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| | elp-1 | Echinoderm microtubule-associated protein-like elp-1; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP family. (891 aa) |
| | che-12 | Crescerin-like protein che-12; Required for normal structure and function of sensory cilia on amphid neurons, especially for the formation of distal ciliary structures, but is less important for normal assembly of middle and basal ciliary structures. Plays a role in the organization of axoneme microtubule bundles in sensory cilia. Required for normal structure and function of the ASER neuron that mediates attraction to NaCl. Required for normal chemotaxis to NaCl. Required for normal avoidance response to high osmolarity. In contrast, is not required for normal chemotaxis to isoamyl al [...] (1282 aa) |
| | casy-1 | CAlSYntenin/Alcadein homolog. (984 aa) |
| | kin-3 | Casein kinase II subunit alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling. Modulates two aspects of male mating behavior; response to hermaphrodite contact and vulval location, acting in the same pathway as lov-1 and pkd-2. (360 aa) |
| | osm-9 | ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (937 aa) |
| | trx-1 | Thioredoxin-1; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Shown to facilitate the reduction of insulin disulfide bonds. Might play a role in the reversible nitrosylation of cysteine residues in target proteins, and thereby contributing to the response to intracellular nitric oxide. Shapes the ASJ sensory neuron biphasic response to nitric oxide (NO) exposure; trans-nitrosylation activity might inhibit calcium flux to the cytoplasm in ASJ neurons when exposed to [...] (115 aa) |
| | daf-11 | Receptor-type guanylate cyclase daf-11; Guanylate cyclase involved in the production of the second messenger cGMP. In addition, regulates cGMP levels by controlling the transcription of 3',5'-cyclic phosphodiesterase pde-1 and pde-5 mRNAs. Involved in the olfactory, light and pheromone sensing pathways. Part of the chemosensory mechanism of the ASJ sensory neuron that controls dauer formation and dauer recovery. Promotes the calcium flux in ASJ sensory neurons in response to onset and removal of a nitric oxide (NO) stimulus and is thereby required for the behavioral avoidance response [...] (1077 aa) |
| | ida-1 | Receptor-type tyrosine-protein phosphatase-like ida-1; Regulates dense-core vesicle (DCV) trafficking and/or secretion. Probably by controlling DCV trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Involved in locomotion by regulating acetylcholine release. Probably by controlling the secretion of FLP neuropeptides, regulates the turning step of male mating behavior. Plays a role in preventing dauer formation. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. (767 aa) |
| | abi-1 | SH3 domain-containing protein. (469 aa) |
| | egl-8 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration [...] (1512 aa) |
| | kcnl-1 | CaMBD domain-containing protein. (792 aa) |
| | cat-2 | Tyrosine 3-monooxygenase; Involved in the synthesis of catecholamines, such as dopamine. Has a role in serotonin signaling. Required for normal explorative and foraging behavior. (524 aa) |
| | jnk-1 | Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...] (463 aa) |
| | unc-76 | Uncharacterized protein. (388 aa) |
| | cam-1 | Tyrosine-protein kinase receptor cam-1; Tyrosine-protein kinase receptor for Wnt ligands egl-20, mom- 2 and cwn-1. Involved in the final positioning of migrating ALM, CAN, BDU and HSN neurons during development. Involved in the anterior-posterior migration of QR neuroblast descendants, QR.p and QR.pa, by maintaining QR.p cell polarization, probably through mig-2. In addition, plays a role in ASI sensory neuron positioning and functions. Regulates asymmetric division of V cells (seam cells) and CA/CP neuroblast, and axon outgrowth. Probably by acting as a receptor for Wnt ligand cwn- 2, [...] (928 aa) |
| | snet-1 | Protein snet-1; Negatively regulates chemotaxis and olfactory plasticity which is the change from positive chemotaxis to dispersal after prolonged exposure to an odorant. May be down-regulated in response to pheromone exposure, resulting in promotion of olfactory plasticity. (101 aa) |
| | tax-6 | Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. Dephosphorylates arrd-17. Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation. Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534'. Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium. Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons a [...] (545 aa) |
| | fbxl-1 | F-box/LRR-repeat protein fbxl-1; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Plays a role in regulating the entry into the dauer state. In hermaphrodites, may play a role in modulating the rate of defecation. (466 aa) |
| | kcnl-3 | Small conductance calcium-activated potassium channel-like protein 3; Forms a voltage-independent potassium channel activated by intracellular calcium. (692 aa) |
| | dyf-3 | Clusterin-associated protein 1 homolog; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for sensory cilia biogenesis ; Belongs to the CLUAP1 family. (404 aa) |
| | mapk-15 | Mitogen-activated protein kinase 15; Atypical MAPK protein. Regulates primary cilium formation in sensory neurons and the localization of ciliary proteins involved in cilium structure, transport, and signaling. Acts in dopamine (DA) neurons to support synaptic membrane dat-1 availability via activation of rho-1 thereby sustaining normal levels of DA clearance. Plays a role in male mating behavior, probably in part through regulating the localization of the polycystin pkd-2. Functions postembryonically in the URX sensory neurons to constrain URX dendrite growth throughout lifetime, prob [...] (470 aa) |
| | lnp-1 | Endoplasmic reticulum junction formation protein lunapark-1; Plays a role in tubular endoplasmic reticulum network formation and maintenance (By similarity). May be involved in central nervous system development. Has a presynaptic role in neurotransmission. Likely to operate in synaptogenesis by regulating vesicular transport or localization. Required for correct localization of rab-3 and snb-1; Belongs to the lunapark family. (346 aa) |
