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| | Y22D7AR.7 | Tyrosine-protein phosphatase domain-containing protein. (767 aa) |
| | Y18H1A.1 | Tyrosine-protein phosphatase domain-containing protein. (483 aa) |
| | Y116A8C.37 | Tyrosine-protein phosphatase domain-containing protein. (298 aa) |
| | Y113G7C.1 | Protein-tyrosine-phosphatase. (1494 aa) |
| | W03F11.4 | Protein-tyrosine-phosphatase. (1371 aa) |
| | W01B6.6 | Uncharacterized protein. (366 aa) |
| | VW02B12L.2 | Uncharacterized protein. (122 aa) |
| | T28F4.3 | Protein-tyrosine-phosphatase. (490 aa) |
| | T27A3.5 | Tyrosine-protein phosphatase. (355 aa) |
| | mtm-3 | Myotubularin-related protein 3; Preferentially dephosphorylates phosphatidylinositol 3- phosphate (PI3P), and has some activity towards phosphatidylinositol 3,5-bisphosphate (PI35P). May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity). Positively regulates autophagy and is recruited to autophagosomes by PI3P where it catalyzes PI3P turnover to promote autophagosome maturation. Thought to have a role in maintenance of muscle function. Involved in locomotion and lifespan determination. (1006 aa) |
| | T22C1.8 | Tyrosine-protein phosphatase. (591 aa) |
| | egg-4 | Inactive protein-tyrosine phosphatase egg-4; Inactive phosphatase which acts redundantly with egg-5 in the oocyte-to-zygote transition. Required for the polarization of cortical actin cytoskeleton rearrangement in the oocyte before and after fertilization. Together with egg-5, required for the cortical localization of kinase mbk-2 and for the inhibition of mbk-2 kinase activity in maturing oocyte until the end of meiosis I. Also required for kinase mbk-2, pseudophosphatase egg-3 and chitin synthase chs-1 localization to cytoplasmic foci after fertilization. (753 aa) |
| | T19D2.2 | Putative prenylated protein tyrosine phosphatase. (190 aa) |
| | T13H5.1 | Tyrosine-protein phosphatase. (864 aa) |
| | T12B3.1 | TYR_PHOSPHATASE_2 domain-containing protein. (446 aa) |
| | daf-18 | Abnormal dauer formation protein 18; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (By similarity). Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate. By dephosphorylating PtdIns(3,4,5)P3 antagonizes PtdIns(3,4,5)P3 production by age-1/PI3K and thus, negatively regulates daf-2-mediated processes including dauer formation, longevity, fat metabolism, chemotaxis towards salt, thermotolerance and axon guidance. Similarly, [...] (962 aa) |
| | T04F3.3 | Uncharacterized protein. (364 aa) |
| | R155.3 | Protein-tyrosine-phosphatase. (1165 aa) |
| | moa-1 | Modifier Of Apl-1 activity. (1238 aa) |
| | egg-5 | Inactive protein-tyrosine phosphatase egg-5; Inactive phosphatase which acts redundantly with egg-4 in the oocyte-to-zygote transition. Required for polarized cortical actin cytoskeleton rearrangement in the oocyte before and after fertilization. Together with egg-4, required for the cortical localization of kinase mbk-2 in maturing oocyte until the end of meiosis I. Also required for kinase mbk-2, pseudophosphatase egg-3 and chitin synthase chs-1 localization to cytoplasmic foci after fertilization. (753 aa) |
| | R10F2.6 | Tyrosine-protein phosphatase domain-containing protein. (1161 aa) |
| | cdc-25.4 | Rhodanese domain-containing protein. (278 aa) |
| | M05D6.3 | Tyrosine-protein phosphatase domain-containing protein. (397 aa) |
| | M05B5.1 | Uncharacterized protein. (445 aa) |
| | M04G7.2 | Tyrosine-protein phosphatase. (550 aa) |
| | tns-1 | Tensin homolog; Probable phosphatase which regulates axon regeneration after injury by linking the svh-2 and integrin signaling pathways. (1354 aa) |
| | M01A12.4 | PTPc_motif domain-containing protein. (232 aa) |
| | K09F6.3 | Protein-tyrosine-phosphatase. (1391 aa) |
| | K07F5.8 | Tyrosine-protein phosphatase. (284 aa) |
| | K07F5.6 | Uncharacterized protein. (470 aa) |
| | F25H5.7 | Protein-tyrosine-phosphatase. (490 aa) |
| | F35C11.2 | Uncharacterized protein. (397 aa) |
| | F36H1.3 | Tyrosine-protein phosphatase. (532 aa) |
