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unc-52 unc-52 tln-1 tln-1 cpz-1 cpz-1 dpy-13 dpy-13 dpy-5 dpy-5 F26E4.3 F26E4.3 gon-1 gon-1 sqt-3 sqt-3 col-153 col-153 him-4 him-4 mig-18 mig-18 spon-1 spon-1 let-2 let-2 col-158 col-158 ensh-1 ensh-1 lam-2 lam-2 C49C8.5 C49C8.5 cut-1 cut-1 ost-1 ost-1 lon-2 lon-2 C03H12.1 C03H12.1 bli-1 bli-1 skpo-2 skpo-2 C16E9.1 C16E9.1 C18H7.1 C18H7.1 cle-1 cle-1 mig-6 mig-6 hse-5 hse-5 emb-9 emb-9 Y43C5A.2 Y43C5A.2 B0393.5 B0393.5 cdh-3 cdh-3 col-19 col-19 lon-3 lon-3 pxn-1 pxn-1 rol-6 rol-6 suro-1 suro-1 cut-6 cut-6 pxn-2 pxn-2 epi-1 epi-1 lect-2 lect-2 gpn-1 gpn-1 mig-17 mig-17 fbl-1 fbl-1 nid-1 nid-1 cut-2 cut-2 dpy-7 dpy-7 elks-1 elks-1 agr-1 agr-1 unc-6 unc-6 lec-1 lec-1 lam-1 lam-1 lam-3 lam-3 T15B7.1 T15B7.1 pxf-1 pxf-1 qua-1 qua-1 T04F3.2 T04F3.2 pat-3 pat-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
unc-52Basement membrane proteoglycan; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable structural role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in body wall muscles and myoepithelial sheath cells. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. Involved in ovulation. (3375 aa)
tln-1Talin. (2553 aa)
cpz-1Cathepsin Z-1; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Probably, required for the degradation of the old cuticle. Belongs to the peptidase C1 family. (306 aa)
dpy-13Cuticle collagen dpy-13; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-13 affects the body shape. (302 aa)
dpy-5Cuticle collagen dpy-5; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (284 aa)
F26E4.3Uncharacterized peptidase C1-like protein F26E4.3. (452 aa)
gon-1A disintegrin and metalloproteinase with thrombospondin motifs gon-1; Secreted metalloprotease required for distal tip cell (DTC) migration along the body wall basement membranes, a key step that promotes gonad morphogenesis. Probably acts by remodeling the basement membrane during cell migration. Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons, probably by controlling collagen IV emb-9 degradation, a component of the synapse basement membrane. Also involved in the organization of adult muscle morphology. Has [...] (2165 aa)
sqt-3Cuticle collagen 1; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (301 aa)
col-153Col_cuticle_N domain-containing protein. (337 aa)
him-4EGF-like domain-containing protein. (5213 aa)
mig-18Abnormal cell migration protein 18; Required for the directional control of distal tip cell migration during gonadogenesis, probably by recruiting fibulin fbl-1 to the gonad basement membrane. (228 aa)
spon-1SPONdin (Extracellular matrix glycoprotein) family. (819 aa)
let-2Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. (1759 aa)
col-158Col_cuticle_N domain-containing protein. (336 aa)
ensh-1Fibrinogen C-terminal domain-containing protein. (465 aa)
lam-2Laminin-like protein lam-2; During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. (1633 aa)
C49C8.5Fibrinogen C-terminal domain-containing protein. (451 aa)
cut-1Cuticlin-1; Component of the cuticles. It forms a ribbon approximately 2 microns wide running along the lateral lines underneath the alae. Contributes to the formation of extracellular envelopes protecting the organism from the environment. (424 aa)
ost-1SPARC; Has a high affinity for collagen. Affects nematode body morphology and mobility. Essential for C.elegans development and muscle function. The cysteine-rich region could have protease inhibitory activity or may provide the framework for a protein binding module. Probable role in skeletal morphogenesis; Belongs to the SPARC family. (264 aa)
lon-2LONg; Belongs to the glypican family. (508 aa)
C03H12.1Uncharacterized protein. (731 aa)
bli-1Cuticle collagen bli-1; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. This collagen is required for proper strut formation within the unique medial layer of the adult cuticle. (948 aa)
skpo-2ShK domain and PerOxidase domain containing protein. (729 aa)
C16E9.1Uncharacterized protein. (565 aa)
C18H7.1VWFA domain-containing protein. (425 aa)
cle-1CoLlagen with Endostatin domain. (1175 aa)
mig-6Papilin; Involved in pharynx morphogenesis probably by remodeling the basement membrane. [Isoform b]: Plays a role in post embryonic distal cell tip migration. Essential extracellular matrix (ECM) protein required for hypodermal enclosure in the embryo. (2167 aa)
