Your Input: | |
| | gcy-5 | Receptor-type guanylate cyclase gcy-5; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Unlike other guanylate cyclases expressed in ASE neurons, may not play a role in chemotaxis responses to salt ions mediated by ASE sensory neurons. (1122 aa) |
| | gcy-1 | Receptor-type guanylate cyclase gcy-1; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Involved in the sensing of K+ gradient by the ASE right (ASER) sensory neuron. (1137 aa) |
| | gcy-6 | Receptor-type guanylate cyclase gcy-6; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward the salt ion Mg(2+) and to a lesser extent toward Cl(1-) in ASE left (ASEL) sensory neuron. (1086 aa) |
| | che-12 | Crescerin-like protein che-12; Required for normal structure and function of sensory cilia on amphid neurons, especially for the formation of distal ciliary structures, but is less important for normal assembly of middle and basal ciliary structures. Plays a role in the organization of axoneme microtubule bundles in sensory cilia. Required for normal structure and function of the ASER neuron that mediates attraction to NaCl. Required for normal chemotaxis to NaCl. Required for normal avoidance response to high osmolarity. In contrast, is not required for normal chemotaxis to isoamyl al [...] (1282 aa) |
| | avr-14 | Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (430 aa) |
| | daf-11 | Receptor-type guanylate cyclase daf-11; Guanylate cyclase involved in the production of the second messenger cGMP. In addition, regulates cGMP levels by controlling the transcription of 3',5'-cyclic phosphodiesterase pde-1 and pde-5 mRNAs. Involved in the olfactory, light and pheromone sensing pathways. Part of the chemosensory mechanism of the ASJ sensory neuron that controls dauer formation and dauer recovery. Promotes the calcium flux in ASJ sensory neurons in response to onset and removal of a nitric oxide (NO) stimulus and is thereby required for the behavioral avoidance response [...] (1077 aa) |
| | unc-5 | Netrin receptor unc-5; Receptor for netrin (unc-6) required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors. Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced- 10/Rac, ced-12/ELMO and mig-2/RhoG. (947 aa) |
| | age-1 | Phosphatidylinositol 3-kinase age-1; Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the [...] (1182 aa) |
| | egl-8 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration [...] (1512 aa) |
| | unc-44 | Uncharacterized protein. (6994 aa) |
| | dac-1 | Ski_Sno domain-containing protein. (420 aa) |
| | unc-30 | Homeobox protein unc-30; Transcriptional regulator within D-type neurons that controls terminal differentiation. Required for the development and function of the 19 inhibitory GABAergic (gamma-aminobutyric-acid- secreting) D-type motor neurons, which control locomotion. Plays a role in regulating synapse formation in dorsal D (DD) and ventral D (VD) GABAergic motor neurons, possibly in part by regulating the expression of the neural regulator oig-1. Also required for expression of flp-13 in DD motor neurons. Plays a role in respecification of DD motor neurons through regulation of gene [...] (323 aa) |
| | nlp-38 | Neuropeptide-like protein 38; Plays a role in several types of aversive gustatory associative learning including gustatory plasticity and salt avoidance learning. [MIP-1-2]: Neuropeptide ligand for the G-protein coupled receptor sprr-2. (120 aa) |
| | rpm-1 | E3 ubiquitin-protein ligase rpm-1; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of target proteins, including dlk-1. Negatively regulates a p38 MA [...] (3766 aa) |
| | cam-1 | Tyrosine-protein kinase receptor cam-1; Tyrosine-protein kinase receptor for Wnt ligands egl-20, mom- 2 and cwn-1. Involved in the final positioning of migrating ALM, CAN, BDU and HSN neurons during development. Involved in the anterior-posterior migration of QR neuroblast descendants, QR.p and QR.pa, by maintaining QR.p cell polarization, probably through mig-2. In addition, plays a role in ASI sensory neuron positioning and functions. Regulates asymmetric division of V cells (seam cells) and CA/CP neuroblast, and axon outgrowth. Probably by acting as a receptor for Wnt ligand cwn- 2, [...] (928 aa) |
| | dyn-1 | Dynamin; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis. Involved in apoptotic cell phagocytosis. Required for recruitment of phosphatidylinositol 3- kinase piki-1 to phagosomes. May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes. Required for embryonic and larval development. Belongs to the TRAFAC class dynamin-like GTPase supe [...] (838 aa) |
| | snet-1 | Protein snet-1; Negatively regulates chemotaxis and olfactory plasticity which is the change from positive chemotaxis to dispersal after prolonged exposure to an odorant. May be down-regulated in response to pheromone exposure, resulting in promotion of olfactory plasticity. (101 aa) |
| | tax-6 | Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. Dephosphorylates arrd-17. Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation. Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534'. Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium. Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons a [...] (545 aa) |
| | dyf-11 | Uncharacterized protein. (535 aa) |
| | dyf-3 | Clusterin-associated protein 1 homolog; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for sensory cilia biogenesis ; Belongs to the CLUAP1 family. (404 aa) |
| | sor-3 | Sop-2-related protein 3; Probably acts synergistically with sop-2 to maintain the transcriptionally repressive state of homeotic genes in order to regulate various neurogenic identities. Specification of some neuronal identities also involves expression of non-Hox genes. Specifies dopaminergic and serotonergic neuronal cell fate, and regulates neurotransmitter choice and axon pathfinding. (531 aa) |
| | lim-7 | LIM domain family. (452 aa) |
| | unc-78 | Actin-interacting protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Regulator of actin organization in myofibrils. (611 aa) |
| | bas-1 | Biogenic Amine Synthesis related. (523 aa) |
| | unc-94 | Tropomodulin; Acts as the pointed end capping protein which maintains the length and dynamics of the actin filament. Blocks the elongation and depolymerization of the actin filaments at the pointed end (By similarity); Belongs to the tropomodulin family. (401 aa) |
| | glr-1 | Glutamate receptor 1; Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. May contribute to a sensory discrimination between mechanical and chemical stimuli. Plays a role in controlling movement in response to environmental cues such as food availability and mechanosensory stimulation such as the nose touch response. In AIB interneurons, promotes om [...] (962 aa) |
| | pak-1 | Serine/threonine-protein kinase pak-1; Required for hypodermal cell fusion, together with cdc-42 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. Plays a redundant role with max-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. Acts probably downstream of Rho GTPases mig-2 and ced-10 to regulate these 2 processes. Involved in orientating axonal growth of HSN neurons. During gonad morphogenesis and probably in association with pix-1 and git-1, involved in the migration of distal tip ce [...] (572 aa) |
| | zig-4 | Zwei Ig domain protein zig-4; Required for maintaining axon position of PVQ and PVP neurons postembryonically in the ventral nerve cord (VNC) by preventing axons drifting into the opposite side of the VNC that could occur during body growth and movement. (253 aa) |
| | ptp-3 | Tyrosine-protein phosphatase Lar-like; Has a role in early neural and epidermal development; neuroblast movements during closure of the gastrulation cleft and epidermal morphogenesis. Vab-1 and ptp-3 may function redundantly within the same sets of neuronal precursors. (2248 aa) |
