STRINGSTRING
vps-15 vps-15 T08G11.1 T08G11.1 vps-25 vps-25 apd-3 apd-3 stg-1 stg-1 C25H3.11 C25H3.11 vps-22 vps-22 stam-1 stam-1 vps-8 vps-8 CD4.11 CD4.11 vps-37 vps-37 ego-2 ego-2 vps-36 vps-36 vps-41 vps-41 sand-1 sand-1 vps-28 vps-28
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
vps-15Related to yeast Vacuolar Protein Sorting factor. (1354 aa)
T08G11.1Uncharacterized protein. (3212 aa)
vps-25Related to yeast Vacuolar Protein Sorting factor. (183 aa)
apd-3AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family. (1251 aa)
stg-1STarGazin (Mammalian calcium channel) homolog. (366 aa)
C25H3.11Ricin B-type lectin domain-containing protein. (3314 aa)
vps-22Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (269 aa)
stam-1Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. (457 aa)
vps-8Vps8 domain-containing protein. (1259 aa)
CD4.11Uncharacterized protein. (496 aa)
vps-37VPS37 C-terminal domain-containing protein. (234 aa)
ego-2BRO1 domain-containing protein. (1494 aa)
vps-36GLUE N-terminal domain-containing protein. (383 aa)
vps-41Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane [...] (901 aa)
sand-1SAND endocytosis protein family. (459 aa)
vps-28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family. (210 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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