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| | lin-9 | Protein lin-9; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. Required for the development of sheath cells in the hermaphrodite gonad and for the development of the male spicule, rays and gonad. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. (644 aa) |
| | znf-207 | BED-type domain-containing protein. (341 aa) |
| | kin-3 | Casein kinase II subunit alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling. Modulates two aspects of male mating behavior; response to hermaphrodite contact and vulval location, acting in the same pathway as lov-1 and pkd-2. (360 aa) |
| | air-2 | Aurora/IPL1-related protein kinase 2; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. Required for histone H3 phosphorylation during segregation of homologous chromosomes in meiosis and mitosis. Required for histone H3 'Ser- 10' phosphorylation. Phosphorylates tlk-1 at 'Ser-634', which enhances its activity. Phosphorylates zen-4 at 'Ser- 680'. Required f [...] (305 aa) |
| | cpg-2 | Chondroitin proteoglycan-2; Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin. (524 aa) |
| | cdk-12 | Cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates 'Ser-2' in the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation. Required for normal reproduction. (734 aa) |
| | cdk-11.1 | Cyclin-dependent kinase 11.1; Probable cyclin-dependent kinase whose activity is most likely regulated by the cyclin cyl-1/Cylin-L. Important for normal oocyte and sperm development; probably required during multiple stages of gametogenesis. Plays a role in the activation of RAS-ERK signaling in the germ line. Also acts partially redundantly with cdk-11.2 to ensure embryonic viability. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (719 aa) |
| | fem-3 | Sex-determination protein fem-3; Required for male development. In XO (male) animals, fem-3 directs male differentiation in all tissues. In XX (hermaphrodite) animals, it specifies the first 80 or so germ cells to be sperm. Negatively regulates male development when bound to tra-2. Together with fem-2 associates with the CBC(fem-1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of tra-1. (388 aa) |
| | knl-1 | Kinetochore null protein 1; Proposed to be part of the KMN network incorporating the MIS12 complex and NDC80 complex that is required for establishing the kinetochore-microtubule interface that aids in chromosome segregation during meiotic and mitotic cell division. Appears to function downstream of hcp-3 (CENP-A) and hcp-4 (CENP-C) in the kinetochore assembly hierarchy. Has a role in the correct localization of the spindly-like protein spdl-1 and the RZZ complex that is composed of rod-1, czw-1 and zwl-1 to kinetochores. Required for the recruitment of spindle-assembly checkpoint comp [...] (1010 aa) |
| | kin-19 | Casein kinase I isoform alpha; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. (341 aa) |
| | lip-1 | Dual specificity protein phosphatase lip-1; Dephosphorylates MAP kinase mpk-1. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa) |
| | cdc-48.1 | Transitional endoplasmic reticulum ATPase homolog 1; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. Can also prevent aggregation of unfolded proteins also in an ATP- independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the act [...] (809 aa) |
| | spdl-1 | Spindly-like protein spdl-1; Transient kinetochore component required for chromosome and spindle pole alignment and chromosome segregation during mitosis. Functions downstream of the RZZ complex to mediate kinetochore-microtubule attachments and nuclear envelope breakdown during cell division. Required for kinetochore assembly and localizes the checkpoint proteins mdf-1 and mdf-2, dynein and dynactin to unattached kinetochores. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end [...] (479 aa) |
| | C06G3.8 | Uncharacterized protein. (137 aa) |
| | pct-1 | Cyclin-dependent kinase 17; Serine/threonine-protein kinase, which, in association with cyy-1, regulates the trafficking of synaptic vesicles in the DA9 motor neuron and probably also in the DD motor neurons and in RIA interneurons. (667 aa) |
| | cpg-1 | Chondroitin proteoglycan 1; Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin. (584 aa) |
| | clk-2 | Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family. (877 aa) |
| | zyg-11 | Early embryogenesis protein zyg-11; Acts as target recruitment subunit in the E3 ubiquitin ligase complex zyg-11-cul-2-elc-1. Required for metaphase to anaphase transition and M phase exit at meiosis II. Regulates polarity establishment. (799 aa) |
| | nhr-67 | Nuclear hormone receptor family member nhr-67; Orphan nuclear receptor. In males, plays an essential role in the migration of the linker cell which guides gonad elongation during the L3 and L4 stages of larval development by negatively regulating the expression of netrin receptor unc-5 at the mid-L3 stage. (416 aa) |
| | cks-1 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function (By similarity). Has a role in the exit from M phase during early mitotic cell division. More specifically, thought to act by degrading B-type cyclins that causes breakdown of nuclear envelope and exit mitosis; Belongs to the CKS family. (94 aa) |
| | oma-1 | CCCH-type zinc finger protein oma-1; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts as a ribonucleoprotein particle component that may exert part of its function within cytoplasmic foci of unfertilized oocytes. Acts redundantly with oma-2 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Recruits the translational repressor ifet-1 to the 3'-UTR of mei-1 and zif- [...] (407 aa) |
| | apc-17 | Anaphase Promoting Complex see also mat. (325 aa) |
| | plk-1 | Serine/threonine-protein kinase plk-1; Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca. In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes. Zygotic role in the development of the germline and nerve cord. In mitotic cells, plays a role in spindle organization and centrosome maturation. Involved in asymmetric nuclear localization of cdc- 25.1 during embryogenesis which affects cell division timing. Together with plk- 2, regulates cytoplasm polarity in early embryos. May play a minor role in chromos [...] (649 aa) |