| | ced-10 | Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] (191 aa) |
| | mks-5 | Protein fantom; Thought to have an important role in cilia formation and cilia-mediated chemosensation. Involved in the docking of other MKS/MKSR proteins localized to the transition zone of the cilia. Belongs to the RPGRIP1 family. (1322 aa) |
| | mau-2 | Maternal uncoordinated protein 2; Required for association of the cohesin complex with chromatin during interphase. Involved in sister chromatid cohesion and normal progression through prometaphase. Required for normal development until the fourth larval stage. Functions cell autonomously to guide migrations during the development of the nervous system. Participates in the guidance of mechanosensory neuron AVM by a slt-1- independent mechanism. Regulates chromosome segregation in early embryos. (593 aa) |
| | akt-1 | Serine/threonine-protein kinase akt-1; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Has an essential role in regulating developmental arrest at the dauer stage. Plays a role in immune function and pathogen resistance. Regulates salt chemotaxis learning. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic devel [...] (546 aa) |
| | pdfr-1 | Calcitonin receptor-like protein 1; G-protein coupled receptor for PDF neuropeptides. Activated by peptides PDF-1 and PDF-2 but to a lesser extent with isoform c. Isoforms a and b are thought to act through the G-alpha(s) type of G proteins to elevate cAMP levels whereas isoform c inhibits cAMP levels through the G-alpha(i/o) type of G proteins. Involved in locomotion; more specifically mate searching behavior independent of nutritional status. Might have a role in touch sensitivity. (546 aa) |
| | lite-1 | High-energy light unresponsive protein 1; Photoreceptor for short wavelength (UV) light that mediates UV-light-induced avoidance behavior. Directly senses and absorbs both UV-A and UV-B light with very high efficiency. Absorption of UV-B but not UV-A light shows resistance to photobleaching. In contrast to other photoreceptors, does not use a prosthetic chromophore to capture photons and only depends on its protein conformation. (439 aa) |
| | zig-3 | Zwei Ig domain protein zig-3; Required for maintaining axon position of PVQ and PVP neurons postembryonically in the ventral nerve cord (VNC) by preventing axons drifting into the opposite side of the VNC that could occur during body growth and movement. (251 aa) |
| | rol-3 | Protein roller-3; Thought to have a role in developmental establishment of posterior morphology. (2481 aa) |
| | dim-1 | Disorganized muscle protein 1; Stabilizes the attachment of the myofilament lattice to the muscle cell membrane. Isoform b is sufficient for wild-type function. (640 aa) |
| | rab-3 | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. (233 aa) |
| | hlh-14 | BHLH domain-containing protein. (148 aa) |
| | klc-2 | Kinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells. (540 aa) |
| | ift-74 | IFT (Chlamydomonas IntraFlagellar Transport) homolog. (624 aa) |
| | twk-18 | TWiK family of potassium channels protein 18; Outwardly rectifying potassium channel protein; activity is sharply augmented by increase in temperature. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (461 aa) |
| | ddr-1 | Discoidin domain-containing receptor A; Receptor which, together with svh-4, is involved in axon guidance to establish the tracts for the ventral and dorsal nerve cords during nervous system development. May play a role in axon regeneration following injury in D-type motor neurons ; Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. (766 aa) |
| | goa-1 | Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. In the 1-cell embryo, probably together with gpa-16, controls nuclear rotation and spindle elongation during mitosis. During the first embryonic cell divisions, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle. Polarity determinants (par genes) may regulate lin- 5/gpr-1/gpr-2/goa-1 locally to create [...] (354 aa) |
| | eff-1 | Epithelial Fusion Failure. (658 aa) |
| | hil-1 | Histone H1.X. (232 aa) |
| | pde-5 | Probable 3',5'-cyclic phosphodiesterase pde-5; Redundantly with pde-1, plays a role in the AFD thermosensory neurons to regulate microvilli receptive ending morphology, possibly by regulating cGMP levels. (728 aa) |
| | unc-11 | Phosphatidylinositol-binding clathrin assembly protein unc-11; Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Required for the efficient targeting of the synaptic vesicle protein synaptobrevin. Belongs to the PICALM/SNAP91 family. (657 aa) |
| | rig-6 | Contactin rig-6; Probable cell adhesion protein involved in patterning of the nervous system, playing a role in ALM and PLM touch receptor axon growth and VNC axon navigation. By associating with the transmembrane protein sax-7, mediates axonal interactions to establish synaptic connections between the AVG interneuron and the two PHC sensory neurons. Also required for non-neuronal cell migration in the excretory canal, regulating excretory canal elongation and excretory cell morphogenesis. Plays a role in regulating male mating behavior. (1196 aa) |
| | max-1 | Motor AXon guidance. (1099 aa) |
| | odr-3 | Guanine nucleotide-binding protein alpha-17 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. This specific G-alpha subunit plays an important role in olfaction and in cilia morphogenesis. Involved in chemotactic responses to attractants diacetyl, pyrazine, 2,4,5-trimethylthiazole, benzaldehyde, isoamyl alcohol, butanone and 2,3-pentanedione. Displays a redundant function with gpa-3 in chemotactic responses. Involved in avoidance responses to copper, sodium dodecyl sulfate and linoleic acid. I [...] (356 aa) |
| | mig-2 | Rac-like GTPase. (195 aa) |
| | cle-1 | CoLlagen with Endostatin domain. (1175 aa) |
| | mlc-1 | Myosin regulatory light chain 1. (170 aa) |
| | mlc-2 | Myosin regulatory light chain 2. (170 aa) |
| | pry-1 | Axin-like protein pry-1; Works in parallel with axl-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Inhibits Wnt signaling, which affects tissue specific expression of Hox genes, egl- 5, lin-39 and mab-5. This in turn affects QR (postembryonic neuroblast) cell migration, vulval cell fate specification, and the development of sensory structures by the seam cell lineage. Has a role in alae V cell patterning, ray formation in the male tail and axon guidance. Does not affect B cell polarity. (586 aa) |
| | ceh-36 | Homeobox protein ceh-36; Mediates chemosensory function of ASE and AWC neurons. In ASE neurons, required to diversify the fate of the ASEL neurons from the ASER neurons. In cooperation with the transcription factor sox-2, required for the differentiation of AWC olfactory neurons. May regulate the expression of sox-2 in AWC olfactory neurons. Belongs to the paired homeobox family. (257 aa) |
| | unc-60 | Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. (152 aa) |
| | enu-3.2 | ENhancer of Uncoordination. (462 aa) |
| | npr-1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (457 aa) |
| | madd-2 | Uncharacterized protein. (765 aa) |
| | ttx-3 | LIM/homeobox protein ttx-3; Required for specification of the AIA and AIY interneurons and the NSM neurons. Positively regulates the expression of a number of genes including ceh-23, kal-1, hen-1, ser-2, unc-17 and sra-11 in AIY interneurons and cat-4, flp-4, bas-1, ptps-1 and mgl-1 in NSM neurons. Also acts in an autoregulatory feedback loop to maintain its own expression. Plays a role in the thermotactic response, olfactory imprinting, regulation of longevity, control of dauer formation and axon outgrowth and pathfinding. Not required for normal chemosensory behavior. (409 aa) |
| | smn-1 | Tudor domain-containing protein. (207 aa) |