| | glr-1 | Glutamate receptor 1; Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. May contribute to a sensory discrimination between mechanical and chemical stimuli. Plays a role in controlling movement in response to environmental cues such as food availability and mechanosensory stimulation such as the nose touch response. In AIB interneurons, promotes om [...] (962 aa) |
| | pak-1 | Serine/threonine-protein kinase pak-1; Required for hypodermal cell fusion, together with cdc-42 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. Plays a redundant role with max-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. Acts probably downstream of Rho GTPases mig-2 and ced-10 to regulate these 2 processes. Involved in orientating axonal growth of HSN neurons. During gonad morphogenesis and probably in association with pix-1 and git-1, involved in the migration of distal tip ce [...] (572 aa) |
| | hot-9 | Homolog of Odr-2 (Two). (206 aa) |
| | ced-10 | Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] (191 aa) |
| | lin-10 | Protein lin-10; Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glutamate receptor glr-1 in the ventral nerve cord. (982 aa) |
| | pcm-1 | Protein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. This enzyme does not act on D-aspartyl residues. (225 aa) |
| | akt-1 | Serine/threonine-protein kinase akt-1; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Has an essential role in regulating developmental arrest at the dauer stage. Plays a role in immune function and pathogen resistance. Regulates salt chemotaxis learning. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic devel [...] (546 aa) |
| | lite-1 | High-energy light unresponsive protein 1; Photoreceptor for short wavelength (UV) light that mediates UV-light-induced avoidance behavior. Directly senses and absorbs both UV-A and UV-B light with very high efficiency. Absorption of UV-B but not UV-A light shows resistance to photobleaching. In contrast to other photoreceptors, does not use a prosthetic chromophore to capture photons and only depends on its protein conformation. (439 aa) |
| | seb-3 | Secretin receptor-like protein SEB-3; Belongs to the G-protein coupled receptor 2 family. (454 aa) |
| | hop-1 | Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. (358 aa) |
| | sax-7 | Fibronectin type-III domain-containing protein. (1331 aa) |
| | che-6 | Cyclic nucleotide-binding domain-containing protein. (655 aa) |
| | ddr-1 | Discoidin domain-containing receptor A; Receptor which, together with svh-4, is involved in axon guidance to establish the tracts for the ventral and dorsal nerve cords during nervous system development. May play a role in axon regeneration following injury in D-type motor neurons ; Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. (766 aa) |
| | srb-5 | Serpentine receptor class beta-5; G-protein coupled receptor (Probable). Plays a role in the navigational capacity of sperm and promotes the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites. (345 aa) |
| | srb-3 | Serpentine receptor class beta-3; G-protein coupled receptor. (341 aa) |
| | trpa-1 | Transient receptor potential cation channel subfamily A member 1 homolog; Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors. (1211 aa) |
| | mps-1 | MiRP K channel accessory Subunit. (257 aa) |
| | aqp-6 | AQuaPorin or aquaglyceroporin related; Belongs to the MIP/aquaporin (TC 1.A.8) family. (291 aa) |
| | lgg-1 | Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] (123 aa) |
| | rig-6 | Contactin rig-6; Probable cell adhesion protein involved in patterning of the nervous system, playing a role in ALM and PLM touch receptor axon growth and VNC axon navigation. By associating with the transmembrane protein sax-7, mediates axonal interactions to establish synaptic connections between the AVG interneuron and the two PHC sensory neurons. Also required for non-neuronal cell migration in the excretory canal, regulating excretory canal elongation and excretory cell morphogenesis. Plays a role in regulating male mating behavior. (1196 aa) |
| | sphk-1 | Sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on sphinganine (By similarity). Required for neurotransmitter release from neuromuscular junctions. Acts by recruiting the synaptic vesicle priming protein unc-13 to synapses (Probable). (473 aa) |
| | odr-3 | Guanine nucleotide-binding protein alpha-17 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. This specific G-alpha subunit plays an important role in olfaction and in cilia morphogenesis. Involved in chemotactic responses to attractants diacetyl, pyrazine, 2,4,5-trimethylthiazole, benzaldehyde, isoamyl alcohol, butanone and 2,3-pentanedione. Displays a redundant function with gpa-3 in chemotactic responses. Involved in avoidance responses to copper, sodium dodecyl sulfate and linoleic acid. I [...] (356 aa) |
| | maph-1.3 | Microtubule-Associated Protein Homolog. (874 aa) |
| | hen-1 | HEsitatioN behavior. (117 aa) |
| | enu-3.2 | ENhancer of Uncoordination. (462 aa) |
| | npr-1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (457 aa) |
| | madd-2 | Uncharacterized protein. (765 aa) |
| | ttx-3 | LIM/homeobox protein ttx-3; Required for specification of the AIA and AIY interneurons and the NSM neurons. Positively regulates the expression of a number of genes including ceh-23, kal-1, hen-1, ser-2, unc-17 and sra-11 in AIY interneurons and cat-4, flp-4, bas-1, ptps-1 and mgl-1 in NSM neurons. Also acts in an autoregulatory feedback loop to maintain its own expression. Plays a role in the thermotactic response, olfactory imprinting, regulation of longevity, control of dauer formation and axon outgrowth and pathfinding. Not required for normal chemosensory behavior. (409 aa) |
| | ire-1 | Serine/threonine-protein kinase/endoribonuclease ire-1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices xbp-1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes. Unfolded protein response (UPR) transcriptional activation by ire-1, as well as translational attenuation by pek-1 in a complementary pathway, maintains ER homeostasis. Regulates the transcriptional up-regulation of nucleoside-diphosphatase apy-1 upon ER str [...] (967 aa) |
