STRINGSTRING
slo-1 slo-1 unc-78 unc-78 unc-94 unc-94 unc-89 unc-89 tnt-3 tnt-3 dyc-1 dyc-1 unc-54 unc-54 dys-1 dys-1 stn-1 stn-1 unc-45 unc-45 myo-6 myo-6 dyb-1 dyb-1 tnt-2 tnt-2 myo-5 myo-5 aipl-1 aipl-1 unc-27 unc-27 myo-3 myo-3 myo-1 myo-1 tnt-4 tnt-4 chn-1 chn-1 myo-2 myo-2 mup-2 mup-2 nmy-3 nmy-3 sorb-1 sorb-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
slo-1Calcium-activated potassium channel slo-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Essential for the regulation of neurotransmitter release at synapses. (1160 aa)
unc-78Actin-interacting protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Regulator of actin organization in myofibrils. (611 aa)
unc-94Tropomodulin; Acts as the pointed end capping protein which maintains the length and dynamics of the actin filament. Blocks the elongation and depolymerization of the actin filaments at the pointed end (By similarity); Belongs to the tropomodulin family. (401 aa)
unc-89Muscle M-line assembly protein unc-89; Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments. The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role. Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles. By binding mel-26, a substrate adapter of t [...] (8081 aa)
tnt-3TropoNin T. (1178 aa)
dyc-1Dystrophin-like protein 1; Together with dys-1 and hlh-1, participates in a common muscular function. (887 aa)
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
dys-1Dystrophin-1; Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning. (3674 aa)
stn-1Syntrophin-1; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (DGC). May also act by slowing calcium channel activity via a direct or indirect mechanism potentially involving other second messengers. Plays an early role in the formation of the neuromuscular junction and is necessary for muscle maintenance. (440 aa)
unc-45TPR_REGION domain-containing protein. (961 aa)
myo-6Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1235 aa)
dyb-1Dystrobrevin-1; Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance. (590 aa)
tnt-2TropoNin T. (428 aa)
myo-5MYOsin heavy chain structural genes; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa)
aipl-1WD_REPEATS_REGION domain-containing protein. (600 aa)
unc-27Troponin I 2; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (242 aa)
myo-3Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1969 aa)
myo-1Myosin-1; Muscle contraction. (1938 aa)
tnt-4TropoNin T. (375 aa)
chn-1C-term of Hsp70-iNteracting protein (CHIP family). (266 aa)
myo-2Myosin-2; Muscle contraction. (1947 aa)
mup-2Troponin T; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (405 aa)
nmy-3Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1464 aa)
sorb-1Sorbin and SH3 domain-containing protein 1 homolog; Required for organization of sarcomeres in body wall muscles and for maintaining normal mitochondrial position in myocytes. (1005 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (16%) [HD]