STRINGSTRING
ykt-6 ykt-6 vps-51 vps-51 snx-1 snx-1 cogc-2 cogc-2 copd-1 copd-1 syx-6 syx-6 C16A11.2 C16A11.2 C18B12.6 C18B12.6 C26C6.9 C26C6.9 sec-15 sec-15 C31E10.5 C31E10.5 C31E10.6 C31E10.6 sec-10 sec-10 cogc-5 cogc-5 rab-8 rab-8 trpp-1 trpp-1 tat-6 tat-6 F07F6.4 F07F6.4 vps-52 vps-52 gos-28 gos-28 erd-2 erd-2 F11A10.6 F11A10.6 sec-24.1 sec-24.1 F13B9.1 F13B9.1 czw-1 czw-1 smgl-1 smgl-1 gon-1 gon-1 F32D8.14 F32D8.14 trpp-4 trpp-4 tat-5 tat-5 copb-2 copb-2 sec-20 sec-20 eas-1 eas-1 sly-1 sly-1 cope-1 cope-1 rer-1 rer-1 trpp-8 trpp-8 F47G9.1 F47G9.1 sec-3 sec-3 syx-5 syx-5 sec-22 sec-22 yif-1 yif-1 F57B10.5 F57B10.5 golg-4 golg-4 rab-6.1 rab-6.1 copz-1 copz-1 nsf-1 nsf-1 hpo-11 hpo-11 unc-26 unc-26 ile-1 ile-1 cogc-6 cogc-6 rpi-2 rpi-2 K08E4.6 K08E4.6 trpp-6 trpp-6 rab-14 rab-14 uso-1 uso-1 erv-46 erv-46 cogc-8 cogc-8 R12B2.2 R12B2.2 sec-31 sec-31 T01G9.2 T01G9.2 T03F1.12 T03F1.12 ile-2 ile-2 T08D2.1 T08D2.1 T08D2.6 T08D2.6 cni-1 cni-1 T10F2.5 T10F2.5 syx-18 syx-18 T14G10.5 T14G10.5 T19B10.8 T19B10.8 vps-54 vps-54 sec-5 sec-5 T24B1.1 T24B1.1 rab-6.2 rab-6.2 sel-9 sel-9 W02D9.2 W02D9.2 apt-9 apt-9 sedl-1 sedl-1 snx-3 snx-3 apd-3 apd-3 W09G3.8 W09G3.8 Y102A11A.6 Y102A11A.6 apg-1 apg-1 exoc-8 exoc-8 sec-8 sec-8 use-1 use-1 sql-1 sql-1 sec-23 sec-23 pad-1 pad-1 copb-1 copb-1 Y41C4A.32 Y41C4A.32 Y47G6A.18 Y47G6A.18 cogc-4 cogc-4 cogc-1 cogc-1 Y54E10BR.2 Y54E10BR.2 tbc-20 tbc-20 Y54G2A.18 Y54G2A.18 trpp-5 trpp-5 vti-1 vti-1 nbet-1 nbet-1 Y60A3A.19 Y60A3A.19 Y60A3A.9 Y60A3A.9 mdt-9 mdt-9 tfg-1 tfg-1 Y66D12A.8 Y66D12A.8 Y71A12B.10 Y71A12B.10 copa-1 copa-1 cogc-3 cogc-3 trpp-10 trpp-10 Y73B6BL.36 Y73B6BL.36 npp-20 npp-20 sec-24.2 sec-24.2 trpp-3 trpp-3 sar-1 sar-1 sec-16 sec-16 ZK970.8 ZK970.8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ykt-6YKT6 (Yeast v-SNARE) homolog; Belongs to the synaptobrevin family. (201 aa)
vps-51Vacuolar protein sorting-associated protein 51 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function. Belongs to the VPS51 family. (700 aa)
snx-1PX domain-containing protein. (472 aa)
cogc-2Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function. (681 aa)
copd-1Probable coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (515 aa)
syx-6Putative syntaxin 6; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. (122 aa)
C16A11.2KOG2701 domain-containing protein. (570 aa)
C18B12.6Uncharacterized protein. (428 aa)
C26C6.9GOLD domain-containing protein. (217 aa)
sec-15Exocyst complex component 6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC15 family. (817 aa)
C31E10.5KOG2701 domain-containing protein. (560 aa)
C31E10.6KOG2701 domain-containing protein. (591 aa)
sec-10Exocyst complex component 5; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC10 family. (704 aa)
cogc-5Conserved Oligomeric Golgi (COG) Component. (656 aa)
rab-8RAB family. (211 aa)
trpp-1Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (142 aa)
tat-6Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1064 aa)
F07F6.4Uncharacterized protein F07F6.4; GTPase-activating protein for the ADP ribosylation factor family. (529 aa)
vps-52Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function. Belongs to the VPS52 family. (702 aa)
gos-28Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. Cooperates with ykt-6 for proper expression of Golgi-resident proteins. Required along with ykt-6 for normal embryonic development, seam cell division or differentiation, and ray formation. (234 aa)
erd-2ER lumen protein-retaining receptor erd-2.1; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi (By similarity); Belongs to the ERD2 family. (213 aa)
F11A10.6Uncharacterized protein. (356 aa)
sec-24.1Yeast SEC homolog. (1126 aa)
F13B9.1Protein transport protein sec16. (1632 aa)
czw-1Centromere/kinetochore protein zw10 homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC8 [...] (778 aa)
smgl-1Uncharacterized protein. (1615 aa)