| | klp-16 | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (587 aa) |
| | apl-1 | Amyloid-beta-like protein; Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg- laying. May play a role in [...] (686 aa) |
| | bicd-1 | Protein bicaudal D homolog; Part of a complex with dlc-1 and egal-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells (Probable). Required for the formation of dendritic branches of PVD sensory neurons ; Belongs to the BicD family. (737 aa) |
| | mec-12 | Detyrosinated tubulin alpha-3 chain; Tubulin is the major constituent of microtubules (Probable). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (Probable). Component of the large-diameter neuronal microtubules which contains 15 protofilaments. Plays a role in mechanosensory transduction (touch sensitivity). (450 aa) |
| | ncs-1 | Neuronal calcium sensor 1; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Can substitute for calmodulin and directly activate PDE, NO synthase, and calcineurin. Regulates associative learning and memory in a calcium dependent manner. (191 aa) |
| | mak-2 | MAP kinase-activated protein kinase mak-2; Serine/threonine-protein kinase which is involved in maintaining synapse and axon morphology as well as touch neuron axon regeneration after injury by regulating cebp-1 mRNA stability downstream of the dlk-1, mkk-4 and pmk-3 signaling cascade. May play a role in body wall muscle contraction. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. (366 aa) |
| | gcy-36 | Soluble guanylate cyclase gcy-36; Plays a central role in social feeding behavior by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which probably binds to its heme-binding sites, may regulate social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in avoidance of hyper [...] (675 aa) |
| | ced-3 | Cell death protein 3 subunit p13; Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates. Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and ced-4 but independently of egl-1. By cleaving and activating ced-8, promotes phosphatidylserine exposure on the surface of apoptotic ce [...] (503 aa) |
| | cho-1 | High-affinity choline transporter 1; Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent. (576 aa) |
| | cil-1 | Inositol polyphosphate 5-phosphatase; Dephosphorylates a number of phosphatidylinositols. Controls the cellular levels and subcellular distribution of phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5- trisphosphate. Has a role in sperm activation and motility. Influences the localization of the transient receptor potential polycystin (TRPP) complex proteins lov-1 and pkd-2; Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. (398 aa) |
| | egl-47 | Egg laying defective EGL-47A; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. (522 aa) |
| | mec-18 | Uncharacterized protein. (638 aa) |
| | flp-17 | FMRF-Like Peptide. (130 aa) |
| | unc-104 | Kinesin-like protein unc-104; Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death. Belongs to the TRAFAC class myosin-kinesin ATPase super [...] (1628 aa) |
| | kcnl-4 | CaMBD domain-containing protein. (485 aa) |
| | odr-10 | Serpentine receptor class r-10; An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway; Belongs to the nematode receptor-like protein str family. (339 aa) |
| | atg-13 | Autophagy-related protein 13 homolog; Component of the unc-51/atg-13 complex required for autophagosome formation. Required for the degradation of germ cell specific P-granule components such as sepa-1 by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May function downstream of the let-363 (Tor) signaling pathway to mediate sepa-1 degradation. Plays a role in survival during limited food availability ; Belongs to the ATG13 family. Metazoan subfamily. (443 aa) |
| | wdr-23 | DDB1- and CUL4-associated factor 11 homolog; Involved in regulation of lifespan. Required for dopaminergic CEP neuron degeneration in response to Mn(2+). (571 aa) |
| | maco-1 | Macoilin; Plays a role in the regulation of neuronal activity. (897 aa) |
| | pkc-2 | Protein kinase C-like 2; PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (936 aa) |
| | gpa-3 | Guanine nucleotide-binding protein alpha-3 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Promotes transcription of 3',5'-cyclic phosphodiesterases pde- 1 and pde-5, leading to reduced cGMP levels in sensory neurons. This causes suppression of insulin production and signaling which leads to increased daf-16 activity and contributes to increased adult lifespan and resistance to oxidative stress. In addition, by reducing cGMP levels, inhibits TGF-beta signaling pathways. Involved in behaviora [...] (353 aa) |
| | egl-21 | Carboxypeptidase E; During FMRFamide-like peptide (FaRPs or FLP) and neuropeptide-like protein (NLP) precursor processing, catalyzes the removal of Arg or Lys residues from the C-terminus following the initial endoprotease cleavage. By processing neuropeptides, modulates basal acetylcholine release at the ventral cord neuromuscular junctions. Involved in egg-laying, defecation and locomotion. By processing FLP neuropeptides, regulates the turning step of male mating behavior. Involved in reducing pharyngeal pumping in response to high CO(2) levels. (472 aa) |
| | kcnl-2 | CaMBD domain-containing protein. (855 aa) |
| | gcy-12 | Receptor-type guanylate cyclase gcy-12; Guanylate cyclase involved in the production of the second messenger cGMP. Acts upstream of cGMP-dependent protein kinase egl-4, most likely by providing cGMP to the kinase in chemosensory neurons to regulate body size. (1679 aa) |
| | vps-52 | Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function. Belongs to the VPS52 family. (702 aa) |
| | lev-1 | Acetylcholine receptor subunit beta-type lev-1; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (507 aa) |
| | mig-10 | Abnormal cell migration protein 10; Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt- 1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration. Belongs to the MRL family. (779 aa) |
