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| | rpa-4 | RPA_C domain-containing protein. (293 aa) |
| | swsn-6 | SWI/SNF nucleosome remodeling complex component; Belongs to the actin family. (436 aa) |
| | zyg-12 | Zygote defective protein 12; Cytoskeletal linker protein, which is essential for attachment of the centrosome to the nucleus. Required for dynein localization to the nuclear envelope. Forms a LINC (LInker of Nucleoskeleton and Cytoskeleton) complex together with unc-84, that may be involved in DNA damage repair ; Belongs to the hook family. (777 aa) |
| | him-3 | HORMA domain-containing protein. (291 aa) |
| | ham-3 | SWIB domain-containing protein. (446 aa) |
| | him-14 | MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. (842 aa) |
| | orc-5 | ORC (Origin Recognition Complex) subunit. (396 aa) |
| | tim-1 | Protein timeless homolog; Plays an important role in chromosome cohesion during both mitosis and meiosis. In prophase of meiosis, it is involved in the formation of the synaptonemal complex (SC) and specifically, in the diplotene and diakinesis phases of prophase, it stabilizes the association of homologous chromosomes during synapsis and sister chromatid cohesion. It regulates cohesin subunits to promote meiotic chromosome cohesion and localizes non-SMC (structural maintenance of chromosome) cohesin subunits to chromatin prior to or during pre-meiotic S phase. Implicated in influencin [...] (1353 aa) |
| | bath-36 | BTB and MATH domain-containing protein 36. (320 aa) |
| | rcor-1 | SANT domain-containing protein. (564 aa) |
| | hil-2 | Histone H1.2; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (191 aa) |
| | htp-2 | HORMA domain-containing protein. (352 aa) |
| | Y73B3A.1 | Uncharacterized protein. (613 aa) |
| | cosa-1 | CrossOver Site Associated. (360 aa) |
| | Y71H2AM.6 | Uncharacterized protein. (277 aa) |
| | swsn-3 | HMG box domain-containing protein. (338 aa) |
| | psf-3 | Sld5 domain-containing protein. (193 aa) |
| | Y59E9AL.8 | BTB domain-containing protein. (279 aa) |
| | cutl-26 | ZP domain-containing protein. (502 aa) |
| | Y54F10AM.11 | BTB domain-containing protein. (286 aa) |
| | Y53F4B.3 | CBFD_NFYB_HMF domain-containing protein. (179 aa) |
| | nol-6 | Nucleolar protein 6. (1058 aa) |
| | set-26 | Histone-lysine N-methyltransferase set-26; Histone methyltransferase that mediates trimethylation of 'Lys-9' of histone H3 in vitro. Involved in transcriptional regulation. Plays a role in the negative regulation of lifespan and in heat resistance. Together with set-9, negatively regulates lifespan in a germline-independent, partially daf-16-dependent fashion. Together with set-9, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline. Together w [...] (1645 aa) |
| | mcd-1 | Modifier of cell death; Promotes programmed cell death. Its role in programmed cell death may be in conjunction with cell cycle regulatory factor efl-1 and the synthetic multivulva class B proteins dpl-1 and lin-35, and is independent of the ced-1, ced-8 and ced-9 pathways. (901 aa) |
| | Y48G1C.1 | Uncharacterized protein. (454 aa) |
| | lin-38 | C2H2-type domain-containing protein. (700 aa) |
| | csc-1 | Chromosome segregation and cytokinesis defective protein 1; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis during mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. In the complex, it may be required to direct the Aurora B/air-2 to centromeric DNA; Belongs to the borealin family. Highly divergent. (249 aa) |
| | sep-1 | Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...] (1262 aa) |
| | pola-1 | DNA polymerase. (1456 aa) |
| | mcm-10 | Mcm10 domain-containing protein. (691 aa) |
| | smc-3 | Structural maintenance of chromosomes protein 3; Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in the repair of double strand breaks during mitosis and meiosis. Required for chromosome segregation during mitosis. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chrom [...] (1261 aa) |
| | Y45F10D.10 | Integrin Cytoplasmic domain-Associated Protein homolog. (157 aa) |
| | Y43F8C.6 | Uncharacterized protein. (427 aa) |
| | klp-19 | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1083 aa) |
| | Y43E12A.3 | BTB domain-containing protein. (316 aa) |
| | rad-51 | DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. (395 aa) |
| | mrt-2 | Cell cycle checkpoint protein RAD1 homolog mrt-2; May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. Promotes DNA double strand break- induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Also required for telomere length maintenance and germline immortality. May possess 3'->5' double stranded DNA exonuclease activity (By similarity). Belongs to the Rad1 family. (267 aa) |