gon-1A disintegrin and metalloproteinase with thrombospondin motifs gon-1; Secreted metalloprotease required for distal tip cell (DTC) migration along the body wall basement membranes, a key step that promotes gonad morphogenesis. Probably acts by remodeling the basement membrane during cell migration. Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons, probably by controlling collagen IV emb-9 degradation, a component of the synapse basement membrane. Also involved in the organization of adult muscle morphology. Has [...] (2165 aa)
F32D8.14Protein YIPF. (261 aa)
trpp-4Trafficking protein particle complex subunit. (224 aa)
tat-5Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1074 aa)
copb-2Probable coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity); Belongs to the WD repeat COPB2 family. (1000 aa)
sec-20Yeast SEC homolog; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (234 aa)
eas-1Probable Golgi transport protein 1; May be involved in fusion of ER-derived transport vesicles with the Golgi complex; Belongs to the GOT1 family. (141 aa)
sly-1SLY1 homolog; Belongs to the STXBP/unc-18/SEC1 family. (675 aa)
cope-1Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (292 aa)
rer-1Protein RER1 homolog; May be involved in protein transport along the secretory pathway; Belongs to the RER1 family. (191 aa)
trpp-8TRansport Protein Particle. (1282 aa)
F47G9.1GOLD domain-containing protein. (204 aa)
sec-3Exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (848 aa)
syx-5Putative syntaxin-5; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. (413 aa)
sec-22Yeast SEC homolog; Belongs to the synaptobrevin family. (214 aa)
yif-1YIP1-Interacting Factor homolog. (380 aa)
F57B10.5GOLD domain-containing protein. (203 aa)
golg-4GRIP domain-containing protein. (1642 aa)
rab-6.1Ras-related protein Rab-6.1; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (205 aa)
copz-1Probable coatomer subunit zeta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its associatio [...] (184 aa)
nsf-1Vesicle-fusing ATPase; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity); Belongs to the AAA ATPase family. (824 aa)
hpo-11Protein kinase domain-containing protein. (649 aa)
unc-26Synaptojanin; Probable inositol 5-phosphatase which regulates synaptic vesicle recycling in neurons by regulating clathrin-mediated endocytosis; In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. (1119 aa)
ile-1L-type lectin-like domain-containing protein. (492 aa)
cogc-6Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. (642 aa)
rpi-2Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. (341 aa)
K08E4.6GOLD domain-containing protein. (234 aa)
trpp-6TRansport Protein Particle. (185 aa)
rab-14RAB family. (210 aa)
uso-1USO1 (Yeast transport protein) homolog. (941 aa)
erv-46Yeast ERV (ER to Golgi transport Vesicle protein) homolog. (380 aa)
cogc-8Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. (743 aa)
R12B2.2Uncharacterized protein. (281 aa)
sec-31WD_REPEATS_REGION domain-containing protein. (1083 aa)
T01G9.2UPF0183 protein T01G9.2; Belongs to the UPF0183 family. (422 aa)
T03F1.12Protein SYS1 homolog; Involved in protein trafficking. Belongs to the SYS1 family. (148 aa)
ile-2L-type lectin-like domain-containing protein. (347 aa)
T08D2.1GOLD domain-containing protein. (167 aa)
T08D2.6Uncharacterized protein. (69 aa)
cni-1Protein cornichon homolog 1; Negatively regulates export of glr-1 from the endoplasmic reticulum to synapses. (145 aa)
T10F2.5Uncharacterized protein. (137 aa)
syx-18t-SNARE coiled-coil homology domain-containing protein. (415 aa)
T14G10.5Probable coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (885 aa)
T19B10.8GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins. (718 aa)
vps-54Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. (1058 aa)
sec-5Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (884 aa)
T24B1.1Golgin-84; May be involved in maintaining Golgi structure and in intra- Golgi transport. (551 aa)
