STRINGSTRING
mut-16 mut-16 henn-1 henn-1 C06A5.6 C06A5.6 C32E8.5 C32E8.5 drh-3 drh-3 E01A2.2 E01A2.2 ddx-23 ddx-23 lin-28 lin-28 rrf-3 rrf-3 ekl-1 ekl-1 ego-1 ego-1 rrf-1 rrf-1 drsh-1 drsh-1 alg-1 alg-1 ddx-17 ddx-17 rde-12 rde-12 pup-2 pup-2 dcr-1 dcr-1 rrf-2 rrf-2 ergo-1 ergo-1 alg-2 alg-2 rde-4 rde-4 pash-1 pash-1 nyn-1 nyn-1 eri-5 eri-5 nyn-2 nyn-2 rde-8 rde-8 mut-7 mut-7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mut-16MUTator. (1054 aa)
henn-1Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of PIWI-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) which are classes of regulatory RNAs that are involved in gene silencing in endogenous RNA interference (RNAi) pathways. Methylation protects the 3'-end of small RNAs from tailing and trimming and could constitute a recognition signal for appropriate argonaute machineries (Probable). Methylates and stabilizes 26G-siRNAs (a class of 26 nucleotide siRNAs that possess a monophosphorylated guanine residue at the 5'-end) when t [...] (442 aa)
C06A5.6Uncharacterized protein. (691 aa)
C32E8.5FHA domain-containing protein. (299 aa)
drh-3Dicer Related Helicase. (1119 aa)
E01A2.2Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA- mediated gene silencing (RNAi) by miRNAs (By similarity). (712 aa)
ddx-23DEAD boX helicase homolog; Belongs to the DEAD box helicase family. (730 aa)
lin-28Protein lin-28; Heterochronic protein which controls the choice of stage specific cell fates. Regulates the timing of the second larval stage events (L2 events) in the hypodermis. May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3. Plays a role in the control of seam cell number and vulval development. Belongs to the lin-28 family. (227 aa)
rrf-3RNA-dependent RNA polymerase Family. (1765 aa)
ekl-1Uncharacterized protein. (606 aa)
ego-1RNA-directed RNA polymerase related EGO-1. (1632 aa)
rrf-1RNA-dependent RNA polymerase Family. (1601 aa)
drsh-1Ribonuclease 3; Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA. Belongs to the ribonuclease III family. (1086 aa)
alg-1Protein argonaute; Belongs to the argonaute family. (1023 aa)
ddx-17DEAD boX helicase homolog; Belongs to the DEAD box helicase family. (561 aa)
rde-12DEAD-box ATP-dependent RNA helicase rde-12; Probable ATP-dependent RNA helicase involved in RNAi-mediated gene silencing. Specifically required in the endogenous siRNA pathway for biogenesis of secondary endogenous small interfering RNA (siRNA) intermediates called 22G-RNAs. May associate with and recruit rde- 10 to primary siRNA-targeted mRNA for secondary siRNA synthesis. May be recruited to target mRNAs by rde-1 and/or ergo-1. (959 aa)
pup-2PAP-associated domain-containing protein. (508 aa)
dcr-1Death-promoting deoxyribonuclease; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing. Belongs to the helicase family. Dicer subfamily. (1910 aa)
rrf-2RNA-dependent RNA polymerase Family. (1579 aa)
ergo-1Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...] (1121 aa)
alg-2Protein argonaute; Belongs to the argonaute family. (910 aa)
rde-4RNA interference promoting factor. (385 aa)
pash-1PArtner of DroSHa (DRSH-1 interactor). (751 aa)
nyn-1RNase_Zc3h12a_2 domain-containing protein. (500 aa)
eri-5Tudor domain-containing protein. (531 aa)
nyn-2RNase_Zc3h12a_2 domain-containing protein. (489 aa)
rde-8RNase_Zc3h12a domain-containing protein. (339 aa)
mut-7Exonuclease mut-7; Represses the transposition of Tc1, Tc3, Tc4, and Tc5, perhaps by degrading transposon-specific messages. Also affects sperm development, sensitivity to RNAi of mainly germline expressed genes, silencing of some germline transgenes, X chromosome loss, and is required for cosuppression (functional silencing of chromosomal loci induced by transgenes) and for silencing induced by antisense RNA oligomers. (910 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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