STRINGSTRING
snt-7 snt-7 hizr-1 hizr-1 snt-3 snt-3 cpna-4 cpna-4 hmt-1 hmt-1 nra-1 nra-1 T27E4.1 T27E4.1 snt-4 snt-4 cdf-2 cdf-2 gem-4 gem-4 snt-5 snt-5 mtl-1 mtl-1 pdk-1 pdk-1 pcs-1 pcs-1 cla-1 cla-1 snt-2 snt-2 snt-1 snt-1 sue-1 sue-1 sur-7 sur-7 DH11.5 DH11.5 cdf-1 cdf-1 snt-6 snt-6 atf-7 atf-7 clp-1 clp-1 cpna-3 cpna-3 cpna-5 cpna-5 pmk-1 pmk-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
snt-7C2 domain-containing protein. (416 aa)
hizr-1High zinc activated nuclear receptor protein; Nuclear receptor transcription factor that binds to DNA enhancer elements to promote the transcription of genes required to maintain micronutrient homeostasis. Direct binding to its ligand zinc allows for nuclear accumulation and activation, which thereby induces the transcription of genes required to promote the storage and detoxification of excess dietary zinc. This in turn, allows for internal zinc levels to be detected and regulated. (413 aa)
snt-3SyNapTotagmin. (284 aa)
cpna-4Copine domain-containing protein. (610 aa)
hmt-1Heavy metal tolerance factor 1. (801 aa)
nra-1Nicotinic receptor-associated protein 1; Exhibits calcium-dependent phospholipid binding properties (By similarity). May function in membrane trafficking. Regulates synaptic levels of nicotinic acetylcholine receptor subunit lev-1 and unc-38 in the nerve cord. Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole. Affects directional sperm motility. (634 aa)
T27E4.1Uncharacterized protein. (309 aa)
snt-4SyNapTotagmin. (381 aa)
cdf-2Cation Diffusion Facilitator family. (360 aa)
gem-4Gon-2 Extragenic Modifier. (625 aa)
snt-5SyNapTotagmin. (458 aa)
mtl-1Metallothionein-1; This protein binds cations of several transition elements. (75 aa)
pdk-13-phosphoinositide-dependent protein kinase 1; Involved in the daf-2/insulin receptor-like transduction pathway, which controls longevity and prevents developmental arrest at the dauer stage. Phosphorylates and activates sgk-1, akt-1 and akt-2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. (636 aa)
pcs-1Peptidase C83 domain-containing protein. (426 aa)
cla-1Protein clarinet; Required for synapse development in the active zone of presynaptic terminals of specific neurons including serotonergic NSM neurons. The active zone is a protein-dense neuronal region within the presynaptic bouton, from which synaptic vesicles send neurotransmitter signals across the synapse. Plays a role in the recruitment and clustering of synaptic vesicles in the active zone of presynaptic terminals in serotonergic NSM neurons, and coordinates the release of synaptic vesicles at presynaptic terminals to regulate neurotransmission at neuromuscular junctions. Regulat [...] (8922 aa)
snt-2Synaptotagmin 2; Ca(2+) sensor involved in Ca(2+)-dependent secretion of the nlp-40 neuropeptide from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. (369 aa)
snt-1Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity). Involved in necrotic cell death. (443 aa)
sue-1SUppressor of Elongation defect. (537 aa)
sur-7SUppressor of activated let-60 Ras. (371 aa)
DH11.5C2 domain-containing protein. (825 aa)
cdf-1Cation diffusion facilitator family protein 1; Involved in the regulation of Pn.p cell fate determination. Involved in zinc metabolism and the decrease of the cytosolic zinc concentration which is thought to modulate Ras signaling. Involved in zinc transport from the intestinal lumen to the pseudocoelum. (561 aa)
snt-6C2 domain-containing protein. (373 aa)
atf-7BZIP domain-containing protein. (509 aa)
clp-1Calpain clp-1; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates (By similarity). Required for assembly and maintenance of integrin attachment complexes which are essential for maintenance of adult muscle. Proteolytic activity is activated in response to increased intracellular Ca(2+) levels during cell degeneration and promotes necrotic cell death. (780 aa)
cpna-3VWFA domain-containing protein. (520 aa)
cpna-5Copine family protein 5. (717 aa)
pmk-1Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] (377 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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