| | dct-1 | NIP3 homolog; Initiates apoptosis in a BH3-independent mechanism possibly by recruiting ced-3 to mitochondria and other cytoplasmic membranes. Has a role in lifespan and tumor growth. Required for the induction of mitophagy under stress conditions. Belongs to the NIP3 family. (221 aa) |
| | cdc-14 | Tyrosine-protein phosphatase cdc-14; Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal. Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development. Has been shown to not be required for cytokinesis. However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and [...] (709 aa) |
| | szy-20 | Suppressor of zyg-1 protein 20; RNA binding protein that is required for normal cell division and cytokinesis during embryonic development. Functions with RNA-binding protein atx-2 to ensure embryonic cell division, and to this end, plays a role in the regulation of centrosome assembly, position and size, and in astral microtubule outgrowth and nucleation. Furthermore, negatively regulates the levels of the protein kinase zyg-1 at the centrosome. Also involved in ensuring centrosome attachment to the nuclear envelope. (563 aa) |
| | syp-2 | Uncharacterized protein. (213 aa) |
| | dsh-2 | DiSHevelled related. (759 aa) |
| | szy-4 | Suppressor of ZYg-1. (739 aa) |
| | lin-35 | Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...] (961 aa) |
| | maph-9 | Protein maph-9. (512 aa) |
| | dsh-1 | DiSHevelled related. (981 aa) |
| | cye-1 | G1/S-specific cyclin-E; Essential for the control of the cell cycle at the G1/S (start) transition. In association with cdk-2, regulates proliferation, quiescent state and cell fate during the development of several cell lineages. In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase. During the development of the vulva, controls the onset of vulval cell terminal differentiation by controlling the duration of G1 phase. During hypoderm development at early larval stages, controls syncytial fate of [...] (524 aa) |
| | cdc-6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (518 aa) |
| | mus-81 | ERCC4 domain-containing protein. (445 aa) |
| | tba-2 | Tubulin alpha-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (448 aa) |
| | trr-1 | Transcription-associated protein 1; Influences germ cell fate in hermaphrodites. Acts downstream of tra-2 and tra-3 and through the Tip60 histone acetyltransferase complex to regulate germ cell fate decisions (By similarity). Required for spermatogenesis and embryonic development (By similarity). Acts with tra-2 to promote expression of fog-3 and control male tail development (By similarity). Involved in the negative regulation of vulval development. Belongs to the PI3/PI4-kinase family. TRA1 subfamily. (4064 aa) |
| | mdf-1 | MAD (Yeast Mitosis arrest DeFicient) related. (679 aa) |
| | pals-37 | Protein containing ALS2cr12 (ALS2CR12) signature. (734 aa) |
| | uri-1 | URI (Unconventional prefoldin RPB5 Interactor) homolog. (446 aa) |
| | D1037.1 | Uncharacterized protein. (786 aa) |
| | nekl-4 | Serine/threonine-protein kinase D1044.8. (981 aa) |
| | D1053.2 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (154 aa) |
| | prg-1 | Piwi-like protein; Belongs to the argonaute family. (824 aa) |
| | atx-2 | Ataxin-2 homolog; Probable RNA-binding protein that negatively regulates the translation of targets. Functions with RNA-binding protein szy-20 to ensure embryonic cell division, and to this end, plays a role in the regulation of centrosome assembly, position and size, and in astral microtubule outgrowth and nucleation. Required for gonad development, germ cell proliferation and for the production of oocytes. Regulates whole body growth and fat accumulation in response to food availability, and this may be through the mTOR pathway, upstream of daf-15 and rheb-1. Belongs to the ataxin-2 [...] (1026 aa) |
| | cul-1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. (780 aa) |
| | etc-1 | E3 ubiquitin-protein ligase etc-1; E3 ubiquitin-protein ligase that accepts ubiquitin from E2 ubiquitin-conjugating enzymes, such as ubc-18, in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ify-1 and cyb-1 targeting them for degradation in post-meiotic embryos. (1001 aa) |
| | lmn-1 | Lamin-1; Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Provides a framework for the nuclear envelope and probably also interacts with chromatin. Essential to maintain the shape and integrity of the nucleus, and for DNA replication. Involved in spatial organization of nuclear pore complexes. It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans. Belongs to the intermediate filament family. (566 aa) |
| | npp-5 | Nuclear pore complex protein 5; Involved in kinetochore assembly and chromosome segregation during embryonic mitosis. Required for the localization of the NDC80 complex member him-10, the chromosomal passenger complex component air- 2 and nuclear pore complex proteins npp-23 and npp-15 to kinetochores during metaphase. Required for npp-23 localization to the nuclear envelope during interphase. Recruits mdf-1, a component of the spindle assembly checkpoint, to the nuclear envelope. Appears dispensable for the assembly of the nuclear pore complex and for nuclear protein import. (813 aa) |
| | F08F1.9 | CYCLIN domain-containing protein; Belongs to the cyclin family. (130 aa) |
| | nmad-1 | DNA N6-methyl adenine demethylase; Dioxygenase that specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA. N(6)-methyladenosine (m6A) DNA is involved in epigenetic transgenerational inheritance. Plays an essential role in DNA replication and repair in the germline during meiosis. Binds to components of the DNA replication machinery such as top-2, and directs their localization to DNA to control DNA replication. (291 aa) |
| | F09G2.2 | Cyclin N-terminal domain-containing protein. (319 aa) |
| | pch-2 | Putative pachytene checkpoint protein 2; Plays a key role in chromosome recombination during meiosis. (424 aa) |
