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| | nlp-28 | Neuropeptide-like protein 28; May have antimicrobial activity; Belongs to the YARP (YGGW-amide related peptide) family. (65 aa) |
| | gad-3 | Probable aldehyde oxidase gad-3; May be involved in the metabolism of 1-methylnicotinamide (MNA). Linked to regulation of longevity through generation of reactive oxygen species, where it probably functions in a pathway downstream of the sirtuin sir-2.1 and the nicotinamide N-methyltransferase anmt-1. Belongs to the xanthine dehydrogenase family. (1257 aa) |
| | ckb-2 | Choline kinase B2; Catalyzes the first step in phosphatidylcholine biosynthesis. Phosphorylates choline. (369 aa) |
| | acl-12 | Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-12; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. (391 aa) |
| | C04F12.1 | Piwi domain-containing protein. (944 aa) |
| | pept-2 | Peptide transporter family 2; Proton-dependent uptake of di- or tripeptides, and to a minor extent tetrapeptides. Transport is independent of sodium and chloride ions. Protein shows high affinity to peptide substrates. Belongs to the PTR2/POT transporter (TC 2.A.17) family. (785 aa) |
| | pdi-2 | Protein disulfide-isomerase 2; Involved in cuticle formation. May play a role in the unfolded protein response. Belongs to the protein disulfide isomerase family. (493 aa) |
| | catp-3 | Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1054 aa) |
| | hsp-70 | Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa) |
| | pdi-1 | Protein disulfide-isomerase 1; Belongs to the protein disulfide isomerase family. (485 aa) |
| | C14B9.2 | Probable protein disulfide-isomerase A4; Belongs to the protein disulfide isomerase family. (618 aa) |
| | hsp-3 | Heat shock 70 kDa protein C; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. (661 aa) |
| | C34B2.10 | Probable signal peptidase complex subunit 1; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (105 aa) |
| | lonp-1 | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. Involved in the degradation of transcription factor atfs-1 in the mi [...] (971 aa) |
| | C36B7.6 | Uncharacterized protein. (602 aa) |
| | fipr-24 | FIP (Fungus-Induced Protein) Related. (89 aa) |
| | ire-1 | Serine/threonine-protein kinase/endoribonuclease ire-1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices xbp-1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes. Unfolded protein response (UPR) transcriptional activation by ire-1, as well as translational attenuation by pek-1 in a complementary pathway, maintains ER homeostasis. Regulates the transcriptional up-regulation of nucleoside-diphosphatase apy-1 upon ER str [...] (967 aa) |
| | cdc-48.2 | Transitional endoplasmic reticulum ATPase homolog 2; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. However, able to prevent aggregation of unfolded proteins also in an ATP-independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents [...] (810 aa) |
| | tag-335 | Mannose-1-phosphate guanyltransferase beta; Belongs to the transferase hexapeptide repeat family. (365 aa) |
| | gale-1 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] (349 aa) |
| | C47E12.3 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (568 aa) |
| | bre-1 | GDP-mannose 4,6 dehydratase 1; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. Involved in susceptibility to pore- forming crystal toxins in conjunction with bre-2, bre-3, bre-4, and bre-5. Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of N-glycans to which Cgl2 binds. Has a role in determining brood size. Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. (399 aa) |
| | snap-1 | SNAP (Soluble NSF Attachment Protein) homolog. (295 aa) |
| | gfat-1 | Glutamine-Fructose 6-phosphate AminoTransferase homolog. (725 aa) |
| | F07F6.4 | Uncharacterized protein F07F6.4; GTPase-activating protein for the ADP ribosylation factor family. (529 aa) |
| | apy-1 | Apyrase apy-1; Hydrolyzes UDP and to a lesser extent GDP. By preventing the accumulation of NDP, may promote the reglucosylation of incompletely folded glycoproteins in the endoplasmic reticulum following the unfolded protein response. (355 aa) |
| | erd-2 | ER lumen protein-retaining receptor erd-2.1; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi (By similarity); Belongs to the ERD2 family. (213 aa) |
| | crld-1 | Protein disulfide isomerase crld-1; Protein disulfide isomerase which associates with the unc-29 subunit of levamisole-sensitive nicotinic acetylcholine receptors (L- nAChR) to promote L-nAChR assembly in the endoplasmic reticulum at neuromuscular junctions. (356 aa) |
