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cec-10 cec-10 B0336.13 B0336.13 rnt-1 rnt-1 gtf-2F1 gtf-2F1 mab-5 mab-5 taf-3 taf-3 taf-13 taf-13 cky-1 cky-1 hlh-14 hlh-14 aha-1 aha-1 nhr-258 nhr-258 unc-86 unc-86 sel-8 sel-8 rgr-1 rgr-1 mdt-18 mdt-18 mec-3 mec-3 daf-14 daf-14 glp-1 glp-1 nhr-25 nhr-25 yap-1 yap-1 nfyc-1 nfyc-1 egl-44 egl-44 fos-1 fos-1 taf-5 taf-5 ceh-20 ceh-20 mdt-31 mdt-31 tag-68 tag-68 taf-11.3 taf-11.3 mxl-3 mxl-3 taf-11.1 taf-11.1 efl-3 efl-3 mnat-1 mnat-1 gtf-2E2 gtf-2E2 taf-7.1 taf-7.1 bro-1 bro-1 nhr-3 nhr-3 nhr-38 nhr-38 taf-10 taf-10 lag-1 lag-1 taf-11.2 taf-11.2 pqn-51 pqn-51 hlh-2 hlh-2 gtf-2H1 gtf-2H1 daf-8 daf-8 lin-12 lin-12 taf-4 taf-4 sma-4 sma-4 sma-3 sma-3 hlh-4 hlh-4 nfya-1 nfya-1 taf-9 taf-9 hlh-6 hlh-6 gtf-2H2C gtf-2H2C mxl-1 mxl-1 tbp-1 tbp-1 hlh-3 hlh-3 sna-1 sna-1 taf-1 taf-1 taf-6.1 taf-6.1 pop-1 pop-1 nfyb-1 nfyb-1 efl-1 efl-1 gtf-2A2 gtf-2A2 taf-7.2 taf-7.2 mdt-17 mdt-17 taf-6.2 taf-6.2 taf-2 taf-2 gtf-2F2 gtf-2F2 cdk-7 cdk-7 cyh-1 cyh-1 nfya-2 nfya-2 let-49 let-49 gtf-2H5 gtf-2H5 taf-12 taf-12 mdt-6 mdt-6 mdt-8 mdt-8 xpb-1 xpb-1 Y73F8A.24 Y73F8A.24 nhr-277 nhr-277 gtf-2H3 gtf-2H3 taf-8 taf-8 sma-2 sma-2 mdt-4 mdt-4 gtf-2E1 gtf-2E1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cec-10C.Elegans Chromodomain protein. (865 aa)
B0336.13Transcription initiation factor IIA small chain homolog. (139 aa)
rnt-1Runt domain-containing protein. (301 aa)
gtf-2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (481 aa)
mab-5Homeobox protein mab-5; Transcription factor that binds to the promoter region of the transcription factor lin-39 to repress its expression in Q neuroblasts and thereby direct left Q neuroblast (QL) daughter cell migration. During postembryonic development, required for posterior-specific pattern formation. Within the posterior body region, controls epidermal, neuronal, and mesodermal cell differentiation. Belongs to the Antp homeobox family. (200 aa)
taf-3PHD-type domain-containing protein. (1007 aa)
taf-13TAF (TBP-associated transcription factor) family. (121 aa)
cky-1BHLH-PAS factor. (676 aa)
hlh-14BHLH domain-containing protein. (148 aa)
aha-1Aryl hydrocarbon receptor nuclear translocator homolog; Has a role in cellular differentiation. Required for pharyngeal development. In collaboration with ahr-1 it is involved in RMEL/R and SDQR neuron cell migration. Acts in the cellular response to hypoxia. Involved in aggregation behavior by regulating soluble guanylate cyclase gene expression in the URX neurons. (453 aa)
nhr-258Nuclear Hormone Receptor family. (398 aa)
unc-86Transcription factor unc-86; Transcription factor required for correct cell fate determination and differentiation in diverse neuronal cell lineages where it plays a role in specifying the fate of daughter cells during cell divisions. Involved in sensory neuron production and function. Binds both alone and with mec-3 to the mec-3 promoter to initiate and maintain mec-3 expression which is required for sensory neuron differentiation. In addition, binds both alone and with mec-3 to the promoters of mec-4 and mec-7 which act to regulate sensory neuron function. Involved in determining the [...] (357 aa)
sel-8Protein lag-3; glp-1 and lin-12 promote signaling by recruiting lag-3 to target promoters, where it functions as a transcriptional activator. May regulate phosphatase lip-1 mRNA transcription downstream of glp-1. (490 aa)
rgr-1Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...] (1388 aa)
mdt-18Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (232 aa)
mec-3Mechanosensory protein 3; Specifies differentiation of the set of six touch receptor neurons. Binds cooperatively as a heterodimer with unc-86 to sites in the mec-3 gene promoter. (321 aa)
daf-14MH2 domain-containing protein. (331 aa)
glp-1Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan. (1295 aa)