| | emb-27 | Cell division cycle protein 16 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating [...] (655 aa) |
| | mat-3 | Cell division cycle protein 23 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating the abundance of glr-1 receptor [...] (673 aa) |
| | ppfr-1 | Serine/threonine-protein phosphatase 4 regulatory subunit 1; Probable regulatory subunit of serine/threonine-protein phosphatase PP4 which may play a role in meiosis and embryonic mitosis. Probably in association with catalytic subunit pph-4.1, regulates microtubule severing during oocyte meiosis II by dephosphorylating and likely activating mei-1, a component of the katanin microtubule severing complex. (1562 aa) |
| | cdc-25.2 | M-phase inducer phosphatase cdc-25.2; Required for intestinal cell division following the 16E cell stage of embryogenesis. Regulates intestinal cell divisions and binucleations probably by modulating the activity of the cell cycle regulator wee-1.3 and by activating the cdk-1/cyb-1 complex. Belongs to the MPI phosphatase family. (480 aa) |
| | scc-3 | Cohesin subunit scc-3; Component of the cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the scc-1 subunit of the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). Has a role in stabilization of homologous chromosome associations during meiotic syn [...] (1096 aa) |
| | cdk-4 | Cyclin-dependent kinase 4 homolog; Serine/threonine-protein kinase which, in association with cyclin D-like protein cyd-1, is required for the progression through the G1 phase of the cell cycle during postembryonic development by phosphorylating and inhibiting lin-35 and fzr-1. In complex with cyd-1, involved in sex determination during gonadogenesis by regulating the asymmetric division of the somatic gonadal precursor cell (SGP). (406 aa) |
| | czw-1 | Centromere/kinetochore protein zw10 homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC8 [...] (778 aa) |
| | bmk-1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa) |
| | tipn-1 | Protein TIPIN homolog; Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. Belongs to the CSM3 family. (233 aa) |
| | F25B5.5 | CDK5RAP1-like protein; Potential regulator of CDK5 activity; Belongs to the methylthiotransferase family. MiaB subfamily. (547 aa) |
| | clsp-1 | CLaSPin homolog. (752 aa) |
| | syp-1 | Synaptonemal complex protein SYP-1. (489 aa) |
| | tba-1 | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa) |
| | phg-1 | Growth arrest-specific protein 1 homolog; Role in pharynx function or development. (228 aa) |
| | egl-44 | Transcription enhancer factor-like protein egl-44; Acts upstream of egl-46 to prevent touch cell differentiation in FLP neurons. Also promotes HSN neuron development. In association with egl-46, regulates cell cycle exit in the neuronal Q cell lineage. May be involved in thermal stress response downstream of yap-1. (493 aa) |
| | atz-1 | Uncharacterized protein. (268 aa) |
| | hpr-17 | Homolog of S. Pombe Rad. (514 aa) |
| | figl-1 | Fidgetin-like protein 1; Has a role in spindle assembly which acts in the progression through mitosis during embryogenesis. Required for fertility. (594 aa) |
| | mel-26 | Protein maternal effect lethal 26; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of microtubule severing protein mei-1 after meiosis. Controls degradation of ppfr-1, the regulatory subunit of PP4 complex, after meiosis. In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of mei-1 downstream of unc-89. May also activate the TORC1 pathway. (399 aa) |
| | lrr-1 | Leucine-Rich Repeat protein. (453 aa) |
| | apc-11 | Anaphase-promoting complex subunit 11; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis. In vitro, recruits the ubiquitin-conjugating enzyme ubc-2 to exert ubiquitin ligase activity. Belongs to the RING-box family. (135 aa) |
| | mus-101 | Uncharacterized protein. (1182 aa) |
| | cdk-8 | Cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C- terminal domain) of the l [...] (588 aa) |
| | smk-1 | SMK-1 domain-containing protein. (1085 aa) |
| | htp-1 | HORMA domain-containing protein. (352 aa) |
| | ccnk-1 | CYCLIN domain-containing protein; Belongs to the cyclin family. (252 aa) |
| | cit-1.2 | Cyclin-T1.2; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy- terminal domain) of the large subunit of RNA polymerase II (RNAP II). (555 aa) |
| | cit-1.1 | Cyclin-T1.1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy- terminal domain) of the large subunit of RNA polymerase II (RNAP II). (468 aa) |
| | skr-2 | SKp1 Related (Ubiquitin ligase complex component). (174 aa) |
| | skr-1 | Skp1-related protein; Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. Involved in synapse elimination in early synapse development. May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress. Plays a role in sex determination. (176 aa) |
| | ubxn-3 | UBX domain-containing protein 3; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-1 and ubxn-2, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. During mitosis, ensures the degradation of DNA licensing factor cdt-1 and the disassembly of the DNA replication CMG helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5. (613 aa) |
| | lon-1 | Protein lon-1; Regulates body size morphogenesis, but does not affect male tail development; Belongs to the CRISP family. (312 aa) |
| | skpt-1 | F-box domain-containing protein. (421 aa) |
| | pam-1 | Puromycin-sensitive aminopeptidase; Aminopeptidase. Required for the exit from meiosis, probably upstream of cyclin cyb-3. Involved in the establishment of the anterior-posterior polarity at the embryonic 1-cell stage by regulating the dynamics of sperm-donated centrosomes. Plays a role in oocyte maturation. Required for embryonic development. Belongs to the peptidase M1 family. (948 aa) |
| | abu-12 | Activated in Blocked Unfolded protein response. (824 aa) |
| | polh-1 | UmuC domain-containing protein. (584 aa) |
| | mnat-1 | CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (310 aa) |
| | emb-30 | Abnormal embryogenesis protein 30; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in somatic and germ cells. Required for embryonic anterior- posterior axis formation. Negatively regulat [...] (1027 aa) |
