Your Input: | |
| | mys-2 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (533 aa) |
| | med-2 | GATA-type domain-containing protein. (174 aa) |
| | apr-1 | Adenomatous polyposis coli protein-related protein 1; Has a role in endoderm cell specification and pharyngeal development. Required for the migration of epithelial cells, organization of the anterior seam cells and ceh-13 expression during embryo morphogenesis. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation. During larval development, apr-1 is required for expression of lin-39 in P3-8.p. Shown to negatively regulate Wnt signaling in vulval precursor cells. Has a role in cell division by establishing [...] (1188 aa) |
| | hmp-2 | Beta-catenin-like protein hmp-2; Required for cell migration during body enclosure and cell shape changes during body elongation. Plays a role in recruitment of the cadherin protein hmr-1 to adherens junctions. (704 aa) |
| | aptf-1 | Transcription factor aptf-1; Transcription factor, which is required in the single sleep- active ring interneuron RIS for sleep-like behavioral quiescence induced by neuropeptide signaling in larvae. Regulates gene expression of sleep-inducing FMRFamide-like neuropeptide flp-11 in RIS. (365 aa) |
| | K06A5.1 | Chromo domain-containing protein. (696 aa) |
| | cmk-1 | Calcium/calmodulin-dependent protein kinase type 1; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade which results in transcriptional activation. Transcriptional activation occurs at least in part through phosphorylation of crh-1. Regulates gene expression, sensory morphology, and function of the AFD thermosensory neurons. Involved in long-term adaptation of AFD neurons to temperatures warmer than the initial acclimatized cultivation temperature. Acts in the FLP thermal nociceptors to moderate the responsiveness to noxious [...] (348 aa) |
| | K07B1.7 | G-patch domain-containing protein. (503 aa) |
| | lag-1 | Lin-12 And Glp-1 phenotype. (790 aa) |
| | atf-2 | ATF (cAMP-dependent transcription factor) family. (401 aa) |
| | nhr-49 | Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa) |
| | taf-11.2 | TAFII28 domain-containing protein. (281 aa) |
| | mep-1 | MOG interacting and ectopic P-granules protein 1; Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR. (870 aa) |
| | hlh-2 | BHLH domain-containing protein. (399 aa) |
| | sek-1 | Dual specificity mitogen-activated protein kinase kinase sek-1; Dual specificity protein kinase which acts as an essential component of the p38 signal transduction pathway which is also composed of upstream effector nsy-1 and downstream effector pmk-1. May phosphorylate pmk-1. Downstream of CaMKII unc-43 and adapter protein tir- 1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive [...] (336 aa) |
| | daf-8 | Dwarfin sma. (546 aa) |
| | lsy-12 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1585 aa) |
| | snfc-5 | SNF chromatin remodeling Complex component; Belongs to the SNF5 family. (381 aa) |
| | cbp-1 | Protein cbp-1; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. (2017 aa) |
| | R11H6.5 | Uncharacterized protein. (391 aa) |
| | mdt-15 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (780 aa) |
| | miz-1 | SP-RING-type domain-containing protein. (803 aa) |
| | sma-3 | Dwarfin sma-3; Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis ; Belongs to the dwarfin/SMAD family. (393 aa) |
| | amx-1 | Amine oxidase family member 1. (824 aa) |
| | daf-16 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa) |
| | egl-43 | Uncharacterized protein. (543 aa) |
| | xbp-1 | BZIP domain-containing protein. (335 aa) |
| | T01C3.2 | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...] (98 aa) |
| | npp-2 | Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (598 aa) |
| | emb-5 | Suppressor of Ty 6 homolog; May regulate transcriptional elongation by RNA polymerase II. Required for several aspects of morphogenesis of C.elegans, including regulation of division in the germline and gut and specification of ventral-uterine precursor cell fate; Belongs to the SPT6 family. (1521 aa) |
| | tag-243 | Costars domain-containing protein. (240 aa) |
| | mbk-1 | Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1; Possible role in the function of olfactory neurons. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. (882 aa) |
| | atf-5 | BZIP domain-containing protein. (208 aa) |
| | sma-9 | SMAll. (2232 aa) |
| | let-355 | Uncharacterized protein. (856 aa) |
| | hsr-9 | Protein hsr-9; May have a role in DNA double-strand break repair following gamma-irradiation. (1165 aa) |
| | hlh-4 | Helix-loop-helix protein 4; Acts as a transcriptional regulator. May mediate transcriptional activation by binding to the E-box motif 5'-CANNTG-3'. Required for the correct morphology, terminal identity and function of the ADL sensory neurons by controlling the expression of the ADL-specific gene repertoire, including chemoreceptor encoding genes, ion channel encoding genes, neuropeptides and the neurotransmitter eat-4. Regulates the expression of the srh-234 chemoreceptor encoding gene in the ADL neurons under feeding conditions. Plays a role in the chemorepulsive response toward asca [...] (205 aa) |
| | rha-1 | ATP-dependent RNA helicase A; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Binds to DNA, RNA and small interfering siRNA. Plays a role in DNA replicat [...] (1301 aa) |
| | lsd-1 | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. (737 aa) |
| | rhgf-2 | DH domain-containing protein. (1149 aa) |
| | ast-1 | ETS domain-containing protein. (377 aa) |
| | mdt-10 | Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...] (183 aa) |
| | set-16 | Histone-lysine N-methyltransferase. (2475 aa) |
| | taf-9 | TAF (TBP-associated transcription factor) family. (183 aa) |
| | lin-59 | Probable histone-lysine N-methyltransferase lin-59; Probable histone methyltransferase (By similarity). Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin. (1312 aa) |
