(8 nodes) Cellular response to amino acid stimulus network (Caenorhabditis elegans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	raga-1	RAs-related GTP-binding protein A. (312 aa)
	ragc-1	RAs-related GTP binding protein C homolog. (338 aa)
	sesn-1	Sestrin homolog; May function as a negative feedback regulator of TOR function. (474 aa)
	lmtr-2	Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family. (124 aa)
	mel-26	Protein maternal effect lethal 26; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of microtubule severing protein mei-1 after meiosis. Controls degradation of ppfr-1, the regulatory subunit of PP4 complex, after meiosis. In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of mei-1 downstream of unc-89. May also activate the TORC1 pathway. (399 aa)
	lmtr-3	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog. (145 aa)
	daf-15	Raptor_N domain-containing protein. (1800 aa)
	lmtr-5	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog. (95 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
daf-15	lmtr-2	C10C5.6c.1	Y97E10AR.7.2	Raptor_N domain-containing protein.	Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family.	0.939
daf-15	lmtr-3	C10C5.6c.1	C06H2.6a.1	Raptor_N domain-containing protein.	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog.	0.980
daf-15	lmtr-5	C10C5.6c.1	R148.2.1	Raptor_N domain-containing protein.	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog.	0.499
daf-15	raga-1	C10C5.6c.1	T24F1.1.1	Raptor_N domain-containing protein.	RAs-related GTP-binding protein A.	0.999
daf-15	ragc-1	C10C5.6c.1	Y24F12A.2a.1	Raptor_N domain-containing protein.	RAs-related GTP binding protein C homolog.	0.999
lmtr-2	daf-15	Y97E10AR.7.2	C10C5.6c.1	Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family.	Raptor_N domain-containing protein.	0.939
lmtr-2	lmtr-3	Y97E10AR.7.2	C06H2.6a.1	Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family.	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog.	0.999
lmtr-2	lmtr-5	Y97E10AR.7.2	R148.2.1	Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family.	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog.	0.900
lmtr-2	raga-1	Y97E10AR.7.2	T24F1.1.1	Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family.	RAs-related GTP-binding protein A.	0.988
lmtr-2	ragc-1	Y97E10AR.7.2	Y24F12A.2a.1	Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family.	RAs-related GTP binding protein C homolog.	0.991
lmtr-3	daf-15	C06H2.6a.1	C10C5.6c.1	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog.	Raptor_N domain-containing protein.	0.980
lmtr-3	lmtr-2	C06H2.6a.1	Y97E10AR.7.2	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog.	Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family.	0.999
lmtr-3	lmtr-5	C06H2.6a.1	R148.2.1	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog.	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog.	0.902
lmtr-3	raga-1	C06H2.6a.1	T24F1.1.1	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog.	RAs-related GTP-binding protein A.	0.990
lmtr-3	ragc-1	C06H2.6a.1	Y24F12A.2a.1	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog.	RAs-related GTP binding protein C homolog.	0.989
lmtr-5	daf-15	R148.2.1	C10C5.6c.1	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog.	Raptor_N domain-containing protein.	0.499
lmtr-5	lmtr-2	R148.2.1	Y97E10AR.7.2	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog.	Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family.	0.900
lmtr-5	lmtr-3	R148.2.1	C06H2.6a.1	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog.	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog.	0.902
lmtr-5	raga-1	R148.2.1	T24F1.1.1	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog.	RAs-related GTP-binding protein A.	0.901
lmtr-5	ragc-1	R148.2.1	Y24F12A.2a.1	Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog.	RAs-related GTP binding protein C homolog.	0.900