| | efn-2 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. (218 aa) |
| | ncs-1 | Neuronal calcium sensor 1; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Can substitute for calmodulin and directly activate PDE, NO synthase, and calcineurin. Regulates associative learning and memory in a calcium dependent manner. (191 aa) |
| | eor-2 | EOR-2A. (972 aa) |
| | hsp-90 | Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...] (702 aa) |
| | unc-112 | Protein unc-112; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable regulator of cell-extracellular matrix adhesion. Required during initial muscle assembly to form dense bodies and M-lines. (720 aa) |
| | unc-130 | Fork-head domain-containing protein. (333 aa) |
| | rin-1 | VPS9 domain-containing protein. (1890 aa) |
| | eya-1 | Eyes absent homolog 1; Tyrosine protein phosphatase (By similarity). Acts probably as a transcription regulator in the embryonic and postembryonic development of several tissues including pharynx, vulva and gonads. Required for the development of anterior tissues during late embryogenesis. Together with ceh-34, required to specify the coelomocyte fate in embryonic and postembryonic precursors. In the anterior part of the embryo, prevents apoptosis in cells that are not fated to die. Together with ceh-34 activates proapoptotic factor egl-1 expression to promote motor neuron M4 sister ce [...] (503 aa) |
| | gcy-8 | Receptor-type guanylate cyclase gcy-8; Guanylate cyclase involved in the production of the second messenger cGMP. Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. Maintains the microvilli receptive ending morphology of the AFD thermosensory neurons by regulating cGMP levels downstream of kcc-3. cGMP levels antagonize the actin cytoskeleton regulator wsp-1. (1152 aa) |
| | unc-36 | Voltage-dependent calcium channel unc-36; May act as an auxiliary subunit of the unc-2 voltage-gated calcium channel which appears to trigger calcium-activated signaling pathways that control the serotonin response. Inhibiting serotonin sensitivity of the vulval muscles results in egg laying defects. May act in both neurons and muscle cells to enhance motor activity as it is required for coordinated movement. Has a role in neural depolarization- induced calcium influx and pharyngeal pumping. Involved in restricting the expression of the putative olfactory receptor str-2 to only one of [...] (1249 aa) |
| | sop-2 | Polycomb protein sop-2; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Also required to repress expression of other genes and for localization of sor-1. Binds RNA. (737 aa) |
| | rig-3 | Neuronal immunoglobulin domain-containing protein rig-3; Cell surface protein which plays a role in the plasticity of cholinergic synapses at neuromuscular junctions and in the polarity of the mechanosensory neuron ALM, possibly by antagonizing Wnt signaling. (487 aa) |
| | odr-10 | Serpentine receptor class r-10; An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway; Belongs to the nematode receptor-like protein str family. (339 aa) |
| | kvs-1 | Uncharacterized protein; Belongs to the potassium channel family. (495 aa) |
| | unc-129 | TGF_BETA_2 domain-containing protein. (407 aa) |
| | ifta-1 | WD_REPEATS_REGION domain-containing protein. (1246 aa) |
| | che-1 | Transcription factor che-1; Transcription factor essential for the identity of ASE chemosensory neurons. Acts by activating expression of genes that are specific for ASE chemosensory neurons, such as seven-transmembrane receptors or guanylate cyclase. Also required to control the left/right asymmetry in ASE chemosensory neurons by regulating expression of genes such as cog-1 and ceh-36. (273 aa) |
| | mlc-4 | Myosin regulatory light chain; Regulates myosin II activity and organization during embryo elongation. May be involved in the organization of mlc-5 into bundles. Required maternally for cytokinesis during meiosis and mitosis in the early embryo and for the establishment of embryonic anterior-posterior polarity. (172 aa) |
| | smu-1 | Smu-1 suppressor of mec-8 and unc-52 protein; Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Selectively regulates alternative splicing of unc-52 exon 17. Thus, smu-1 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17 and enhance the effects of unc-52 mutations that affect the exon 16 splice donor site. In contrast, smu-1 mutants do not suppress unc-52 nonsense mutations in exon 18. (510 aa) |
| | ceh-17 | Homeobox domain-containing protein. (237 aa) |
| | smp-2 | Sema domain-containing protein; Belongs to the semaphorin family. (649 aa) |
| | aex-1 | C2 domain-containing protein aex-1; Involved in retrograde signaling from post-synaptic cells to pre-synaptic neurons, probably by regulating vesicle exocytosis in post-synaptic cells. Acts in muscles, to regulate the localization of synaptic vesicle fusion protein unc-13 likely during vesicle exocytosis and thus regulate retrograde signaling at the neuromuscular junction (NMJ). Regulates anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). Probably by regulating DMP, plays a homeostatic role in the uptake of triglycerides. Regulat [...] (1009 aa) |
| | maco-1 | Macoilin; Plays a role in the regulation of neuronal activity. (897 aa) |
| | pde-3 | Probable 3',5'-cyclic phosphodiesterase pde-3. (693 aa) |
| | pink-1 | Serine/threonine-protein kinase pink-1, mitochondrial; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins (By similarity). Plays a role in mitophagy. (641 aa) |
| | sin-3 | Paired amphipathic helix protein sin-3; Probable transcriptional repressor required for the deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (both autosomes and sex chromosomes) during meiosis, but this does not seem to solely affect the transcriptional status. Plays a role in ray fusion and patterning in the male tail, and this may be through activity of the histone deacetylase complex (HDAC). (1507 aa) |
| | ncam-1 | NCAM (Neural cell adhesion molecule) homolog. (955 aa) |
| | unc-15 | Paramyosin; Structural component of the muscle thick filaments which is involved in assembly and organization of sarcomere myofilaments. Involved in ovulation. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. Belongs to the paramyosin family. (872 aa) |
| | F07B7.12 | Uncharacterized protein. (1964 aa) |
| | dgn-3 | Peptidase S72 domain-containing protein. (251 aa) |
| | unc-98 | Zinc finger protein unc-98; Probable transcription factor required for muscle structure. Its dual subcellular localization suggests that it may function both as a muscle adhesion complex protein and as a transcription factor, or work together with transcription factors, to influence gene expression. Thought to act as a molecular bridge between unc-97 and myo-3 at the M-line of muscles, possibly in a signaling role. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. (310 aa) |
| | tub-1 | Tubby protein homolog 1; Has a role in fat regulation independent of daf-16. Implicated in ciliar sensory function which is required for normal sensory behavior such as chemotaxis. Functions in life span control via the insulin/IGF-1 pathway. Thought to be involved in neuronal trafficking. (426 aa) |
| | spon-1 | SPONdin (Extracellular matrix glycoprotein) family. (819 aa) |
| | mig-10 | Abnormal cell migration protein 10; Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt- 1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration. Belongs to the MRL family. (779 aa) |
| | eak-6 | Tyrosine-protein phosphatase non-receptor type eak-6; Putative phosphatase which, together with eak-4 and sdf-9, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel of age-1, pdk-1 and akt-1. (405 aa) |
| | daf-12 | Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] (753 aa) |