| | T13F2.2 | Putative RNA polymerase II transcriptional coactivator; General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. Binds single-stranded DNA (By similarity). (124 aa) |
| | dop-3 | Dopamine receptor 3; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. In terms of antagonist responses, would be classed with the D2-like dopamine receptor group. Mediates the effect of dopamine on the inhibition of locomotion. Acts as an antagonist of dop-1. (607 aa) |
| | fkh-2 | Fork-head domain-containing protein. (270 aa) |
| | hlh-6 | Helix-loop-helix protein 6; Transcription factor that regulates the development of the g2 pharyngeal gland cells and pharyngeal gland function and thereby is required for feeding. Required for the expression of a number of genes in the pharyngeal gland, possibly by binding to the E box motif (5'-CANNTG-3') in the promoter region of these genes. Positively regulates the expression of genes encoding mucin-like proteins, which lubricate the pharyngeal tract to ensure efficient passage of the bacterial food source. Exhibits pharyngeal gland-specific positive autoregulation activity. (268 aa) |
| | odr-7 | Nuclear hormone receptor family member odr-7; Required for the function of one pair of chemosensory neurons called AWA neurons that are involved in chemotaxis to volatile odorants. Acts in a pathway that specifies olfactory neuronal fate. Regulates the transcription of olfactory signaling molecules such as odr-10 that specify AWA neuron identity and function. Represses the expression in AWA neurons of factors such as str-2 which specify AWC neuron identity. (457 aa) |
| | mxl-1 | BHLH domain-containing protein. (124 aa) |
| | skn-1 | Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa) |
| | tbp-1 | TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. (340 aa) |
| | his-67 | Histone H4. (103 aa) |
| | cfi-1 | AT-rich interactive domain-containing protein cfi-1; Transcription factor which regulates neuronal subtype identity. Promotes differentiation of URA sensory neurons and prevents them to express male-specific CEM features. Promotes differentiation of AVD and PVC interneurons and their glutamate receptor expression. (467 aa) |
| | sys-1 | SYmmetrical Sister cell hermaphrodite gonad defect. (811 aa) |
| | tlp-1 | C2H2-type domain-containing protein. (354 aa) |
| | hlh-3 | Helix-loop-helix protein 3; Probable transcriptional regulator. May mediate transcriptional activation by binding to the E-box motif 5'-CANNTG-3'. Plays a role in the differentiation of the hermaphrodite-specific motor neurons (HSN) that are required for normal egg laying. Might play a role in serotonin production by regulating expression of the tryptophan hydrolase tph-1 which catalyzes serotonin synthesis, in the HSN neurons. Also plays a role in HSN axon guidance towards the vulva and the ventral nerve cord, possibly by promoting the expression of the netrin receptor unc-40. Under f [...] (170 aa) |
| | med-1 | GATA-type domain-containing protein. (174 aa) |
| | dbl-1 | TGF_BETA_2 domain-containing protein. (365 aa) |
| | lin-40 | Uncharacterized protein. (1022 aa) |
| | skp-1 | Uncharacterized protein T27F2.1. (535 aa) |
| | mys-1 | Histone acetyltransferase Tip60 homolog; Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A. Acts in the determination of vulval and distal tip cell (DTC) precursor cell fates. Belongs to the MYST (SAS/MOZ) family. (458 aa) |
| | hlh-30 | BHLH domain-containing protein. (524 aa) |
| | sna-1 | Small Nuclear RNA (snRNA) Associated protein. (186 aa) |
| | ceh-10 | Homeobox protein ceh-10; Required for larval development and for cell fate specification and migration of CAN neurons. (344 aa) |
| | lin-29 | Transcription factor. (459 aa) |
| | nhl-3 | B box-type domain-containing protein. (698 aa) |
| | nhr-85 | Nuclear hormone receptor family member nhr-85; Orphan nuclear receptor. (514 aa) |
| | zip-3 | BZIP domain-containing protein. (307 aa) |
| | taf-6.1 | TAF domain-containing protein. (470 aa) |
| | elt-1 | Transcription factor elt-1; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' and variations thereof. During embryonic development, required for specification of cell fate of major hypodermal (epidermal) cells at the blastomere stage. The requirement is true for all four lineages derived from ABarp, ABpra and C blastomeres. Required for seam cell maintenance in late embryogenesis, for proper formation of dauer larvae and locomotion. Regulates expression of bro-1, a regulator of seam cell proliferation, via a GATA-like binding motif. Probably represses ex [...] (488 aa) |
| | pop-1 | Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. (438 aa) |
| | mef-2 | MADS-box domain-containing protein. (340 aa) |
| | nfyb-1 | CBFD_NFYB_HMF domain-containing protein. (403 aa) |
| | mdt-20 | Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (198 aa) |
| | ttx-1 | Homeobox domain-containing protein. (391 aa) |
| | swsn-1 | SANT domain-containing protein. (792 aa) |
| | nhr-91 | Nuclear hormone receptor family member nhr-91; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (474 aa) |
| | unc-3 | Transcription factor unc-3; May play a role in the expression of proteins essential for axonal pathfinding and/or neuronal differentiation in both sensory and motor neurons. Cooperates with jmjd-3.1 and wdr-5.1 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development. (491 aa) |
| | crtc-1 | CREB-regulated transcription coactivator 1 homolog; Transcriptional coactivator for crh-1, the homolog of vertebrate transcription factor CREB1. Regulates the transcription of metabolic genes and may have a role in mitochondrial dynamics and metabolism. Through crh-1, counteracts the pro-lifespan-extension signals of AMPK both cell autonomously and, when expressed in neurons, at a systemic level, possibly using the catecholamine analog, octopamine, as a messenger ; Belongs to the TORC family. (486 aa) |