| | kpc-1 | Furin-like protease kpc-1; Furin-like protease which cleaves proproteins at the RX(K/R)R consensus motif. During neuronal development, regulates the formation and extension of dendrite branches and cellular positioning of various type of neurons. Promotes the formation, extension and self-avoidance of dendritic branches of PVD and FLP mechanosensory neurons. In PVD neurons, regulates plasma membrane levels of branching receptor dma-1 by targeting it to late endosomes and thus promotes normal dendrite branching and dendrite self-avoidance. Also controls dendrite extension in AIY and D-t [...] (692 aa) |
| | ddr-2 | Discoidin domain-containing receptor tyrosine kinase B; Tyrosine-protein kinase receptor which, together with ddr-1, is involved in axon guidance to establish the tracts for the ventral and dorsal nerve cords during nervous system development. Acts upstream of the adapter shc-1, and the tyrosine kinase receptors svh-1 and svh-2 to regulate axon regeneration following injury in D-type motor neurons. May mediate axon regeneration in association with the collagen emb-9. (797 aa) |
| | ins-1 | IlGF domain-containing protein. (109 aa) |
| | rhgf-1 | RHo Guanine nucleotide exchange Factor. (1340 aa) |
| | shw-1 | BTB domain-containing protein; Belongs to the potassium channel family. (619 aa) |
| | cng-1 | Cyclic nucleotide-binding domain-containing protein. (661 aa) |
| | gpa-13 | Guanine nucleotide-binding protein alpha-13 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (402 aa) |
| | nfyc-1 | CBFD_NFYB_HMF domain-containing protein. (232 aa) |
| | pef-1 | Serine/threonine-protein phosphatase with EF-hands pef-1; Probably acts as a protein phosphatase. (707 aa) |
| | maph-1.2 | Microtubule-Associated Protein Homolog. (874 aa) |
| | ubc-25 | Ubiquitin-conjugating enzyme E2 25; Catalyzes the covalent attachment of ubiquitin to other proteins (Potential). Required for the maintenance of neuromuscular function. (387 aa) |
| | tba-1 | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa) |
| | selt-1.2 | Thioredoxin reductase-like selenoprotein T homolog selt-1.2; Probably has thioredoxin reductase-like oxidoreductase activity; Belongs to the SelWTH family. SELT subfamily. (216 aa) |
| | maph-1.1 | Microtubule-associated protein homolog maph-1.1; Belongs to the MAP1A/MAP1B/MAP1S family. (878 aa) |
| | dlk-1 | Mitogen-activated protein kinase kinase kinase dlk-1; Component of a MAP kinase pathway that functions presynaptically to regulate synaptic architecture and presynaptic differentiation. Phosphorylates and activates mkk-4. Has a role in axonal regrowth following injury and synaptogenesis. Also promotes tubulin post-translational modifications that protect microtubules. Plays a role in cilium length regulation, possibly by reducing rab-5 mediated endocytosis, and may also have a role in intraflagellar transport in cilia. Plays a role in the formation of muscle connections, also called mu [...] (928 aa) |
| | ptrn-1 | Patronin (microtubule-binding protein) homolog; Required for microtubule stability and anchorage by binding to the minus ends of microtubules. Acts redundantly with noca-1 to control circumferential microtubule assembly along the body which is necessary for larval development, viability, morphology and integrity of the epidermis. Promotes microtubule stability and polymerization in neurons. Involved in the maintenance of neurite morphology in ALM and PLM neurons. May play a role in synaptic protein localization in the PLM neuron. May act upstream of dlk-1 in neuronal regeneration. Play [...] (1112 aa) |
| | jkk-1 | Dual specificity mitogen-activated protein kinase kinase jkk-1; Dual specificity protein kinase which acts as an essential component of the JNK signal transduction pathway. May phosphorylate jnk-1. Plays a role in coordinating locomotion via D-type GABAergic motoneurons and in regulating synaptic vesicle transport downstream of adapter protein unc-16 and probably by activating jnk-1. Positively regulates lifespan. Upon environmental stress such as heat stress regulates daf-16 nuclear translocation probably by activating jnk-1. Regulates germline cell apoptosis in response to heavy meta [...] (435 aa) |
| | sel-12 | Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family. (444 aa) |
| | gpa-2 | Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Involved in behavioral responses to P.aeruginosa by controlling the expression of daf-7, a member of the TGF-beta family, in ASJ sensory neurons. Belongs to the G-alpha family. G(q) subfamily. (356 aa) |
| | let-92 | Serine/threonine-protein phosphatase 2A catalytic subunit; Protein phosphatase which plays an essential role in early embryonic cell division. Probably together with constant regulatory subunit paa-1 and regulatory subunit sur-6, positively regulates centriole duplication by preventing the degradation of sas-5 and kinase zyg-1. In addition, plays a role in the recruitment of sas- 6 and maybe sas-5 to centrioles and may dephosphorylate sas-5 and zyg-1 negative regulator szy-20. During vulva development, may play a role with regulatory subunits paa-1 and sur-6 in the induction of vulva c [...] (318 aa) |
| | uev-1 | Ubiquitin-conjugating enzyme E2 variant 1; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. Required for glr-1-containing glutamate receptor trafficking in neurons. May have a role in synaptic transmission at motorneurons. May be involved in the ubiquitination and growth of intracellular polygluta [...] (139 aa) |
| | wrk-1 | Wrapper/Rega-1/Klingon homolog. (452 aa) |
| | mig-13 | Abnormal cell migration protein 13; Probable receptor that acts as an upstream signaling protein to promote the guidance, migration and positioning of the right Q neuroblast (QR) and its descendants along the anteroposterior body axis, and also the anterior migration of BDU interneurons during larval development. Associates with and recruits the downstream components tyrosine kinase abl-1 and the tyrosine kinase adapter protein sem-5 to the leading edge of migrating Q neuroblasts and their descendants to activate signaling through the two parallel wve-1 and wsp-1 pathways, respectively [...] (362 aa) |