| | glc-1 | Glutamate-gated chloride channel alpha; Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration. Channels containing only glc- 1 are activated by ivermectin, but not by glutamate alone (in vitro). The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid. P [...] (461 aa) |
| | unc-54 | Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa) |
| | ddr-2 | Discoidin domain-containing receptor tyrosine kinase B; Tyrosine-protein kinase receptor which, together with ddr-1, is involved in axon guidance to establish the tracts for the ventral and dorsal nerve cords during nervous system development. Acts upstream of the adapter shc-1, and the tyrosine kinase receptors svh-1 and svh-2 to regulate axon regeneration following injury in D-type motor neurons. May mediate axon regeneration in association with the collagen emb-9. (797 aa) |
| | unc-96 | Uncharacterized protein. (418 aa) |
| | unc-63 | Acetylcholine receptor subunit alpha-type unc-63; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine and levamisole. (502 aa) |
| | ttx-7 | Inositol monophosphatase ttx-7; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. Has broad substrate specificity and can use myo-inositol monophosphates, myo- inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo- inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity). Required in central interneurons of the mature nervous system for correct localization of synaptic components. Required for ther [...] (285 aa) |
| | efn-3 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. (211 aa) |
| | sad-1 | Serine/threonine kinase SAD-1; Regulates both neuronal polarity and synaptic organization when bound to strd-1. Kinase activity is required for the establishment, but not the maintenance, of both processes. Binding to nab-1 is essential for role in restricting axonal fate during neuronal polarization but is not required for regulating synapse morphology. (914 aa) |
| | fmi-1 | FlaMIngo (Cadherin plus 7TM domain) homolog. (2596 aa) |
| | dys-1 | Dystrophin-1; Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning. (3674 aa) |
| | acy-1 | Adenylyl CYclase. (1253 aa) |
| | F20H11.4 | Protein-tyrosine-phosphatase. (446 aa) |
| | unc-38 | Acetylcholine receptor subunit alpha-type unc-38; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (511 aa) |
| | tbx-2 | T-box protein 2; Involved in the development of pharyngeal muscles derived from the ABa lineage. (423 aa) |
| | daf-10 | Intraflagellar transport protein 122 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs). Plays a role in chemotaxis and sensory perception. Required for entry into and exit from the dauer larval stage and this may be mediated by daf-12, daf-16 and daf-41. Controls the behavioral response, namely the avoidance response, and pathogen-responsive gene expression in the response to pathogenic bacteria such as E.coli and P. aeruginosa. (1192 aa) |
| | F23H12.5 | Uncharacterized protein. (802 aa) |
| | rgef-1 | Rap Guanine nucleotide Exchange Factor homolog. (654 aa) |
| | ubc-25 | Ubiquitin-conjugating enzyme E2 25; Catalyzes the covalent attachment of ubiquitin to other proteins (Potential). Required for the maintenance of neuromuscular function. (387 aa) |
| | unc-4 | Homeobox protein unc-4; Transcription factor that regulates synaptic specificity. Determines the pattern of synaptic input to VA motor neurons. Acts together with unc-37 by repressing the expression of VB-specific genes such as ceh-12, thereby preventing the adoption of VB motor neurons. Has no role in axonal guidance or outgrowth. Belongs to the paired homeobox family. Unc-4 subfamily. (252 aa) |
| | zag-1 | Zinc finger E-box-binding homeobox protein zag-1; Down-regulates expression of genes involved in either the synthesis or reuptake of serotonin, dopamine and GABA. Acts as a transcriptional repressor to regulate multiple, discrete, neuron- specific aspects of terminal differentiation, including cell migration, axonal development and gene expression. Required for axon guidance. Involved in the proper development of the pharynx. Directly represses its own transcription by interacting with conserved E-box sequence motifs 5'-CACCTG-3' in its own promoter. (596 aa) |
| | col-99 | Putative cuticle collagen 99; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity). (735 aa) |
| | unc-45 | TPR_REGION domain-containing protein. (961 aa) |
| | ift-81 | IFT81_CH domain-containing protein. (638 aa) |
| | aex-5 | Endoprotease aex-5; Probable serine endoprotease which cleaves preproteins at paired basic amino acids. May process FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides. In muscles, involved in neuronal retrograde signaling by regulating presynaptic activity and localization of synaptic vesicle fusion protein unc-13 at the neuromuscular junction (NMJ). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). Probably by regulating DMP, required for fatty acid uptake by intestinal cell [...] (537 aa) |
| | jkk-1 | Dual specificity mitogen-activated protein kinase kinase jkk-1; Dual specificity protein kinase which acts as an essential component of the JNK signal transduction pathway. May phosphorylate jnk-1. Plays a role in coordinating locomotion via D-type GABAergic motoneurons and in regulating synaptic vesicle transport downstream of adapter protein unc-16 and probably by activating jnk-1. Positively regulates lifespan. Upon environmental stress such as heat stress regulates daf-16 nuclear translocation probably by activating jnk-1. Regulates germline cell apoptosis in response to heavy meta [...] (435 aa) |
| | syd-1 | Rho GTPase-activating protein syd-1; Probable GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Regulates the localization and assembly of presynaptic components during presynaptic development and is required for specifying the identity of axons during initial polarity acquisition. In these roles it is thought to act cell autonomously downstream of syg-1 and syg-2 and upstream of syd-2, possibly as a positive regulator of the latter. Required for the control of movement, egg-laying and the correct localization of elks-1. (987 aa) |
| | tax-2 | Cyclic nucleotide-binding domain-containing protein. (800 aa) |
| | odr-8 | Ufm1-specific protease; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ufm-1, a ubiquitin-like modifier protein bound to a number of target proteins (By similarity). Required, with oct-4, for the localization of a subset of 7 transmembrane domain odorant receptors, including odr-10, to the cilia of olfactory neurons AWA and AWC. Operates in aggregation behavior, and responses to oxygen levels; Belongs to the peptidase C78 family. (589 aa) |
| | che-2 | CHE-2 protein. (760 aa) |
| | slt-1 | Slit homolog 1 protein; Functions as a ligand for sax-3 receptor during larval development. Acts via the sax-3/Robo receptor to direct ventral axon guidance and guidance at the midline during embryonic development. (1410 aa) |
| | unc-6 | Netrin unc-6; Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation [...] (612 aa) |
| | wrk-1 | Wrapper/Rega-1/Klingon homolog. (452 aa) |
| | sprr-2 | Sex peptide receptor-related protein 2; G-protein coupled receptor for the neuropeptide like protein nlp-38. Plays a role in several types of aversive gustatory associative learning including gustatory plasticity and salt avoidance learning. Its role in salt avoidance learning may be through activation of the transcription factor crh- 1/CREB and de novo transcription and translation, which in turn promotes the formation of long-term memory. (451 aa) |
| | tni-1 | Troponin I 1; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (250 aa) |
| | zig-2 | Zwei Ig domain protein zig-2; Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons. (238 aa) |
| | unc-53 | Adapter protein unc-53; Involved in the migration and outgrowth of muscles, axons and excretory canals. (1654 aa) |
