suppressor with Morphological effect on Genitalia. (1144 aa)
smg-7TPR_REGION domain-containing protein. (458 aa)
exos-4.2RNase_PH domain-containing protein. (241 aa)
wah-1Worm AIF (Apoptosis inducing factor) Homolog. (700 aa)
ccf-1CCR4-NOT transcription complex subunit 7; Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression; Belongs to the CAF1 family. (310 aa)
ntl-3NOT2_3_5 domain-containing protein. (701 aa)
dcap-1mRNA_decap_C domain-containing protein. (332 aa)
smg-6PINc domain-containing protein. (1241 aa)
smg-9Protein smg-9; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes. Belongs to the SMG9 family. (385 aa)
rpb-7S1 motif domain-containing protein. (197 aa)
smg-2Regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an smg-2-3-4 surveillance complex is believed to activate NMD (By similarity). (1069 aa)
xrn-25'-3' exoribonuclease 2 homolog; Possesses 5'->3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Degradation role is enhanced when in complex with paxt-1. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle. (975 aa)
Y48A6B.7CMP/dCMP-type deaminase domain-containing protein. (168 aa)
Y47H10A.5Uncharacterized protein. (331 aa)
Y47H10A.4Uncharacterized protein. (327 aa)
crn-1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa)
ttc-37TeTratriCopeptide repeat domain protein related. (1114 aa)
tiar-2TIA-1/TIAL RNA binding protein homolog. (434 aa)
Y44E3A.6FHA domain-containing protein. (843 aa)
xrn-15'-3' exoribonuclease 1. (1591 aa)
ndx-3Nudix hydrolase 3; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. PCD1 subfamily. (240 aa)
ndx-4Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. (138 aa)
smgl-2Uncharacterized protein. (1089 aa)
cyn-13Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. (331 aa)
dcs-1m7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs of the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) and tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with up to 2 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7- methylguanosine monophosphate (m7GMP). Does not hydrolyze unmethylated cap analog (GpppG) and shows no decap [...] (311 aa)
W08E3.2Btz domain-containing protein. (584 aa)
mtr-4mRNA transport homolog 4. (1026 aa)
puf-9PUM-HD domain-containing protein. (703 aa)
W02F12.4Uncharacterized protein. (401 aa)
smg-5Nonsense-mediated mRNA decay protein. (549 aa)
eol-1RAI1 domain-containing protein. (316 aa)
rnh-2Ribonuclease H2 subunit A; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity). (297 aa)
prp-19Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Core component of the NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity (By similarity). Together with emb-4, necessary for interaction of rnp-4, a probable exon junction complex component, with mRNAs and spliceosomal snRNAs. Plays a role in nuclear retention of unspliced mRNAs. Belongs to the WD repeat PRP19 family. (492 aa)
T09F3.5Uncharacterized protein. (528 aa)
T09F3.4Uncharacterized protein. (223 aa)
eri-13'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. (582 aa)
pelo-1Protein pelota homolog; Required for normal chromosome segregation during cell division and genomic stability. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity. (381 aa)
pde-12Endo/exonuclease/phosphatase domain-containing protein. (628 aa)
pde-4Probable 3',5'-cyclic phosphodiesterase pde-4; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Antagonizes dorsal D (DD) motor neuron respecification by reducing levels of cAMP. (674 aa)
R13A5.10CMP/dCMP-type deaminase domain-containing protein. (153 aa)
nth-1Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (298 aa)
mag-1Protein mago nashi homolog; Involved in hermaphrodite germline sex determination. May allow oogenesis by inhibiting the function of one or more of the masculinizing genes (fog, fem, and gld) which act during the fourth larval stage to promote transient sperm production in the hermaphrodite germline; Belongs to the mago nashi family. (152 aa)
pde-2Probable 3',5'-cyclic phosphodiesterase pde-2; May negatively regulate the activity of cGMP-dependent protein kinase egl-4 which in turn controls body size. (831 aa)
rnp-4RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (142 aa)
mig-23Nucleoside-diphosphatase mig-23; Seems to be able to hydrolyze ADP, UDP and GDP. Supports mig- 17 glycosylation and surface expression, which is required for proper migration of distal tip cells during gonad morphogenesis. (552 aa)
