Your Input: | |
| | eat-6 | Sodium/potassium-transporting ATPase subunit alpha. (996 aa) |
| | snet-1 | Protein snet-1; Negatively regulates chemotaxis and olfactory plasticity which is the change from positive chemotaxis to dispersal after prolonged exposure to an odorant. May be down-regulated in response to pheromone exposure, resulting in promotion of olfactory plasticity. (101 aa) |
| | fbxl-1 | F-box/LRR-repeat protein fbxl-1; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Plays a role in regulating the entry into the dauer state. In hermaphrodites, may play a role in modulating the rate of defecation. (466 aa) |
| | aex-3 | MAP kinase-activating death domain protein; Plays a novel and significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of rab-3 and cab-1 to the GTP-bound active forms. Regulator of presynaptic activity that interacts with rab-3 to regulate synaptic vesicle release. Is also a regulator of the cab-1 synaptic transmission pathway. Probably by converting rab-3 to its GTP-bound active form, plays a role [...] (1409 aa) |
| | unc-89 | Muscle M-line assembly protein unc-89; Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments. The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role. Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles. By binding mel-26, a substrate adapter of t [...] (8081 aa) |
| | dgk-1 | Diacylglycerol kinase. (952 aa) |
| | tnt-3 | TropoNin T. (1178 aa) |
| | npr-4 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (490 aa) |
| | dsc-1 | Homeobox protein dsc-1; Transcriptional regulator which plays a role in the expulsion step of defecation by controlling enteric muscle-specific expression of exp-1 which is required for enteric muscle contraction. Not required for exp-1 expression in the PDA neuron. Also involved in controlling the length of the defecation cycle. (310 aa) |
| | pat-4 | Integrin-linked protein kinase homolog pat-4; Probable pseudokinase that acts as an adapter protein. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M lines during body wall muscle development by recruiting several of their components including integrin pat-3, cpna-1, unc-89 and unc- 112 to integrin-mediated attachment sites. Plays a role in distal tip cell (DTC) migration and in oocyte development probably by regulating the actin cytoskeleton. During the formation of neuromus [...] (466 aa) |
| | unc-103 | Potassium voltage-gated channel unc-103; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly (By similarity). Regulates the movements of the male's copulatory spicules before and during male mating behavior ; Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily. (898 aa) |
| | rig-6 | Contactin rig-6; Probable cell adhesion protein involved in patterning of the nervous system, playing a role in ALM and PLM touch receptor axon growth and VNC axon navigation. By associating with the transmembrane protein sax-7, mediates axonal interactions to establish synaptic connections between the AVG interneuron and the two PHC sensory neurons. Also required for non-neuronal cell migration in the excretory canal, regulating excretory canal elongation and excretory cell morphogenesis. Plays a role in regulating male mating behavior. (1196 aa) |
| | mlc-1 | Myosin regulatory light chain 1. (170 aa) |
| | mlc-2 | Myosin regulatory light chain 2. (170 aa) |
| | npr-1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (457 aa) |
| | mec-12 | Detyrosinated tubulin alpha-3 chain; Tubulin is the major constituent of microtubules (Probable). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (Probable). Component of the large-diameter neuronal microtubules which contains 15 protofilaments. Plays a role in mechanosensory transduction (touch sensitivity). (450 aa) |
| | unc-93 | Putative potassium channel regulatory protein unc-93; May contribute to coordination of muscle contraction as regulatory subunit of a nonessential potassium channel complex. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord ; Belongs to the unc-93 family. (705 aa) |
| | unc-112 | Protein unc-112; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable regulator of cell-extracellular matrix adhesion. Required during initial muscle assembly to form dense bodies and M-lines. (720 aa) |
| | egl-19 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1877 aa) |
| | C50C3.5 | Uncharacterized calcium-binding protein C50C3.5. (189 aa) |
| | mec-9 | Uncharacterized protein. (838 aa) |
| | egl-3 | Neuroendocrine convertase 2; Serine endoprotease which cleaves preproteins at paired basic amino acids. Processes FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides. Probably by processing flp-1 and flp-18, modulates the neuronal excitation-inhibition balance and thus the level of activity of the locomotor circuit. Regulates sensitivity to mechanosensory stimuli. By processing neuropeptides, modulates basal acetylcholine release at the ventral cord neuromuscular junctions. Probably by processing flp neuropeptides, regulates the turning step of male mating behavior. [...] (652 aa) |
| | unc-104 | Kinesin-like protein unc-104; Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death. Belongs to the TRAFAC class myosin-kinesin ATPase super [...] (1628 aa) |
| | aex-1 | C2 domain-containing protein aex-1; Involved in retrograde signaling from post-synaptic cells to pre-synaptic neurons, probably by regulating vesicle exocytosis in post-synaptic cells. Acts in muscles, to regulate the localization of synaptic vesicle fusion protein unc-13 likely during vesicle exocytosis and thus regulate retrograde signaling at the neuromuscular junction (NMJ). Regulates anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). Probably by regulating DMP, plays a homeostatic role in the uptake of triglycerides. Regulat [...] (1009 aa) |