| | nlp-37 | PDF (Arthropod Pigment Dispersing Factor) homolog. (89 aa) |
| | nmy-1 | Non-muscle MYosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa) |
| | gcy-7 | Receptor-type guanylate cyclase gcy-7; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Unlike other guanylate cyclases expressed in ASE neurons, may not play a role in chemotaxis responses toward salt ions in ASEL (ASE left) sensory neurons. (1111 aa) |
| | nud-1 | CS domain-containing protein. (320 aa) |
| | madd-4 | Protein madd-4; Component of an extracellular matrix cue that is involved in the guidance of dorsoventral midline migrations and in the specification of postsynaptic domains at neuromuscular junctions (NMJs). Acts as a ligand for the netrin receptor unc-40 and the neuroligin receptor nlg-1. Secreted by the dorsal and ventral nerve cords to attract sensory axons and muscle membrane extensions called muscle arms. In parallel with unc-6 and slt-1, involved in the netrin receptor unc-40 dependent guidance of the AVM and PVM mechanosensory axons along the dorsal-ventral axis. The unc-40 cor [...] (1045 aa) |
| | unc-60-2 | Actin-depolymerizing factor 1, isoforms a/b; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Competes with unc-87 for actin binding and inhibits the actin-bundling activity of unc-87. (165 aa) |
| | unc-108 | Uncharacterized protein. (223 aa) |
| | unc-84 | Nuclear migration and anchoring protein unc-84; Involved in nuclear migration and anchoring in hypodermal precursor cells. Most likely recruits anc-1 to the nuclear envelope where anc-1 functions to tether the nucleus to the actin cytoskeleton. Component of the unc-83-unc-84 LINC (LInker of Nucleoskeleton and Cytoskeleton) complex where it recruits and interacts with unc-83 to form a bridge connecting the nuclear envelope to the cytoskeleton which allows for nuclear transport along microtubules. Its role in nuclear migration may be in association with lamin, lmn-1. Regulates nuclear mi [...] (1111 aa) |
| | zig-7 | Zwei Ig domain protein zig-7; Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons. (239 aa) |
| | F54F12.1 | Protein-tyrosine-phosphatase. (1217 aa) |
| | nid-1 | NIDogen (Basement membrane protein). (1584 aa) |
| | dgk-3 | Probable diacylglycerol kinase 3; Involved in AFD-neuron mediated thermotaxis. Regulates behavior to environmental temperature. Thought to have a role in olfactory adaptation by affecting diacylglycerol levels. Belongs to the eukaryotic diacylglycerol kinase family. (795 aa) |
| | egl-4 | cGMP-dependent protein kinase egl-4; Promotes chemoreceptor gene expression in response to increased cGMP levels by antagonizing the gene repression functions of the class II HDAC hda-4 and the mef-2 transcription factor. Regulates gene expression via recruitment of a histone deacetylase complex containing hda-2, saeg-1 and saeg-2. Represses body size and lifespan through the dbl-1 and insulin pathways, respectively. May also signal through daf-3 and/or daf-5. Role in egg-laying, dauer formation and motility. Regulates behavioral responses to various chemosensory stimuli in sensory neu [...] (783 aa) |
| | unc-73 | Guanine nucleotide exchange factor UNC-73A. (2488 aa) |
| | gex-2 | Cytoplasmic FMR1-interacting protein homolog; Required for initial steps of body morphogenesis. May play a role in egg laying and yolk protein clatherin-mediated endocytosis by oocytes during oogenesis. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. (1262 aa) |
| | efn-4 | Ephrin-4; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, involved in ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting together with mab-20 and allows the formation of distinct sensory rays. Probably acts as a ligand for lad-2 to regulate axon guidance of several neurons including SDQL, SDQR, SMD and PLN neurons during neurogenesis. (348 aa) |
| | unc-39 | Homeobox protein unc-39; Probable transcription factor required for differentiation and migration of neuronal cells, such as RID and CAN neurons. Specifically, plays a role in the terminal differentiation of RID peptidergic neurons. Also required for CAN neuron axon guidance. (335 aa) |
| | unc-64 | Syntaxin-1A homolog; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the qui [...] (291 aa) |
| | dgn-2 | Peptidase S72 domain-containing protein. (399 aa) |
| | fax-1 | Nuclear receptor domain-containing protein. (419 aa) |
| | sdn-1 | Probable syndecan; Cell surface proteoglycan that bears heparan sulfate (By similarity). Required for correct mitotic spindle orientation of the ABar blastomere division plane and this may be through modulation of astral microtubule array, and in association with the wnt-signaling proteins mig-5 and dsh-2. Involved in the migration of AQR and PQR neurons, which descend from the Q neuroblasts. Promotes the axon guidance of D-type motor neurons. (288 aa) |
| | pkc-1 | Protein kinase C-like 1B; PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Involved in neuropeptide secretion in motor axons. Likely to act via the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway in the signaling response to various sensory neurons; temperature, odor, taste, and osmolality. Its role in regulation differs depending on the neuron in which it is acting; thermosensation in AFD neurons, osmolality in ASH neuro [...] (763 aa) |
| | ldb-1 | LID domain-containing protein. (629 aa) |
| | unc-42 | Homeobox domain-containing protein. (279 aa) |
| | nsy-1 | Mitogen-activated protein kinase kinase kinase nsy-1; Serine/threonine-protein kinase which, by phosphorylating and activating sek-1, plays an important role in the activation of the p38 pathway also composed of the downstream effectors sek-1 and pmk-1. Downstream of CaMKII unc-43 and adapter protein tir-1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive and Gram-negative bacteri [...] (1498 aa) |
| | sam-4 | Uncharacterized protein. (240 aa) |
| | syd-2 | Liprin-alpha; May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. This may be in association with the liprin-beta protein hlb-1 ; Belongs to the liprin family. Liprin-alpha subfamily. (1139 aa) |
| | enu-3.1 | ENhancer of Uncoordination. (204 aa) |
| | adr-1 | A-to-I RNA editing regulator adr-1; Required for the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. Does not have deaminase activity but binds to dsRNA and regulates A-to-I RNA editing, possibly by modulating the accessibility of the double-stranded RNA-specific adenosine deaminase adr-2 for target adenosines. Regulates editing efficiency of specific adenosines in 3' untranslated regions of target mRNAs. Represses editing efficiency of the Y75B8A.8 3' UTR in neurons. Required for correct expression and A-to-I editing of [...] (964 aa) |
| | unc-26 | Synaptojanin; Probable inositol 5-phosphatase which regulates synaptic vesicle recycling in neurons by regulating clathrin-mediated endocytosis; In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. (1119 aa) |
| | enu-3.6 | ENhancer of Uncoordination. (319 aa) |
| | axl-1 | Axin-like protein 1; Works in parallel with pry-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Shown to have a role in excretory cell development. (400 aa) |
| | hid-1 | High temperature-Induced Dauer formation. (729 aa) |
| | dnj-14 | J domain-containing protein. (217 aa) |
| | rac-2 | Ras-related protein rac-2; During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation. (195 aa) |
| | plx-2 | Plexin-2; Involved as a receptor for mab-20/sema-2a in the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, involved in precursor cell sorting and in the formation of distinct sensory rays. Involved in axon guidance of SDQL neurons during neurogenesis. Probably in response to stimulation by mab-20, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus axon guidance and/or fasciculation of DD/VD neurons. Bel [...] (1766 aa) |