| | fis-2 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (151 aa) |
| | rtcb-1 | RNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs. Required for the ligation of mRNAs and specifically, regulates xbp-1 mRNA splicing during the endoplasmic reticulum stress- induced unfolded protein response. Has a neuroprotective role in the age-dependent degeneration of dopamine neurons, which is mediated by xbp-1. Belongs to the RtcB family. (505 aa) |
| | col-89 | Col_cuticle_N domain-containing protein. (296 aa) |
| | F18H3.4 | Uncharacterized protein. (459 aa) |
| | srp-7 | SERPIN domain-containing protein; Belongs to the serpin family. (373 aa) |
| | F22E5.6 | BTB domain-containing protein. (225 aa) |
| | ckb-4 | Choline Kinase B. (381 aa) |
| | ubxn-1 | UBX domain-containing protein 1; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. (299 aa) |
| | cup-2 | Derlin-1; Specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Belongs to the derlin family. (245 aa) |
| | tag-353 | Ubiquitin-like domain-containing protein. (361 aa) |
| | uggt-2 | UDP-Glucose Glycoprotein glucosylTransferase. (1381 aa) |
| | irld-6 | Recep_L_domain domain-containing protein. (525 aa) |
| | F38E1.9 | Mannose-P-dolichol utilization defect 1 protein homolog. (242 aa) |
| | F41B4.3 | Uncharacterized protein. (134 aa) |
| | acs-11 | Fatty Acid CoA Synthetase family. (505 aa) |
| | F41E6.11 | Uncharacterized protein. (316 aa) |
| | ech-3 | Enoyl-CoA Hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa) |
| | sel-1 | Suppressor/Enhancer of Lin-12. (685 aa) |
| | arf-1.1 | ADP-ribosylation factor 1-like 1; GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus; Belongs to the small GTPase superfamily. Arf family. (179 aa) |
| | rer-1 | Protein RER1 homolog; May be involved in protein transport along the secretory pathway; Belongs to the RER1 family. (191 aa) |
| | F46C5.9 | WD_REPEATS_REGION domain-containing protein. (451 aa) |
| | uggt-1 | UDP-Glucose Glycoprotein glucosylTransferase. (1493 aa) |
| | F52B11.2 | Probable phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions; Belongs to the eukaryotic PMM family. (254 aa) |
| | F54C8.7 | Uncharacterized protein F54C8.7. (307 aa) |
| | stc-1 | STCH (Truncated HSP) family. (450 aa) |
| | sel-11 | E3 ubiquitin-protein ligase hrd-1; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Thought to play [...] (610 aa) |
| | sec-22 | Yeast SEC homolog; Belongs to the synaptobrevin family. (214 aa) |
| | let-607 | BZIP domain-containing protein. (690 aa) |
| | nsf-1 | Vesicle-fusing ATPase; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity); Belongs to the AAA ATPase family. (824 aa) |
| | cdr-4 | Cadmium-inducible lysosomal protein CDR-4. (277 aa) |
| | sec-12 | WD_REPEATS_REGION domain-containing protein. (425 aa) |
| | K02B12.7 | Arf-GAP domain-containing protein. (423 aa) |
| | dsc-4 | Microsomal triglyceride transfer protein. (892 aa) |
| | dhhc-10 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (327 aa) |
| | frpr-11 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (370 aa) |
| | ile-1 | L-type lectin-like domain-containing protein. (492 aa) |
| | sox-2 | Transcription factor sox-2; Probable transcription factor that regulates the lineage progression of embryonic blast cells and controls the postmitotic specification and differentiation of neurons. Cooperates with additional factors to direct the differentiation of the olfactory neurons, functioning with the transcription factor ceh-36 to specify AWC neurons and with the LIM homeodomain factor lim-4 to suppress AWC terminal differentiation and promote AWB neuron differentiation. Plays a role in the terminal differentiation of glutamatergic and cholinergic neurons. Required for natural r [...] (283 aa) |
| | K08E4.6 | GOLD domain-containing protein. (234 aa) |
| | unc-68 | Uncharacterized protein. (5202 aa) |
| | sca-1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1059 aa) |
| | K12H4.2 | Uncharacterized protein K12H4.2; Belongs to the Iojap/RsfS family. (190 aa) |
| | K12H4.4 | Probable signal peptidase complex subunit 3; Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (180 aa) |
| | rrf-2 | RNA-dependent RNA polymerase Family. (1579 aa) |
| | calu-1 | CALUmenin (Calcium-binding protein) homolog. (314 aa) |
| | ger-1 | GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily. (315 aa) |
| | lec-8 | Probable galaptin lec-8. (180 aa) |
| | R07E5.7 | Uncharacterized protein. (191 aa) |
