node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD4.11 | stam-1 | CD4.11.1 | C34G6.7a.1 | Uncharacterized protein. | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | 0.622 |
CD4.11 | vps-22 | CD4.11.1 | C27F2.5.1 | Uncharacterized protein. | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. | 0.597 |
CD4.11 | vps-25 | CD4.11.1 | W02A11.2.2 | Uncharacterized protein. | Related to yeast Vacuolar Protein Sorting factor. | 0.723 |
CD4.11 | vps-28 | CD4.11.1 | Y87G2A.10a.1 | Uncharacterized protein. | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family. | 0.955 |
CD4.11 | vps-36 | CD4.11.1 | F17C11.8.2 | Uncharacterized protein. | GLUE N-terminal domain-containing protein. | 0.692 |
CD4.11 | vps-37 | CD4.11.1 | CD4.4.1 | Uncharacterized protein. | VPS37 C-terminal domain-containing protein. | 0.670 |
apd-3 | vps-41 | W09G10.4a.1 | F32A6.3c.1 | AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane [...] | 0.761 |
ego-2 | stam-1 | Y53H1C.2c.1 | C34G6.7a.1 | BRO1 domain-containing protein. | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | 0.602 |
ego-2 | vps-25 | Y53H1C.2c.1 | W02A11.2.2 | BRO1 domain-containing protein. | Related to yeast Vacuolar Protein Sorting factor. | 0.419 |
ego-2 | vps-28 | Y53H1C.2c.1 | Y87G2A.10a.1 | BRO1 domain-containing protein. | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family. | 0.566 |
sand-1 | vps-41 | F41H10.11.2 | F32A6.3c.1 | SAND endocytosis protein family. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane [...] | 0.902 |
sand-1 | vps-8 | F41H10.11.2 | C42C1.4a.1 | SAND endocytosis protein family. | Vps8 domain-containing protein. | 0.821 |
stam-1 | CD4.11 | C34G6.7a.1 | CD4.11.1 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | Uncharacterized protein. | 0.622 |
stam-1 | ego-2 | C34G6.7a.1 | Y53H1C.2c.1 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | BRO1 domain-containing protein. | 0.602 |
stam-1 | vps-22 | C34G6.7a.1 | C27F2.5.1 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. | 0.881 |
stam-1 | vps-25 | C34G6.7a.1 | W02A11.2.2 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | Related to yeast Vacuolar Protein Sorting factor. | 0.914 |
stam-1 | vps-28 | C34G6.7a.1 | Y87G2A.10a.1 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family. | 0.959 |
stam-1 | vps-36 | C34G6.7a.1 | F17C11.8.2 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | GLUE N-terminal domain-containing protein. | 0.933 |
stam-1 | vps-37 | C34G6.7a.1 | CD4.4.1 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | VPS37 C-terminal domain-containing protein. | 0.895 |
vps-22 | CD4.11 | C27F2.5.1 | CD4.11.1 | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. | Uncharacterized protein. | 0.597 |