STRINGSTRING
elpc-3 elpc-3 arf-1.2 arf-1.2 lip-1 lip-1 sir-2.4 sir-2.4 oma-1 oma-1 pptr-2 pptr-2 tra-2 tra-2 tag-250 tag-250 meg-4 meg-4 drh-3 drh-3 atx-2 atx-2 glp-1 glp-1 inx-14 inx-14 rsd-6 rsd-6 elli-1 elli-1 csr-1 csr-1 ekl-1 ekl-1 ego-1 ego-1 atz-1 atz-1 tut-1 tut-1 msp-77 msp-77 emo-1 emo-1 itr-1 itr-1 copb-2 copb-2 mpk-1 mpk-1 mbk-2 mbk-2 meg-3 meg-3 ife-1 ife-1 copz-1 copz-1 fbf-1 fbf-1 cyb-2.2 cyb-2.2 meg-1 meg-1 meg-2 meg-2 mek-1 mek-1 lag-1 lag-1 msp-38 msp-38 vab-1 vab-1 mep-1 mep-1 gsa-1 gsa-1 acy-4 acy-4 cdk-1 cdk-1 cyb-3 cyb-3 kgb-1 kgb-1 rme-2 rme-2 aph-1 aph-1 rab-7 rab-7 pptr-1 pptr-1 elpc-1 elpc-1 eri-5 eri-5 cyb-2.1 cyb-2.1 inx-22 inx-22 wee-1.3 wee-1.3 cyb-1 cyb-1 oma-2 oma-2 ceh-18 ceh-18 npp-10 npp-10 pgl-1 pgl-1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
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elpc-3Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at po [...] (547 aa)
arf-1.2ADP-ribosylation factor 1-like 2; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Involved in endoplasmic reticulum dynamics during embryogenesis. Also required for adult germline function. Plays a role in cell shedding during embryogenesis probably by promoting the endocytosis of cell adhesion molecules. During neurogenesis, involved in cell autonomous Q.p neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell, probably by controlling endocytosis. (181 aa)
lip-1Dual specificity protein phosphatase lip-1; Dephosphorylates MAP kinase mpk-1. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
sir-2.4NAD-dependent protein deacetylase sir-2.4; NAD-dependent protein deacetylase. (292 aa)
oma-1CCCH-type zinc finger protein oma-1; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts as a ribonucleoprotein particle component that may exert part of its function within cytoplasmic foci of unfertilized oocytes. Acts redundantly with oma-2 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Recruits the translational repressor ifet-1 to the 3'-UTR of mei-1 and zif- [...] (407 aa)
pptr-2Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (607 aa)
tra-2Sex-determining transformer protein 2; Plays a major role in controlling sexual cell fates. Promotes female development in XX animals where it sequesters one or more of the FEM proteins to the membrane thereby freeing the tra-1 protein (a putative transcription factor) to enter the nucleus and promote female development. In XO animals it acts as a receptor for her-1 which prevents it from binding to FEM proteins thereby repressing the activity of tra-1. Negatively regulates male development when bound to fem-3 and is required together with tra-1 for promoting spermatogenesis. Also requ [...] (1475 aa)
tag-250Putative protein tag-250. (626 aa)
meg-4Uncharacterized protein. (832 aa)
drh-3Dicer Related Helicase. (1119 aa)
atx-2Ataxin-2 homolog; Probable RNA-binding protein that negatively regulates the translation of targets. Functions with RNA-binding protein szy-20 to ensure embryonic cell division, and to this end, plays a role in the regulation of centrosome assembly, position and size, and in astral microtubule outgrowth and nucleation. Required for gonad development, germ cell proliferation and for the production of oocytes. Regulates whole body growth and fat accumulation in response to food availability, and this may be through the mTOR pathway, upstream of daf-15 and rheb-1. Belongs to the ataxin-2 [...] (1026 aa)
glp-1Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan. (1295 aa)
inx-14Innexin-14; Structural component of the gap junctions. (434 aa)
rsd-6Tudor domain-containing protein. (689 aa)
elli-1Enlarged germline granules protein 1; Plays a role in modulating RNAi activity and P-granule accumulation in the germline. May function in association with CSR-1 complex components such as drh-3 to regulate RNA transcript accumulation in germ cells. (277 aa)
csr-1Piwi domain-containing protein. (1030 aa)
ekl-1Uncharacterized protein. (606 aa)
ego-1RNA-directed RNA polymerase related EGO-1. (1632 aa)
atz-1Uncharacterized protein. (268 aa)
tut-1Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position; Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily. (373 aa)
msp-77Major sperm protein 77/79; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (127 aa)
emo-1Protein transport protein Sec61 subunit gamma; Required for oocyte development and ovulation. Required for the translocation of secretory and transmembrane proteins into the endoplasmic reticulum in vitro ; Belongs to the SecE/SEC61-gamma family. (68 aa)
itr-1Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...] (2892 aa)
copb-2Probable coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity); Belongs to the WD repeat COPB2 family. (1000 aa)
mpk-1Mitogen-activated protein kinase mpk-1; Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid h [...] (444 aa)
mbk-2Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2; Required for oocyte-to-zygote transition in which it phosphorylates oocyte proteins, including mei-1, oma-1, oma-2, mex-5, and mex-6, modifying their activity and/or stability following meiosis. Functions in both spindle positioning and in the posterior localization of cytoplasmic determinants, including pie-1, pos-1, and pgl-1, in early embryos. Involved in the asymmetric distribution of plk-1 at the 2-cell embryonic stage. (817 aa)
meg-3Uncharacterized protein. (862 aa)
ife-1Eukaryotic translation initiation factor 4E-1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivit [...] (231 aa)
copz-1Probable coatomer subunit zeta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its associatio [...] (184 aa)
fbf-1Fem-3 mRNA-binding factor 1; Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression, possibly by directly binding to two sites within the 3'-UTR of gld-3 isoform b. In association with the cye-1/cdk-2 complex, negatively regulates gld-1 expression in the distal germline cells of the mitotic zone. By binding to the 3'-UTR, repres [...] (614 aa)