| | Y23H5B.5 | WD_REPEATS_REGION domain-containing protein. (561 aa) |
| | ell-1 | Occludin_ELL domain-containing protein. (678 aa) |
| | thoc-5 | THO Complex (Transcription factor/nuclear export) subunit. (599 aa) |
| | ccar-1 | SAP domain-containing protein. (1215 aa) |
| | mrg-1 | MRG domain-containing protein. (337 aa) |
| | taf-6.2 | TAF6_C domain-containing protein. (835 aa) |
| | cdk-7 | Cyclin-dependent kinase 7; Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Required for maintaining chromosome ploidy. May phosphorylate the large subunit of RNA polymerase II, ama-1; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (330 aa) |
| | sptf-3 | SP (Specificity Protein) Transcription Factor. (412 aa) |
| | spr-5 | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together wi [...] (770 aa) |
| | crh-1 | BZIP domain-containing protein. (428 aa) |
| | dmd-3 | Doublesex- and mab-3-related transcription factor dmd-3; Transcriptional activator which promotes male-specific development. Acts partially redundantly with the transcription factor mab-3 to coordinate tail tip cell fusion and retraction and thereby regulate male tail tip morphogenesis. This is most likely through the regulation of downstream effectors such as eff-1. May also negatively regulate the expression of other proteins implicated in male tail morphogenesis including nhr-25, vav-1 and arl-1 in tail tip cells. In males, plays a role in the development of ray A-neurons by negativ [...] (250 aa) |
| | tra-1 | Sex-determining transformer protein 1; Plays a major role in controlling sexual phenotype. Terminal global regulator in a well-characterized cascade of sex-determining genes. Promotes female development. Interacts with tra-2 to promote spermatogenesis. Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development (By similarity). Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2. With trr-1, activates the fog-3 gene to determine sperm/oocyte cell fate (By s [...] (1110 aa) |
| | sbp-1 | BHLH domain-containing protein. (1113 aa) |
| | pcaf-1 | P300/CBP Associated Factor homolog. (767 aa) |
| | sam-10 | Single-stranded DNA-binding protein homolog sam-10; Involved cell autonomously in PLM neuron pre-synaptic differentiation by negatively regulating prk-2 expression and in neurite branch positioning. (455 aa) |
| | Y48G8AL.10 | C2H2-type domain-containing protein. (1245 aa) |
| | grh-1 | Grainyhead transcription factor. (563 aa) |
| | sta-1 | Signal transducer and activator of transcription 1; Carries out a dual function: signal transduction and activation of transcription. Activated STAT proteins play a role in repression of dauer formation. Neuronal expression is held in check by negative signals through the TGF-beta pathway that target the daf-3 transcription factor. (706 aa) |
| | hsf-1 | HSF_DOMAIN domain-containing protein. (671 aa) |
| | mab-3 | Protein male abnormal 3; Transcription factor which binds the DNA motif 5'- [CGA][TCA][TA]ACAATGT[AT][TGA]C-3', probably as a monomer. Acts partially redundantly with the transcription factor dmd-3 to coordinate tail tip cell fusion and retraction and thereby regulate male tail tip morphogenesis. Promotes male-specific development of two tissues, the peripheral nervous system and the intestine. In the peripheral nervous system, directs differentiation of sensory ray neuroblasts into peripheral sense organs. In the intestine, causes repression of vitellogenin gene transcription. (290 aa) |
| | trip-4 | Zf-C2HC5 domain-containing protein. (425 aa) |
| | nhr-239 | Nuclear receptor domain-containing protein. (262 aa) |
| | daf-2 | Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] (1928 aa) |
| | Y56A3A.2 | Peptidase_M50 domain-containing protein. (616 aa) |
| | Y56A3A.28 | C2H2-type domain-containing protein. (386 aa) |
| | mdt-6 | Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Acts to r [...] (250 aa) |
| | ngn-1 | BHLH domain-containing protein. (184 aa) |
| | set-27 | SET domain-containing protein. (502 aa) |
| | mdt-19 | Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (199 aa) |
| | Y73E7A.1 | Uncharacterized protein. (223 aa) |
| | Y75B8A.6 | Uncharacterized protein. (447 aa) |
| | atfs-1 | Stress activated transcription factor atfs-1; Acts as a transcription factor during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR). Induces nuclear and mitochondrial gene transcription, including genes coding for mitochondrial chaperones and proteins involved in glycolysis, amino acid catabolism and innate immunity. Following mitochondrial stress, restores mitochondrial respiratory capacity by limiting the transcription of oxidative phosphorylation (OXPHOS) machinery genes and by promoting the assembly of OXPHOS complexes via the up-regulation of [...] (488 aa) |
| | clk-1 | 5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner; Belongs to the COQ7 family. (187 aa) |
| | tax-4 | Cyclic nucleotide-gated cation channel; Required for normal thermosensation and chemosensation sensory behavior. Required, downstream of receptor- type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons. Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons. Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation. Required for the calcium flux to the cytoplasm in the ASJ sensory neurons [...] (733 aa) |
| | ham-3 | SWIB domain-containing protein. (446 aa) |
| | nfi-1 | CTF/NF-I domain-containing protein. (823 aa) |
| | his-26 | Histone H4. (103 aa) |
| | tbx-35 | Putative T-box protein 35. (325 aa) |
| | ubxn-4 | UBX domain-containing protein 4; Probably acts as an adapter for ATPase cdc-48.1 and/or cdc- 48.2, conferring substrate specificity. May play a role in the ER- associated protein degradation pathway (ERAD) possibly acting as a platform to recruit both ubql-1 and cdc-48.1 and/or cdc-48.2 to the ER during ERAD. (469 aa) |