| | mec-5 | MEC-5. (327 aa) |
| | egl-21 | Carboxypeptidase E; During FMRFamide-like peptide (FaRPs or FLP) and neuropeptide-like protein (NLP) precursor processing, catalyzes the removal of Arg or Lys residues from the C-terminus following the initial endoprotease cleavage. By processing neuropeptides, modulates basal acetylcholine release at the ventral cord neuromuscular junctions. Involved in egg-laying, defecation and locomotion. By processing FLP neuropeptides, regulates the turning step of male mating behavior. Involved in reducing pharyngeal pumping in response to high CO(2) levels. (472 aa) |
| | unc-87 | Protein unc-87; Thin filament-associated protein that is implicated in actin bundling and actin filament dynamics. Exhibits F-actin cross-linking activity. Required for the maintenance of sarcomeric actin organization in striated muscles. Competes with unc-60 isoform b for actin binding and protects actin filaments from depolymerization by unc-60, thereby contributing to actin filament stability. Cooperates with myosin to form actomyosin bundles and inhibits actomyosin ATPase activity and actomyosin motility. Might protect the myofilaments from mechanical stress. (565 aa) |
| | mec-2 | Mechanosensory protein 2; Positively regulates the activity of the putative mechanosensory transduction channel. May link the mechanosensory channel and the microtubule cytoskeleton of the touch receptor neurons. Required for the function of a set of six touch receptor neurons. (1239 aa) |
| | flp-16 | FMRFamide-like neuropeptides 16; FMRFamides and FMRFamide-like peptides are neuropeptides. AQTFVRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system. (92 aa) |
| | mec-10 | Degenerin mec-10; Amiloride-sensitive sodium channel subunit required for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior. (724 aa) |
| | acy-1 | Adenylyl CYclase. (1253 aa) |
| | unc-38 | Acetylcholine receptor subunit alpha-type unc-38; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (511 aa) |
| | flp-1 | FMRFamide-like neuropeptides 1; Together with flp-18, plays a homeostatic role by acting on the GABAergic neural transmission at neuromuscular junctions to prevent overexcitation of the locomotor circuit. DPNFLRF-amide: Inhibits the activity of dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family. (175 aa) |
| | aex-5 | Endoprotease aex-5; Probable serine endoprotease which cleaves preproteins at paired basic amino acids. May process FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides. In muscles, involved in neuronal retrograde signaling by regulating presynaptic activity and localization of synaptic vesicle fusion protein unc-13 at the neuromuscular junction (NMJ). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). Probably by regulating DMP, required for fatty acid uptake by intestinal cell [...] (537 aa) |
| | msp-77 | Major sperm protein 77/79; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (127 aa) |
| | sup-9 | Two pore potassium channel protein sup-9; Potassium channel involved in coordination of muscle contraction. Activity is regulated by sup-18 ; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (329 aa) |
| | syx-3 | Putative syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). (306 aa) |
| | mec-14 | Aldo_ket_red domain-containing protein. (453 aa) |
| | tnt-2 | TropoNin T. (428 aa) |
| | ric-7 | Uncharacterized protein. (709 aa) |
| | exp-1 | Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. (539 aa) |
| | unc-26 | Synaptojanin; Probable inositol 5-phosphatase which regulates synaptic vesicle recycling in neurons by regulating clathrin-mediated endocytosis; In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. (1119 aa) |
| | msp-38 | Major sperm protein 38; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (127 aa) |
| | pbo-4 | Na(+)/H(+) exchanger protein 7; Na+/H+ exchanger which mediates the transient acidification of the coelomic space and plays a role in contraction of posterior body muscles during defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. (783 aa) |
| | acr-2 | Acetylcholine receptor subunit beta-type acr-2; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (575 aa) |
| | egl-30 | Heterotrimeric G protein alpha subunit. (355 aa) |
| | acr-12 | Nicotinic acetylcholine receptor-like subunit ACR-12. (573 aa) |
| | gsa-1 | G protein, Subunit Alpha. (378 aa) |
| | sup-10 | Putative potassium channel regulatory protein sup-10; May contribute to coordination of muscle contraction as regulatory subunit of a nonessential potassium channel complex. (332 aa) |
| | inx-16 | Innexin-16; Structural component of the gap junctions (By similarity). Required for signals downstream of defecation clock. Belongs to the pannexin family. (372 aa) |
| | mec-4 | Degenerin mec-4; Probable sodium channel subunit. May be needed for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior. (768 aa) |
| | mec-15 | F-box/WD repeat-containing protein mec-15; Plays a role in mechanosensory transduction (touch sensitivity), touch receptor neuron development and synapse formation. Regulates expression of the protein snb-1 and the distribution of synaptic vesicles at synapses to promote synaptic transmission at the neuromuscular junctions of GABAergic motor neurons. (406 aa) |
| | sbt-1 | Seven B Two (Mammalian 7BT prohormone convertase chaperone) homolog. (211 aa) |
| | unc-58 | Uncoordinated protein 58; Has a role in mobility, possibly in the transport of potassium in muscles; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (591 aa) |
| | unc-50 | Protein unc-50; Required for cell surface expression of acetylcholine receptors in body-wall muscles. (301 aa) |
