STRINGSTRING
dyf-13 dyf-13 maph-9 maph-9 xbx-1 xbx-1 yap-1 yap-1 ccdc-149 ccdc-149 K04F10.2 K04F10.2 nphp-1 nphp-1 bbs-5 bbs-5 nphp-4 nphp-4 bbs-8 bbs-8 ifta-2 ifta-2 cil-7 cil-7 rpi-1 rpi-1 cfap-36 cfap-36 rab-28 rab-28 famh-161 famh-161 osm-5 osm-5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dyf-13Intraflagellar transport protein 56 homolog; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. (574 aa)
maph-9Protein maph-9. (512 aa)
xbx-1X-BoX promoter element regulated. (370 aa)
yap-1Yes-associated protein homolog 1; Plays a role in thermal stress response and in aging. (442 aa)
ccdc-149Coiled-coil domain-containing protein 149; Belongs to the CCDC149 family. (369 aa)
K04F10.2Protein KIAA0556 homolog; May regulate ciliary A-tubule number and, along with arl-13, controls cilium integrity. (568 aa)
nphp-1Nephrocystin-1-like protein; May be necessary for initial assembly of the cilium. (682 aa)
bbs-5Bardet-Biedl syndrome 5 protein homolog; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity). Required, redundantly with bbs-4, for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins al [...] (361 aa)
nphp-4NePHronoPhthisis (Human kidney disease) homolog. (1305 aa)
bbs-8Tetratricopeptide repeat protein 8; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization. Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme. Plays a role in guanylyl cyclase loca [...] (506 aa)
ifta-2Intraflagellar transport associated protein 2; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Regulates specific signaling activities in the cilia, such as the daf-2/insulin receptor-like transduction pathway. (252 aa)
cil-7CILiary localization. (548 aa)
rpi-1Protein rpi-1. (450 aa)
cfap-36Cilia- and flagella-associated protein 36. (685 aa)
rab-28Ras-related protein Rab-28; GTPase. Intraflagellar transport (IFT) cargo that undergoes bidirectional IFT along the ciliary axoneme when in active GTP-bound state in amphid and phasmid ciliated sensory neurons. Targeting and function as IFT cargo may depend on the BBSome, an IFT cargo adapter. Does not undergo IFT when in inactive GDP-bound state. May in turn play a role in cilium structure and/or function in ciliated sensory neurons. Belongs to the small GTPase superfamily. Rab family. (248 aa)
famh-161Protein fam-161. (814 aa)
osm-5OSM-5. (820 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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