| | rack-1 | Guanine nucleotide-binding protein subunit beta-2-like 1; Required for the expression of antimicrobial peptide nlp-29 in response to fungal infection or physical injury. (325 aa) |
| | crml-1 | Carm_PH domain-containing protein. (1056 aa) |
| | epi-1 | Laminin-like protein epi-1; During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. (3715 aa) |
| | aipl-1 | WD_REPEATS_REGION domain-containing protein. (600 aa) |
| | pxn-2 | PeroXidasiN (Drosophila peroxidase) homolog. (1328 aa) |
| | zig-1 | Zwei Ig domain protein zig-1; Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons. (265 aa) |
| | unc-68 | Uncharacterized protein. (5202 aa) |
| | egl-46 | C2H2-type domain-containing protein. (286 aa) |
| | smo-1 | Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] (91 aa) |
| | vab-8 | Kinesin-like protein vab-8; Required for posterior migration of cells and axon growth cones during nervous system assembly. [Isoform b]: Specifically required for CAN cell migration. (1066 aa) |
| | zig-12 | Ig-like domain-containing protein. (197 aa) |
| | vab-1 | Ephrin receptor 1; Receptor for members of the ephrin family (By similarity). Receptor for major sperm proteins (MSPs), that functions as sperm- sensing checkpoint which inhibits oocyte meiotic maturation and ovulation when sperm are not available for fertilization. Specifically, functions to negatively regulates oocyte maturation and MAPK activation in the absence of MSPs. Required for the MSP-mediated increase in the basal sheath cell contraction rate in somatic cells. Phosphorylates phosphatase daf-18/PTEN which probably promotes daf-18 degradation. By inactivating daf-18, regulates [...] (1122 aa) |
| | M04G7.2 | Tyrosine-protein phosphatase. (550 aa) |
| | unc-119 | Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa) |
| | unc-116 | Kinesin heavy chain; Microtubule-dependent motor protein required for organelle transport. Plays a role in endosome transport. Required for the transport of mitochondria along the axon of motor neurons. Involved in the nuclear migration of hyp7 hypodermal precursor cells. Required for the formation of dendritic branches of PVD sensory neurons. In non-ciliated neurons such as the PVD and PHC neurons, required for the organization of minus-end out microtubules in dendrites. Involved in the localization of unc-33 to neurites. (815 aa) |
| | wve-1 | WH2 domain-containing protein. (468 aa) |
| | unc-7 | Innexin unc-7; Structural component of the gap junctions (By similarity). Required for coordinated locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin- 23 and phospholipase plc-3 in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. (546 aa) |
| | pde-2 | Probable 3',5'-cyclic phosphodiesterase pde-2; May negatively regulate the activity of cGMP-dependent protein kinase egl-4 which in turn controls body size. (831 aa) |
| | eor-1 | EOR-1. (909 aa) |
| | avr-15 | Neur_chan_memb domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (657 aa) |
| | mdt-15 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (780 aa) |
| | unc-8 | Degenerin unc-8. (778 aa) |
| | ten-1 | Teneurin-1; Plays a role in the gonadal basement membrane maintenance and/or adhesion early in development. Contributes to the guidance of pharyngeal neurons. (2837 aa) |
| | osm-6 | Osm-6 protein. (472 aa) |
| | gcy-28 | Receptor-type guanylate cyclase gcy-28; Guanylate cyclase involved in the production of the second messenger cGMP. Regulates olfactory perception in AWC sensory neurons although may not be involved in the primary sensory transduction steps. [Isoform d]: Regulates sensory integration of conflicting sensory cues in AIA interneurons. (1276 aa) |
| | T01D3.1 | Uncharacterized protein. (3226 aa) |
| | dma-1 | LRRCT domain-containing protein. (603 aa) |
| | gcy-22 | Receptor-type guanylate cyclase gcy-22; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Li(1-), Mg(2+), Cl(1-), Br(1)- and I(1-) salt ions and methionine in ASE right (ASER) sensory neuron. May regulate ASER neuronal activity such as axon sprouting and calcium responses to changes in salt concentrations. (1058 aa) |
| | lis-1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division. Part of a complex with nud-2, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells. Plays a role in GABAergic synaptic vesicle localization in [...] (404 aa) |
| | zig-6 | Zwei Ig domain protein zig-6; Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons. (243 aa) |
| | act-2 | Actin-2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa) |
| | pde-1 | Probable 3',5'-cyclic phosphodiesterase pde-1; Redundantly with pde-5, plays a role in the AFD thermosensory neurons to regulate microvilli receptive ending morphology, possibly by regulating cGMP levels. (664 aa) |
| | gcy-35 | Soluble guanylate cyclase gcy-35; Plays a central role in social feeding behavior and oxygen sensation by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which binds to its heme-binding sites, probably regulates social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in [...] (688 aa) |
| | unc-58 | Uncoordinated protein 58; Has a role in mobility, possibly in the transport of potassium in muscles; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (591 aa) |
| | daf-18 | Abnormal dauer formation protein 18; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (By similarity). Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate. By dephosphorylating PtdIns(3,4,5)P3 antagonizes PtdIns(3,4,5)P3 production by age-1/PI3K and thus, negatively regulates daf-2-mediated processes including dauer formation, longevity, fat metabolism, chemotaxis towards salt, thermotolerance and axon guidance. Similarly, [...] (962 aa) |
| | pdf-1 | PDF (Arthropod Pigment Dispersing Factor) homolog. (88 aa) |
| | unc-29 | Acetylcholine receptor subunit beta-type unc-29; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine and levasimole. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (493 aa) |
| | lin-5 | Spindle apparatus protein lin-5; Essential component of the spindle apparatus required for spindle positioning and chromosome movement. Acts to recruit or anchor gpr-1/gpr-2 complex to the spindle and cortex. Also involved, directly or indirectly, in cytokinesis and in the coupling of DNA replication, centrosome duplication and mitotic division. (821 aa) |
| | chn-1 | C-term of Hsp70-iNteracting protein (CHIP family). (266 aa) |
| | unc-10 | Rab-3-interacting molecule unc-10; Regulates the efficiency of a post-docking step of the release pathway. Acts after vesicle docking likely via regulating priming. May regulate the conformational changes in syntaxin. Binding of vesicles via rab-3[GTP] to Rim may signal the presence of a docked synaptic vesicle. Rim may then signal to unc-13 to change the conformation of syntaxin from the closed to the open state. Syntaxin could then engage synaptobrevin on the docked vesicle to form SNARE complexes and to prime the vesicle for release. Not required for the development or the structura [...] (1563 aa) |
| | scd-2 | ALK tyrosine kinase receptor homolog scd-2; Probable tyrosine-protein kinase receptor which regulates the dauer/non-dauer developmental decision probably by controlling daf-3 transcriptional activity in parallel or together with the TGF-beta pathway. Regulates integration of conflicting sensory cues in AIA interneurons. May act as a receptor for hen-1. (1421 aa) |
| | lin-59 | Probable histone-lysine N-methyltransferase lin-59; Probable histone methyltransferase (By similarity). Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin. (1312 aa) |
| | dpy-10 | Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (356 aa) |