edc-3DFDF domain-containing protein. (566 aa)
rle-1Regulation of longevity by E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase. Regulates the activity of daf-16 and is thereby involved in regulating aging and stress resistance. Regulates nsy-1 activity and thereby attenuates the activation of sek-1 and pmk-1, two components of the p38 pathway, which results in susceptibility to pathogenic bacterial infection. (952 aa)
M01G12.9Uncharacterized protein. (469 aa)
M01G12.7Uncharacterized protein. (460 aa)
M01G12.14Uncharacterized protein. (350 aa)
dcr-1Death-promoting deoxyribonuclease; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing. Belongs to the helicase family. Dicer subfamily. (1910 aa)
K12D12.5RNase H domain-containing protein. (648 aa)
K10C9.3Ribonuclease T2 protein rnst-2; Probable endoribonuclease involved in the autophagy-mediated degradation of ribosomal RNA and ribosomal proteins in lysosomes. (279 aa)
parn-13'-5' exoribonuclease parn-1; Involved in transcriptome surveillance. Required for piwi- interacting RNAs (piRNAs) 3'-end trimming, which is important for both fertility and piRNA-directed gene silencing. Has 3' to 5' exonuclease activity in vitro. (566 aa)
uda-1Nucleoside-diphosphatase uda-1; Hydrolyzes UDP and GDP but not any other nucleoside di-, mono- or triphosphates. May promote reglycosylation reactions involved in glycoproteins folding and quality control in the endoplasmic reticulum; Belongs to the GDA1/CD39 NTPase family. (479 aa)
dut-1Deoxyuridinetriphosphatase. (491 aa)
crn-6Cell death-related nuclease 6; Involved in the degradation of chromosomal DNA. Contributes to cell killing; Belongs to the DNase II family. (378 aa)
smg-8Protein smg-8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes. Belongs to the SMG8 family. (873 aa)
ahcy-1Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. (437 aa)
exos-3KH_dom_type_1 domain-containing protein. (226 aa)
rnh-1.0Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (251 aa)
let-711Not1 domain-containing protein. (2641 aa)
eme-1Essential Meiotic Endonuclease. (454 aa)
dom-3Decapping nuclease dom-3; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). (393 aa)
dcap-2mRNA-decapping enzyme 2; RNA-decapping enzyme although it does not bind cap. May contribute to gene regulation in multiple RNA pathways including monomethylguanosine- and trimethylguanosine-capped RNAs. Belongs to the Nudix hydrolase family. DCP2 subfamily. (786 aa)
cdd-2Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (166 aa)
disl-2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. (848 aa)
smg-4Smg4_UPF3 domain-containing protein. (368 aa)
tag-153NOT2_3_5 domain-containing protein. (733 aa)
patr-1Protein PAT1 homolog 1; RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery (By similarity); Belongs to the PAT1 family. (833 aa)
rpb-4RPOL4c domain-containing protein. (144 aa)
lem-3Ankyrin repeat and LEM domain-containing protein 1 homolog; Endonuclease which, in association with baf-1, plays an essential role during embryogenesis in the DNA repair response following DNA damage probably by ensuring proper chromosome segregation. Also required during postembryonic cell divisions after DNA damage caused by ionizing radiation to ensure normal cell proliferation. Resolves chromatin bridges in late mitosis that result from incomplete DNA replication, defective chromosome condensation or unresolved recombination intermediates. Together with brc-1, contributes to genome [...] (704 aa)
exos-8RNase_PH domain-containing protein. (277 aa)
lsm-1U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (125 aa)
ncbp-1Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-1 does not bind directly capped RNAs (m7GpppG- capped RNA) but is required to stabilize the movement of the N-terminal loop of ncbp-2 and lock the CBC into a high affinity cap-binding state with the c [...] (798 aa)
exos-9EXOSome (Multiexonuclease complex) component. (434 aa)
mlcd-1MaLonyl CoA Decarboxylase. (442 aa)
F33D11.10Uncharacterized protein; Belongs to the DEAD box helicase family. (399 aa)
panl-2Uncharacterized protein F31E3.4. (1131 aa)
exos-7RNase_PH domain-containing protein. (312 aa)
drsh-1Ribonuclease 3; Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA. Belongs to the ribonuclease III family. (1086 aa)
F21D5.6RNase_H2-Ydr279 domain-containing protein. (290 aa)