| | hot-1 | Ly-6-related protein HOT-1. (218 aa) |
| | fer-1 | Sperm vesicle fusion protein fer-1; Required for the fusion of the membranous organelles (MOs) with the plasma membrane, a process essential in spermiogenesis. (2034 aa) |
| | dyf-6 | Intraflagellar transport protein 46 homolog; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for normal morphology and function of ciliated amphid sensory neurons. (471 aa) |
| | gpa-6 | Guanine nucleotide-binding protein alpha-6 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (364 aa) |
| | gpb-2 | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (369 aa) |
| | gpa-5 | Guanine nucleotide-binding protein alpha-5 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (385 aa) |
| | unc-108 | Uncharacterized protein. (223 aa) |
| | arr-1 | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. (435 aa) |
| | stau-1 | STAUfen (DsRNA binding protein) homolog. (705 aa) |
| | efn-4 | Ephrin-4; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, involved in ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting together with mab-20 and allows the formation of distinct sensory rays. Probably acts as a ligand for lad-2 to regulate axon guidance of several neurons including SDQL, SDQR, SMD and PLN neurons during neurogenesis. (348 aa) |
| | unc-64 | Syntaxin-1A homolog; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the qui [...] (291 aa) |
| | klp-4 | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1610 aa) |
| | ccpp-1 | Cytosolic carboxypeptidase 1; Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia. In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles. Also regulates microtubule dynamics in uterine muscle cells. (1015 aa) |
| | dmsr-1 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (510 aa) |
| | srb-12 | Serpentine receptor class beta-12; G-protein coupled receptor (Probable). Plays a role in the navigational capacity of sperm and promotes the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites. (350 aa) |
| | srb-13 | Serpentine receptor class beta-13; G-protein coupled receptor that antagonizes the negative effects of the gcy-35 oxygen sensor on spermatogenesis. This leads to the maintenance of mitochondrial function in developing spermatocytes and/or spermatids prior to testis maturation during the early larval stages. Regulates the navigational capacity of sperm during hyperoxic conditions ensuring the proper targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites. May act in the same signaling pathway as the neuropeptide flp-21. (345 aa) |
| | srb-16 | Serpentine receptor class beta-16; G-protein coupled receptor (Probable). Plays a role in the navigational capacity of sperm and promotes the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites ; Belongs to the nematode receptor-like protein srb family. (342 aa) |
| | nsy-1 | Mitogen-activated protein kinase kinase kinase nsy-1; Serine/threonine-protein kinase which, by phosphorylating and activating sek-1, plays an important role in the activation of the p38 pathway also composed of the downstream effectors sek-1 and pmk-1. Downstream of CaMKII unc-43 and adapter protein tir-1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive and Gram-negative bacteri [...] (1498 aa) |
| | rab-6.1 | Ras-related protein Rab-6.1; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (205 aa) |
| | vps-35 | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (821 aa) |
| | enu-3.1 | ENhancer of Uncoordination. (204 aa) |
| | ttll-11 | Tubulin polyglutamylase ttll-11; Polyglutamylase which preferentially modifies tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction. By controlling tubulin glutamylation, regulates ciliary specialization and motor-based transport. Promotes the formation of A and B tubule singlets by splaying microtubule doublets in cilia. Together with ttll-4 and 5, required for male mating. [Isoform b]: Specifically promotes tubulin glutamylation in male ciliated CEM, HOB and RnB neurons that release bioactive extracellular vesicles. Regulates the localization of TRP c [...] (707 aa) |
| | pdk-1 | 3-phosphoinositide-dependent protein kinase 1; Involved in the daf-2/insulin receptor-like transduction pathway, which controls longevity and prevents developmental arrest at the dauer stage. Phosphorylates and activates sgk-1, akt-1 and akt-2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. (636 aa) |
| | tdc-1 | Tyrosine decarboxylase; Required for the decarboxylation of tyrosine to tyramine, a precursor of octopamine but probably also itself a neurotransmitter. Involved in the regulation of egg laying, which is inhibited by tyramine. Also involved in controlling locomotion and head movements. Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity which requires octopamine signaling ; Belongs to the group II decarboxylase family. (705 aa) |
| | enu-3.6 | ENhancer of Uncoordination. (319 aa) |
| | lect-2 | Peptidase_M23 domain-containing protein. (335 aa) |
| | mod-1 | Serotonin-gated chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (489 aa) |
| | hot-5 | Ly-6-related protein HOT-5. (180 aa) |
| | pdr-1 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (386 aa) |
| | unc-43 | Calcium/calmodulin-dependent protein kinase type II; Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the [...] (681 aa) |
| | nlp-12 | Neuropeptide-Like Protein. (80 aa) |
| | egl-30 | Heterotrimeric G protein alpha subunit. (355 aa) |
| | hmit-1.3 | MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (604 aa) |
| | osm-3 | Osmotic avoidance abnormal protein 3; Kinesin motor protein which is required for the anterograde intraflagellar transport (IFT) along the middle segment of the sensory neuron cilia together with the kinesin II motor complex (composed of klp-11, klp-20 and kap-1) and on its own, is required for IFT along the distal segment. In addition, regulates the length of cilia. May have a role during neurogenesis and axonal transport. (699 aa) |
| | zig-12 | Ig-like domain-containing protein. (197 aa) |
