(16 nodes) Post-embryonic body morphogenesis network (Caenorhabditis elegans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	skr-10	SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (192 aa)
	eff-1	Epithelial Fusion Failure. (658 aa)
	unc-98	Zinc finger protein unc-98; Probable transcription factor required for muscle structure. Its dual subcellular localization suggests that it may function both as a muscle adhesion complex protein and as a transcription factor, or work together with transcription factors, to influence gene expression. Thought to act as a molecular bridge between unc-97 and myo-3 at the M-line of muscles, possibly in a signaling role. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. (310 aa)
	dpy-5	Cuticle collagen dpy-5; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (284 aa)
	cpz-1	Cathepsin Z-1; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Probably, required for the degradation of the old cuticle. Belongs to the peptidase C1 family. (306 aa)
	dpy-7	Cuticle collagen dpy-7; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-7 affects the body shape. (318 aa)
	dpy-11	Thioredoxin domain-containing protein. (246 aa)
	duox-2	DUal OXidase. (1503 aa)
	bli-3	Dual oxidase 1; Plays a role in cuticle biogenesis. In complex with doxa-1 and tsp-15, produces reactive oxygen species (ROS), which are probably used by mlt-7 for tyrosine cross-linking, thus stabilizing cuticular extracellular matrix. May regulate the production of ROS by playing a role in modulating proline catabolism. Required in combination with mlt-7 for correct formation of cross-links in cuticle collagens. Association with the GTPase rho-1 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity. In [...] (1497 aa)
	cct-4	T-complex protein 1 subunit delta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (540 aa)
	ten-1	Teneurin-1; Plays a role in the gonadal basement membrane maintenance and/or adhesion early in development. Contributes to the guidance of pharyngeal neurons. (2837 aa)
	mboa-6	Lysophospholipid acyltransferase 5; Probable acyltransferase which may mediate the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). May also catalyze the conversion of lysophosphatidylethanolamine (1-acyl-2-hydroxy-sn-glycero-3- phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl- sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity), as well as the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero- 3-phospho-L-serine or LPS) in [...] (473 aa)
	dpy-2	Cuticle collagen dpy-2; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-2 affects the body shape. (380 aa)
	dpy-10	Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (356 aa)
	tni-3	Troponin I 3; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (260 aa)
	mlt-7	Peroxidase mlt-7 heavy chain; Plays an essential role in cuticle biogenesis. Required in combination with bli-3 for correct formation of cross-links in cuticle collagens. (724 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
bli-3	duox-2	F56C11.1.1	F53G12.3.1	Dual oxidase 1; Plays a role in cuticle biogenesis. In complex with doxa-1 and tsp-15, produces reactive oxygen species (ROS), which are probably used by mlt-7 for tyrosine cross-linking, thus stabilizing cuticular extracellular matrix. May regulate the production of ROS by playing a role in modulating proline catabolism. Required in combination with mlt-7 for correct formation of cross-links in cuticle collagens. Association with the GTPase rho-1 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity. In [...]	DUal OXidase.	0.818
bli-3	mlt-7	F56C11.1.1	ZK430.8.1	Dual oxidase 1; Plays a role in cuticle biogenesis. In complex with doxa-1 and tsp-15, produces reactive oxygen species (ROS), which are probably used by mlt-7 for tyrosine cross-linking, thus stabilizing cuticular extracellular matrix. May regulate the production of ROS by playing a role in modulating proline catabolism. Required in combination with mlt-7 for correct formation of cross-links in cuticle collagens. Association with the GTPase rho-1 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity. In [...]	Peroxidase mlt-7 heavy chain; Plays an essential role in cuticle biogenesis. Required in combination with bli-3 for correct formation of cross-links in cuticle collagens.	0.463
dpy-10	dpy-11	T14B4.7.1	F46E10.9.2	Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.	Thioredoxin domain-containing protein.	0.469
dpy-10	dpy-2	T14B4.7.1	T14B4.6.1	Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.	Cuticle collagen dpy-2; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-2 affects the body shape.	0.775
dpy-10	dpy-7	T14B4.7.1	F46C8.6.1	Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.	Cuticle collagen dpy-7; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-7 affects the body shape.	0.659
dpy-11	dpy-10	F46E10.9.2	T14B4.7.1	Thioredoxin domain-containing protein.	Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.	0.469
dpy-11	dpy-2	F46E10.9.2	T14B4.6.1	Thioredoxin domain-containing protein.	Cuticle collagen dpy-2; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-2 affects the body shape.	0.516
dpy-11	dpy-5	F46E10.9.2	F27C1.8.1	Thioredoxin domain-containing protein.	Cuticle collagen dpy-5; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.	0.781
dpy-2	dpy-10	T14B4.6.1	T14B4.7.1	Cuticle collagen dpy-2; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-2 affects the body shape.	Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.	0.775
dpy-2	dpy-11	T14B4.6.1	F46E10.9.2	Cuticle collagen dpy-2; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-2 affects the body shape.	Thioredoxin domain-containing protein.	0.516
dpy-2	dpy-5	T14B4.6.1	F27C1.8.1	Cuticle collagen dpy-2; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-2 affects the body shape.	Cuticle collagen dpy-5; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.	0.433
dpy-2	dpy-7	T14B4.6.1	F46C8.6.1	Cuticle collagen dpy-2; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-2 affects the body shape.	Cuticle collagen dpy-7; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-7 affects the body shape.	0.999
dpy-5	dpy-11	F27C1.8.1	F46E10.9.2	Cuticle collagen dpy-5; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.	Thioredoxin domain-containing protein.	0.781
dpy-5	dpy-2	F27C1.8.1	T14B4.6.1	Cuticle collagen dpy-5; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.	Cuticle collagen dpy-2; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-2 affects the body shape.	0.433
dpy-7	dpy-10	F46C8.6.1	T14B4.7.1	Cuticle collagen dpy-7; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-7 affects the body shape.	Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.	0.659
dpy-7	dpy-2	F46C8.6.1	T14B4.6.1	Cuticle collagen dpy-7; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-7 affects the body shape.	Cuticle collagen dpy-2; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-2 affects the body shape.	0.999
duox-2	bli-3	F53G12.3.1	F56C11.1.1	DUal OXidase.	Dual oxidase 1; Plays a role in cuticle biogenesis. In complex with doxa-1 and tsp-15, produces reactive oxygen species (ROS), which are probably used by mlt-7 for tyrosine cross-linking, thus stabilizing cuticular extracellular matrix. May regulate the production of ROS by playing a role in modulating proline catabolism. Required in combination with mlt-7 for correct formation of cross-links in cuticle collagens. Association with the GTPase rho-1 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity. In [...]	0.818
mlt-7	bli-3	ZK430.8.1	F56C11.1.1	Peroxidase mlt-7 heavy chain; Plays an essential role in cuticle biogenesis. Required in combination with bli-3 for correct formation of cross-links in cuticle collagens.	Dual oxidase 1; Plays a role in cuticle biogenesis. In complex with doxa-1 and tsp-15, produces reactive oxygen species (ROS), which are probably used by mlt-7 for tyrosine cross-linking, thus stabilizing cuticular extracellular matrix. May regulate the production of ROS by playing a role in modulating proline catabolism. Required in combination with mlt-7 for correct formation of cross-links in cuticle collagens. Association with the GTPase rho-1 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity. In [...]	0.463