STRINGSTRING
air-2 air-2 C02F5.12 C02F5.12 C04F12.1 C04F12.1 rrbs-1 rrbs-1 syp-2 syp-2 dpy-26 dpy-26 smc-5 smc-5 pal-1 pal-1 cdc-6 cdc-6 C56G2.4 C56G2.4 zhp-2 zhp-2 drh-3 drh-3 nubp-1 nubp-1 csr-1 csr-1 ekl-1 ekl-1 ego-1 ego-1 syp-1 syp-1 F26F4.8 F26F4.8 syp-3 syp-3 htp-1 htp-1 smc-6 smc-6 zhp-1 zhp-1 mei-2 mei-2 htp-3 htp-3 hus-1 hus-1 syp-4 syp-4 lin-54 lin-54 zhp-3 zhp-3 air-1 air-1 cid-1 cid-1 R06C7.2 R06C7.2 nifk-1 nifk-1 spo-11 spo-11 atl-1 atl-1 brc-2 brc-2 zim-2 zim-2 zim-3 zim-3 him-8 him-8 zim-1 zim-1 mrpl-50 mrpl-50 lin-14 lin-14 ceh-39 ceh-39 rec-8 rec-8 ska-1 ska-1 hpr-9 hpr-9 dpy-28 dpy-28 zhp-4 zhp-4 mrt-2 mrt-2 rad-51 rad-51 klp-19 klp-19 smc-3 smc-3 sep-1 sep-1 csc-1 csc-1 nol-6 nol-6 cosa-1 cosa-1 htp-2 htp-2 him-14 him-14 him-3 him-3 zyg-12 zyg-12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
air-2Aurora/IPL1-related protein kinase 2; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. Required for histone H3 phosphorylation during segregation of homologous chromosomes in meiosis and mitosis. Required for histone H3 'Ser- 10' phosphorylation. Phosphorylates tlk-1 at 'Ser-634', which enhances its activity. Phosphorylates zen-4 at 'Ser- 680'. Required f [...] (305 aa)
C02F5.12Putative zinc finger protein C02F5.12. (380 aa)
C04F12.1Piwi domain-containing protein. (944 aa)
rrbs-1Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (333 aa)
syp-2Uncharacterized protein. (213 aa)
dpy-26Condensin complex subunit dpy-26; Required for both chromosome condensation and segregation and for X-chromosome dosage compensation depending on its binding partners. Member of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes and for proper chromosome segregation in mitosis and meiosis. As a member of the condensin I complex, further controls the crossover number and distribution in meiosis by restricting double strand break formation, probably by influencing higher-order chromosome structure. Plays a role in rob [...] (1263 aa)
smc-5Structural maintenance of chromosomes protein 5; Core component of the smc-5/smc-6 complex. Functions in DNA double strand break repair by promoting sister- chromatid homologous recombination during meiosis. Acts in a DNA repair pathway for removal of ionizing radiation- and ultraviolet (UV) radiation-induced DNA lesions that is distinct from classical nucleotide excision repair and the translesion synthesis pathway. Also involved in the recovery of stalled replication forks. Belongs to the SMC family. SMC5 subfamily. (1076 aa)
pal-1Homeobox protein pal-1; Transcriptional activator. Interacts with promoter regions for tbx-8.9, tbx-9, elt-1, hnd-1, scrt-1, and vab-7 genes. Binds the sequence ATTTATGAC. Binds to the enhancer region of the hlh-1 gene promoter during embryonic body wall muscle development. Activates the gene for mab-5 in embryo development. Necessary for vab-7 expression in C blastomeres in the posterior of embryos. Required for posterior V6 neuroectoblast cell fate specification during postembryonic neurogenesis (patterning) which generates the characteristic ray lineage during male tail development. [...] (270 aa)
cdc-6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (518 aa)
C56G2.4Uncharacterized protein C56G2.4. (538 aa)
zhp-2RING-type domain-containing protein. (240 aa)
drh-3Dicer Related Helicase. (1119 aa)
nubp-1Cytosolic Fe-S cluster assembly factor NUBP1 homolog; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity). Regulates cilium formation and structure ; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (313 aa)
csr-1Piwi domain-containing protein. (1030 aa)
ekl-1Uncharacterized protein. (606 aa)
ego-1RNA-directed RNA polymerase related EGO-1. (1632 aa)
syp-1Synaptonemal complex protein SYP-1. (489 aa)
F26F4.8Uncharacterized protein. (302 aa)
syp-3Uncharacterized protein. (224 aa)
htp-1HORMA domain-containing protein. (352 aa)
smc-6Structural maintenance of chromosomes protein 6 homolog smc-6; Core component of the smc-5/smc-6 complex. Involved in DNA double-strand break repair by promoting sister- chromatid homologous recombination during meiosis. Also plays a role in the DNA damage repair of ultraviolet (UV) radiation-induced DNA lesions. Promotes efficient DNA replication. (1149 aa)
zhp-1Zip (Yeast meiotic zipper) Homologous Protein. (220 aa)
mei-2Meiotic spindle formation protein 2; Forms a heterodimeric complex in conjunction with mei-1 which severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. May act to target mei-1 within the cell. Required specifically for meiotic spindle formation in the female germline. (280 aa)
htp-3HORMA domain-containing protein. (739 aa)
hus-1Checkpoint protein. (277 aa)
syp-4Synaptonemal complex protein 4; Constitutes an element of the transverse filaments of the synaptonemal complex (SC), formed between homologous chromosomes during meiotic prophase I, and is required for the assembly of the central region of the SC. Required for chromosome synapsis and chiasma formation between homologous chromosomes during meiosis, mechanisms that are crucial for crossover formation and meiotic recombination. (605 aa)
lin-54Protein lin-54; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that repress transcription; Belongs to the lin-54 family. (435 aa)
zhp-3RING-type domain-containing protein. (389 aa)