nhr-25Nuclear hormone receptor family member nhr-25; Orphan nuclear receptor required during development. Plays a role in male tail tip morphogenesis regulating the expression of the transcription factor dmd-3 in a negative feedback loop. (572 aa)
yap-1Yes-associated protein homolog 1; Plays a role in thermal stress response and in aging. (442 aa)
nfyc-1CBFD_NFYB_HMF domain-containing protein. (232 aa)
egl-44Transcription enhancer factor-like protein egl-44; Acts upstream of egl-46 to prevent touch cell differentiation in FLP neurons. Also promotes HSN neuron development. In association with egl-46, regulates cell cycle exit in the neuronal Q cell lineage. May be involved in thermal stress response downstream of yap-1. (493 aa)
fos-1Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. (467 aa)
taf-5TAF (TBP-associated transcription factor) family. (648 aa)
ceh-20Homeobox protein ceh-20; Transcription factor that binds to the 5'-TGATNNAT(G/T)(G/A)- 3' PBC/Hox lineage enhancer region of sem-2 to promote cell fate specification in the postembryonic mesoderm (also known as the M lineage). Has a role in the mig-13 pathway to promote the guidance, migration and positioning of Q neuroblasts and their descendants along the anteroposterior body axis and the anterior migration of BDU interneurons. Also required for normal vulval formation. (338 aa)
mdt-31Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (178 aa)
tag-68Dwarfin sma. (415 aa)
taf-11.3TAFII28 domain-containing protein. (228 aa)
mxl-3BHLH domain-containing protein. (235 aa)
taf-11.1TAFII28 domain-containing protein. (345 aa)
efl-3E2F-like (Mammalian transcription factor). (600 aa)
mnat-1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (310 aa)
gtf-2E2Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (289 aa)
taf-7.1TAFII55_N domain-containing protein. (254 aa)
bro-1BROther (Drosophila tx factor partner) homolog. (152 aa)
nhr-3Nuclear hormone receptor family member nhr-3; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (463 aa)
nhr-38Nuclear receptor domain-containing protein. (355 aa)
taf-10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (179 aa)
lag-1Lin-12 And Glp-1 phenotype. (790 aa)
taf-11.2TAFII28 domain-containing protein. (281 aa)
pqn-51Prion-like-(Q/N-rich)-domain-bearing protein. (354 aa)
hlh-2BHLH domain-containing protein. (399 aa)
gtf-2H1General Transcription Factor homolog. (532 aa)
daf-8Dwarfin sma. (546 aa)
lin-12Protein lin-12; Involved in several cell fate decisions that require cell- cell interactions. It is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10. Functions in uterine cells to promote basement membrane mobility during tissue remodeling. (1429 aa)
taf-4TAFH domain-containing protein. (523 aa)
sma-4Dwarfin sma-4; Involved in TGF-beta pathway; Belongs to the dwarfin/SMAD family. (565 aa)
sma-3Dwarfin sma-3; Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis ; Belongs to the dwarfin/SMAD family. (393 aa)
hlh-4Helix-loop-helix protein 4; Acts as a transcriptional regulator. May mediate transcriptional activation by binding to the E-box motif 5'-CANNTG-3'. Required for the correct morphology, terminal identity and function of the ADL sensory neurons by controlling the expression of the ADL-specific gene repertoire, including chemoreceptor encoding genes, ion channel encoding genes, neuropeptides and the neurotransmitter eat-4. Regulates the expression of the srh-234 chemoreceptor encoding gene in the ADL neurons under feeding conditions. Plays a role in the chemorepulsive response toward asca [...] (205 aa)
nfya-1Nuclear transcription Factor Y, A (Alpha) subunit. (482 aa)
taf-9TAF (TBP-associated transcription factor) family. (183 aa)