hse-5D-glucuronyl C5-epimerase; Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acids (By similarity). Plays a role in the early migration of AQR and PQR neurons, which descend from the Q neuroblasts ; Belongs to the D-glucuronyl C5-epimerase family. (616 aa)
emb-9Collagen alpha-1(IV) chain; Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons. May play a role in axon regeneration in embryos following injury in D-type motor neurons. (1759 aa)
Y43C5A.2Fibrinogen C-terminal domain-containing protein. (452 aa)
B0393.5Uncharacterized protein. (1183 aa)
cdh-3Cadherin-3; Cell adhesion protein involved in the control of epithelial morphogenesis. Together with metalloproteinase zmp-1 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development. (3361 aa)
col-19Cuticle collagen 19; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (289 aa)
lon-3Cuticle collagen lon-3; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Dose-dependent regulator of body length and shape. (324 aa)
pxn-1Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. (1285 aa)
rol-6Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa)
suro-1Putative carboxypeptidase suro-1; May play a role in processing or organization of cuticle collagen proteins, including rol-6 and col-19. (664 aa)
cut-6CUTiclin. (572 aa)
pxn-2PeroXidasiN (Drosophila peroxidase) homolog. (1328 aa)
epi-1Laminin-like protein epi-1; During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. (3715 aa)
lect-2Peptidase_M23 domain-containing protein. (335 aa)
gpn-1GlyPicaN; Belongs to the glypican family. (543 aa)
mig-17Metalloprotease mig-17; Metalloprotease. Acts in the basement membrane to control directional migration of distal tip cells (DTCs) along the body wall basement membranes, a key step that promotes gonad morphogenesis. Regulates DTC migration probably by recruiting fibulin fbl-1, type IV collagen let-2 and nidogen nid-1 to the gonad basement membrane thereby promoting the remodeling of the basement membrane. During larval development and probably upstream of basement membrane proteins fbl-1, let-2 and nid-1, regulates pharynx length, probably by regulating pharyngeal cell length. Does no [...] (509 aa)
fbl-1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. Plays a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Important for certain developmental processes and contributes to the supramolecular organization of ECM architecture, in particular to those of basement membranes. [Isoform c]: Involved in the assembly of the flexible hemicentin-containing tracks found joining the pharynx and body-wall- muscle basement membranes; Belongs to the fibulin family. (751 aa)
nid-1NIDogen (Basement membrane protein). (1584 aa)
cut-2Cuticlin-2; Component of the insoluble part of the cuticles. (215 aa)
dpy-7Cuticle collagen dpy-7; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-7 affects the body shape. (318 aa)
elks-1Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. (836 aa)
agr-1AGRin (Synaptic protein) homolog family member. (1473 aa)
unc-6Netrin unc-6; Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation [...] (612 aa)
lec-132 kDa beta-galactoside-binding lectin; Binds galactose. (285 aa)
lam-1LAMinin related. See also lmb. (1790 aa)
lam-3LAMinin related. See also lmb. (3102 aa)
T15B7.1Uncharacterized protein. (372 aa)
pxf-1Rap guanine nucleotide exchange factor; Acts as a guanine nucleotide exchange factor for small G protein GTPases like rap-1 and rap-2. Required in the hypodermis, especially in the seam cells, for proper formation of the cuticle. Belongs to the RAPGEF2 family. (1470 aa)
qua-1Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development. (1169 aa)
T04F3.2Sparc (SPARC) related MOdular Calcium binding protein homolog. (260 aa)
pat-3Integrin beta pat-3; Integrin alpha ina-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable). Plays a role in cell migration, morphogenesis and probably in cell-cell interactions. During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M line [...] (809 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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