| | dot-1.2 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (315 aa) |
| | ppk-1 | PIPK domain-containing protein. (611 aa) |
| | sel-10 | F-box/WD repeat-containing protein sel-10; Probable substrate recognition component of SCF (SKP1-CUL-F- box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates synapse elimination in early development in the motor neuron HSNL. Cell autonomous negative regulator of lin-12/Notch-mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis. May target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation. Involved in sex determin [...] (587 aa) |
| | rfip-1 | FIP-RBD domain-containing protein. (471 aa) |
| | rod-1 | Kinetochore-associated protein rod-1; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores and spindle pole separation. Plays a role in nuclear envelope breakdown. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome [...] (2049 aa) |
| | plk-3 | Serine/threonine-protein kinase plk-3; May be required for cell division and may have a role during G1 or S phase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. (615 aa) |
| | dot-1.4 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (383 aa) |
| | spd-5 | Spindle-defective protein 5; Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development. (1198 aa) |
| | eme-1 | Essential Meiotic Endonuclease. (454 aa) |
| | sun-1 | Sun domain-containing protein 1; Involved in centrosome attachment to the nucleus. Required for zyg-12 localization to the nuclear envelope. Together with pot-1, it is required to anchor telomeres to the nuclear envelope in embryos. (473 aa) |
| | spat-1 | Suppressor of PAr-Two defect. (547 aa) |
| | hcp-3 | Histone H3-like centromeric protein hcp-3; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). Might promote cleavage furrow stability during cytokinesis. Not required for chromosome segregation during meiosis. (288 aa) |
| | tbg-1 | Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. (444 aa) |
| | zyg-1 | Probable serine/threonine-protein kinase zyg-1; Protein kinase that plays a central role in centrosome duplication, control of centrosome size, spindle formation and nuclear envelope breakdown during cell divisions. Paternal copy is required to regulate synthesis of daughter centrioles prior to fertilization. Maternal copy regulates centrosome duplication during later cell cycles. Functions upstream of sas-5 and sas-6, and is required for their localization to the centrosome. Its role in nuclear envelope breakdown is mediated by the spindly-like protein spdl-1 and the RZZ complex, whic [...] (706 aa) |
| | cya-2 | CYCLIN domain-containing protein; Belongs to the cyclin family. (123 aa) |
| | dyf-18 | Protein kinase domain-containing protein. (323 aa) |
| | fbf-1 | Fem-3 mRNA-binding factor 1; Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression, possibly by directly binding to two sites within the 3'-UTR of gld-3 isoform b. In association with the cye-1/cdk-2 complex, negatively regulates gld-1 expression in the distal germline cells of the mitotic zone. By binding to the 3'-UTR, repres [...] (614 aa) |
| | mog-2 | Probable U2 small nuclear ribonucleoprotein A; This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA. Required maternally for early embryonic development and zygotically for germline and somatic development. Has a role in the switch from mitosis to meiosis. Might function in alternative splicing. (253 aa) |
| | cdk-9 | Probable cyclin-dependent kinase 9; Essential member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAP II) and spt-5. (478 aa) |
| | hus-1 | Checkpoint protein. (277 aa) |
| | cyb-2.2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (339 aa) |
| | taf-10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (179 aa) |
| | cdk-2 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase which, in association with cye-1, regulates proliferation, quiescent state and cell fate during the development of several cell lineages. . In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase. Phosphorylation and inhibition of the translational repressor gld-1 by the cdk-2/cye-1 complex regulates the pool of germline stem cells and the size of the mitotic zone in the gonads by preventing entry into meiosis. (338 aa) |
| | cdc-25.1 | M-phase inducer phosphatase cdc-25.1. (604 aa) |
| | apc-2 | Anaphase-promoting complex subunit 2; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis. (731 aa) |
| | air-1 | Protein kinase domain-containing protein. (326 aa) |
| | npp-1 | Nup54 domain-containing protein. (639 aa) |
| | lin-23 | F-box/WD repeat-containing protein lin-23; Functions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation (By similarity). (667 aa) |
| | klp-7 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (747 aa) |
| | egl-46 | C2H2-type domain-containing protein. (286 aa) |
| | npp-3 | Nuclear Pore complex Protein. (1696 aa) |
| | zen-4 | Kinesin-like protein. (787 aa) |
| | par-5 | 14-3-3-like protein 1. (248 aa) |
| | gfi-3 | Protein gfi-3; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Required for the metaphase to anaphase transition in meiosis. (800 aa) |
| | abl-1 | Tyrosine-protein kinase abl-1; Functions downstream of migratory protein mig-13 and is involved in Q neuroblast migration during larval development. Recruited by mig-13 to the leading edge of Q neuroblasts and their descendents to signal downstream, likely to the wve-1 pathway, and direct migration along the anteroposterior body axis. Promotes germline cell apoptosis in response to oxidative, osmotic and heat shock stresses. Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. (1224 aa) |
| | R02C2.1 | Protein kinase domain-containing protein. (312 aa) |
| | R02D3.4 | INTegrator complex Subunit homolog. (782 aa) |
| | R02F2.1 | CYCLIN domain-containing protein; Belongs to the cyclin family. (311 aa) |