| | gst-1 | Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). Prevents dopaminergic CEP neuron degeneration in response to Mn(2+). (208 aa) |
| | R12E2.13 | Uncharacterized protein. (206 aa) |
| | R151.6 | Derlin-2; May be required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Its precise function remains unclear, but its ability to complement der1 mutations in C.cerevisiae, suggests a similar function in the degradation of ER misfolded proteins. (237 aa) |
| | xbp-1 | BZIP domain-containing protein. (335 aa) |
| | imp-2 | Intramembrane protease 2; Acts as intramembrane protease (Probable). In larvae, required for the complete shedding of the cuticle during molting, possibly by regulating cholesterol uptake via lrp-1. Involved in embryonic and larval development ; Belongs to the peptidase A22B family. (468 aa) |
| | T06D8.9 | Uncharacterized protein. (316 aa) |
| | T06E4.8 | Uncharacterized protein. (199 aa) |
| | ostb-1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...] (445 aa) |
| | lips-11 | LIPaSe related. (288 aa) |
| | bca-1 | Beta carbonic anhydrase 1; Reversible hydration of carbon dioxide; Belongs to the beta-class carbonic anhydrase family. (270 aa) |
| | T13C5.6 | AcidPPc domain-containing protein. (186 aa) |
| | T14G8.3 | Uncharacterized protein. (921 aa) |
| | skn-1 | Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa) |
| | T24H7.2 | Uncharacterized protein. (925 aa) |
| | hsp-16.11 | Heat shock protein Hsp-16.1/Hsp-16.11. (145 aa) |
| | hsp-16.48 | Heat shock protein Hsp-16.48/Hsp-16.49; Belongs to the small heat shock protein (HSP20) family. (143 aa) |
| | hsp-16.1 | Heat shock protein Hsp-16.1/Hsp-16.11. (145 aa) |
| | hsp-16.49 | Heat shock protein Hsp-16.48/Hsp-16.49. (143 aa) |
| | ero-1 | Endoplasmic reticulum oxidoreductin-1; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity). (513 aa) |
| | hut-1 | Yeast Homolog UDP-Gal Transporter. (340 aa) |
| | cdkr-3 | CDK5RAP3-like protein; Potential regulator of CDK5 activity. (489 aa) |
| | clec-121 | C-type LECtin. (500 aa) |
| | hpo-21 | Probable signal peptidase complex subunit 2; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (180 aa) |
| | crt-1 | Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle (By similarity). This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). Probably by controlling the folding of extracellular matrix protein unc-52/Perlecan, may play a role in the formation of fibrous organelles, a hemidesmosome-like structure attaching muscles to the epidermis. Protects dopaminergic neurons against oxidative stress-induced neurodegen [...] (395 aa) |
| | col-109 | Col_cuticle_N domain-containing protein. (291 aa) |
| | Y38F1A.2 | RING-type domain-containing protein. (283 aa) |
| | gly-5 | Polypeptide N-acetylgalactosaminyltransferase 5; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. (626 aa) |
| | Y41C4A.11 | LITAF domain-containing protein. (101 aa) |
| | Y41E3.8 | Uncharacterized protein. (110 aa) |
| | hsp-16.41 | Heat shock protein Hsp-16.41; Belongs to the small heat shock protein (HSP20) family. (143 aa) |
| | dpy-18 | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. (559 aa) |
| | rft-2 | Riboflavin transporter rft-2; Riboflavin transporter. (476 aa) |
| | dnj-27 | DNaJ domain (Prokaryotic heat shock protein). (788 aa) |
| | Y54E10BR.5 | Signal peptidase complex catalytic subunit SEC11. (183 aa) |
| | Y54G2A.18 | 4D656. (213 aa) |
| | atln-1 | GB1/RHD3-type G domain-containing protein. (573 aa) |
| | ubc-13 | Ubiquitin-conjugating enzyme E2 13; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates. May have a role in AMPA-type glutamate receptor trafficking in neurons. (151 aa) |
| | Y73B6BL.12 | Thioredoxin; Belongs to the thioredoxin family. (136 aa) |
| | sdz-35 | BTB domain-containing protein. (225 aa) |
| | ZK1307.8 | Uncharacterized protein. (507 aa) |
| | sre-23 | Serpentine Receptor, class E (Epsilon). (383 aa) |
| | cutc-1 | Copper homeostasis protein cutC homolog; Involved in copper homeostasis. Affects body morphology and length, egg laying and brood size; Belongs to the CutC family. (250 aa) |
| | unc-13 | Phorbol ester/diacylglycerol-binding protein unc-13; May form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions. One such function could be the release of neurotransmitter from neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. (2155 aa) |
| | cnx-1 | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity). Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death. (619 aa) |