| | dyf-5 | Serine/threonine-protein kinase dyf-5; Serine/threonine-protein kinase which is required for ciliogenesis. Regulates the length and the morphology of sensory neuron cilia. In addition, plays a role in the anterograde intraflagellar transport (IFT) in the cilia by regulating the undocking of kinesin-II motor complex (composed of klp-11, klp-20 and kap-1) before reaching the distal segment and the docking of kinesin motor osm-3 onto IFT cargos; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. RCK subfamily. (489 aa) |
| | irk-1 | Inward rectifier potassium channel irk-1; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Required for modulation of the activity of the hermaphrodite-specific neurons (HSNs) by the G-protein coupled neuropeptide receptor egl-6 which in turn controls egg-laying behavior. (544 aa) |
| | egl-36 | Potassium voltage-gated channel protein egl-36; Voltage-dependent potassium channel involved in the excitation of muscles operating egg-laying and defecation. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Shaw sub-subfamily. (558 aa) |
| | sru-38 | Serpentine Receptor, class U. (322 aa) |
| | ebax-1 | SWIM-type domain-containing protein. (1717 aa) |
| | usp-46 | Ubiquitin carboxyl-terminal hydrolase 46; Regulates the abundance of the glr-1 glutamate receptor in the ventral nerve cord by promoting its deubiquitination and preventing its degradation in the lysosome. Contributes to the regulation of embryonic polarity. (426 aa) |
| | unc-8 | Degenerin unc-8. (778 aa) |
| | klp-6 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (928 aa) |
| | shw-3 | BTB domain-containing protein; Belongs to the potassium channel family. (500 aa) |
| | osm-6 | Osm-6 protein. (472 aa) |
| | gcy-28 | Receptor-type guanylate cyclase gcy-28; Guanylate cyclase involved in the production of the second messenger cGMP. Regulates olfactory perception in AWC sensory neurons although may not be involved in the primary sensory transduction steps. [Isoform d]: Regulates sensory integration of conflicting sensory cues in AIA interneurons. (1276 aa) |
| | odr-2 | Ly-6-related protein ODR-2 isoform 2b. (201 aa) |
| | aak-2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] (626 aa) |
| | mec-15 | F-box/WD repeat-containing protein mec-15; Plays a role in mechanosensory transduction (touch sensitivity), touch receptor neuron development and synapse formation. Regulates expression of the protein snb-1 and the distribution of synaptic vesicles at synapses to promote synaptic transmission at the neuromuscular junctions of GABAergic motor neurons. (406 aa) |
| | kin-10 | Casein kinase II subunit beta; Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). Modulates two aspects of male mating behavior; response to hermaphrodite contact and vulval location, acting in the same pathway as lov-1 and pkd-2; Belongs to the casein kinase 2 subunit beta family. (235 aa) |
| | lis-1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division. Part of a complex with nud-2, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells. Plays a role in GABAergic synaptic vesicle localization in [...] (404 aa) |
| | snf-11 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (610 aa) |
| | gcy-35 | Soluble guanylate cyclase gcy-35; Plays a central role in social feeding behavior and oxygen sensation by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which binds to its heme-binding sites, probably regulates social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in [...] (688 aa) |
| | vps-53 | Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function. (798 aa) |
| | unc-69 | Uncharacterized protein. (176 aa) |
| | daf-18 | Abnormal dauer formation protein 18; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (By similarity). Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate. By dephosphorylating PtdIns(3,4,5)P3 antagonizes PtdIns(3,4,5)P3 production by age-1/PI3K and thus, negatively regulates daf-2-mediated processes including dauer formation, longevity, fat metabolism, chemotaxis towards salt, thermotolerance and axon guidance. Similarly, [...] (962 aa) |
| | ced-9 | Apoptosis regulator ced-9; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway. (280 aa) |
| | unc-29 | Acetylcholine receptor subunit beta-type unc-29; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine and levasimole. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (493 aa) |
| | cni-1 | Protein cornichon homolog 1; Negatively regulates export of glr-1 from the endoplasmic reticulum to synapses. (145 aa) |
| | srx-43 | Serpentine receptor class X-43; Receptor for the ascaroside pheromone icas#9 which suppresses exploratory forgaging behavior. In response to ascaroside icas#9, may furthermore play a role in the expression of genes in the TGF-beta signaling pathway, such as daf-7, and in insulin signaling pathway, such as daf-28, which may in turn contribute to exploratory behavior. Belongs to the G-protein coupled receptor 1 family. (319 aa) |
| | hot-4 | Homolog of Odr-2 (Two). (196 aa) |
| | daf-9 | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] (572 aa) |
| | hot-8 | Homolog of Odr-2 (Two). (193 aa) |
| | tmc-1 | Transmembrane channel-like protein 1; Sodium-sensor ion channel that acts specifically in salt taste chemosensation. Required for salt-evoked neuronal activity and behavioral avoidance of high concentrations of NaCl. Belongs to the TMC family. (1285 aa) |
| | ric-3 | Resistance to inhibitors of cholinesterase protein 3; Required for maturation and cell surface expression of acetylcholine receptors; Belongs to the ric-3 family. (378 aa) |
| | inx-19 | Innexin-19; Structural component of the gap junctions that specifically coordinates left-right asymmetry in the developing nervous system. Acts by forming gap junction network linking embryonic neurons and providing electrical coupling between cells, leading to promote or inhibit AWC signaling. Required for the left and right AWC olfactory neurons to establish asymmetric patterns of gene expression during embryogenesis. Acts autonomously. (454 aa) |
| | rund-1 | RUN domain-containing protein. (549 aa) |
