STRINGSTRING
vab-3 vab-3 grd-9 grd-9 mab-5 mab-5 ptr-1 ptr-1 eff-1 eff-1 ptr-2 ptr-2 grd-8 grd-8 ptr-4 ptr-4 smp-2 smp-2 sin-3 sin-3 mab-21 mab-21 grd-2 grd-2 unc-73 unc-73 pdi-3 pdi-3 grd-1 grd-1 sma-3 sma-3 qua-1 qua-1 lin-29 lin-29 ptr-18 ptr-18 ptr-20 ptr-20 smp-1 smp-1 plx-1 plx-1 mab-20 mab-20 wrt-1 wrt-1 ptr-23 ptr-23 sma-2 sma-2 wrt-4 wrt-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
vab-3Homeobox domain-containing protein. (455 aa)
grd-9Ground-like domain-containing protein. (588 aa)
mab-5Homeobox protein mab-5; Transcription factor that binds to the promoter region of the transcription factor lin-39 to repress its expression in Q neuroblasts and thereby direct left Q neuroblast (QL) daughter cell migration. During postembryonic development, required for posterior-specific pattern formation. Within the posterior body region, controls epidermal, neuronal, and mesodermal cell differentiation. Belongs to the Antp homeobox family. (200 aa)
ptr-1SSD domain-containing protein. (956 aa)
eff-1Epithelial Fusion Failure. (658 aa)
ptr-2SSD domain-containing protein. (933 aa)
grd-8Ground-like domain-containing protein. (373 aa)
ptr-4SSD domain-containing protein. (960 aa)
smp-2Sema domain-containing protein; Belongs to the semaphorin family. (649 aa)
sin-3Paired amphipathic helix protein sin-3; Probable transcriptional repressor required for the deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (both autosomes and sex chromosomes) during meiosis, but this does not seem to solely affect the transcriptional status. Plays a role in ray fusion and patterning in the male tail, and this may be through activity of the histone deacetylase complex (HDAC). (1507 aa)
mab-21Protein male abnormal 21; Acts in a cell autonomous fashion to specify the properties of the sensory ray and non-autonomously in the choice of hypodermal versus neuroblast cell fate. Belongs to the mab-21 family. (364 aa)
grd-2GRounDhog (Hedgehog-like family). (946 aa)
unc-73Guanine nucleotide exchange factor UNC-73A. (2488 aa)
pdi-3Protein disulfide-isomerase. (488 aa)
grd-1GRounDhog (Hedgehog-like family). (1160 aa)
sma-3Dwarfin sma-3; Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis ; Belongs to the dwarfin/SMAD family. (393 aa)
qua-1Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development. (1169 aa)
lin-29Transcription factor. (459 aa)
ptr-18SSD domain-containing protein. (895 aa)
ptr-20SSD domain-containing protein. (860 aa)
smp-1Semaphorin-1A; May function in growth cone guidance; Belongs to the semaphorin family. (712 aa)
plx-1Sema domain-containing protein. (1956 aa)
mab-20Semaphorin-2A; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting and allows the formation of distinct sensory rays. Seems to control cell-cell contact formation through 2 parallel pathways, one involving efn-4 and one involving plx-2 and unc-129. Involved in axon guidance. Probably by binding receptor plx-2, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus [...] (658 aa)
wrt-1Warthog protein 1 C-product; Intercellular signal essential for a variety of patterning events during development. (484 aa)
ptr-23SSD domain-containing protein. (983 aa)
sma-2Dwarfin sma-2; Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis. (418 aa)
wrt-4Warthog protein 4 C-product; Intercellular signal essential for a variety of patterning events during development. (557 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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