| | zhp-4 | Zip (Yeast meiotic zipper) Homologous Protein. (283 aa) |
| | dpy-28 | Condensin complex subunit 1; Required for both chromosome condensation and segregation during mitosis and meiosis and X-chromosome dosage compensation depending on its binding partners. Regulatory subunit of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). The condensin I complex func [...] (1499 aa) |
| | hpr-9 | Cell cycle checkpoint protein hpr-9; May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. (521 aa) |
| | orc-4 | ORC (Origin Recognition Complex) subunit. (387 aa) |
| | orc-1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (636 aa) |
| | mes-4 | Histone-lysine N-methyltransferase mes-4; Histone methyltransferase. Dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation. Plays a central role in early development and is responsible for all H3 'Lys- 36' dimethylation until about the 40-cell stage. Indirectly involved in the global inactivation of the X chromosomes in germline cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes. Not related to transcription elongation. Required for small-RNA-induced H3K27 trimethylation. May suppress sensitivity to [...] (898 aa) |
| | Y14H12B.2 | SPK domain-containing protein. (414 aa) |
| | sld-5 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa) |
| | swsn-1 | SANT domain-containing protein. (792 aa) |
| | ssl-1 | Helicase ssl-1; Probable catalytic component of a chromatin-remodeling complex which mediates the ATP-dependent exchange of histone H2A variant H2AV/htz-1 for H2A, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in foregut development, and may be involved in vulval development. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (2395 aa) |
| | pqn-80 | HUN domain-containing protein. (1449 aa) |
| | ska-1 | Spindle and kinetochore-associated protein 1; Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (By similarity). The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (By similarity). The complex facilitates the processive movement of micr [...] (243 aa) |
| | ekl-4 | Uncharacterized protein. (488 aa) |
| | rad-54 | Uncharacterized protein. (818 aa) |
| | pri-2 | DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. (503 aa) |
| | rec-8 | Meiotic recombination protein rec-8; Plays a role in meiotic chromosome cohesion and segregation. Necessary for sister chromatid co- orientation and sister chromatid cohension until meiosis II. May also be required for repair of programmed meiotic double stranded breaks. During spermatogenesis, likely involved in spermatocyte centriole cohesion, thus preventing their separation during the second meiotic division. Belongs to the rad21 family. Highly divergent. (781 aa) |
| | lin-40 | Uncharacterized protein. (1022 aa) |
| | bath-25 | BTB domain-containing protein. (298 aa) |
| | ceh-39 | Homeobox protein ceh-39; Probable DNA-binding regulatory protein involved in cell-fate specification; Belongs to the CUT homeobox family. (399 aa) |
| | T26A5.8 | CBFD_NFYB_HMF domain-containing protein. (137 aa) |
| | lin-14 | Protein lin-14; Heterochronic protein which controls the choice of stage specific cell fates. Involved in the temporal progression of vulval fate patterning, possibly by inhibiting lin-12. Acts as a transcription factor involved in the stage-specific repression of insulin/insulin- like growth factor gene ins-33. Isoform A may be involved in specifying L1 cell fates while isoform B1 and isoform B2 may specify L2 and later cell fates, creating a temporal switch. (539 aa) |
| | T24C4.5 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (318 aa) |
| | T23F6.1 | Uncharacterized protein. (160 aa) |
| | ruvb-2 | RuvB-like 2; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). May participate in several chromatin remodeling complexes that mediate the ATP-dependent exchange of histones and remodel chromatin by shifting nucleosomes (By similarity). Involvement in these complexes is likely required for transcriptional activation of selected genes and DNA repair in response to DNA damage (By similarity). Has a role in gonadal development. Involved in the en [...] (448 aa) |
| | mrpl-50 | Mitochondrial Ribosomal Protein, Large. (285 aa) |
| | hmg-4 | FACT complex subunit SSRP1-A; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment [...] (697 aa) |