| | toe-1 | HEAT repeat-containing protein 1 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity); Belongs to the HEATR1/UTP10 family. (1650 aa) |
| | ceh-23 | Homeobox protein ceh-23. (305 aa) |
| | nhr-48 | Nuclear hormone receptor family member nhr-48; Orphan nuclear receptor. (817 aa) |
| | ces-2 | Cell death specification protein 2; Required to activate programmed cell death in the sister cells of the serotoninergic neurosecretory motor (NSM) neurons. Negatively regulates the activity of ces-1 which in turn negatively regulates the activities of cell-killing genes. Binds to the DNA sequence 5'-RTTACGTAAY-3'; Belongs to the bZIP family. (211 aa) |
| | cec-10 | C.Elegans Chromodomain protein. (865 aa) |
| | ZK973.9 | Uncharacterized protein. (233 aa) |
| | amx-2 | Amino_oxidase domain-containing protein. (724 aa) |
| | leo-1 | RNA polymerase-associated protein LEO1; Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification. (430 aa) |
| | pmk-1 | Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] (377 aa) |
| | cdk-12 | Cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates 'Ser-2' in the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation. Required for normal reproduction. (734 aa) |
| | hlh-1 | Myoblast determination protein 1 homolog; Accumulation defines the body wall muscle cell fate during embryogenesis. Acts redundantly with fozi-1 to promote body wall muscle cell and coelomocyte specification in postembryonic mesoderm progenitors, probably through suppression of sem-2. (324 aa) |
| | wrm-1 | Armadillo repeat-containing protein wrm-1; Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1- dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome [...] (796 aa) |
| | daf-7 | Dauer larva development regulatory growth factor daf-7; May act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. Involved in sensitivity to CO2 levels. (350 aa) |
| | rnt-1 | Runt domain-containing protein. (301 aa) |
| | tag-342 | Uncharacterized protein. (348 aa) |
| | unc-30 | Homeobox protein unc-30; Transcriptional regulator within D-type neurons that controls terminal differentiation. Required for the development and function of the 19 inhibitory GABAergic (gamma-aminobutyric-acid- secreting) D-type motor neurons, which control locomotion. Plays a role in regulating synapse formation in dorsal D (DD) and ventral D (VD) GABAergic motor neurons, possibly in part by regulating the expression of the neural regulator oig-1. Also required for expression of flp-13 in DD motor neurons. Plays a role in respecification of DD motor neurons through regulation of gene [...] (323 aa) |
| | gmeb-1 | SAND domain-containing protein. (374 aa) |
| | sup-37 | SUPpressor. (940 aa) |
| | gtf-2F1 | Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (481 aa) |
| | let-526 | ARID domain-containing protein. (1768 aa) |
| | nhr-23 | Nuclear hormone receptor family member nhr-23; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. NR1 subfamily. (588 aa) |
| | hlh-8 | Twist-related protein; Acts as a transcriptional regulator. Involved in postembryonic mesodermal cell fate specification. Activates ceh-24 and egl-15 during mesodermal patterning. (178 aa) |
| | lin-13 | Zinc finger protein lin-13; Involved in repression of vulval fate, possibly by a tumor suppressor protein Rb-mediated mechanism. (2248 aa) |
| | egl-38 | Paired domain-containing protein. (289 aa) |
| | daf-4 | Cell surface receptor daf-4; Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (744 aa) |
| | nhr-76 | Nuclear Hormone Receptor family; Belongs to the nuclear hormone receptor family. (480 aa) |
| | spr-3 | Suppressor of presenilin protein 3; Probable transcriptional regulator, which participates in the transcriptional repression of the presenilin protein hop-1. (684 aa) |
| | atf-7 | BZIP domain-containing protein. (509 aa) |
| | lin-39 | Homeobox protein lin-39; Transcription factor that binds to the consensus 5'- TGATNNAT(G/T)(G/A)-3' PBC/Hox motif of target genes to regulate gene expression. Binds to the consensus PBC/Hox motif lineage enhancer region of sem-2 to promote cell fate specification in the postembryonic mesoderm (also known as the M lineage). Regulates the expression of mig-13 which controls the asymmetric distribution of actin cytoskeleton-binding protein cor-1 in Q neuroblasts. This in turn controls the polarity migration of Q neuroblasts and the subsequent mid-body region-specific development. Belongs [...] (253 aa) |
| | egl-5 | Homeobox protein egl-5; Essential for the determination of specific neurons. (223 aa) |
| | mab-5 | Homeobox protein mab-5; Transcription factor that binds to the promoter region of the transcription factor lin-39 to repress its expression in Q neuroblasts and thereby direct left Q neuroblast (QL) daughter cell migration. During postembryonic development, required for posterior-specific pattern formation. Within the posterior body region, controls epidermal, neuronal, and mesodermal cell differentiation. Belongs to the Antp homeobox family. (200 aa) |
| | nhr-67 | Nuclear hormone receptor family member nhr-67; Orphan nuclear receptor. In males, plays an essential role in the migration of the linker cell which guides gonad elongation during the L3 and L4 stages of larval development by negatively regulating the expression of netrin receptor unc-5 at the mid-L3 stage. (416 aa) |
| | lin-41 | Protein lin-41; Heterochronic protein which acts downstream of let-7 in temporal patterning. Plays a role in the developmental timing of postembryonic hypodermal seam cell division and fusion events and adult alae production. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Involved in post-transcriptional gene regulation, uses two independent pathways. Has direct and specific RNA-binding activity and, depending on the location (5'UTR or 3'UTR) of the target site, triggers either mRNA decay or repr [...] (1147 aa) |