| | met-2 | Histone-lysine N-methyltransferase met-2; Histone methyltransferase which is required for the mono- and dimethylation of 'Lys-9' of histone H3. This increases the efficiency of set-25-mediated trimethylation of histone H3 'Lys-9'. Involved in the transcriptional repression of lin-3 which is required for the negative regulation of vulval cell fate specification during postembryonic development. Has a role in blocking checkpoint signaling and mediating the transcriptional silencing of meiotic sex chromosome inactivation; a mechanism which enables checkpoint proteins to distinguish betwee [...] (1304 aa) |
| | cdc-25.4 | Rhodanese domain-containing protein. (278 aa) |
| | mig-14 | Protein wntless homolog; Probable sorting receptor which regulates endocytosis and secretion of the wnt ligand egl-20. Recycling of mig-14 from the plasma membrane to the Golgi apparatus by the retromer complex is essential for its function. Its endosomal trafficking is regulated by its association with sorting nexin snx-3 on early endosomes and the mtm-6/mtm-9 myotubularin complex. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Functions during vulval development, [...] (549 aa) |
| | bub-1 | Mitotic checkpoint serine/threonine-protein kinase bub-1; Serine/threonine-protein kinase essential for spindle- assembly checkpoint signaling. Plays a key role in the recruitment of the checkpoint proteins bub-3, mdf-1 and mdf-2 to unattached kinetochores. mdf-1 recruitment is independent of bub-1 kinase activity. Has a role in the correct kinetochore localization of the spindly-like protein spdl-1. In addition, during meiotic anaphase I, controls the recruitment of hcp- 1/2 and klp-19 to the ring-shaped domain formed between chromosomes. Involved in chromosome alignment, chromosome h [...] (987 aa) |
| | npp-19 | Nucleoporin NUP35; Functions as a component of the nuclear pore complex (NPC) (By similarity). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity). Required for the proper organization of chromosomes on the mitotic spindle during anaphase. (381 aa) |
| | npp-21 | Nuclear Pore complex Protein. (1987 aa) |
| | wapl-1 | Wings apart-like protein homolog 1; Regulator of meiotic chromosome structure and function, playing a role in sister chromatid cohesion, possibly via antagonizing the coh-3/-4 association with axial elements in nuclei during late prophase, cohesin association with chromatin, DNA double strand break repair and polar body positioning following meiotic divisions during oogenesis. Regulates the morphogenesis and temporal assembly of axial elements to control the organization of meiotic chromosomes in pachytene nuclei and is also involved in meiotic chromosomal remodeling in late pachytene [...] (748 aa) |
| | taf-4 | TAFH domain-containing protein. (523 aa) |
| | R11D1.10 | FYVE-type domain-containing protein. (394 aa) |
| | daf-16 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa) |
| | egl-43 | Uncharacterized protein. (543 aa) |
| | syx-4 | Putative syntaxin-4; Potentially involved in docking of synaptic vesicles at presynaptic active zones. (296 aa) |
| | cdt-2 | WD_REPEATS_REGION domain-containing protein. (682 aa) |
| | mei-1 | Meiotic spindle formation protein mei-1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays. Required specifically for meiotic spindle formation in the female germline; the presence of this protein is inimical to the formation of mitotic spindles. In body wall muscles, regulates organization of myosin thick filaments. (475 aa) |
| | hcp-4 | HoloCentric chromosome binding Protein. (866 aa) |
| | him-6 | Bloom syndrome protein homolog; Participates in DNA replication and repair (By similarity). Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Negatively regulates sister chromatid exchange (SCE) ; Belongs to the helicase family. RecQ subfamily. (988 aa) |
| | sel-13 | Suppressor/Enhancer of Lin-12. (234 aa) |
| | cki-1 | Cyclin-dependent kinase inhibitor 1; Negative cell-cycle regulator that functions at the G1-to-S- phase transition. Required for suspension of the cell cycle in dauer larvae and starved L1 larvae. In vulval precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G1 during the L2 larval stage. Cul-2 may function in ubiquitin-mediated degradation by targeting cki-1 for degradation. Involved in distal tip cell development by repressing and modulating cye-1/cdk-2 activity levels in Z1.aa/Z4.pp and in Z1.ap/Z4.pa. Belongs to the CDI family. (184 aa) |
| | cki-2 | CKI family (Cyclin-dependent Kinase Inhibitor). (259 aa) |
| | mig-5 | Segment polarity protein dishevelled homolog mig-5; Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Functions redundantly with other dishevelled family members throughout development. During embryonic and larval development, controls cell migration and/or cell fate specification of hypodermal cells, hypodermal seam cells, vulval precursor cells and, through distal tip cell migration, somatic gonad precursor cells. In early embryos, regulates the orientation of the mitotic spindle of blastomeres and specifically, along with dsh-2, is required for the cor [...] (672 aa) |
| | hsr-9 | Protein hsr-9; May have a role in DNA double-strand break repair following gamma-irradiation. (1165 aa) |
| | pzf-1 | Paired Zinc Finger protein. (504 aa) |
| | cdk-1 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). (332 aa) |
| | gad-1 | Gastrulation defective protein 1; Required for initiation of gastrulation. (620 aa) |
| | atl-1 | Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (By similarity). Recognizes the substrate consensus sequence [ST]-Q (By similarity). Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination (By similarity). Prevents mitotic catastrophe by functioning in the S-phase checkpoint and cooperating with atm-1 in the c [...] (2531 aa) |
| | cyb-3 | G2/mitotic-specific cyclin-B3; Could be involved at the G2/M (mitosis) transition (Probable). Interacts with the CDK1 and CDK2 protein kinases (Probable). G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis (Probable). Plays a role during oocyte meiosis II. (385 aa) |
| | T07F10.5 | Uncharacterized protein. (116 aa) |