| | F36H12.10 | Tyrosine-protein phosphatase. (398 aa) |
| | F38H4.4 | Uncharacterized protein. (501 aa) |
| | F40G12.10 | Uncharacterized protein. (438 aa) |
| | F42C5.5 | Tyrosine-protein phosphatase domain-containing protein. (330 aa) |
| | egg-3 | Protein tyrosine phosphatase-like protein egg-3; Probable pseudophosphatase required for the oocyte-to-zygote transition during which it regulates the polarized dispersal of the cortical actin cytoskeleton, the synthesis of the eggshell chitin layer and the formation of the polar bodies after meiosis I and II. Acts as scaffold to tether kinase mbk-2 and pseudophosphatases egg-4 and egg-5 to the oocyte cortex and thus restricts mbk-2 activity to the cortex during meiosis I. Regulates mbk-2 localization to cytoplasmic foci during meiosis II. Also required for chitin synthase chs-1 locali [...] (555 aa) |
| | dep-1 | Receptor-type tyrosine-protein phosphatase dep-1; Phosphatase which may dephosphorylate receptor let-23 and thereby regulate cell fate during the development of the vulva and the excretory system. By inhibiting let-23 signaling prevents the establishment of a primary cell fate in the descendants of vulva precursor cells P5.p and P7.p. Similarly, may prevent duct cell fate in ABpr precursor. Also dephosphorylates the beta-integrin subunit pat-3, probably within the alpha pat-2/beta pat-3 integrin receptor complex, which leads to down- stream effects including the negative regulation of [...] (1367 aa) |
| | F47B3.1 | Tyrosine-protein phosphatase. (363 aa) |
| | F47B3.2 | Uncharacterized protein. (130 aa) |
| | F47B3.7 | Tyrosine-protein phosphatase. (374 aa) |
| | F54C8.4 | Probable tyrosine-protein phosphatase F54C8.4. (359 aa) |
| | F54F12.1 | Protein-tyrosine-phosphatase. (1217 aa) |
| | F55F8.7 | Protein-tyrosine-phosphatase. (491 aa) |
| | F55H12.5 | Tyrosine-protein phosphatase domain-containing protein. (287 aa) |
| | clr-1 | Receptor-type tyrosine-protein phosphatase; Possesses an intrinsic protein tyrosine phosphatase (PTPase) activity. Regulates egl-15 activity which is required for hypodermis-mediated fluid homeostasis and protein degradation in muscle. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine. Regulates synaptic levels of nAchR subunit lev-1 in the nerve cord. Promotes the outgrowth of the quaternary dendritic branches of [...] (1444 aa) |
| | F57H12.5 | Uncharacterized protein. (543 aa) |
| | ptp-2 | Tyrosine-protein phosphatase non-receptor type ptp-2; Involved in embryonic and larval development. Plays a role in oogenesis by regulating mpk-1 phosphorylation and oocyte maturation in response to major sperm protein (MSP). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of receptor egl-15. Plays a role in fluid homeostasis probably downstream of receptor egl-15 and adapter soc-1. Promotes vulva induction and negatively regulates fertility probably downstream of receptor let-23. N [...] (668 aa) |
| | ptp-4 | Tyrosine-protein phosphatase 4. (1159 aa) |
| | B0207.1 | Tyrosine-protein phosphatase. (564 aa) |
| | ida-1 | Receptor-type tyrosine-protein phosphatase-like ida-1; Regulates dense-core vesicle (DCV) trafficking and/or secretion. Probably by controlling DCV trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Involved in locomotion by regulating acetylcholine release. Probably by controlling the secretion of FLP neuropeptides, regulates the turning step of male mating behavior. Plays a role in preventing dauer formation. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. (767 aa) |
| | B0280.11 | Putative tyrosine-protein phosphatase B0280.11. (441 aa) |
| | C02B10.6 | Tyrosine-protein phosphatase. (398 aa) |
| | cel-1 | Polynucleotide 5'-triphosphatase; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. (623 aa) |
| | lip-1 | Dual specificity protein phosphatase lip-1; Dephosphorylates MAP kinase mpk-1. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa) |
| | C07E3.4 | Tyrosine-protein phosphatase domain-containing protein. (512 aa) |
