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cpb-3 cpb-3 cpb-2 cpb-2 cpb-1 cpb-1 eif-6 eif-6 ola-1 ola-1 C52E12.1 C52E12.1 eif-2A eif-2A eef-2 eef-2 dnj-11 dnj-11 ZK1236.1 ZK1236.1 Y62E10A.20 Y62E10A.20 sec-61 sec-61 fog-1 fog-1 gcn-1 gcn-1 eif-2alpha eif-2alpha iff-2 iff-2 rack-1 rack-1 K10C3.5 K10C3.5 iff-1 iff-1 eif-3.K eif-3.K
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cpb-3Cytoplasmic polyadenylation element-binding protein 3; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs (By similarity). May not be required for oogenesis. (745 aa)
cpb-2Cytoplasmic polyadenylation element-binding protein 2; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs (By similarity). Not required for oogenesis. (570 aa)
cpb-1Cytoplasmic polyadenylation element-binding protein 1; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs. Essential for progression through meiosis. Involved in spermatogenesis. (560 aa)
eif-6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. Involved in miRNA-mediated gene silencing. (246 aa)
ola-1Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. (395 aa)
C52E12.1RING-type domain-containing protein. (925 aa)
eif-2AEukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner; Belongs to the WD repeat EIF2A family. (570 aa)
eef-2Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Involved in the morphogenesis of epidermal tissues; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic trans [...] (852 aa)
dnj-11DNaJ domain (Prokaryotic heat shock protein). (589 aa)
ZK1236.1Translation factor GUF1 homolog, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily. (645 aa)
Y62E10A.20Uncharacterized protein. (220 aa)
sec-61Plug_translocon domain-containing protein. (473 aa)
fog-1RRM domain-containing protein. (619 aa)
gcn-1TOG domain-containing protein. (2651 aa)
eif-2alphaS1 motif domain-containing protein. (342 aa)
iff-2Eukaryotic translation initiation factor 5A-2; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity). Acts in somatic tissues and its function in the soma is essential for normal growth and reproduction. (161 aa)
rack-1Guanine nucleotide-binding protein subunit beta-2-like 1; Required for the expression of antimicrobial peptide nlp-29 in response to fungal infection or physical injury. (325 aa)
K10C3.5Tr-type G domain-containing protein. (894 aa)
iff-1Eukaryotic translation initiation factor 5A-1; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity). Required for mitotic germ cell proliferation, gametogenesis after entry into meiosis, and localization of the P granule component pgl-1 on P granules; Belongs to the eIF-5A family. (195 aa)
eif-3.KEukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (240 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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