| | gld-3 | Defective in germ line development protein 3; Required maternally for germline survival and embryogenesis. Forms a complex with gls-1 which promotes the oogenic cell fate by freeing the translational repressor fbf to repress sperm promoting factors. Promotes maturation of primary spermatocytes to mature sperm. Required during hermaphrodite development to promote sperm fate, which is critical for determining the normal number of sperm. Promotion of sperm fate is at the expense of oogenesis, possibly through the negative regulation of fbf. Required during male development for the continu [...] (969 aa) |
| | mom-1 | Protein-serine O-palmitoleoyltransferase porcupine; Key regulator of the Wnt signaling pathway that mediates lipid modification of Wnt proteins. Acts as a protein-serine O-palmitoleoyltransferase that catalyzes the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins (By similarity). Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors (By similarity). Has a role in cell specification, specifically in blastomere signaling. Involved in cytosketetal polarity. Required for the orientation of mitotic spindle [...] (442 aa) |
| | T08D2.7 | Uncharacterized protein; Belongs to the protein kinase superfamily. (469 aa) |
| | sds-22 | Protein phosphatase 1 regulatory subunit SDS22 homolog; Regulatory subunit of protein phosphatase 1; Belongs to the SDS22 family. (326 aa) |
| | him-17 | High Incidence of Males (Increased X chromosome loss). (954 aa) |
| | knl-3 | Kinetochore NuLl. (343 aa) |
| | gen-1 | GEN1 Holliday junction resolvase homolog. (434 aa) |
| | T12C9.7 | CYCLIN domain-containing protein; Belongs to the cyclin family. (400 aa) |
| | taf-9 | TAF (TBP-associated transcription factor) family. (183 aa) |
| | T12E12.6 | Peptidase_M1 domain-containing protein. (641 aa) |
| | T16G12.1 | Putative aminopeptidase-2; Putative aminopeptidase which plays a role in oocyte maturation. (1890 aa) |
| | kin-18 | Serine/threonine-protein kinase SULU; Acts as a negative regulator of cortical contractions during early embryonic cell division, possibly by regulating rho-1-dependent actomyosin contractility. Plays a role in polarity establishment in early embryos by regulating the size of the anterior and posterior cortex in the first asymmetric cell division. Might play a role in cell cycle progression. In the germline, involved in the regulation of meiotic progression during oogenesis, possibly by modulating the timing of mpk-1 activation. Plays a role in meiotic recombination events. Involved in [...] (982 aa) |
| | npp-7 | Nuclear Pore complex Protein. (1217 aa) |
| | ect-2 | ECT2 (Mammalian Rho GEF) homolog. (932 aa) |
| | cmd-1 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa) |
| | mom-5 | Protein mom-5; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (Probable). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for Wnt-mediated inactivation of gsk-3 kinase (Probable). B [...] (570 aa) |
| | cdka-1 | Cyclin-dependent kinase 5 activator 1; Activator of the kinase cdk-5 (By similarity). In several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles. In the ventral nerve cord, regulates the synaptic localization of the glutamate receptor, glr-1. In DA motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the polarized distribution of dense-core vesicles in DB motor neurons. May regulate these processes in association with cdk-5. May also play a role in GABAergic [...] (366 aa) |
| | dpl-1 | Transcription factor dpl-1; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. May also negatively regulate vulval development in association with other SynMuv class B proteins such as lin-15A. Can stimulate E2F-dependent transcription. Plays a role in negatively regulating the progression through the G1 phase of the cell cycle during postembryonic development, most likely by acting as a transcriptional repress [...] (598 aa) |
| | T24A6.1 | Uncharacterized protein. (91 aa) |
| | jun-1 | Transcription factor jun-1; Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3'. Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. (319 aa) |
| | dbl-1 | TGF_BETA_2 domain-containing protein. (365 aa) |
| | cdk-5 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] (292 aa) |
| | ndc-80 | Kinetochore protein ndc-80; Acts as a component of the essential kinetochore-associated ndc-80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity. Plays a role in kinetochore assembly and recruits the checkpoint protein mdf-2 and the spindly-like protein spdl-1 to unattached kinetochores. Mediates the formation of end-on kinetochore-microtubule attachments through recruitment of spdl-1. The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolym [...] (590 aa) |
| | rec-8 | Meiotic recombination protein rec-8; Plays a role in meiotic chromosome cohesion and segregation. Necessary for sister chromatid co- orientation and sister chromatid cohension until meiosis II. May also be required for repair of programmed meiotic double stranded breaks. During spermatogenesis, likely involved in spermatocyte centriole cohesion, thus preventing their separation during the second meiotic division. Belongs to the rad21 family. Highly divergent. (781 aa) |
| | dot-1.3 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (313 aa) |
| | mat-2 | Anaphase-promoting complex subunit 1; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating the abundance of glr-1 receptors [...] (1505 aa) |
| | gei-17 | E3 SUMO-protein ligase gei-17; Functions as an E3-type smo-1 ligase. Mediates smo-1 conjugation to air-2 in vitro and is required for proper chromosome alignment. In the early embryo, specifically suppresses checkpoint activation in response to DNA damage, maybe by promoting mus-101 sumoylation. In embryos, plays a role in determining telomere localization in the nucleus. (780 aa) |
| | csnk-1 | Casein kinase I gamma; Involved in the asymmetric cell division of the embryo downstream of par-2 and par-3 by regulating the asymmetric cortical distribution of pkk-1, a phosphatidylinositol 4,5-bisphosphate- producing enzyme, which in turn regulates the asymmetrical distribution of grp-1, grp-2 and lin-5. (407 aa) |
| | pab-1 | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (646 aa) |