| | ceh-16 | Homeobox protein engrailed-like ceh-16; Required in the seam cells during embryonic development. Represses the fusion of the seam cells with the neighboring dorsal and ventral epidermal cells by repressing the expression of the fusion effector eff-1. Required for early seam cell differentiation. Triggers the expression of elt-5 and other seam cell markers and is indispensable for alae formation (a hallmark of seam cell differentiation). Required for the maintenance of correct boundaries between the lateral rows of seam cells and the ventral and dorsal row of epidermal cells during embr [...] (187 aa) |
| | cky-1 | BHLH-PAS factor. (676 aa) |
| | hlh-14 | BHLH domain-containing protein. (148 aa) |
| | C18B2.4 | GRAM domain-containing protein. (296 aa) |
| | pqn-15 | Prion-like-(Q/N-rich)-domain-bearing protein. (2171 aa) |
| | aha-1 | Aryl hydrocarbon receptor nuclear translocator homolog; Has a role in cellular differentiation. Required for pharyngeal development. In collaboration with ahr-1 it is involved in RMEL/R and SDQR neuron cell migration. Acts in the cellular response to hypoxia. Involved in aggregation behavior by regulating soluble guanylate cyclase gene expression in the URX neurons. (453 aa) |
| | spe-44 | SAND domain-containing protein. (424 aa) |
| | dcp-66 | Deacetylase Complex Protein. (724 aa) |
| | dpff-1 | Zinc finger protein dpff-1; Belongs to the requiem/DPF family. (372 aa) |
| | C29F9.5 | Uncharacterized protein. (261 aa) |
| | unc-86 | Transcription factor unc-86; Transcription factor required for correct cell fate determination and differentiation in diverse neuronal cell lineages where it plays a role in specifying the fate of daughter cells during cell divisions. Involved in sensory neuron production and function. Binds both alone and with mec-3 to the mec-3 promoter to initiate and maintain mec-3 expression which is required for sensory neuron differentiation. In addition, binds both alone and with mec-3 to the promoters of mec-4 and mec-7 which act to regulate sensory neuron function. Involved in determining the [...] (357 aa) |
| | sel-8 | Protein lag-3; glp-1 and lin-12 promote signaling by recruiting lag-3 to target promoters, where it functions as a transcriptional activator. May regulate phosphatase lip-1 mRNA transcription downstream of glp-1. (490 aa) |
| | sma-6 | Serine/threonine-protein kinase sma-6; Involved in TGF-beta pathway. May be a receptor for daf-7; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (636 aa) |
| | nhr-2 | Nuclear hormone receptor family member nhr-2; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (472 aa) |
| | elt-2 | Transcription factor elt-2; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3'. Predominantly directs the transcription of intestinal genes such as ges-1, cpr-6, pho-1, ftn-1 and lev-11, and itself. Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-7 to control normal gene expression and promote normal formation of the intestine. Regulates intestinal gene expression in response to hypoxia to promote longevity. Regulates tissue specific gene expression at basal levels and in response to bac [...] (433 aa) |
| | mys-4 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (617 aa) |
| | zip-5 | BZIP domain-containing protein. (216 aa) |
| | brc-1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of polyubiquitin chains and plays a central role in DNA repair. Plays a role in triggering cellular responses at damage sites in response to DNA damage that may be induced by UV and ionizing radiation for example. Functions in double-strand break repair, and is required for homologous recombination between sister chromatids in meiotic and mitotic cells. In particular, protects against chromosome non-disjunction and nuclear fragmentation during meiotic double-strand [...] (612 aa) |
| | ceh-36 | Homeobox protein ceh-36; Mediates chemosensory function of ASE and AWC neurons. In ASE neurons, required to diversify the fate of the ASEL neurons from the ASER neurons. In cooperation with the transcription factor sox-2, required for the differentiation of AWC olfactory neurons. May regulate the expression of sox-2 in AWC olfactory neurons. Belongs to the paired homeobox family. (257 aa) |
| | pal-1 | Homeobox protein pal-1; Transcriptional activator. Interacts with promoter regions for tbx-8.9, tbx-9, elt-1, hnd-1, scrt-1, and vab-7 genes. Binds the sequence ATTTATGAC. Binds to the enhancer region of the hlh-1 gene promoter during embryonic body wall muscle development. Activates the gene for mab-5 in embryo development. Necessary for vab-7 expression in C blastomeres in the posterior of embryos. Required for posterior V6 neuroectoblast cell fate specification during postembryonic neurogenesis (patterning) which generates the characteristic ray lineage during male tail development. [...] (270 aa) |
| | elt-4 | GATA-type domain-containing protein. (72 aa) |
| | mls-2 | Homeobox domain-containing protein. (341 aa) |
| | ttx-3 | LIM/homeobox protein ttx-3; Required for specification of the AIA and AIY interneurons and the NSM neurons. Positively regulates the expression of a number of genes including ceh-23, kal-1, hen-1, ser-2, unc-17 and sra-11 in AIY interneurons and cat-4, flp-4, bas-1, ptps-1 and mgl-1 in NSM neurons. Also acts in an autoregulatory feedback loop to maintain its own expression. Plays a role in the thermotactic response, olfactory imprinting, regulation of longevity, control of dauer formation and axon outgrowth and pathfinding. Not required for normal chemosensory behavior. (409 aa) |
| | ire-1 | Serine/threonine-protein kinase/endoribonuclease ire-1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices xbp-1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes. Unfolded protein response (UPR) transcriptional activation by ire-1, as well as translational attenuation by pek-1 in a complementary pathway, maintains ER homeostasis. Regulates the transcriptional up-regulation of nucleoside-diphosphatase apy-1 upon ER str [...] (967 aa) |
