STRINGSTRING
nrde-3 nrde-3 C04F12.1 C04F12.1 lin-41 lin-41 hrde-1 hrde-1 ppw-1 ppw-1 alg-1 alg-1 sago-2 sago-2 wago-4 wago-4 rde-1 rde-1 sago-1 sago-1 wago-1 wago-1 ergo-1 ergo-1 alg-2 alg-2 alg-3 alg-3 wago-10 wago-10 alg-5 alg-5 ppw-2 ppw-2 wago-5 wago-5 alg-4 alg-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nrde-3Nuclear RNAi defective-3 protein; Transports small interfering RNAs (siRNAs) from the cytoplasm to the nucleus. Required for RNA interference (RNAi) in nuclei. Required for exogenous RNAi-induced H3K27 methylation. (1057 aa)
C04F12.1Piwi domain-containing protein. (944 aa)
lin-41Protein lin-41; Heterochronic protein which acts downstream of let-7 in temporal patterning. Plays a role in the developmental timing of postembryonic hypodermal seam cell division and fusion events and adult alae production. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Involved in post-transcriptional gene regulation, uses two independent pathways. Has direct and specific RNA-binding activity and, depending on the location (5'UTR or 3'UTR) of the target site, triggers either mRNA decay or repr [...] (1147 aa)
hrde-1Uncharacterized protein C16C10.3. (1032 aa)
ppw-1Piwi-like protein; Belongs to the argonaute family. (887 aa)
alg-1Protein argonaute; Belongs to the argonaute family. (1023 aa)
sago-2Piwi-like protein; Belongs to the argonaute family. (887 aa)
wago-4Argonaute protein wago-4; Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway and is required for RNA-mediated gene silencing (RNAi) in the germline. Interacts with secondary 22G-RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue. Also interacts with the mRNA targets of 22G-RNAs. Associates with znfx-1 to mediate small RNA-directed transgenerational epigenetic inheritance of both germline- and soma-expressed genes. Belongs to the argonaute family. WAGO subfamily. (965 aa)
rde-1RNA interference promoting factor RDE-1. (1020 aa)
sago-1Piwi-like protein; Belongs to the argonaute family. (881 aa)
wago-1Argonaute protein wago-1; Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway. Interacts with secondary 22G- RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue. In the germline, functions in a genome surveillance system to silence transposons and aberrant transcripts. (945 aa)
ergo-1Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...] (1121 aa)
alg-2Protein argonaute; Belongs to the argonaute family. (910 aa)
alg-3Argonaute (Plant)-Like protein. (1035 aa)
wago-10Piwi-like protein; Belongs to the argonaute family. (990 aa)
alg-5Protein argonaute; Belongs to the argonaute family. (905 aa)
ppw-2Piwi-like protein; Belongs to the argonaute family. (975 aa)
wago-5Piwi-like protein; Belongs to the argonaute family. (912 aa)
alg-4Putative protein tag-76. (1040 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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