STRINGSTRING
ced-10 ced-10 mig-2 mig-2 enu-3.2 enu-3.2 unc-130 unc-130 pink-1 pink-1 enu-3.1 enu-3.1 enu-3.6 enu-3.6 rac-2 rac-2 dgn-1 dgn-1 lrk-1 lrk-1 enu-3.3 enu-3.3 enu-3.5 enu-3.5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ced-10Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] (191 aa)
mig-2Rac-like GTPase. (195 aa)
enu-3.2ENhancer of Uncoordination. (462 aa)
unc-130Fork-head domain-containing protein. (333 aa)
pink-1Serine/threonine-protein kinase pink-1, mitochondrial; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins (By similarity). Plays a role in mitophagy. (641 aa)
enu-3.1ENhancer of Uncoordination. (204 aa)
enu-3.6ENhancer of Uncoordination. (319 aa)
rac-2Ras-related protein rac-2; During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation. (195 aa)
dgn-1Peptidase S72 domain-containing protein. (584 aa)
lrk-1Leucine-rich repeat serine/threonine-protein kinase 1; Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite- specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2393 aa)
enu-3.3ENhancer of Uncoordination. (462 aa)
enu-3.5ENhancer of Uncoordination. (458 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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