| | bec-1 | Beclin homolog; Regulates autophagy. Together with phosphatidyl-3-phosphate kinase vps-34, acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate (PtdIns3P), thereby regulating membrane trafficking. In association with sorf-1 and sorf-2, negatively regulates phosphatidylinositol 3- phosphate in early endosomes to allow for the conversion to late endosomes. Involved in the clearance of engulfed apoptotic cell corpses. Together with ced-9, negatively regulates somatic and germline apoptosis. Plays a role in endosome-to-Golgi retrograde tra [...] (375 aa) |
| | osm-10 | Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (419 aa) |
| | pat-6 | Paralyzed arrest at two-fold protein 6; Involved in the regulation of cell adhesion and cytoskeleton organization. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments composed of integrins pat-2/pat-3, pat-4 and unc-112. Also required to reposition the integrin-based attachments so that they form the highly ordered array of dense body and M-line attachments that are characteristic of mature muscle cells. Du [...] (375 aa) |
| | dat-1 | Sodium-dependent dopamine transporter; Dopamine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. (615 aa) |
| | rab-10 | Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for basolateral endocytic recycling, the return of macromolecules and fluid from endosomes to the plasma membrane, in polarized epithelial cells of the intestine upstream of rm [...] (201 aa) |
| | inpp-1 | IPPc domain-containing protein. (432 aa) |
| | rab-6.2 | Ras-related protein Rab-6.2; Protein transport. Probably involved in vesicular traffic (By similarity). (205 aa) |
| | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1; Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite- specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2393 aa) |
| | T27C4.1 | Uncharacterized protein. (243 aa) |
| | ppk-3 | PIP Kinase. (1497 aa) |
| | hot-3 | Homolog of Odr-2 (Two). (196 aa) |
| | kel-8 | Kelch-like protein 8; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates degradation of glutamate receptors in neurons. The BCR(kel-8) ubiquitin ligase complex mediates ubiquitination and subsequent degradation of rpy-1. Indirectly regulates the protein turnover of glr-1, possibly via ubiquitination and degradation of rpy-1. (727 aa) |
| | enu-3.3 | ENhancer of Uncoordination. (462 aa) |
| | cil-7 | CILiary localization. (548 aa) |
| | elt-1 | Transcription factor elt-1; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' and variations thereof. During embryonic development, required for specification of cell fate of major hypodermal (epidermal) cells at the blastomere stage. The requirement is true for all four lineages derived from ABarp, ABpra and C blastomeres. Required for seam cell maintenance in late embryogenesis, for proper formation of dauer larvae and locomotion. Regulates expression of bro-1, a regulator of seam cell proliferation, via a GATA-like binding motif. Probably represses ex [...] (488 aa) |
| | dkf-1 | Serine/threonine-protein kinase dkf-1; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC. Role in the regulation of growth and neuromuscular control of movement. Involved in immune response to S.aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. (722 aa) |
| | nfyb-1 | CBFD_NFYB_HMF domain-containing protein. (403 aa) |
| | elpc-1 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1250 aa) |
| | ift-20 | Intraflagellar transport protein 20 homolog; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. (129 aa) |
| | lgc-55 | Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (538 aa) |
| | rab-28 | Ras-related protein Rab-28; GTPase. Intraflagellar transport (IFT) cargo that undergoes bidirectional IFT along the ciliary axoneme when in active GTP-bound state in amphid and phasmid ciliated sensory neurons. Targeting and function as IFT cargo may depend on the BBSome, an IFT cargo adapter. Does not undergo IFT when in inactive GDP-bound state. May in turn play a role in cilium structure and/or function in ciliated sensory neurons. Belongs to the small GTPase superfamily. Rab family. (248 aa) |
| | enu-3.5 | ENhancer of Uncoordination. (458 aa) |
| | flp-14 | FMRFamide-like neuropeptides 14; FMRFamides and FMRFamide-like peptides are neuropeptides. KHEYLRF-amide has an excitatory effect on dissected pharyngeal myogenic muscle system. Functions in RID peptidergic neurons to promote forward locomotory behavior. (143 aa) |
| | unc-25 | Glutamic acid decarboxylase. (508 aa) |
| | nape-1 | Lactamase_B domain-containing protein. (356 aa) |
| | max-2 | Serine/threonine-protein kinase max-2; Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk- 1/mek-1/kgb-1 pathway. In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc- 6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons. Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstre [...] (649 aa) |
| | hot-2 | Homolog of Odr-2 (Two). (287 aa) |
| | srd-23 | Serpentine Receptor, class D (Delta). (323 aa) |
| | sup-1 | Protein SUP-1; May be involved in trafficking or stabilization of the vesicular acetylcholine transporter unc-17. (103 aa) |
| | dmd-3 | Doublesex- and mab-3-related transcription factor dmd-3; Transcriptional activator which promotes male-specific development. Acts partially redundantly with the transcription factor mab-3 to coordinate tail tip cell fusion and retraction and thereby regulate male tail tip morphogenesis. This is most likely through the regulation of downstream effectors such as eff-1. May also negatively regulate the expression of other proteins implicated in male tail morphogenesis including nhr-25, vav-1 and arl-1 in tail tip cells. In males, plays a role in the development of ray A-neurons by negativ [...] (250 aa) |
| | qui-1 | WD_REPEATS_REGION domain-containing protein. (1592 aa) |
| | rsks-1 | Ribosomal protein S6 kinase beta; Serine/threonine-protein kinase which regulates mRNA translation. Negatively regulates lifespan and resistance to starvation, oxidative stress, protein aggregation and P.aeruginosa-mediated infection. May regulate these processes by preventing the activation of transcription factor hif-1. Required, probably downstream of let-363/TOR, for the establishment of the proper number of germline progenitors by promoting cell cycle progression and preventing differentiation during larval development. Regulates germ cell size. In addition required for sperm prod [...] (550 aa) |