| | hlh-15 | BHLH domain-containing protein. (89 aa) |
| | gmeb-3 | SAND domain-containing protein. (376 aa) |
| | hcf-1 | Host cell factor 1. (782 aa) |
| | ref-2 | REgulator of Fusion. (315 aa) |
| | nhr-6 | Nuclear hormone receptor family member nhr-6; Transcriptional activator that induces gene expression by binding to the NGFI-B response element (NBRE) 5'-AAAGGTCA-3'. Required for proper morphogenesis of the spermatheca and the spermatheca-uterine valve formation. Promotes cell proliferation and differentiation of the spermatheca precursor cells during spermatheca development in larval stage L4. Might play a role in promoting G1/S phase progression in the spermatheca precursor cell lineage. Also required for the differentiation of the spermatheca-uterine junction core (sujc) cells which [...] (619 aa) |
| | eya-1 | Eyes absent homolog 1; Tyrosine protein phosphatase (By similarity). Acts probably as a transcription regulator in the embryonic and postembryonic development of several tissues including pharynx, vulva and gonads. Required for the development of anterior tissues during late embryogenesis. Together with ceh-34, required to specify the coelomocyte fate in embryonic and postembryonic precursors. In the anterior part of the embryo, prevents apoptosis in cells that are not fated to die. Together with ceh-34 activates proapoptotic factor egl-1 expression to promote motor neuron M4 sister ce [...] (503 aa) |
| | C49F5.5 | TAZ-type domain-containing protein. (151 aa) |
| | hda-1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. In association with akir-1, plays a role in regula [...] (461 aa) |
| | bar-1 | Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...] (811 aa) |
| | tag-294 | RanBP2-type domain-containing protein. (430 aa) |
| | che-1 | Transcription factor che-1; Transcription factor essential for the identity of ASE chemosensory neurons. Acts by activating expression of genes that are specific for ASE chemosensory neurons, such as seven-transmembrane receptors or guanylate cyclase. Also required to control the left/right asymmetry in ASE chemosensory neurons by regulating expression of genes such as cog-1 and ceh-36. (273 aa) |
| | ceh-17 | Homeobox domain-containing protein. (237 aa) |
| | eaf-1 | EAF domain-containing protein. (251 aa) |
| | D1044.6 | Uncharacterized protein D1044.6. (1006 aa) |
| | unc-120 | MADS-box domain-containing protein. (327 aa) |
| | D2013.6 | GRAM domain-containing protein. (235 aa) |
| | akir-1 | Akirin homolog; Plays a role in antifungal innate immunity. Forms a complex with components of the NuRD (Nucleosome Remodeling and Deacetylase) and MEC chromatin remodeling complexes which binds to the promoters of antimicrobial peptide genes and may recruit other proteins such as ceh-18 to control gene expression in response to fungal infection. During meiotic prophase I, plays a role in the disassembly of synaptonemal complex proteins and in the regulation of chromosome condensation and segregation. Not required for chromosome pairing or recombination during meiosis ; Belongs to the [...] (218 aa) |
| | mec-3 | Mechanosensory protein 3; Specifies differentiation of the set of six touch receptor neurons. Binds cooperatively as a heterodimer with unc-86 to sites in the mec-3 gene promoter. (321 aa) |
| | swsn-4 | SWI/SNF nucleosome remodeling complex component. (1474 aa) |
| | glp-1 | Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan. (1295 aa) |
| | daf-12 | Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] (753 aa) |
| | lex-1 | Tat-binding homolog 7; Thought to form a complex that enhances transcription from repetitive DNA sequences by modulating chromatin structure. Belongs to the AAA ATPase family. (1291 aa) |
| | nhr-25 | Nuclear hormone receptor family member nhr-25; Orphan nuclear receptor required during development. Plays a role in male tail tip morphogenesis regulating the expression of the transcription factor dmd-3 in a negative feedback loop. (572 aa) |
| | tir-1 | NAD(+) hydrolase tir-1; NAD(+) hydrolase, which plays a key role in non-apoptotic cell death by regulating NAD(+) metabolism. In response to stress, homooligomerizes and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage promoting non-apoptotic neuronal cell death. In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development. Required for both innate immune response and specification of AWC(OFF) neuron. During late embryogenesis, it. acts downstream of CAMKII (unc-43) to regulate specification [...] (984 aa) |
| | yap-1 | Yes-associated protein homolog 1; Plays a role in thermal stress response and in aging. (442 aa) |
| | vab-3 | Homeobox domain-containing protein. (455 aa) |
| | ubql-1 | Ubiquilin; May play a role in the ER-associated protein degradation pathway (ERAD) possibly via its interaction with ER-localized proteins ubxn-4 and cdc-48.1 and/or cdc48.2, providing a link between the polyubiquitinated ERAD substrates and the proteasome. Also plays an important role in the regulation of other protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS) and autophagy (By similarity). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by intera [...] (502 aa) |
| | zip-9 | BZIP transcription factor family. (291 aa) |
| | lin-26 | Transcription factor lin-26; Presumed to be a transcription factor required to specify the fates of hypodermal and neuron-associated support cells. Functions during vulval development, playing a role in vulval precursor cell fate specification. (490 aa) |
| | sea-1 | T-box transcription factor 18; Probable transcriptional regulator involved in developmental processes. Activates xol-1 transcription, either directly or indirectly, establishing that xol-1 acts as the master regulator to integrate both X chromosome and autosomal signals to determine sexual fate. (376 aa) |
