STRINGSTRING
sli-1 sli-1 vps-32.1 vps-32.1 pho-1 pho-1 pcp-3 pcp-3 hop-1 hop-1 pcp-2 pcp-2 stl-1 stl-1 F32A5.3 F32A5.3 F35E12.10 F35E12.10 dct-17 dct-17 sel-12 sel-12 lec-2 lec-2 F53C11.1 F53C11.1 F54E2.1 F54E2.1 nep-17 nep-17 F56F10.1 F56F10.1 gfi-1 gfi-1 F57F4.4 F57F4.4 K08D8.6 K08D8.6 K10C2.1 K10C2.1 cav-2 cav-2 act-4 act-4 vha-1 vha-1 lmtr-5 lmtr-5 cav-1 cav-1 T19D12.4 T19D12.4 nep-22 nep-22 T27F6.6 T27F6.6 tre-3 tre-3 lec-1 lec-1 pcp-4 pcp-4 Y12A6A.1 Y12A6A.1 tag-10 tag-10 Y16B4A.2 Y16B4A.2 ctsa-2 ctsa-2 hpo-6 hpo-6 Y54G2A.18 Y54G2A.18 vha-19 vha-19 lmtr-2 lmtr-2 lec-5 lec-5 spe-4 spe-4 dod-19 dod-19 ZK6.11 ZK6.11 C29F3.7 C29F3.7 C26B9.5 C26B9.5 B0024.4 B0024.4 unc-5 unc-5 lec-4 lec-4 lmtr-3 lmtr-3 hsp-90 hsp-90
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sli-1Suppressor of LIneage defect. (582 aa)
vps-32.1Related to yeast Vacuolar Protein Sorting factor. (221 aa)
pho-1Intestinal acid phosphatase; Acid phosphatase required for normal growth and development. Specifically required for normal gut differentiation. (449 aa)
pcp-3Prolyl Carboxy Peptidase like. (1080 aa)
hop-1Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. (358 aa)
pcp-2Prolyl Carboxy Peptidase like. (1080 aa)
stl-1PHB domain-containing protein. (324 aa)
F32A5.3Serine carboxypeptidase ctsa-3.1; Belongs to the peptidase S10 family. (574 aa)
F35E12.10CUB_2 domain-containing protein. (487 aa)
dct-17CUB_2 domain-containing protein. (739 aa)
sel-12Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family. (444 aa)
lec-2Galectin. (1245 aa)
F53C11.1CUB_2 domain-containing protein. (494 aa)
F54E2.1Uncharacterized protein. (391 aa)
nep-17NEPrilysin metallopeptidase family. (1589 aa)
F56F10.1Putative serine protease F56F10.1; Belongs to the peptidase S28 family. (540 aa)
gfi-1GEI-4 (Four) Interacting protein. (2153 aa)
F57F4.4Uncharacterized protein. (2090 aa)
K08D8.6CUB_2 domain-containing protein. (491 aa)
K10C2.1Carboxypeptidase; Belongs to the peptidase S10 family. (2314 aa)
cav-2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can regulate their activity. Thought to have a role in the uptake of lipids and proteins in the intestinal cells; operates in the apical uptake of lipid markers and trafficking of yolk proteins. Affects fecundity and egg laying. Belongs to the caveolin family. (351 aa)
act-4Actin-4; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
vha-1V-type proton ATPase 16 kDa proteolipid subunit 1; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of sperm triggers V-AT [...] (169 aa)
lmtr-5Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog. (95 aa)
cav-1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. (235 aa)
T19D12.4VWFA domain-containing protein. (1028 aa)
nep-22NEPrilysin metallopeptidase family. (798 aa)
T27F6.6Putative neutral sphingomyelinase. (434 aa)
tre-3Trehalase. (608 aa)
lec-132 kDa beta-galactoside-binding lectin; Binds galactose. (285 aa)
pcp-4Prolyl Carboxy Peptidase like. (1042 aa)
Y12A6A.1Uncharacterized protein. (209 aa)
tag-10Uncharacterized protein. (473 aa)
Y16B4A.2Carboxypeptidase; Belongs to the peptidase S10 family. (2161 aa)
ctsa-2Carboxypeptidase; Belongs to the peptidase S10 family. (512 aa)
hpo-6Uncharacterized protein. (453 aa)
Y54G2A.184D656. (213 aa)
vha-19Vacuolar H ATPase. (451 aa)
lmtr-2Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family. (124 aa)
lec-5Galectin. (314 aa)
spe-4Presenilin spe-4; Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II. May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis. (465 aa)
dod-19Downstream Of DAF-16 (Regulated by DAF-16). (406 aa)
ZK6.11Uncharacterized protein. (386 aa)
C29F3.7CUB_2 domain-containing protein. (491 aa)
C26B9.5Uncharacterized protein. (516 aa)
B0024.4Uncharacterized protein. (390 aa)
unc-5Netrin receptor unc-5; Receptor for netrin (unc-6) required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors. Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced- 10/Rac, ced-12/ELMO and mig-2/RhoG. (947 aa)
lec-4Galectin. (283 aa)
lmtr-3Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog. (145 aa)
hsp-90Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...] (702 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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