Uncharacterized protein.

Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for basolateral endocytic recycling, the return of macromolecules and fluid from endosomes to the plasma membrane, in polarized epithelial cells of the intestine upstream of rm [...]

Uncharacterized protein.

RAB family.

C2 domain-containing protein.

Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...]

5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...]

14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family.

5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...]

Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...]

t-SNARE protein aex-4; t-SNARE protein which regulates the secretion of aex-5 from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds; Belongs to the SNAP-25 family.

LLGL domain-containing protein.

t-SNARE protein aex-4; t-SNARE protein which regulates the secretion of aex-5 from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds; Belongs to the SNAP-25 family.

Receptor Mediated Endocytosis; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

t-SNARE protein aex-4; t-SNARE protein which regulates the secretion of aex-5 from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds; Belongs to the SNAP-25 family.

SNAPIN protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis. Belongs to the SNAPIN family.

t-SNARE protein aex-4; t-SNARE protein which regulates the secretion of aex-5 from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds; Belongs to the SNAP-25 family.

LLGL domain-containing protein.

ADP-Ribosylation Factor related; Belongs to the small GTPase superfamily. Arf family.

Arf-GAP with ANK repeat and PH domain-containing protein cnt-1; GTPase-activating protein for the ADP ribosylation factor family (Probable). Regulates endosome recycling downstream of rab-10 and upstream of arf-6.

ADP-Ribosylation Factor related; Belongs to the small GTPase superfamily. Arf family.

Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for basolateral endocytic recycling, the return of macromolecules and fluid from endosomes to the plasma membrane, in polarized epithelial cells of the intestine upstream of rm [...]

ADP-Ribosylation Factor related; Belongs to the small GTPase superfamily. Arf family.

RAB family.

ADP-Ribosylation Factor related; Belongs to the small GTPase superfamily. Arf family.

Receptor Mediated Endocytosis; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

ADP-Ribosylation Factor related; Belongs to the small GTPase superfamily. Arf family.

Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...]

Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...]

C2 domain-containing protein.

Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...]

Kinesin-like protein unc-104; Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death. Belongs to the TRAFAC class myosin-kinesin ATPase super [...]

Arf-GAP with ANK repeat and PH domain-containing protein cnt-1; GTPase-activating protein for the ADP ribosylation factor family (Probable). Regulates endosome recycling downstream of rab-10 and upstream of arf-6.

ADP-Ribosylation Factor related; Belongs to the small GTPase superfamily. Arf family.

Arf-GAP with ANK repeat and PH domain-containing protein cnt-1; GTPase-activating protein for the ADP ribosylation factor family (Probable). Regulates endosome recycling downstream of rab-10 and upstream of arf-6.

RAB family.

AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles (By similarity). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). AP50 is a subunit of the plasma membrane adaptor (By similarity). Essential wnt/egl-20 signaling protein that functions in wnt/egl-20-producing cells. Required for the AP-2 complex-mediated endocytosis of membrane proteins including wntless homolog mig-14 in egl-20-producing cells. During [...]

Protein wntless homolog; Probable sorting receptor which regulates endocytosis and secretion of the wnt ligand egl-20. Recycling of mig-14 from the plasma membrane to the Golgi apparatus by the retromer complex is essential for its function. Its endosomal trafficking is regulated by its association with sorting nexin snx-3 on early endosomes and the mtm-6/mtm-9 myotubularin complex. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Functions during vulval development, [...]

AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles (By similarity). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). AP50 is a subunit of the plasma membrane adaptor (By similarity). Essential wnt/egl-20 signaling protein that functions in wnt/egl-20-producing cells. Required for the AP-2 complex-mediated endocytosis of membrane proteins including wntless homolog mig-14 in egl-20-producing cells. During [...]

Receptor-mediated endocytosis protein 6; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis. Acts by regulating the activation of rab-5 by exchanging bound GDP for free GTP at clathrin coated pits.