STRINGSTRING
D1053.2 D1053.2 mec-3 mec-3 dot-1.5 dot-1.5 dot-1.2 dot-1.2 dot-1.4 dot-1.4 ddl-1 ddl-1 kgb-1 kgb-1 ddl-2 ddl-2 dot-1.1 dot-1.1 dot-1.3 dot-1.3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
D1053.2Histone-lysine N-methyltransferase, H3 lysine-79 specific. (154 aa)
mec-3Mechanosensory protein 3; Specifies differentiation of the set of six touch receptor neurons. Binds cooperatively as a heterodimer with unc-86 to sites in the mec-3 gene promoter. (321 aa)
dot-1.5Histone-lysine N-methyltransferase, H3 lysine-79 specific. (361 aa)
dot-1.2Histone-lysine N-methyltransferase, H3 lysine-79 specific. (315 aa)
dot-1.4Histone-lysine N-methyltransferase, H3 lysine-79 specific. (383 aa)
ddl-1WASH complex subunit homolog 3; Belongs to the CCDC53 family. (189 aa)
kgb-1GLH-binding kinase 1; Mitogen-activated protein kinase which is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Phosphorylates the transcription factor fos-1 which prevents fos-1 dimerization and promoter binding and results in activation of target genes including F53A9.2/kreg-1 and lys-3/kreg-2. Phosphorylates jun-1 and activates the AP-1 transcription factor which is a heterodimer of jun-1 and fos-1. Phosphorylates glh-1 in vitro which may play a role in controlling glh-1 protein levels in the germline by targeting it for degradation by the proteasome. R [...] (390 aa)
ddl-2WASH_WAHD domain-containing protein. (497 aa)
dot-1.1Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase, which in complex with zfp-1, methylates 'Lys-79' of histone H3 to activate transcription (Probable). During stress, the zfp-1-dot-1.1 complex also plays a role in the deubiquitination of histone H2B sites, which negatively modulates the RNA polymerase II-induced transcription of highly expressed genes. Involved in controlling tissue-specific gene expression, particularly in the epidermis. (946 aa)
dot-1.3Histone-lysine N-methyltransferase, H3 lysine-79 specific. (313 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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