| | mat-1 | Cell division cycle protein 27 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating [...] (788 aa) |
| | cdkr-3 | CDK5RAP3-like protein; Potential regulator of CDK5 activity. (489 aa) |
| | gsk-3 | Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting [...] (362 aa) |
| | szy-2 | Suppressor of ZYg-1. (193 aa) |
| | npp-13 | Nuclear pore protein. (787 aa) |
| | cyd-1 | G1/S-specific cyclin-D; In association with cdk-4, regulates the progression through the G1 phase of the cell cycle during postembryonic development. Regulates proliferation of the coelomocyte lineage and intestinal cells during late embryogenesis. In complex with cdk-4, involved in sex determination during gonadogenesis by regulating the asymmetric division of the somatic gonadal precursor cell (SGP). (405 aa) |
| | orc-1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (636 aa) |
| | hpr-9 | Cell cycle checkpoint protein hpr-9; May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. (521 aa) |
| | dpy-28 | Condensin complex subunit 1; Required for both chromosome condensation and segregation during mitosis and meiosis and X-chromosome dosage compensation depending on its binding partners. Regulatory subunit of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). The condensin I complex func [...] (1499 aa) |
| | Y39E4B.6 | Uncharacterized protein. (237 aa) |
| | cdk-7 | Cyclin-dependent kinase 7; Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Required for maintaining chromosome ploidy. May phosphorylate the large subunit of RNA polymerase II, ama-1; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (330 aa) |
| | icp-1 | INCENP_ARK-bind domain-containing protein. (622 aa) |
| | dot-1.1 | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase, which in complex with zfp-1, methylates 'Lys-79' of histone H3 to activate transcription (Probable). During stress, the zfp-1-dot-1.1 complex also plays a role in the deubiquitination of histone H2B sites, which negatively modulates the RNA polymerase II-induced transcription of highly expressed genes. Involved in controlling tissue-specific gene expression, particularly in the epidermis. (946 aa) |
| | zwl-1 | Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1- mdf-2 complexes onto kinetochores and spindle pole separation. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome segregation, the complex also inhibits the attachment of [...] (630 aa) |
| | chk-1 | Serine/threonine-protein kinase chk-1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Required for checkpoint mediated cell cycle arrest in response to DNA damage in germline cells. Delays cell-cycle reentry of the Z2 and Z3 primordial germ cells in response to transcription-induced DNA damage as they emerge from cell cycle arrest in L1 larvae. Essential for embryogene [...] (503 aa) |
| | mrt-2 | Cell cycle checkpoint protein RAD1 homolog mrt-2; May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. Promotes DNA double strand break- induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Also required for telomere length maintenance and germline immortality. May possess 3'->5' double stranded DNA exonuclease activity (By similarity). Belongs to the Rad1 family. (267 aa) |
| | npp-8 | Nuclear Pore complex Protein. (1340 aa) |
| | fcd-2 | FANCD2 (Fanconi's anemia defect) ortholog. (1440 aa) |
| | cdkl-1 | Cyclin-dependent kinase-like 1; Modulates cilium assembly. (484 aa) |
| | cyb-2.1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (317 aa) |
| | pqn-85 | Nipped-B-like protein pqn-85; Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity). (2203 aa) |
| | sas-6 | Spindle assembly abnormal protein 6; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication. (492 aa) |
| | sep-1 | Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...] (1262 aa) |
| | atm-1 | Serine/threonine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling in the presence of DNA double strand breaks (DSBs) and other forms of DNA damage induced by ionizing radiation and other genotoxic stresses such as UV. Plays a role in maintaining genome stability. Belongs to the PI3/PI4-kinase family. ATM subfamily. (2378 aa) |
| | cyh-1 | CYclin H. (332 aa) |
| | wee-1.3 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase during oocyte maturation. Required for oocyte maturation, embryonic development, germline proliferation and initiation of meiosis during spermatogenesis. Required for chromosome structure during mitosis and negative regulation of nuclear envelope breakdown. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (677 aa) |
| | nos-3 | Nanos-type domain-containing protein. (871 aa) |
| | cdt-1 | CDT1 domain-containing protein. (684 aa) |
| | bub-3 | Mitotic checkpoint protein bub-3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments of chromosomes. Necessary for expression and kinetochore localization of bub-1. Plays a role in synapsis checkpoint signaling inducing apoptosis in response to unsynapsed chromosomes and thus controlling chromosomal segregation during oocyte meiosis. (343 aa) |
| | efa-6 | Exchange factor for Arf-6; Guanine nucleotide exchange factor for arf-6 (By similarity). Involved in response to injury in mechanosensory neurons. Inhibits axon regrowth via microtubule dynamics, possibly by inducing axonal microtubule catastrophes. Limits microtubule growth near the cellular cortex of early embryonic cells. (818 aa) |
| | par-4 | Serine/threonine-protein kinase par-4; Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Controls the asymmetric cell division of the Q.p neuroblast lineage. Involved in mediating cell polarization via regulation of anillin family scaffold proteins. Phosphorylates and restricts the asymmetry effectors mex-5 and mex-6 to the anterior cytoplasm of the zygote and maintains these phosphorylations until fertilization. May phosphorylate par-1. Required for strd-1 localization to the cell cortex of early embryos and may be required for strd-1 protein s [...] (617 aa) |
| | chk-2 | Serine/threonine-protein kinase chk-2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase. (476 aa) |
