STRINGSTRING
best-26 best-26 best-3 best-3 best-2 best-2 best-1 best-1 best-5 best-5 C09B9.85 C09B9.85 ggr-1 ggr-1 best-7 best-7 best-8 best-8 best-9 best-9 best-10 best-10 best-11 best-11 acc-2 acc-2 best-12 best-12 glc-2 glc-2 exl-1 exl-1 best-13 best-13 ttyh-1 ttyh-1 acc-3 acc-3 acc-1 acc-1 best-15 best-15 best-16 best-16 best-17 best-17 best-18 best-18 best-19 best-19 acc-4 acc-4 exc-4 exc-4 best-20 best-20 best-21 best-21 gab-1 gab-1 best-22 best-22 best-23 best-23 best-24 best-24 best-25 best-25 best-4 best-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
best-26Bestrophin homolog 26; Forms chloride channels. (411 aa)
best-3Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (612 aa)
best-2Bestrophin homolog 2; Forms chloride channels. (421 aa)
best-1Bestrophin homolog 1; Forms chloride channels. (450 aa)
best-5Bestrophin homolog 5; Forms chloride channels. (453 aa)
C09B9.85Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (555 aa)
ggr-1Glycine receptor subunit beta-type 4; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Contributes to the generation of inhibitory postsynaptic currents. (473 aa)
best-7Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (540 aa)
best-8Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (512 aa)
best-9Bestrophin homolog 9; Forms chloride channels. (399 aa)
best-10Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (423 aa)
best-11Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (444 aa)
acc-2Acetylcholine-gated chloride channel subunit acc-2; Acetylcholine-gated chloride channel subunit. Currents in channels are triggered in response to acetylcholine. Channel properties may be modulated by the formation of homomeric and heteromeric channels. (445 aa)
best-12Bestrophin homolog 12; Forms chloride channels. (434 aa)
glc-2Glutamate-gated chloride channel subunit beta; Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration. Channels containing only glc- 2 are activated by glutamate, but not by ivermectin (in vitro). The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid. (434 aa)
exl-1Chloride intracellular channel exl-1; Probable chloride channel; Belongs to the chloride channel CLIC family. (238 aa)
best-13Bestrophin homolog 13; Forms chloride channels. (413 aa)
ttyh-1Protein tweety homolog 1; Probable chloride channel. (519 aa)
acc-3Acetylcholine-gated chloride channel subunit acc-3; Probable acetylcholine-gated chloride channel regulatory subunit. Does not have ion channel activity alone as a homopentamer, but forms a functional heteropentameric ion channel with acc-1. Belongs to the ligand-gated ion channel (TC 1.A.9) family. (517 aa)
acc-1Acetylcholine-gated chloride channel subunit acc-1; Acetylcholine-gated chloride channel subunit. Forms functional homopentameric (in vitro) and functional heteropentameric ion channels with acc-3 and acc-4 ion channel subunits. Currents in channels are triggered in response to acetylcholine, but not in response to GABA, glutamate, glycine, histamine or dopamine. (470 aa)
best-15Bestrophin homolog 15; Forms chloride channels. (525 aa)
best-16Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (463 aa)
best-17Bestrophin homolog 17; Forms chloride channels. (501 aa)
best-18Bestrophin homolog 18; Forms chloride channels. (456 aa)
best-19Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (569 aa)
acc-4Acetylcholine-gated ion channel acc-4; Probable acetylcholine-gated chloride channel subunit. Does not have ion channel activity alone as a homopentamer, but forms a functional heteropentameric ion channel with acc-1. May function with lgc-46 to regulate synaptic transmission and synaptic vesicle release in response to acetylcholine in cholinergic motor neurons. (408 aa)
exc-4Chloride intracellular channel exc-4; May insert into membranes and form chloride ion channels. Involved in the formation of the excretory canal. Required to prevent cystic lumenal expansions in the excretory cell. Not required for formation of the initial tube, but is required for regulating the size of the tube lumen as it grows. (290 aa)
best-20Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (486 aa)
best-21Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (395 aa)
gab-1Gamma-aminobutyric acid receptor subunit beta; GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. (550 aa)
best-22Bestrophin homolog 22; Forms chloride channels. (510 aa)
best-23Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (405 aa)
best-24Bestrophin homolog 24; Forms chloride channels. (632 aa)
best-25Bestrophin homolog 25; Forms chloride channels. (602 aa)
best-4Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (558 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.