| | gen-1 | GEN1 Holliday junction resolvase homolog. (434 aa) |
| | T10B10.8 | Uncharacterized protein. (449 aa) |
| | sftb-1 | SF3b1 domain-containing protein. (1322 aa) |
| | math-38 | MATH (Meprin-associated Traf homology) domain containing. (440 aa) |
| | zim-1 | C2H2-type domain-containing protein. (606 aa) |
| | him-8 | C2H2-type domain-containing protein. (361 aa) |
| | zim-3 | Zinc finger In Meiosis. (581 aa) |
| | zim-2 | C2H2-type domain-containing protein. (584 aa) |
| | brc-2 | DNA repair protein brc-2; Required for the homologous recombination repair of DNA double strand breaks, thereby playing a role in chromosome integrity. Acts by targeting rad-51 to sites of DNA damage and stabilizing rad-51-DNA filaments by blocking ATP hydrolysis catalyzed by rad-51. Promotes rad-51 mediated displacement-loop (D-loop) formation during strand invasion between the invading single-stranded DNA (ssDNA) and the homologous duplex DNA. Also functions independently of rad-51 in DNA double-strand break (DSB) repair by promoting DNA single-strand annealing (SSA) when the homolog [...] (394 aa) |
| | atl-1 | Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (By similarity). Recognizes the substrate consensus sequence [ST]-Q (By similarity). Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination (By similarity). Prevents mitotic catastrophe by functioning in the S-phase checkpoint and cooperating with atm-1 in the c [...] (2531 aa) |
| | spo-11 | Meiotic recombination protein spo-11; Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. (425 aa) |
| | nifk-1 | RRM domain-containing protein. (307 aa) |
| | him-18 | High Incidence of Males (Increased X chromosome loss). (718 aa) |
| | psf-1 | Probable DNA replication complex GINS protein PSF1; The GINS complex plays an essential role in the initiation of DNA replication. (201 aa) |
| | pcf-11 | Polyadenylation and cleavage factor homolog 11. (823 aa) |
| | dpy-27 | Chromosome condensation protein dpy-27; Central component of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription throughout development. Its strong similarity with the condensin subunit smc4 suggests that it may reduce the X-chromosome transcript level by condensing the chromatin structure during interphase. Involved in the recruitment of the dosage compensation proteins mix-1 and dpy-21 to the X chromosome. Might be involved in the reduction of histone H4 lysine 16 acetylation (H4K16ac) on do [...] (1469 aa) |
| | R10H10.7 | Uncharacterized protein. (915 aa) |
| | R10E4.1 | BTB domain-containing protein. (377 aa) |
| | snfc-5 | SNF chromatin remodeling Complex component; Belongs to the SNF5 family. (381 aa) |
| | R06C7.2 | Uncharacterized protein. (233 aa) |
| | R04F11.3 | Uncharacterized protein. (385 aa) |
| | R03H10.7 | REPA_OB_2 domain-containing protein. (359 aa) |
| | R03H10.6 | REPA_OB_2 domain-containing protein. (324 aa) |
| | div-1 | DNA polymerase alpha subunit B; May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery. Required for the distribution of pie-1 in cell divsion. (581 aa) |
| | rpa-2 | RPA_C domain-containing protein. (288 aa) |
| | cid-1 | 4Fe-4S ferredoxin-type domain-containing protein. (1425 aa) |
| | K08E4.7 | BTB domain-containing protein. (326 aa) |
| | air-1 | Protein kinase domain-containing protein. (326 aa) |
| | lin-53 | Probable histone-binding protein lin-53; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation. Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that repres [...] (417 aa) |
| | rba-1 | Probable histone-binding protein rba-1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Plays a role in regulating cell cycle progression. Required to repress the induction of vulval development by Ras signaling. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. (412 aa) |
| | K04C2.2 | Uncharacterized protein. (990 aa) |
| | K03B8.4 | Uncharacterized protein. (96 aa) |
| | zhp-3 | RING-type domain-containing protein. (389 aa) |
| | K02B12.5 | ANK_REP_REGION domain-containing protein. (1204 aa) |
| | lin-54 | Protein lin-54; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that repress transcription; Belongs to the lin-54 family. (435 aa) |
| | H31G24.3 | BTB domain-containing protein. (314 aa) |
| | mcrs-1 | FHA domain-containing protein. (478 aa) |
| | syp-4 | Synaptonemal complex protein 4; Constitutes an element of the transverse filaments of the synaptonemal complex (SC), formed between homologous chromosomes during meiotic prophase I, and is required for the assembly of the central region of the SC. Required for chromosome synapsis and chiasma formation between homologous chromosomes during meiosis, mechanisms that are crucial for crossover formation and meiotic recombination. (605 aa) |