| | tnt-4 | TropoNin T. (375 aa) |
| | unc-29 | Acetylcholine receptor subunit beta-type unc-29; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine and levasimole. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (493 aa) |
| | snb-1 | Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. (109 aa) |
| | ric-3 | Resistance to inhibitors of cholinesterase protein 3; Required for maturation and cell surface expression of acetylcholine receptors; Belongs to the ric-3 family. (378 aa) |
| | aex-2 | G-protein coupled receptor aex-2; G-protein coupled receptor for the nlp-40 neuropeptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Plays a role in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. Specifically, acts in GABAergic neurons, such as AVL and DVB, to control the expulsion step of defecation. Required for fatty acid uptake and metabolism by intestinal cells and therefore regulates the levels of triglycerides in the intestine. (321 aa) |
| | aex-4 | t-SNARE protein aex-4; t-SNARE protein which regulates the secretion of aex-5 from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds; Belongs to the SNAP-25 family. (234 aa) |
| | rund-1 | RUN domain-containing protein. (549 aa) |
| | mup-2 | Troponin T; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (405 aa) |
| | eol-1 | RAI1 domain-containing protein. (316 aa) |
| | cpd-2 | Peptidase_M14 domain-containing protein. (492 aa) |
| | mec-6 | Mechanosensory abnormality protein 6; Probable touch-cell sodium channel subunit. May be needed for mechanosensory transduction (touch sensitivity). Interacts with degenerin channel proteins and stabilizes the channel. Non-voltage- gated amiloride-sensitive cation channel permeable for sodium, potassium, lithium and N-methylglucamine. Belongs to the paraoxonase family. (377 aa) |
| | W03A5.6 | Uncharacterized protein. (612 aa) |
| | pbo-5 | Proton-gated ion channel subunit pbo-5; Forms a proton-gated ion channel with pbo-6 that is activated by acidification of the posterior coelomic space, leading to posterior body wall muscle contraction (pBoc) during the defecation cycle. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. Does not bind neurotransmitters such as acetylcholine, gamma- aminobutyric acid, glycine, serotonin, glutamate or choline ; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (509 aa) |
| | flp-18 | FMRFamide-like neuropeptide 18; Together with flp-1, plays a homeostatic role by acting on the GABAergic neural transmission at neuromuscular junctions to prevent overexcitation of the locomotor circuit. Plays a role in the navigational capacity of sperm and the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites. [EMPGVLRF-amide]: Inhibits the activity of dissected pharyngeal myogenic muscle system. (208 aa) |
| | stim-1 | Stromal interaction molecule 1; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor which upon Ca(2+) depletion, activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, orai-1. Essential for Ca (2+) and IP3-dependent contractile activity of gonad sheath cells and spermatheca. Essential for fertility. Does not play a role in posterior body wall muscle contraction (pBoc) rhythmicity, intestinal cell oscillatory Ca(2+) signaling or intestinal ER Ca(2+) hemostasis. (530 aa) |
| | npr-5 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (433 aa) |
| | nlp-40 | Neuropeptide-like peptides nlp-40; [Peptide P3]: Neuropeptide ligand for the G-protein coupled receptor aex-2. Activates and regulates the rhythmic calcium influx in DVB GABergic neurons during the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. (123 aa) |
| | aex-6 | Rab27. (215 aa) |
| | unc-17 | Vesicular acetylcholine transporter unc-17; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. (532 aa) |
| | pat-3 | Integrin beta pat-3; Integrin alpha ina-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable). Plays a role in cell migration, morphogenesis and probably in cell-cell interactions. During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M line [...] (809 aa) |
| | mec-7 | Tubulin beta-1 chain; Tubulin is the major constituent of microtubules (Probable). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (Probable). Plays a role in mechanosensory transduction (touch sensitivity). (441 aa) |
| | mtd-1 | Mec-3 (Three) Dependent expression. (278 aa) |
| | gcy-9 | Receptor-type guanylate cyclase gcy-9; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Involved in the sensing of CO2 levels and acidity by the BAG neurons. May act as a direct receptor for CO2 and H+. (1081 aa) |
| | unc-22 | Twitchin; Regulator of muscle contraction and relaxation. Senses mechanical strain that occurs during muscle activity by unfolding in clearly resolvable steps at differing forces. Plays a role in the organization of sarcomeres in body wall muscles ; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (7158 aa) |
| | spv-1 | Spermathecal Physiology Variant. (966 aa) |
| | unc-31 | Calcium-dependent secretion activator; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). Specifically required to activate the neuronal G-alpha pathway. Functions with G-alpha proteins from the same motor neurons to regulate locomotion. Involved in regulating entry into quiescence triggered by sat [...] (1401 aa) |
| | pop-1 | Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. (438 aa) |
| | lev-11 | Tropomyosin isoforms a/b/d/f; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Protects actin filaments from depolymerization by unc-60 in vitro. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin. (284 aa) |
| | unc-63 | Acetylcholine receptor subunit alpha-type unc-63; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine and levamisole. (502 aa) |