| | myrf-2 | Myelin regulatory factor homolog 2, C-terminal; [Myelin regulatory factor homolog 2]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 2, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation. [Myelin regulatory factor homolog 2, N-terminal]: Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation. Specifically required for dorsal D (DD) GABA [...] (1009 aa) |
| | F21A9.2 | C2H2-type domain-containing protein. (392 aa) |
| | his-64 | Histone H4. (103 aa) |
| | nfyc-1 | CBFD_NFYB_HMF domain-containing protein. (232 aa) |
| | rpt-4 | Probable 26S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (406 aa) |
| | blmp-1 | B lymphocyte-induced maturation protein 1 homolog; Transcription factor which binds to enhancer elements in the promoter region of genes. Regulates the expression of the transcription factor bed-3 to control vulval development. Promotes terminal differentiation in the hypodermis and is involved in regulation of gonadal outgrowth and entry into the dauer stage. Regulates the timing of dorsalward migration of the distal tip cells of the hermaphrodite gonad by inhibiting precocious unc-5 and lin-29 expression which in turn prevents early dorsalward turning. Plays a role in male tail tip m [...] (817 aa) |
| | F26F4.12 | ANK_REP_REGION domain-containing protein. (231 aa) |
| | nhl-2 | NHL (Ring finger b-box coiled coil) domain containing. (1032 aa) |
| | tam-1 | RING-type domain-containing protein. (944 aa) |
| | nurf-1 | Nucleosome-remodeling factor subunit NURF301-like; Histone-binding component of a NURF-like (nucleosome remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates. Belongs to the BPTF family. (2197 aa) |
| | egl-44 | Transcription enhancer factor-like protein egl-44; Acts upstream of egl-46 to prevent touch cell differentiation in FLP neurons. Also promotes HSN neuron development. In association with egl-46, regulates cell cycle exit in the neuronal Q cell lineage. May be involved in thermal stress response downstream of yap-1. (493 aa) |
| | aptf-4 | TF_AP-2 domain-containing protein. (486 aa) |
| | aptf-3 | TF_AP-2 domain-containing protein. (535 aa) |
| | daf-1 | Cell surface receptor daf-1; Controls the dauer/nondauer developmental decision in a range of environmental conditions. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. (669 aa) |
| | ceh-22 | Homeobox protein ceh-22; Involved in combinatorial activation of gene expression in pharyngeal muscle. Specifically binds a site necessary for activity of the B subelement of myo-2 enhancer. (379 aa) |
| | fos-1 | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. (467 aa) |
| | ceh-20 | Homeobox protein ceh-20; Transcription factor that binds to the 5'-TGATNNAT(G/T)(G/A)- 3' PBC/Hox lineage enhancer region of sem-2 to promote cell fate specification in the postembryonic mesoderm (also known as the M lineage). Has a role in the mig-13 pathway to promote the guidance, migration and positioning of Q neuroblasts and their descendants along the anteroposterior body axis and the anterior migration of BDU interneurons. Also required for normal vulval formation. (338 aa) |
| | ada-2 | SANT domain-containing protein. (596 aa) |
| | nhr-8 | Nuclear hormone receptor family member nhr-8; Orphan nuclear receptor. (560 aa) |
| | phf-10 | PHD-type domain-containing protein. (447 aa) |
| | daf-19 | RFX-like transcription factor daf-19; May be a transcription factor that regulates some genes of ciliated sensory neurons. May activate the expression of the shared components of sensory cilia, but not the cell-type-specific expression; Belongs to the RFX family. (805 aa) |
| | cdc-73 | Cell division cycle protein 73; Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification; Belongs to the CDC73 family. (517 aa) |
| | zfp-2 | Zinc finger protein zfp-2; Probable zinc finger transcription factor that acts as a transcriptional repressor. Acts redundantly with the transcriptional repressor lin-35 to control the development of somatic gonad lineages. May, in addition, suppress sensitivity to RNAi. (422 aa) |
| | ama-1 | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] (1856 aa) |
| | F36F2.1 | Costars domain-containing protein. (162 aa) |
| | tax-2 | Cyclic nucleotide-binding domain-containing protein. (800 aa) |
| | isw-1 | Chromatin-remodeling complex ATPase chain isw-1; Energy-transducing component of a NURF-like (nucleosome- remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates. Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. (1009 aa) |
| | row-1 | Relative of Woc homolog. (584 aa) |
| | pha-4 | Defective pharyngeal development protein 4; Acts as a transcription factor required for formation of the pharyngeal primordium. Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression. Activates a wide array of pharyngeal genes including ceh-22 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate. Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Acts in the regul [...] (506 aa) |
| | hif-1 | Hypoxia-inducible factor 1; A transcription factor which is a key regulator in various cellular processes; including environment stress resistance (oxygen levels, hydrogen sulfide and cyanide levels and heat), negative regulation of cell apoptosis in ASJ neurons by inhibition of cep-1 via transcriptional activation of tyr-2, resistance/susceptibility to pathogenic bacteria, lifespan and brood size. Involved in mediating susceptibility to enteropathogenic E.coli. Increased levels of hif-1 activity confer resistance to P.aeruginosa-mediated death but also confer susceptibility to S.aureu [...] (721 aa) |
| | hlh-17 | BHLH domain-containing protein. (101 aa) |
| | tlf-1 | TBP-Like Factor. (508 aa) |
| | sig-7 | Peptidyl-prolyl cis-trans isomerase sig-7; Probable PPIase that accelerates the folding of proteins (By similarity). It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Involved in RNA polymerase II (RNA pol II)-mediated transcription elongation, and in primary transcript splicing, including co-transcriptional trans- splicing, in association with the catalytic subunit of the RNA pol II complex ama-1. Also plays a role in the regulation of elongation-dependent phosphorylation of ama-1 to control transcription. Involved in the transc [...] (427 aa) |