| | odr-7 | Nuclear hormone receptor family member odr-7; Required for the function of one pair of chemosensory neurons called AWA neurons that are involved in chemotaxis to volatile odorants. Acts in a pathway that specifies olfactory neuronal fate. Regulates the transcription of olfactory signaling molecules such as odr-10 that specify AWA neuron identity and function. Represses the expression in AWA neurons of factors such as str-2 which specify AWC neuron identity. (457 aa) |
| | unc-40 | Unc-40 protein. (1415 aa) |
| | adr-2 | Double-stranded RNA-specific adenosine deaminase adr-2; Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. Acts primarily on non-coding regions of protein- coding genes including introns and untranslated regions (UTR). Required for normal chemotaxis. Edits the 3' UTR of clec-41 which is required for normal clec-41 expression and for chemotaxis. Plays a role in determining lifespan. Not required for RNA interference. Likely to play a role in determining whether a dsRNA enters the RNAi pathway. (495 aa) |
| | dgn-1 | Peptidase S72 domain-containing protein. (584 aa) |
| | lam-3 | LAMinin related. See also lmb. (3102 aa) |
| | jph-1 | JunctoPHilin. (747 aa) |
| | cdka-1 | Cyclin-dependent kinase 5 activator 1; Activator of the kinase cdk-5 (By similarity). In several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles. In the ventral nerve cord, regulates the synaptic localization of the glutamate receptor, glr-1. In DA motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the polarized distribution of dense-core vesicles in DB motor neurons. May regulate these processes in association with cdk-5. May also play a role in GABAergic [...] (366 aa) |
| | mtm-3 | Myotubularin-related protein 3; Preferentially dephosphorylates phosphatidylinositol 3- phosphate (PI3P), and has some activity towards phosphatidylinositol 3,5-bisphosphate (PI35P). May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity). Positively regulates autophagy and is recruited to autophagosomes by PI3P where it catalyzes PI3P turnover to promote autophagosome maturation. Thought to have a role in maintenance of muscle function. Involved in locomotion and lifespan determination. (1006 aa) |
| | zig-10 | 2 (Zwei) IG domain protein. (322 aa) |
| | clec-38 | C-type LECtin. (382 aa) |
| | bbs-8 | Tetratricopeptide repeat protein 8; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization. Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme. Plays a role in guanylyl cyclase loca [...] (506 aa) |
| | gcy-23 | Receptor-type guanylate cyclase gcy-23; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. (1073 aa) |
| | mab-9 | T-box protein 12; Involved in cell fate determination; required to pattern the posterior hindgut. (346 aa) |
| | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1; Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite- specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2393 aa) |
| | skp-1 | Uncharacterized protein T27F2.1. (535 aa) |
| | T28F4.3 | Protein-tyrosine-phosphatase. (490 aa) |
| | unc-83 | Nuclear migration protein unc-83; Cargo-specific adapter that is involved in nuclear migration during development and thereafter. Component of the unc-83-unc-84 LINC (LInker of Nucleoskeleton and Cytoskeleton) complex where it interacts with unc-84 to form a bridge connecting the nuclear envelope to the cytoskeleton which allows for nuclear transport along microtubules. Within the complex, connects the nuclear envelope to the microtubule cytoskeleton through the kinesin-1 light chain protein klc-2 (most likely within the Kinesin 1 motor complex) to regulate nuclear migrations. Moreover [...] (1041 aa) |
| | cwn-2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Involved in the correct positioning of the developing nerve ring and in axon guidance of SIA and SIB neurons, probably by binding to tyrosine kinase receptor cam-1. In addition, regulates the positioning of some head neuronal cells, muscle arms associated with the nerve ring and the excretory pore. Together with Wnt ligand cwn- [...] (360 aa) |
| | grk-2 | G protein-coupled receptor kinase 2; Specifically phosphorylates the activated forms of G protein- coupled receptors (By similarity). Required in adult sensory neurons for chemotaxis. Plays a role in the ASH sensory neurons in the chemotaxis response to NaCl where it is likely to modulate the strength of the NaCl avoidance response which occurs at high NaCl concentrations. Required in the HSN motor neurons for normal egg laying by promoting phosphorylation of amine oxidase amx-2 which inhibits amx-2 activity, preventing metabolism of serotonin. Acts in head acetylcholine neurons to pos [...] (707 aa) |
| | ceh-10 | Homeobox protein ceh-10; Required for larval development and for cell fate specification and migration of CAN neurons. (344 aa) |
| | W03F11.4 | Protein-tyrosine-phosphatase. (1371 aa) |
| | enu-3.3 | ENhancer of Uncoordination. (462 aa) |
| | flp-2 | FMRFamide-like peptide 2a. (106 aa) |
| | fat-3 | Delta(6)-fatty-acid desaturase fat-3; Delta(6) fatty acid desaturase that acts on a range of substrates. Catalyzes the desaturation of linoleic acid (Delta(9,12)- 18:2, or C18:2(n-6)) to gamma-linolenic acid (Delta(6,9,12)-18:3, or C18:3(n-6)). Plays a role in synaptic vesicle recycling by regulating synaptojanin unc-26 localization at synapses. (443 aa) |
| | unc-59 | Septin-type G domain-containing protein. (459 aa) |
| | odr-4 | Odorant response abnormal protein 4; Required, with oct-8, for the localization of a subset of 7 transmembrane domain odorant receptors, including odr-10, to the cilia of olfactory neurons AWA and AWC. Regulates chemotaxis responses to benzaldehyde, diacetyl and 2,4,5- trimethylthiazole in AWA and AWC neurons. Plays a role in nociceptive neurons to mediate avoidance of high oxygen. (475 aa) |
| | lev-10 | LEV-10A protein. (906 aa) |
| | gcy-4 | Receptor-type guanylate cyclase gcy-4; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Br(1-) and I(1-) salt ions in ASE right (ASER) sensory neuron. (1136 aa) |
| | gcy-18 | Receptor-type guanylate cyclase gcy-18; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. (1113 aa) |
| | dpy-30 | Dosage compensation protein dpy-30; Essential for dosage compensation. Required for the sex-specific association of the dosage compensation complex proteins dpy-27 and dpy-26 with the hermaphrodite X chromosomes. Plays a role in developmental rate and body fat regulation downstream of the TOR complex 2. Required for the robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development. (123 aa) |
| | unc-27 | Troponin I 2; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (242 aa) |
| | unc-32 | Probable V-type proton ATPase 116 kDa subunit a; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (Probable). Regulates the size of gut granules during embryonic development. (905 aa) |
| | ZK616.65 | Tyrosine-protein phosphatase. (543 aa) |
| | dyf-2 | WD repeat-containing protein dyf-2; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Moves along the ciliary axoneme and is involved in the assembly, localization and the movement of other intraflagellar transport (IFT) proteins along the cilia axoneme. May also associate with the BBSome complex in order to mediate ciliary transport. Regulates cilia biogenesis, morphology and sensitivity to environmental cues. (1383 aa) |
| | sax-3 | Protein sax-3; Required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. Belongs to the immunoglobulin superfamily. ROBO/SAX3 family. (1273 aa) |
| | unc-16 | JNK-interacting protein; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the [...] (1190 aa) |
| | tax-4 | Cyclic nucleotide-gated cation channel; Required for normal thermosensation and chemosensation sensory behavior. Required, downstream of receptor- type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons. Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons. Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation. Required for the calcium flux to the cytoplasm in the ASJ sensory neurons [...] (733 aa) |