air-1Protein kinase domain-containing protein. (326 aa)
cid-14Fe-4S ferredoxin-type domain-containing protein. (1425 aa)
R06C7.2Uncharacterized protein. (233 aa)
nifk-1RRM domain-containing protein. (307 aa)
spo-11Meiotic recombination protein spo-11; Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. (425 aa)
atl-1Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (By similarity). Recognizes the substrate consensus sequence [ST]-Q (By similarity). Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination (By similarity). Prevents mitotic catastrophe by functioning in the S-phase checkpoint and cooperating with atm-1 in the c [...] (2531 aa)
brc-2DNA repair protein brc-2; Required for the homologous recombination repair of DNA double strand breaks, thereby playing a role in chromosome integrity. Acts by targeting rad-51 to sites of DNA damage and stabilizing rad-51-DNA filaments by blocking ATP hydrolysis catalyzed by rad-51. Promotes rad-51 mediated displacement-loop (D-loop) formation during strand invasion between the invading single-stranded DNA (ssDNA) and the homologous duplex DNA. Also functions independently of rad-51 in DNA double-strand break (DSB) repair by promoting DNA single-strand annealing (SSA) when the homolog [...] (394 aa)
zim-2C2H2-type domain-containing protein. (584 aa)
zim-3Zinc finger In Meiosis. (581 aa)
him-8C2H2-type domain-containing protein. (361 aa)
zim-1C2H2-type domain-containing protein. (606 aa)
mrpl-50Mitochondrial Ribosomal Protein, Large. (285 aa)
lin-14Protein lin-14; Heterochronic protein which controls the choice of stage specific cell fates. Involved in the temporal progression of vulval fate patterning, possibly by inhibiting lin-12. Acts as a transcription factor involved in the stage-specific repression of insulin/insulin- like growth factor gene ins-33. Isoform A may be involved in specifying L1 cell fates while isoform B1 and isoform B2 may specify L2 and later cell fates, creating a temporal switch. (539 aa)
ceh-39Homeobox protein ceh-39; Probable DNA-binding regulatory protein involved in cell-fate specification; Belongs to the CUT homeobox family. (399 aa)
rec-8Meiotic recombination protein rec-8; Plays a role in meiotic chromosome cohesion and segregation. Necessary for sister chromatid co- orientation and sister chromatid cohension until meiosis II. May also be required for repair of programmed meiotic double stranded breaks. During spermatogenesis, likely involved in spermatocyte centriole cohesion, thus preventing their separation during the second meiotic division. Belongs to the rad21 family. Highly divergent. (781 aa)
ska-1Spindle and kinetochore-associated protein 1; Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (By similarity). The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (By similarity). The complex facilitates the processive movement of micr [...] (243 aa)
hpr-9Cell cycle checkpoint protein hpr-9; May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. (521 aa)
dpy-28Condensin complex subunit 1; Required for both chromosome condensation and segregation during mitosis and meiosis and X-chromosome dosage compensation depending on its binding partners. Regulatory subunit of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). The condensin I complex func [...] (1499 aa)
zhp-4Zip (Yeast meiotic zipper) Homologous Protein. (283 aa)
mrt-2Cell cycle checkpoint protein RAD1 homolog mrt-2; May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. Promotes DNA double strand break- induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Also required for telomere length maintenance and germline immortality. May possess 3'->5' double stranded DNA exonuclease activity (By similarity). Belongs to the Rad1 family. (267 aa)
rad-51DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. (395 aa)
klp-19Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1083 aa)
smc-3Structural maintenance of chromosomes protein 3; Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in the repair of double strand breaks during mitosis and meiosis. Required for chromosome segregation during mitosis. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chrom [...] (1261 aa)
sep-1Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...] (1262 aa)
csc-1Chromosome segregation and cytokinesis defective protein 1; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis during mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. In the complex, it may be required to direct the Aurora B/air-2 to centromeric DNA; Belongs to the borealin family. Highly divergent. (249 aa)
nol-6Nucleolar protein 6. (1058 aa)
cosa-1CrossOver Site Associated. (360 aa)
htp-2HORMA domain-containing protein. (352 aa)
him-14MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. (842 aa)
him-3HORMA domain-containing protein. (291 aa)
zyg-12Zygote defective protein 12; Cytoskeletal linker protein, which is essential for attachment of the centrosome to the nucleus. Required for dynein localization to the nuclear envelope. Forms a LINC (LInker of Nucleoskeleton and Cytoskeleton) complex together with unc-84, that may be involved in DNA damage repair ; Belongs to the hook family. (777 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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