| | pqm-1 | C2H2-type domain-containing protein. (295 aa) |
| | drap-1 | CBFD_NFYB_HMF domain-containing protein. (331 aa) |
| | F42A6.5 | BRCT domain-containing protein. (102 aa) |
| | ccnk-1 | CYCLIN domain-containing protein; Belongs to the cyclin family. (252 aa) |
| | taf-11.3 | TAFII28 domain-containing protein. (228 aa) |
| | sex-1 | Steroid hormone receptor family member cnr14; Belongs to the nuclear hormone receptor family. NR1 subfamily. (534 aa) |
| | cit-1.2 | Cyclin-T1.2; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy- terminal domain) of the large subunit of RNA polymerase II (RNAP II). (555 aa) |
| | cit-1.1 | Cyclin-T1.1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy- terminal domain) of the large subunit of RNA polymerase II (RNAP II). (468 aa) |
| | nhr-111 | Nuclear hormone receptor family member nhr-111; Orphan nuclear receptor. (311 aa) |
| | atf-6 | BZIP domain-containing protein. (589 aa) |
| | ceh-14 | Homeobox protein ceh-14; Confers thermosensory function to neurons. Required for correct AFD-mediated thermotaxis. (351 aa) |
| | mxl-3 | BHLH domain-containing protein. (235 aa) |
| | dpy-22 | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functio [...] (3498 aa) |
| | hmg-1.2 | High mobility group protein 1.2. (235 aa) |
| | taf-11.1 | TAFII28 domain-containing protein. (345 aa) |
| | F49D11.10 | Uncharacterized protein. (727 aa) |
| | ctbp-1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. (727 aa) |
| | cfp-1 | Zf-CpG_bind_C domain-containing protein. (508 aa) |
| | cep-1 | Transcription factor cep-1; Transcriptional activator that binds the same DNA consensus sequence as p53. Has a role in normal development to ensure proper meiotic chromosome segregation. Promotes apoptosis under conditions of cellular and genotoxic stress in response to DNA damage, hypoxia, or starvation. Regulates germline apoptosis in response to DNA damage. Its pro-apoptotic activity is inhibited when bound to ape-1 in vitro. Plays a role in cell cycle arrest in the germline in response to DNA damage by UV-C light. However, not required for survival in response to DNA damage induced [...] (644 aa) |
| | elt-6 | GATA-like transcription factor ELT-6. (367 aa) |
| | dro-1 | CBFD_NFYB_HMF domain-containing protein. (184 aa) |
| | ham-1 | Stork_head domain-containing protein. (414 aa) |
| | tra-4 | TRAnsformer: XX animals transformed into males. (543 aa) |
| | csb-1 | CSB (Cockayne Syndrome B) homolog. (957 aa) |
| | gmeb-2 | SAND domain-containing protein. (517 aa) |
| | hmbx-1 | Homeobox domain-containing protein. (424 aa) |
| | spt-4 | Transcription elongation factor SPT4; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF may enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex. (120 aa) |
| | nhr-7 | Nuclear hormone receptor family member nhr-7; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (536 aa) |
| | sumv-2 | Protein sumv-2; Influences the activity of genes involved in vulval development. (1145 aa) |
| | taf-7.1 | TAFII55_N domain-containing protein. (254 aa) |
| | spt-16 | FACT complex subunit spt-16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment [...] (1030 aa) |
| | egl-18 | GATA-type domain-containing protein. (379 aa) |
| | unc-55 | Nuclear hormone receptor unc-55; Acts as a transcriptional regulator. Required for ventral D (VD) motor neurons to adopt their normal synaptic pattern. Suppresses expression of flp-13 in VD motor neurons to ensure formation of the correct synaptic pattern. Maintains low cAMP levels in VD motor neurons by enhancing expression of pde-4 which hydrolyzes cAMP and repressing expression of acy-1 which catalyzes cAMP formation. This prevents respecification of synapses by VD neurons. During copulation, required in males for correct movement of the spicules, a pair of prong-like structures whi [...] (370 aa) |
| | bro-1 | BROther (Drosophila tx factor partner) homolog. (152 aa) |
| | fax-1 | Nuclear receptor domain-containing protein. (419 aa) |
| | ldb-1 | LID domain-containing protein. (629 aa) |
| | end-1 | GATA-type domain-containing protein. (221 aa) |
| | end-3 | GATA-type domain-containing protein. (242 aa) |
| | unc-42 | Homeobox domain-containing protein. (279 aa) |
| | nsy-1 | Mitogen-activated protein kinase kinase kinase nsy-1; Serine/threonine-protein kinase which, by phosphorylating and activating sek-1, plays an important role in the activation of the p38 pathway also composed of the downstream effectors sek-1 and pmk-1. Downstream of CaMKII unc-43 and adapter protein tir-1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive and Gram-negative bacteri [...] (1498 aa) |
| | myrf-1 | Myelin regulatory factor homolog 1, C-terminal; [Myelin regulatory factor homolog 1]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 1, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation. [Myelin regulatory factor homolog 1, N-terminal]: Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation. Specifically required for dorsal D (DD) GABA [...] (931 aa) |
| | nhr-80 | Nuclear Hormone Receptor family. (504 aa) |
| | cic-1 | Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase cdk-8 that phosphoryl [...] (302 aa) |
| | mcrs-1 | FHA domain-containing protein. (478 aa) |
| | lpin-1 | LNS2 domain-containing protein. (794 aa) |
| | elt-3 | GATA-type domain-containing protein. (317 aa) |
| | zip-2 | BZIP domain-containing protein. (308 aa) |
| | his-38 | Histone H4. (103 aa) |
| | ceh-28 | NK-2 family homeodomain protein CEH-28. (201 aa) |
| | taf-10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (179 aa) |
| | fkh-9 | Fork-head domain-containing protein. (300 aa) |
| | lim-6 | LIM domain family. (316 aa) |