| | plr-1 | Probable E3 ubiquitin-protein ligase plr-1; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled (By similarity). Acts on both canonical and non- canonical Wnt signaling pathway (By similarity). Plays a role in the migration and axon guidance of different neuronal cell types including CAN, HSN, AVK and AVG. Promotes the differentiation and regulates the anteroposterior polarity of AVG unpaired interneurons by sequestering the [...] (487 aa) |
| | kvs-4 | Probable voltage-gated potassium channel subunit kvs-4; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. (512 aa) |
| | cccp-1 | CARD domain-containing protein. (743 aa) |
| | hmit-1.2 | MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (613 aa) |
| | strd-1 | STE20-related kinase adapter protein strd-1; Pseudokinase which may act as an adapter for kinases sad-1 and par-4 and thereby is involved in several developmental processes. Regulates cell-autonomously both neuronal polarity and synaptic organization when bound to sad-1. Required for sad-1 localization to synapses. Required to establish germline stem cell (GSC) quiescence during dauer development, to promote cell shedding during embryogenesis and to control asymmetric cell division of the Q.p neuroblast lineage, probably when bound to par-4. May be involved in maintaining the integrity [...] (388 aa) |
| | nipa-1 | NIPA1 (NonImprinted gene in Prader-Willi/Angelman syndrome region 1) homolog. (397 aa) |
| | tac-1 | Transforming acid coiled-coil-containing protein 1; Involved in microtubule formation, polymerization and assembly, regulating microtubule nucleation and length. Plays a role in pronuclear migration and mitotic and meiotic spindle elongation during early embryogenesis. In complex with zyg-9, functions during the early stages of embryonic development to regulate microtubule assembly throughout the cell cycle. Specifically, the complex is required for the formation and growth of astral microtubules and spindle microtubules during mitotic spindle assembly. At anaphase, the complex is requ [...] (260 aa) |
| | stim-1 | Stromal interaction molecule 1; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor which upon Ca(2+) depletion, activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, orai-1. Essential for Ca (2+) and IP3-dependent contractile activity of gonad sheath cells and spermatheca. Essential for fertility. Does not play a role in posterior body wall muscle contraction (pBoc) rhythmicity, intestinal cell oscillatory Ca(2+) signaling or intestinal ER Ca(2+) hemostasis. (530 aa) |
| | daf-2 | Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] (1928 aa) |
| | unc-51 | Serine/threonine-protein kinase unc-51; Protein kinase important for axonal elongation and axonal guidance. Functions in the CAN axons to direct both anterior and posterior migrations. Phosphorylates both unc-14 and vab-8. Component of the unc-51/atg-13 complex that is probably recruited by lgg-1 to preautophagosomes and is required for autophagosome formation. Interaction with autophagy related proteins such as atg-13 links it to the autophagy machinery to in turn promote P-granule degradation in somatic cells. Plays a role in mitophagy during limited food availability. Regulates cell [...] (856 aa) |
| | lag-2 | Protein lag-2; Putative intercellular signal for lin-12 and GLP-1 receptors. Functions in uterine cells to promote basement membrane mobility during tissue remodeling. (402 aa) |
| | pkd-2 | Polycystin-2; Functions as a calcium permeable cation channel. Required for 2 aspects of male mating behavior: response to hermaphrodite contact and vulva location. Acts in the same pathway as lov-1 and atp-2 in response behavior. (716 aa) |
| | cng-2 | Cyclic nucleotide-binding domain-containing protein. (819 aa) |
| | cha-1 | Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses (By similarity). Required in SIA sublateral cholinergic motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis ; Belongs to the carnitine/choline acetyltransferase family. (627 aa) |
| | gur-3 | Gustatory receptor family protein 3; Chemoreceptor involved in light-induced avoidance behavior. Probably acts as a molecular sensor in I2 pharyngeal neurons, required for the inhibition of feeding in response to light and hydrogen peroxide. Involved in circadian rhythms, probably by acting as a light sensor. In contrast to lite-1, does not act as a photoreceptor. (447 aa) |
| | pat-3 | Integrin beta pat-3; Integrin alpha ina-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable). Plays a role in cell migration, morphogenesis and probably in cell-cell interactions. During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M line [...] (809 aa) |
| | mec-7 | Tubulin beta-1 chain; Tubulin is the major constituent of microtubules (Probable). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (Probable). Plays a role in mechanosensory transduction (touch sensitivity). (441 aa) |
| | gcy-9 | Receptor-type guanylate cyclase gcy-9; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Involved in the sensing of CO2 levels and acidity by the BAG neurons. May act as a direct receptor for CO2 and H+. (1081 aa) |
| | spe-4 | Presenilin spe-4; Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II. May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis. (465 aa) |
| | asna-1 | ATPase asna-1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] (342 aa) |
| | unc-31 | Calcium-dependent secretion activator; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). Specifically required to activate the neuronal G-alpha pathway. Functions with G-alpha proteins from the same motor neurons to regulate locomotion. Involved in regulating entry into quiescence triggered by sat [...] (1401 aa) |
| | lov-1 | Location of vulva defective 1; Required for two aspects of male mating behavior: response to hermaphrodite contact and vulva location. Acts in the same pathway as pkd-2 and atp-2 in response behavior. May be required for ciliary targeting of pkd-2. (3284 aa) |