| | ptp-3 | Tyrosine-protein phosphatase Lar-like; Has a role in early neural and epidermal development; neuroblast movements during closure of the gastrulation cleft and epidermal morphogenesis. Vab-1 and ptp-3 may function redundantly within the same sets of neuronal precursors. (2248 aa) |
| | C15H7.3 | Putative tyrosine-protein phosphatase C15H7.3. (398 aa) |
| | cdc-14 | Tyrosine-protein phosphatase cdc-14; Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal. Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development. Has been shown to not be required for cytokinesis. However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and [...] (709 aa) |
| | C17H12.3 | Tyrosine-protein phosphatase. (374 aa) |
| | C17H12.5 | Uncharacterized protein. (443 aa) |
| | C24D10.1 | Protein Tyrosine Phosphatase. (482 aa) |
| | C24F3.2 | Uncharacterized protein. (272 aa) |
| | pph-2 | Protein PHosphatase. (430 aa) |
| | C33F10.8 | Uncharacterized protein. (463 aa) |
| | C33H5.16 | Tyrosine-protein phosphatase. (341 aa) |
| | hpo-7 | Uncharacterized protein. (285 aa) |
| | C43E11.5 | Tyrosine-protein phosphatase domain-containing protein. (368 aa) |
| | cdc-25.1 | M-phase inducer phosphatase cdc-25.1. (604 aa) |
| | C46A5.1 | Uncharacterized protein. (497 aa) |
| | C48B6.4 | Tyrosine-protein phosphatase domain-containing protein. (623 aa) |
| | ptp-1 | Tyrosine-protein phosphatase 1. (1026 aa) |
| | eya-1 | Eyes absent homolog 1; Tyrosine protein phosphatase (By similarity). Acts probably as a transcription regulator in the embryonic and postembryonic development of several tissues including pharynx, vulva and gonads. Required for the development of anterior tissues during late embryogenesis. Together with ceh-34, required to specify the coelomocyte fate in embryonic and postembryonic precursors. In the anterior part of the embryo, prevents apoptosis in cells that are not fated to die. Together with ceh-34 activates proapoptotic factor egl-1 expression to promote motor neuron M4 sister ce [...] (503 aa) |
| | C50F2.5 | Tyrosine-protein phosphatase domain-containing protein. (368 aa) |
| | C55B7.3 | Tyrosine-protein phosphatase. (346 aa) |
| | vhp-1 | Tyrosine-protein phosphatase vhp-1; Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response and in axon regeneration by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (661 aa) |
| | F10G8.1 | Tyrosine-protein phosphatase. (346 aa) |
| | cdc-25.2 | M-phase inducer phosphatase cdc-25.2; Required for intestinal cell division following the 16E cell stage of embryogenesis. Regulates intestinal cell divisions and binucleations probably by modulating the activity of the cell cycle regulator wee-1.3 and by activating the cdk-1/cyb-1 complex. Belongs to the MPI phosphatase family. (480 aa) |
| | F20H11.4 | Protein-tyrosine-phosphatase. (446 aa) |
| | Y39A3A.4 | Tyrosine-protein phosphatase. (331 aa) |
| | Y39B6A.30 | Uncharacterized protein. (1408 aa) |
| | Y41D4A.5 | Tyrosine-protein phosphatase. (469 aa) |
| | sdf-9 | Protein sdf-9; Together with eak-4 and phosphatase eak-6, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel of age-1, pdk-1 and akt-1. (345 aa) |
| | Y48G1C.5 | Uncharacterized protein. (1161 aa) |
| | Y48G9A.9 | Tyrosine-protein phosphatase. (361 aa) |
| | Y54F10BM.3 | Uncharacterized protein. (781 aa) |
| | Y57G11C.6 | Protein Tyrosine Phosphatase. (482 aa) |
| | Y62F5A.10 | Uncharacterized protein. (437 aa) |
| | Y69A2AR.19 | Uncharacterized protein. (1338 aa) |
| | Y71F9AL.4 | Uncharacterized protein. (557 aa) |
| | Y71G12B.31 | Tyrosine-protein phosphatase. (423 aa) |
| | Y80D3A.8 | Uncharacterized protein. (1275 aa) |
| | Y94H6A.7 | LMWPc domain-containing protein. (164 aa) |
| | ZK354.8 | Tyrosine-protein phosphatase. (483 aa) |
| | ZK484.7 | Tyrosine-protein phosphatase. (344 aa) |
| | ZK616.65 | Tyrosine-protein phosphatase. (543 aa) |
| | cdc-25.3 | M-phase inducer phosphatase cdc-25.3. (316 aa) |
| | ZK809.1 | Uncharacterized protein. (428 aa) |