cyb-2.2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (339 aa)
meg-1Uncharacterized protein. (636 aa)
meg-2Uncharacterized protein. (819 aa)
mek-1Dual specificity mitogen-activated protein kinase kinase mek-1; Dual specificity protein kinase which may phosphorylate kgb-1 and thereby is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. May also have a synergistic role with sek-1 in phosphorylating pmk-1. Involved in the response to environmental stress including heavy metal ions (Cu(2+) and Cd(2+)), oxidative stress and starvation. In association with sek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses. Involved in resistance to pathogenic bacteria infecti [...] (347 aa)
lag-1Lin-12 And Glp-1 phenotype. (790 aa)
msp-38Major sperm protein 38; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (127 aa)
vab-1Ephrin receptor 1; Receptor for members of the ephrin family (By similarity). Receptor for major sperm proteins (MSPs), that functions as sperm- sensing checkpoint which inhibits oocyte meiotic maturation and ovulation when sperm are not available for fertilization. Specifically, functions to negatively regulates oocyte maturation and MAPK activation in the absence of MSPs. Required for the MSP-mediated increase in the basal sheath cell contraction rate in somatic cells. Phosphorylates phosphatase daf-18/PTEN which probably promotes daf-18 degradation. By inactivating daf-18, regulates [...] (1122 aa)
mep-1MOG interacting and ectopic P-granules protein 1; Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR. (870 aa)
gsa-1G protein, Subunit Alpha. (378 aa)
acy-4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1013 aa)
cdk-1Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). (332 aa)
cyb-3G2/mitotic-specific cyclin-B3; Could be involved at the G2/M (mitosis) transition (Probable). Interacts with the CDK1 and CDK2 protein kinases (Probable). G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis (Probable). Plays a role during oocyte meiosis II. (385 aa)
kgb-1GLH-binding kinase 1; Mitogen-activated protein kinase which is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Phosphorylates the transcription factor fos-1 which prevents fos-1 dimerization and promoter binding and results in activation of target genes including F53A9.2/kreg-1 and lys-3/kreg-2. Phosphorylates jun-1 and activates the AP-1 transcription factor which is a heterodimer of jun-1 and fos-1. Phosphorylates glh-1 in vitro which may play a role in controlling glh-1 protein levels in the germline by targeting it for degradation by the proteasome. R [...] (390 aa)
rme-2Receptor Mediated Endocytosis. (925 aa)
aph-1Gamma-secretase subunit aph-1; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors (lin-12 or glp-1). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Required for the localization of aph-2. (308 aa)
rab-7RAB family. (209 aa)
pptr-1Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1; Probable regulatory subunit of serine/threonine-protein phosphatase let-92 which negatively regulates the insulin receptor signaling cascade composed of daf-2, age-1, akt-1, akt-2 and sgk-1 by promoting the dephosphorylation of akt-1 on 'Thr-350'. Negatively regulates several functions controlled by the insulin pathway including dauer formation, lifespan, fat storage and stress resistance. Plays a role in the asymmetric segregation of the P granule components during embryonic cell divisions but does not play an essentia [...] (542 aa)
elpc-1Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1250 aa)
eri-5Tudor domain-containing protein. (531 aa)
cyb-2.1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (317 aa)
inx-22Innexin; Structural component of the gap junctions. Belongs to the pannexin family. (462 aa)
wee-1.3Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase during oocyte maturation. Required for oocyte maturation, embryonic development, germline proliferation and initiation of meiosis during spermatogenesis. Required for chromosome structure during mitosis and negative regulation of nuclear envelope breakdown. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (677 aa)
cyb-1G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. (361 aa)
oma-2CCCH-type zinc finger protein oma-2; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts redundantly with oma-1 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Also, together with oma-1, is involved in P-granule distribution during embryonic development. (393 aa)
ceh-18Homeobox protein ceh-18; Directs gonadal sheath cell differentiation and function. Also directs gonad migration and plays a role in specifying the differentiated phenotypes of epidermal cells during postembryonic development. Plays a role in oogenesis, regulating a sheath cell signal that causes oocytes to maintain diakinesis arrest during meiosis. Negatively regulates oocyte maturation, ovulation and MAPK activation in oocytes when sperm are not available for fertilization. May be recruited by akir-1 to the promoter regions of antimicrobial peptide genes to control gene expression in [...] (542 aa)
npp-10Nuclear pore complex protein Nup98-Nup96; Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Regulates nucleoporin npp-5 localization to the nuclear membrane during interphase and to kinetochores during metaphase. Has a role in P granule integrity; may promote the 'liquid phase' of P granules by increasing the number of interacting RNA-protein complexes. Binds nos-2 mRNA, probably indirectly, and promotes its accu [...] (1678 aa)
pgl-1Guanyl-specific ribonuclease pgl-1; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. Together with the P-granule component pgl-3, is involved in the formation of P-granules. Together with pgl-3, probably recruits other granule components such as pos-1, mex-3 and glh-1 to P-granules. In addition, may act redundantly with pgl-3 to protect germ cells from excessive germline apoptosis du [...] (771 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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