| | hus-1 | Checkpoint protein. (277 aa) |
| | athp-2 | AT Hook plus PHD finger transcription factor. (1427 aa) |
| | chd-1 | Chromodomain and Helicase Domain protein. (1461 aa) |
| | bath-1 | BTB and MATH domain containing. (302 aa) |
| | bath-5 | BTB and MATH domain containing. (305 aa) |
| | bath-3 | BTB and MATH domain containing. (306 aa) |
| | orc-2 | Origin recognition complex subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). (430 aa) |
| | pri-1 | DNA primase small subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. (410 aa) |
| | htp-3 | HORMA domain-containing protein. (739 aa) |
| | mei-2 | Meiotic spindle formation protein 2; Forms a heterodimeric complex in conjunction with mei-1 which severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. May act to target mei-1 within the cell. Required specifically for meiotic spindle formation in the female germline. (280 aa) |
| | slx-1 | Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (Potential). Has a preference for replication forks over 5' flap structures or Holliday junctions and shows much lower activity toward 3' flap structures. Required for proper crossover distribution through inhibition of crossover formation at the c [...] (443 aa) |
| | spt-16 | FACT complex subunit spt-16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment [...] (1030 aa) |
| | zhp-1 | Zip (Yeast meiotic zipper) Homologous Protein. (220 aa) |
| | smc-6 | Structural maintenance of chromosomes protein 6 homolog smc-6; Core component of the smc-5/smc-6 complex. Involved in DNA double-strand break repair by promoting sister- chromatid homologous recombination during meiosis. Also plays a role in the DNA damage repair of ultraviolet (UV) radiation-induced DNA lesions. Promotes efficient DNA replication. (1149 aa) |
| | F53H4.6 | Helicase C-terminal domain-containing protein. (933 aa) |
| | csb-1 | CSB (Cockayne Syndrome B) homolog. (957 aa) |
| | F53H1.4 | PHD-type domain-containing protein. (1275 aa) |
| | bath-38 | BTB and MATH domain-containing protein 38. (387 aa) |
| | sdc-1 | Zinc finger protein sdc-1; Embryonic transcription factor regulating downstream genes involved specifically in the sex determination and dosage compensation pathways, or regulating other genes involved in the coordinate control of both processes. Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Involved in the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodit [...] (1201 aa) |
| | bath-4 | BTB and MATH domain containing. (306 aa) |
| | bath-2 | BTB and MATH domain containing. (304 aa) |
| | bath-7 | BTB domain-containing protein. (301 aa) |
| | ubxn-3 | UBX domain-containing protein 3; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-1 and ubxn-2, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. During mitosis, ensures the degradation of DNA licensing factor cdt-1 and the disassembly of the DNA replication CMG helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5. (613 aa) |
| | sdz-18 | BTB domain-containing protein. (277 aa) |
| | math-29 | MATH domain-containing protein. (224 aa) |
| | htp-1 | HORMA domain-containing protein. (352 aa) |
| | bath-13 | BTB and MATH domain containing. (301 aa) |
| | syp-3 | Uncharacterized protein. (224 aa) |
| | srh-241 | Serpentine Receptor, class H. (335 aa) |
| | srh-243 | Serpentine Receptor, class H. (337 aa) |
| | srh-186 | Serpentine Receptor, class H. (329 aa) |
| | pifk-1 | PhosphoInositide Four Kinase (PI-4 Kinase); Belongs to the PI3/PI4-kinase family. (666 aa) |
| | pole-1 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2144 aa) |
| | phf-10 | PHD-type domain-containing protein. (447 aa) |
| | cec-5 | Chromo domain-containing protein. (374 aa) |
| | srh-245 | Serpentine Receptor, class H. (330 aa) |
| | psf-2 | Probable DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication. (180 aa) |
| | nurf-1 | Nucleosome-remodeling factor subunit NURF301-like; Histone-binding component of a NURF-like (nucleosome remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates. Belongs to the BPTF family. (2197 aa) |
| | F26F4.8 | Uncharacterized protein. (302 aa) |
| | let-418 | Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] (1829 aa) |
| | syp-1 | Synaptonemal complex protein SYP-1. (489 aa) |
| | ego-1 | RNA-directed RNA polymerase related EGO-1. (1632 aa) |
| | bath-39 | BTB and MATH domain-containing protein 39. (334 aa) |