| | mig-15 | Serine/threonine-protein kinase mig-15; Involved in cell migration and signal transduction. Important in several developmental processes including epidermal development, Q neuroblast migrations and muscle arm targeting. Required with ina-1/pat-3 to stabilize the commissural axons growth cone along a precise direction and are required for the cell to respond appropriately when signaling in the growth cone must change. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. (1096 aa) |
| | gcy-14 | Receptor-type guanylate cyclase gcy-14; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Na(1+) and Li(1+) salt ions and alkaline pH in ASE left (ASEL) sensory neuron. Directly senses environmental alkalinity in ASEL neuron which probably leads to the activation of cGMP-gated cation channel tax2/tax4. (1111 aa) |
| | glc-3 | Glutamate-gated chloride channel subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (484 aa) |
| | unc-52 | Basement membrane proteoglycan; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable structural role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in body wall muscles and myoepithelial sheath cells. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. Involved in ovulation. (3375 aa) |
| | Y97E10AL.1 | Uncharacterized protein. (220 aa) |
| | Y95B8A.8 | DZF domain-containing protein. (764 aa) |
| | src-1 | Tyrosine protein-kinase src-1; Non-receptor tyrosine-protein kinase which plays a role in endoderm development by controlling spindle orientation in EMS blastomere, probably downstream of receptor mes-1. Also involved in embryonic body morphogenesis, especially in the formation of the pharynx and the intestine. May be dispensable for pharyngeal muscle organization in the adult. Probably phosphorylates netrin receptor unc-5, to regulate distal tip cell (DTC) migration during gonad development and in axon repulsion. Plays a role in the migration of the QR neuroblast, a precursor of the A [...] (537 aa) |
| | osm-12 | Bardet-Biedl syndrome 7 protein homolog; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization (By similarity). Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme. Plays a role in [...] (721 aa) |
| | seu-1 | Suppressor of Ectopic Unc-5. (672 aa) |
| | Y71H2AM.12 | Uncharacterized protein. (195 aa) |
| | mab-20 | Semaphorin-2A; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting and allows the formation of distinct sensory rays. Seems to control cell-cell contact formation through 2 parallel pathways, one involving efn-4 and one involving plx-2 and unc-129. Involved in axon guidance. Probably by binding receptor plx-2, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus [...] (658 aa) |
| | lin-17 | Transmembrane receptor LIN-17; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa) |
| | fln-1 | Calponin-homology (CH) domain-containing protein. (2259 aa) |
| | unc-51 | Serine/threonine-protein kinase unc-51; Protein kinase important for axonal elongation and axonal guidance. Functions in the CAN axons to direct both anterior and posterior migrations. Phosphorylates both unc-14 and vab-8. Component of the unc-51/atg-13 complex that is probably recruited by lgg-1 to preautophagosomes and is required for autophagosome formation. Interaction with autophagy related proteins such as atg-13 links it to the autophagy machinery to in turn promote P-granule degradation in somatic cells. Plays a role in mitophagy during limited food availability. Regulates cell [...] (856 aa) |
| | plx-1 | Sema domain-containing protein. (1956 aa) |
| | lad-2 | Immunoglobulin domain-containing protein Y54G2A.25. (1187 aa) |
| | smp-1 | Semaphorin-1A; May function in growth cone guidance; Belongs to the semaphorin family. (712 aa) |
| | slo-1 | Calcium-activated potassium channel slo-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Essential for the regulation of neurotransmitter release at synapses. (1160 aa) |
| | unc-34 | WH1 domain-containing protein. (468 aa) |
| | smu-2 | Smu-2 suppressor of mec-8 and unc-52 protein; Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Selectively regulates alternative splicing of unc-52 exon 17. Thus, smu-2 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17. In contrast, smu-2 mutants do not suppress the effects of an unc-52 mutation that affects the 5' splice site of exon 16. Required for normal accumulation of smu-1. Belongs to the RED family. (547 aa) |
| | ani-1 | Anillin-like protein 1; Required for contractile events in embryos that occur prior to mitosis, such as cortical ruffling and pseudocleavage. Promotes membrane ruffling by organizing cortical patches of septins and myosin II. Not generally required for cytokinesis in mitotic cells. Required for the asymmetric cleavage events that extrude the two polar bodies during oocyte meiosis. Not required for meiotic contractile ring assembly, initiation or closure but is required for the transformation of the contractile ring from a disk above the spindle to a tube around the spindle midzone. Pro [...] (1159 aa) |
| | sbp-1 | BHLH domain-containing protein. (1113 aa) |
| | sdf-9 | Protein sdf-9; Together with eak-4 and phosphatase eak-6, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel of age-1, pdk-1 and akt-1. (345 aa) |
| | Y41D4A.5 | Tyrosine-protein phosphatase. (469 aa) |
| | mcm-4 | DNA replication licensing factor mcm-4; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentia [...] (823 aa) |
| | max-2 | Serine/threonine-protein kinase max-2; Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk- 1/mek-1/kgb-1 pathway. In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc- 6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons. Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstre [...] (649 aa) |
| | unc-33 | Protein unc-33; During neurogenesis, plays an essential role in axonal guidance and outgrowth by regulating the polarization of both microtubule and actin cytoskeletons. Establishes the asymmetry of axonal and dendrite microtubules and the polarized sorting of neuronal proteins. This is achieved in part by regulating the localization of kinesin-like protein unc-104. In neurons without a distal microtubule- organizing center (MTOC), also controls the organization of microtubules in dendrites. During the dorso-ventral axonal guidance and outgrowth of VD neurons, required downstream of Ra [...] (854 aa) |
| | vab-2 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. (279 aa) |
| | enu-3.5 | ENhancer of Uncoordination. (458 aa) |
| | zig-11 | Ig-like domain-containing protein. (304 aa) |
| | crp-1 | Cdc-42 Related Protein. (187 aa) |
| | unc-3 | Transcription factor unc-3; May play a role in the expression of proteins essential for axonal pathfinding and/or neuronal differentiation in both sensory and motor neurons. Cooperates with jmjd-3.1 and wdr-5.1 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development. (491 aa) |
| | bet-1 | Bromodomain-containing protein bet-1; Required for the establishment and maintenance of stable cell fate in several lineages including V5.pa, T, Z1/Z4 and QR lineages probably by repressing the expression of cell fate determinants. Required to maintain non-distal tip cell (DTC) fate of somatic gonadal cells through the htz-1-mediated repression of transcription factor ceh-22. Regulates the subnuclear localization of histone variant htz-1 in somatic gonadal cells. Plays a role in the attenuation of the let-60/ras pathway, probably by preventing expression of activators of the pathway. I [...] (853 aa) |
| | lev-11 | Tropomyosin isoforms a/b/d/f; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Protects actin filaments from depolymerization by unc-60 in vitro. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin. (284 aa) |