| | such-1 | Suppressor of spindle checkpoint defect 1; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Required for the metaphase to anaphase transition in meiosis. Plays a role in the segregation of DNA and centrioles during meiosis in male germ cells. Belongs to the APC5 family. (798 aa) |
| | Y66D12A.9 | Uncharacterized protein. (248 aa) |
| | Y67D8C.9 | Uncharacterized protein. (1144 aa) |
| | mdf-2 | HORMA domain-containing protein. (203 aa) |
| | Y71F9B.6 | Cyclin N-terminal domain-containing protein. (534 aa) |
| | plk-2 | Serine/threonine-protein kinase plk-2; Serine/threonine-protein kinase which plays a role, during oogenesis, in chromosome pairing and synapsis, by facilitating the recruitment and attachment of meiotic chromosomes to the nuclear envelope during prophase. Regulates the formation of sun-1 patches along the nuclear envelope. Promotes meiotic nuclei apoptosis in response to chromosomal asynapsis. Plays a redundant role with plk-1 in the establishment of cell polarity downstream of mex-5 and mex-6 during the first embryonic cell divisions. Plays a role in nicotinic acetylcholine receptor- [...] (632 aa) |
| | Y71G12B.27 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (118 aa) |
| | htp-2 | HORMA domain-containing protein. (352 aa) |
| | gmn-1 | Geminin homolog. (180 aa) |
| | tim-1 | Protein timeless homolog; Plays an important role in chromosome cohesion during both mitosis and meiosis. In prophase of meiosis, it is involved in the formation of the synaptonemal complex (SC) and specifically, in the diplotene and diakinesis phases of prophase, it stabilizes the association of homologous chromosomes during synapsis and sister chromatid cohesion. It regulates cohesin subunits to promote meiotic chromosome cohesion and localizes non-SMC (structural maintenance of chromosome) cohesin subunits to chromatin prior to or during pre-meiotic S phase. Implicated in influencin [...] (1353 aa) |
| | pph-4.1 | Serine/threonine-protein phosphatase 4 catalytic subunit 1; Protein phosphatase which plays an essential role in meiosis and in early embryonic mitosis. During spermatocyte meiosis and the first embryonic mitosis, regulates centrosome maturation, and thus spindle formation, by recruiting some of the components of the pericentriolar material (PCM). During oocyte meiosis I, regulates meiotic chromosome dynamics including synapsis-independent chromosome pairing, restriction of synapsis to homologous chromosomes, programmed DNA double-strand break initiation and crossover formation resulti [...] (333 aa) |
| | npp-20 | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Belongs to the WD repeat SEC13 family. (313 aa) |
| | zyg-8 | Serine/threonine-protein kinase zyg-8; Plays a role in spindle positioning during asymmetric division of one-cell stage embryos. Affects spindle position by promoting microtubule assembly during anaphase. (802 aa) |
| | elc-1 | Skp1_POZ domain-containing protein. (124 aa) |
| | him-19 | High Incidence of Males (Increased X chromosome loss). (413 aa) |
| | ZC123.4 | Protein kinase domain-containing protein. (536 aa) |
| | cyb-1 | G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. (361 aa) |
| | mre-11 | Double-strand break repair protein mre-11; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. In response to ionizing radiation, probably required for the association between the brc-1-brd-1 heterodimer and rad-51 and let-70 in order to activate E3-ubiquitin ligase activity of the heterodimer and induce ubiquitination at DNA damage sites. Belongs to the MRE11/RAD32 family. (728 aa) |
| | gld-2 | Poly(A) RNA polymerase gld-2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Acts as a regulator of mitosis/meiosis required for progression through meiotic prophase during oogenesis and spermatogenesis and for promotion of the entry into meiosis from the mitotic cell cycle. May act by regulating and activating gld-1 mRNA activity in germline. (1113 aa) |
| | san-1 | BUB1 N-terminal domain-containing protein. (390 aa) |
| | cdk-11.2 | Cyclin-dependent kinase 11.2; Probable cyclin-dependent kinase whose activity is most likely regulated by the cyclin cyl-1/Cylin-L. Acts partially redundantly with cdk-11.1 to ensure embryonic viability. In contrast to cdk-11.1, not essential for male and female fertility. (668 aa) |
| | oma-2 | CCCH-type zinc finger protein oma-2; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts redundantly with oma-1 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Also, together with oma-1, is involved in P-granule distribution during embryonic development. (393 aa) |
| | dot-1.5 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (361 aa) |
| | nos-2 | Nanos-type domain-containing protein; Belongs to the nanos family. (259 aa) |
| | fzy-1 | WD repeat-containing protein fzy-1; Plays a role in metaphase-anaphase transition during meiosis I. Required for embryonic anterior-posterior axis formation ; Belongs to the WD repeat CDC20/Fizzy family. (507 aa) |
| | rbx-1 | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. (110 aa) |
| | cyy-1 | Cyclin-Y; In association with pct-1, regulates the trafficking of synaptic vesicle precursors in DA motor neurons by promoting anterograde trafficking to the axon and preventing dynein-dependent trafficking to the dendrite. May also regulate synaptic vesicle trafficking in DD motor neurons and in RIA interneurons. Involved in synapse formation during DD motor neuron remodeling by disassembling ventral presynaptic structures. May activate cdk-5. Belongs to the cyclin family. (357 aa) |
| | him-3 | HORMA domain-containing protein. (291 aa) |
| | ZK484.4 | TRESlin (TRESLIN) homolog. (919 aa) |
| | cya-1 | G2/mitotic-specific cyclin-A1; Involved in the control of the cell cycle after S phase. May bind to and activate cdk-1 and/or cdk-2 to promote cell cycle progression. Necessary for embryogenesis. Belongs to the cyclin family. Cyclin AB subfamily. (485 aa) |
| | cul-2 | Cullin-2; Core component of multiple cullin-RING-based CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell [...] (791 aa) |
| | cdc-25.3 | M-phase inducer phosphatase cdc-25.3. (316 aa) |