hlh-6Helix-loop-helix protein 6; Transcription factor that regulates the development of the g2 pharyngeal gland cells and pharyngeal gland function and thereby is required for feeding. Required for the expression of a number of genes in the pharyngeal gland, possibly by binding to the E box motif (5'-CANNTG-3') in the promoter region of these genes. Positively regulates the expression of genes encoding mucin-like proteins, which lubricate the pharyngeal tract to ensure efficient passage of the bacterial food source. Exhibits pharyngeal gland-specific positive autoregulation activity. (268 aa)
gtf-2H2CGeneral transcription factor IIH subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] (376 aa)
mxl-1BHLH domain-containing protein. (124 aa)
tbp-1TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. (340 aa)
hlh-3Helix-loop-helix protein 3; Probable transcriptional regulator. May mediate transcriptional activation by binding to the E-box motif 5'-CANNTG-3'. Plays a role in the differentiation of the hermaphrodite-specific motor neurons (HSN) that are required for normal egg laying. Might play a role in serotonin production by regulating expression of the tryptophan hydrolase tph-1 which catalyzes serotonin synthesis, in the HSN neurons. Also plays a role in HSN axon guidance towards the vulva and the ventral nerve cord, possibly by promoting the expression of the netrin receptor unc-40. Under f [...] (170 aa)
sna-1Small Nuclear RNA (snRNA) Associated protein. (186 aa)
taf-1Transcription initiation factor TFIID subunit 1; Component of general transcription factor TFIID which establishes the initiation site for mRNA transcription (By similarity). May regulate RNA polymerase II activity and thereby may control transcription initiation by RNA polymerase II. Required for early embryonic development. Essential for embryonic transcription of several genes. (1744 aa)
taf-6.1TAF domain-containing protein. (470 aa)
pop-1Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. (438 aa)
nfyb-1CBFD_NFYB_HMF domain-containing protein. (403 aa)
efl-1E2F_TDP domain-containing protein; Belongs to the E2F/DP family. (342 aa)
gtf-2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. (113 aa)
taf-7.2TAFII55_N domain-containing protein. (236 aa)
mdt-17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (667 aa)
taf-6.2TAF6_C domain-containing protein. (835 aa)
taf-2Transcription initiation factor TFIID subunit 2; Component of general transcription factor TFIID which establishes the initiation site for mRNA transcription (By similarity). May regulate RNA polymerase II activity and thereby may control transcription initiation by RNA polymerase II. Belongs to the TAF2 family. (1092 aa)
gtf-2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (263 aa)
cdk-7Cyclin-dependent kinase 7; Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Required for maintaining chromosome ploidy. May phosphorylate the large subunit of RNA polymerase II, ama-1; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (330 aa)
cyh-1CYclin H. (332 aa)
nfya-2Nuclear transcription Factor Y, A (Alpha) subunit. (281 aa)
let-49Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...] (253 aa)
gtf-2H5General Transcription Factor homolog. (71 aa)
taf-12TFIID_20kDa domain-containing protein. (342 aa)
mdt-6Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Acts to r [...] (250 aa)
mdt-8Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (325 aa)
xpb-1XPB (Xeroderma Pigmentosum complementation group B) related. (789 aa)
Y73F8A.24General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (485 aa)
nhr-277Nuclear Hormone Receptor family. (498 aa)
gtf-2H3General Transcription Factor homolog. (296 aa)
taf-8BTP domain-containing protein. (497 aa)
sma-2Dwarfin sma-2; Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis. (418 aa)
mdt-4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (334 aa)
gtf-2E1HTH TFE/IIEalpha-type domain-containing protein. (433 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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