hint-1Histidine triad nucleotide-binding protein 1. (130 aa)
smgl-1Uncharacterized protein. (1615 aa)
puf-6Pumilio domain-containing protein 6; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-5 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. (485 aa)
ndx-9NADH pyrophosphatase; Belongs to the Nudix hydrolase family. NudC subfamily. (374 aa)
tir-1NAD(+) hydrolase tir-1; NAD(+) hydrolase, which plays a key role in non-apoptotic cell death by regulating NAD(+) metabolism. In response to stress, homooligomerizes and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage promoting non-apoptotic neuronal cell death. In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development. Required for both innate immune response and specification of AWC(OFF) neuron. During late embryogenesis, it. acts downstream of CAMKII (unc-43) to regulate specification [...] (984 aa)
tsn-1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (914 aa)
F10E7.5Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (220 aa)
crn-7Cell-death-related nuclease 7; Belongs to the DNase II family. (367 aa)
F09E5.3Putative deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (303 aa)
apy-1Apyrase apy-1; Hydrolyzes UDP and to a lesser extent GDP. By preventing the accumulation of NDP, may promote the reglucosylation of incompletely folded glycoproteins in the endoplasmic reticulum following the unfolded protein response. (355 aa)
F07H5.10RAI1 domain-containing protein. (334 aa)
F02A9.10-2Ribosomal protein L44, mitochondrial; Component of the mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. (394 aa)
skih-2SKI (Yeast SuperKIller) Helicase homolog. (1266 aa)
crn-2Cell death-related nuclease 2. (286 aa)
smg-1Serine/threonine-protein kinase smg-1; Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating smg-2. (2322 aa)
cdd-1Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (158 aa)
C44B7.12Adenosine deaminase-like protein; Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (388 aa)
mus-81ERCC4 domain-containing protein. (445 aa)
cps-6Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. (308 aa)
C37H5.14RAI1 domain-containing protein. (322 aa)
ntp-1Nucleoside-triphosphatase ntp-1; Seems to be able to hydrolyze CTP, ATP and UTP. (543 aa)
ntl-9NOT-Like (Yeast CCR4/NOT complex component). (330 aa)
hel-1Spliceosome RNA helicase DDX39B homolog; Required for mRNA export out of the nucleus. May play a role in spliceosome assembly. (425 aa)
dpyd-1Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). Involved in the degradation of the chemotherapeutic drug 5-fluorouracil. (1059 aa)
tiar-1RRM domain-containing protein. (408 aa)
crn-5RNase_PH domain-containing protein. (214 aa)
crn-3HRDC domain-containing protein. (876 aa)
lin-41Protein lin-41; Heterochronic protein which acts downstream of let-7 in temporal patterning. Plays a role in the developmental timing of postembryonic hypodermal seam cell division and fusion events and adult alae production. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Involved in post-transcriptional gene regulation, uses two independent pathways. Has direct and specific RNA-binding activity and, depending on the location (5'UTR or 3'UTR) of the target site, triggers either mRNA decay or repr [...] (1147 aa)
C08F8.2ATP-dependent RNA helicase SUV3 homolog, mitochondrial; ATPase and DNA/RNA helicase able to unwind DNA/DNA, DNA/RNA and RNA/RNA duplexes in the 5'-3' direction. (719 aa)
nuc-1Deoxyribonuclease-2; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Implicated in apoptosis. Belongs to the DNase II family. (375 aa)
C06G3.5A_deaminase domain-containing protein. (391 aa)
ain-1ALG-1 INteracting protein. (641 aa)
dis-3Probable exosome complex exonuclease RRP44; Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. dis-3 has both 3'-5' exonuclease and endonuclease activities (By similarity). (961 aa)
rnh-1.3RNase H domain-containing protein. (139 aa)
BE0003N10.1S1 motif domain-containing protein. (738 aa)
exos-4.1Putative exosome complex component RRP41; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events; Belongs to the RNase PH family. (240 aa)
ntl-2NOT2_3_5 domain-containing protein. (444 aa)
ain-2ALG-1 INteracting protein. (748 aa)
crn-4Cell death-related nuclease 4; Involved in the degradation of chromosomal DNA. Contributes to cell killing. (298 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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