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hipr-1 hipr-1 fbxl-1 fbxl-1 hpo-9 hpo-9 C05E11.6 C05E11.6 flr-1 flr-1 flr-4 flr-4 kin-20 kin-20 lin-42 lin-42 nlp-37 nlp-37 atf-2 atf-2 pdf-1 pdf-1 Y53G8AL.4 Y53G8AL.4 ZC168.2 ZC168.2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hipr-1Huntington interacting protein related 1; Regulates pre-synaptic vesicle recycling at neuromuscular junctions of mechanosensory neurons. Plays a role in maintaining a normal defecation cycle; Belongs to the SLA2 family. (927 aa)
fbxl-1F-box/LRR-repeat protein fbxl-1; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Plays a role in regulating the entry into the dauer state. In hermaphrodites, may play a role in modulating the rate of defecation. (466 aa)
hpo-9BTB domain-containing protein. (581 aa)
C05E11.6Uncharacterized protein; Belongs to the arthropod CHH/MIH/GIH/VIH hormone family. (152 aa)
flr-1FLR-1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (638 aa)
flr-4Serine/threonine-protein kinase flr-4; Probable serine-threonine protein kinase involved in the control of defecation rhythms. Required to increase the length of defecation cycle period. Acts in a cell-functional rather than developmental aspect in the regulation of defecation rhythms. (570 aa)
kin-20Casein kinase I isoform delta; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Is a developmental timer that specifies temporal cell fate selection; acts to control the temporal identity of hypodermal seam cells. Required during late-larval development to prevent adult fates, particularly cell cycle exit and fusion, from being expressed too early. (497 aa)
lin-42Period protein homolog lin-42; Transcriptional repressor which interacts with the promoter region of target genes. Has a specific role in developmental timing where it regulates temporal expression of a number of miRNAs and mRNAs. Controls temporal cell fate transition during embryonic and early larval development by restricting the expression of specific miRNAs, including let-7, miR-48, lin-4, miR-35 and miR-58. Restricts the accumulation of lin-29 in the hypodermis to the larval L4 stage, thus controlling terminal differentiation of seam cells. Has a role in the miRNA-mediated specif [...] (654 aa)
nlp-37PDF (Arthropod Pigment Dispersing Factor) homolog. (89 aa)
atf-2ATF (cAMP-dependent transcription factor) family. (401 aa)
pdf-1PDF (Arthropod Pigment Dispersing Factor) homolog. (88 aa)
Y53G8AL.4Uncharacterized protein; Belongs to the arthropod CHH/MIH/GIH/VIH hormone family. (93 aa)
ZC168.2Uncharacterized protein ZC168.2; Belongs to the arthropod CHH/MIH/GIH/VIH hormone family. (108 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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