rab-6.2Ras-related protein Rab-6.2; Protein transport. Probably involved in vesicular traffic (By similarity). (205 aa)
sel-9Suppressor/enhancer of lin-12 protein 9; May have a role in the negative regulation of lin-12 and glp- 1 transport to the cell surface. May also have a role in a quality control mechanism for endoplasmic reticulum-Golgi transport; the budding of coatomer-coated and other species of coated vesicles, could bind cargo molecules to collect them into budding vesicles. Involved in regulating the expression of proteasomal subunits such as rpt-3 in order to confer resistance to proteasomal dysfunction. Belongs to the EMP24/GP25L family. (203 aa)
W02D9.2Protein YIPF. (240 aa)
apt-9AdaPTin or adaptin-related protein. (588 aa)
sedl-1Probable trafficking protein particle complex subunit 2; May play a role in vesicular transport from endoplasmic reticulum to Golgi. Required for the systemic spread of the RNAi response; Belongs to the TRAPP small subunits family. Sedlin subfamily. (141 aa)
snx-3PX domain-containing protein. (162 aa)
apd-3AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family. (1251 aa)
W09G3.8Uncharacterized protein. (80 aa)
Y102A11A.6Uncharacterized protein. (286 aa)
apg-1AP-1 complex subunit gamma. (829 aa)
exoc-8Exo84_C domain-containing protein. (686 aa)
sec-8Exocyst complex component 4; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (893 aa)
use-1Vesicle transport protein USE1; SNARE that may be involved in targeting and fusion of Golgi- derived retrograde transport vesicles with the ER; Belongs to the USE1 family. (254 aa)
sql-1Suppressor of gpa-3QL dye-filling defect. (1328 aa)
sec-23Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (821 aa)
pad-1Protein pad-1; May be involved in protein traffic between late Golgi and early endosomes (By similarity). Essential for cell patterning during gastrulation. (2417 aa)
copb-1Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (971 aa)
Y41C4A.32WD_REPEATS_REGION domain-containing protein. (291 aa)
Y47G6A.18Uncharacterized protein. (280 aa)
cogc-4Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function; Belongs to the COG4 family. (801 aa)
cogc-1Conserved Oligomeric Golgi (COG) Component. (787 aa)
Y54E10BR.2Uncharacterized protein. (191 aa)
tbc-20Rab-GAP TBC domain-containing protein. (411 aa)
Y54G2A.184D656. (213 aa)
trpp-5Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET3 subfamily. (185 aa)
vti-1t-SNARE coiled-coil homology domain-containing protein. (224 aa)
nbet-1t-SNARE coiled-coil homology domain-containing protein. (107 aa)
Y60A3A.19Protein YIPF. (255 aa)
Y60A3A.9GOLD domain-containing protein. (211 aa)
mdt-9Putative guanine nucleotide exchange factor MSS4 homolog; Guanine-nucleotide-releasing protein that acts on members of the sec4/ypt1/rab subfamily. (147 aa)
tfg-1PB1 domain-containing protein. (486 aa)
Y66D12A.8Uncharacterized protein. (244 aa)
Y71A12B.10PB1 domain-containing protein. (338 aa)
copa-1Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1232 aa)
cogc-3Conserved Oligomeric Golgi (COG) Component. (794 aa)
trpp-10TRansport Protein Particle. (1112 aa)
Y73B6BL.36GOLD domain-containing protein. (222 aa)
npp-20Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Belongs to the WD repeat SEC13 family. (313 aa)
sec-24.2Yeast SEC homolog. (984 aa)
trpp-3Trafficking protein particle complex subunit 3 homolog; May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity). Required for the systemic spread of the RNAi response ; Belongs to the TRAPP small subunits family. BET3 subfamily. (181 aa)
sar-1GTP-binding protein SAR1; Involved in transport from the endoplasmic reticulum to the Golgi apparatus; Belongs to the small GTPase superfamily. SAR1 family. (193 aa)
sec-16Protein transport protein Sec16. (1232 aa)
ZK970.8Uncharacterized protein. (143 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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