Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| F23H12.5 | lon-3 | F23H12.5.1 | ZK836.1.1 | Uncharacterized protein. | Cuticle collagen lon-3; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Dose-dependent regulator of body length and shape. | 0.725 |
| clec-38 | rpm-1 | T25E12.10.1 | C01B7.6.1 | C-type LECtin. | E3 ubiquitin-protein ligase rpm-1; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of target proteins, including dlk-1. Negatively regulates a p38 MA [...] | 0.532 |
| clec-38 | unc-40 | T25E12.10.1 | T19B4.7.1 | C-type LECtin. | Unc-40 protein. | 0.535 |
| daf-16 | egl-4 | R13H8.1h.1 | F55A8.2h.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | cGMP-dependent protein kinase egl-4; Promotes chemoreceptor gene expression in response to increased cGMP levels by antagonizing the gene repression functions of the class II HDAC hda-4 and the mef-2 transcription factor. Regulates gene expression via recruitment of a histone deacetylase complex containing hda-2, saeg-1 and saeg-2. Represses body size and lifespan through the dbl-1 and insulin pathways, respectively. May also signal through daf-3 and/or daf-5. Role in egg-laying, dauer formation and motility. Regulates behavioral responses to various chemosensory stimuli in sensory neu [...] | 0.564 |
| daf-16 | unc-119 | R13H8.1h.1 | M142.1c.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. | 0.781 |
| daf-16 | vhp-1 | R13H8.1h.1 | F08B1.1e.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Tyrosine-protein phosphatase vhp-1; Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response and in axon regeneration by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.692 |
| egl-4 | daf-16 | F55A8.2h.1 | R13H8.1h.1 | cGMP-dependent protein kinase egl-4; Promotes chemoreceptor gene expression in response to increased cGMP levels by antagonizing the gene repression functions of the class II HDAC hda-4 and the mef-2 transcription factor. Regulates gene expression via recruitment of a histone deacetylase complex containing hda-2, saeg-1 and saeg-2. Represses body size and lifespan through the dbl-1 and insulin pathways, respectively. May also signal through daf-3 and/or daf-5. Role in egg-laying, dauer formation and motility. Regulates behavioral responses to various chemosensory stimuli in sensory neu [...] | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | 0.564 |
| egl-4 | gcy-12 | F55A8.2h.1 | F08B1.2a.1 | cGMP-dependent protein kinase egl-4; Promotes chemoreceptor gene expression in response to increased cGMP levels by antagonizing the gene repression functions of the class II HDAC hda-4 and the mef-2 transcription factor. Regulates gene expression via recruitment of a histone deacetylase complex containing hda-2, saeg-1 and saeg-2. Represses body size and lifespan through the dbl-1 and insulin pathways, respectively. May also signal through daf-3 and/or daf-5. Role in egg-laying, dauer formation and motility. Regulates behavioral responses to various chemosensory stimuli in sensory neu [...] | Receptor-type guanylate cyclase gcy-12; Guanylate cyclase involved in the production of the second messenger cGMP. Acts upstream of cGMP-dependent protein kinase egl-4, most likely by providing cGMP to the kinase in chemosensory neurons to regulate body size. | 0.678 |
| fsn-1 | glo-4 | C26E6.5.1 | F07C3.4.1 | F-box/SPRY domain-containing protein 1; Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf- 2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM an [...] | X-linked retinitis pigmentosa GTPase regulator homolog; Could be a guanine-nucleotide releasing factor for glo-1. May play a role in gut granule biogenesis. Regulates axon termination in PLM and ALM neurons. | 0.935 |
| fsn-1 | ppm-2 | C26E6.5.1 | T23F11.1.1 | F-box/SPRY domain-containing protein 1; Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf- 2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM an [...] | Probable protein phosphatase 2C T23F11.1. | 0.759 |
| fsn-1 | rpm-1 | C26E6.5.1 | C01B7.6.1 | F-box/SPRY domain-containing protein 1; Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf- 2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM an [...] | E3 ubiquitin-protein ligase rpm-1; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of target proteins, including dlk-1. Negatively regulates a p38 MA [...] | 0.999 |
| gcy-12 | egl-4 | F08B1.2a.1 | F55A8.2h.1 | Receptor-type guanylate cyclase gcy-12; Guanylate cyclase involved in the production of the second messenger cGMP. Acts upstream of cGMP-dependent protein kinase egl-4, most likely by providing cGMP to the kinase in chemosensory neurons to regulate body size. | cGMP-dependent protein kinase egl-4; Promotes chemoreceptor gene expression in response to increased cGMP levels by antagonizing the gene repression functions of the class II HDAC hda-4 and the mef-2 transcription factor. Regulates gene expression via recruitment of a histone deacetylase complex containing hda-2, saeg-1 and saeg-2. Represses body size and lifespan through the dbl-1 and insulin pathways, respectively. May also signal through daf-3 and/or daf-5. Role in egg-laying, dauer formation and motility. Regulates behavioral responses to various chemosensory stimuli in sensory neu [...] | 0.678 |
| glo-4 | fsn-1 | F07C3.4.1 | C26E6.5.1 | X-linked retinitis pigmentosa GTPase regulator homolog; Could be a guanine-nucleotide releasing factor for glo-1. May play a role in gut granule biogenesis. Regulates axon termination in PLM and ALM neurons. | F-box/SPRY domain-containing protein 1; Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf- 2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM an [...] | 0.935 |
| glo-4 | ppm-2 | F07C3.4.1 | T23F11.1.1 | X-linked retinitis pigmentosa GTPase regulator homolog; Could be a guanine-nucleotide releasing factor for glo-1. May play a role in gut granule biogenesis. Regulates axon termination in PLM and ALM neurons. | Probable protein phosphatase 2C T23F11.1. | 0.760 |
| glo-4 | rpm-1 | F07C3.4.1 | C01B7.6.1 | X-linked retinitis pigmentosa GTPase regulator homolog; Could be a guanine-nucleotide releasing factor for glo-1. May play a role in gut granule biogenesis. Regulates axon termination in PLM and ALM neurons. | E3 ubiquitin-protein ligase rpm-1; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of target proteins, including dlk-1. Negatively regulates a p38 MA [...] | 0.740 |
| lon-1 | lon-2 | F48E8.1a.1 | C39E6.1.1 | Protein lon-1; Regulates body size morphogenesis, but does not affect male tail development; Belongs to the CRISP family. | LONg; Belongs to the glypican family. | 0.810 |
| lon-1 | lon-3 | F48E8.1a.1 | ZK836.1.1 | Protein lon-1; Regulates body size morphogenesis, but does not affect male tail development; Belongs to the CRISP family. | Cuticle collagen lon-3; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Dose-dependent regulator of body length and shape. | 0.816 |
| lon-1 | lon-8 | F48E8.1a.1 | Y59A8B.20.1 | Protein lon-1; Regulates body size morphogenesis, but does not affect male tail development; Belongs to the CRISP family. | Protein lon-8; Secreted protein that is involved in larval elongation, early adult growth and male tail development. | 0.667 |
| lon-2 | lon-1 | C39E6.1.1 | F48E8.1a.1 | LONg; Belongs to the glypican family. | Protein lon-1; Regulates body size morphogenesis, but does not affect male tail development; Belongs to the CRISP family. | 0.810 |
| lon-2 | lon-3 | C39E6.1.1 | ZK836.1.1 | LONg; Belongs to the glypican family. | Cuticle collagen lon-3; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Dose-dependent regulator of body length and shape. | 0.693 |
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