| | lurp-3 | LU (Ly6 Urokinase plasminogen) domain Receptor-related Protein. (352 aa) |
| | F25H9.2 | BTB domain-containing protein. (310 aa) |
| | lurp-2 | UPAR/Ly6 domain-containing protein. (359 aa) |
| | tipn-1 | Protein TIPIN homolog; Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. Belongs to the CSM3 family. (233 aa) |
| | ekl-1 | Uncharacterized protein. (606 aa) |
| | nars-1 | Asparagine--tRNA ligase, cytoplasmic; Involved in protein synthesis. Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Belongs to the class-II aminoacyl-tRNA synthetase family. (545 aa) |
| | csr-1 | Piwi domain-containing protein. (1030 aa) |
| | rpa-1 | Probable replication factor A 73 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (655 aa) |
| | ctf-4 | Mcl1_mid domain-containing protein. (1101 aa) |
| | phf-32 | PHD domain-containing protein. (208 aa) |
| | set-9 | Histone-lysine N-methyltransferase set-9; Histone methyltransferase (By similarity). Might play a role in transcriptional regulation. Together with set-26, negatively regulates lifespan in a germline-independent, partially daf- 16-dependent fashion. Together with set-26, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline ; Belongs to the class V-like SAM-binding methyltransferase superfamily. (1623 aa) |
| | F12F6.7 | Probable DNA polymerase delta small subunit; The function of the small subunit is not yet clear; Belongs to the DNA polymerase delta/II small subunit family. (451 aa) |
| | bath-31 | BTB and MATH domain containing. (306 aa) |
| | nubp-1 | Cytosolic Fe-S cluster assembly factor NUBP1 homolog; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity). Regulates cilium formation and structure ; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (313 aa) |
| | F10C2.4 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). (1081 aa) |
| | pole-2 | Probable DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). (521 aa) |
| | sin-3 | Paired amphipathic helix protein sin-3; Probable transcriptional repressor required for the deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (both autosomes and sex chromosomes) during meiosis, but this does not seem to solely affect the transcriptional status. Plays a role in ray fusion and patterning in the male tail, and this may be through activity of the histone deacetylase complex (HDAC). (1507 aa) |
| | set-8 | SET domain-containing protein. (512 aa) |
| | swsn-4 | SWI/SNF nucleosome remodeling complex component. (1474 aa) |
| | drh-3 | Dicer Related Helicase. (1119 aa) |
| | zhp-2 | RING-type domain-containing protein. (240 aa) |
| | spr-1 | REST corepressor spr-1; Probable corepressor protein, which probably participates in the transcriptional repression of the presenilin protein hop-1. Probably acts via the formation of a multiprotein complex that deacetylates and demethylates specific sites on histones. Acts redundantly with the transcriptional repressor lin-35 to play a role in vulval morphogenesis and promote germline proliferation ; Belongs to the CoREST family. (558 aa) |
| | zhit-1 | HIT-type domain-containing protein. (194 aa) |
| | C56G2.4 | Uncharacterized protein C56G2.4. (538 aa) |
| | hda-1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. In association with akir-1, plays a role in regula [...] (461 aa) |
| | athp-1 | AT Hook plus PHD finger transcription factor. (1150 aa) |
| | ndx-7 | Putative nudix hydrolase 7; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. (295 aa) |
| | mus-81 | ERCC4 domain-containing protein. (445 aa) |
| | cdc-6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (518 aa) |
| | pal-1 | Homeobox protein pal-1; Transcriptional activator. Interacts with promoter regions for tbx-8.9, tbx-9, elt-1, hnd-1, scrt-1, and vab-7 genes. Binds the sequence ATTTATGAC. Binds to the enhancer region of the hlh-1 gene promoter during embryonic body wall muscle development. Activates the gene for mab-5 in embryo development. Necessary for vab-7 expression in C blastomeres in the posterior of embryos. Required for posterior V6 neuroectoblast cell fate specification during postembryonic neurogenesis (patterning) which generates the characteristic ray lineage during male tail development. [...] (270 aa) |
| | sdc-2 | Sex determination and dosage compensation protein sdc-2; Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Required for the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development. Plays a central role in X-chromosome recognition and in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto [...] (2962 aa) |
| | lurp-4 | UPAR/Ly6 domain-containing protein. (360 aa) |
| | swd-2.2 | WD_REPEATS_REGION domain-containing protein. (326 aa) |
| | hmg-3 | FACT complex subunit ssrp1-B; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment [...] (689 aa) |
| | C30F12.4 | Uncharacterized protein. (246 aa) |
| | dpff-1 | Zinc finger protein dpff-1; Belongs to the requiem/DPF family. (372 aa) |
| | ubc-23 | UAS domain-containing protein. (395 aa) |
| | ruvb-1 | RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). May participate in several chromatin remodeling complexes that mediate the ATP-dependent exchange of histones and remodel chromatin by shifting nucleosomes (By similarity). Involvement in these complexes is likely required for transcriptional activation of selected genes and DNA repair in response to DNA damage (By similarity). Involved in the Ce- Tor signaling pathway whereby it i [...] (476 aa) |
| | rad-26 | Uncharacterized protein. (1274 aa) |
| | smc-5 | Structural maintenance of chromosomes protein 5; Core component of the smc-5/smc-6 complex. Functions in DNA double strand break repair by promoting sister- chromatid homologous recombination during meiosis. Acts in a DNA repair pathway for removal of ionizing radiation- and ultraviolet (UV) radiation-induced DNA lesions that is distinct from classical nucleotide excision repair and the translesion synthesis pathway. Also involved in the recovery of stalled replication forks. Belongs to the SMC family. SMC5 subfamily. (1076 aa) |
| | mbd-2 | MBD_C domain-containing protein. (210 aa) |
| | set-2 | Histone-lysine N-methyltransferase set-2; Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids. Methylation in th [...] (1510 aa) |
| | pbrm-1 | HMG box domain-containing protein. (1883 aa) |
| | dpy-26 | Condensin complex subunit dpy-26; Required for both chromosome condensation and segregation and for X-chromosome dosage compensation depending on its binding partners. Member of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes and for proper chromosome segregation in mitosis and meiosis. As a member of the condensin I complex, further controls the crossover number and distribution in meiosis by restricting double strand break formation, probably by influencing higher-order chromosome structure. Plays a role in rob [...] (1263 aa) |
| | syp-2 | Uncharacterized protein. (213 aa) |
| | swsn-2.2 | SWIB domain-containing protein. (449 aa) |
| | C16A11.4 | SPK domain-containing protein. (527 aa) |
| | C16A11.3 | SPK domain-containing protein. (299 aa) |
| | rrbs-1 | Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (333 aa) |
| | C15C8.5 | Uncharacterized protein. (340 aa) |
| | gei-8 | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. (1778 aa) |
| | bath-33 | BTB domain-containing protein. (277 aa) |
| | arp-6 | Actin-like protein C08B11.6; Belongs to the actin family. ARP6 subfamily. (418 aa) |
| | swsn-7 | SWI/SNF nucleosome remodeling complex component. (1244 aa) |
| | hda-2 | Putative histone deacetylase 2; Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase e [...] (507 aa) |
| | clk-2 | Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family. (877 aa) |
| | C06B3.16 | Uncharacterized protein. (74 aa) |
| | C04F5.9 | Uncharacterized protein. (534 aa) |
| | C04F12.1 | Piwi domain-containing protein. (944 aa) |
| | egl-27 | Egg-laying defective protein 27; Transcription factor which promotes stress survival and delays aging. Required for cell cycle progression and development of the mesodermal and endodermal embryonic lineages. Required for normal T-cell polarity, for correct migration of QL neuroblast descendants and other cells, for embryonic patterning and for the embryonic expression of hlh-8. Also required for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development. (1129 aa) |
| | srh-244 | Serpentine Receptor, class H. (336 aa) |
| | C02F5.12 | Putative zinc finger protein C02F5.12. (380 aa) |
| | swsn-9 | Bromo domain-containing protein. (636 aa) |
| | let-526 | ARID domain-containing protein. (1768 aa) |
| | air-2 | Aurora/IPL1-related protein kinase 2; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. Required for histone H3 phosphorylation during segregation of homologous chromosomes in meiosis and mitosis. Required for histone H3 'Ser- 10' phosphorylation. Phosphorylates tlk-1 at 'Ser-634', which enhances its activity. Phosphorylates zen-4 at 'Ser- 680'. Required f [...] (305 aa) |
| | bath-24 | BTB and MATH domain containing. (242 aa) |
