STRINGSTRING
fbxa-169 fbxa-169 tbc-8 tbc-8 C44H4.4 C44H4.4 marc-4 marc-4 marc-4-2 marc-4-2 aka-1 aka-1 wdfy-2 wdfy-2 usp-50 usp-50 rabn-5 rabn-5 mon-2 mon-2 F11A5.3 F11A5.3 F11A5.4 F11A5.4 snx-17 snx-17 rme-8 rme-8 mrp-6 mrp-6 ehbp-1 ehbp-1 cup-2 cup-2 snx-27 snx-27 rab-5 rab-5 F33E11.3 F33E11.3 F40E10.6 F40E10.6 sand-1 sand-1 F41H10.4 F41H10.4 sdpn-1 sdpn-1 tbc-16 tbc-16 rme-6 rme-6 sorf-2 sorf-2 unc-108 unc-108 ubxn-6 ubxn-6 rab-14 rab-14 lst-2 lst-2 rab-21 rab-21 eea-1 eea-1 rab-10 rab-10 snx-3 snx-3 rme-1 rme-1 hmt-1 hmt-1 snx-13 snx-13 cnt-1 cnt-1 rabx-5 rabx-5 rab-35 rab-35 plr-1 plr-1 tat-1 tat-1 marc-5 marc-5 Y57G11C.22 Y57G11C.22 sorf-1 sorf-1 emc-5 emc-5 B0334.4 B0334.4 B0334.5 B0334.5 snx-1 snx-1 C07A12.7 C07A12.7 hgrs-1 hgrs-1 ocrl-1 ocrl-1 stam-1 stam-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fbxa-169F-box domain-containing protein. (390 aa)
tbc-8Rab-GAP TBC domain-containing protein. (913 aa)
C44H4.4Chorein_N domain-containing protein. (996 aa)
marc-4RING-CH-type domain-containing protein. (317 aa)
marc-4-2Uncharacterized protein. (73 aa)
aka-1FYVE-type domain-containing protein. (1284 aa)
wdfy-2WD repeat and FYVE domain-containing protein 2; Plays a role in coelomocyte endocytosis. (415 aa)
usp-50USP domain-containing protein; Belongs to the peptidase C19 family. (811 aa)
rabn-5FYVE-type domain-containing protein. (414 aa)
mon-2Monensin-resistant homolog 2; May be required for traffic between late Golgi and early endosomes. (1648 aa)
F11A5.3Uncharacterized protein. (201 aa)
F11A5.4Uncharacterized protein. (203 aa)
snx-17Sorting nexin-17 homolog; Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). (540 aa)
rme-8J domain-containing protein. (2279 aa)
mrp-6Uncharacterized protein. (1415 aa)
ehbp-1EH (Eps-15-homology) domain Binding Protein family. (901 aa)
cup-2Derlin-1; Specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Belongs to the derlin family. (245 aa)
snx-27Sorting NeXin. (578 aa)
rab-5RAB family. (208 aa)
F33E11.3KLRAQ domain-containing protein. (651 aa)
F40E10.6Uncharacterized protein. (398 aa)
sand-1SAND endocytosis protein family. (459 aa)
F41H10.4Uncharacterized protein. (575 aa)
sdpn-1SynDaPiN (Synaptic dynamin binding protein) homolog. (495 aa)
tbc-16Rab-GAP TBC domain-containing protein. (725 aa)
rme-6Receptor-mediated endocytosis protein 6; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis. Acts by regulating the activation of rab-5 by exchanging bound GDP for free GTP at clathrin coated pits. (1093 aa)
sorf-2Suppressor of organelle fusion 2; Together with sorf-1 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-1 and the sorf-1-sorf- 2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels. Belongs to the WD repeat WDR81 family. (1422 aa)
unc-108Uncharacterized protein. (223 aa)
ubxn-6UBX domain-containing protein 6; Probably acts as an adapter for ATPase cdc-48.1 and/or cdc- 48.2, conferring substrate specificity. Involved in the lysosomal clearance of cellular material in diet restricted conditions. (437 aa)
rab-14RAB family. (210 aa)
lst-2Lateral signaling target protein 2; Negative regulator of epidermal growth factor receptor (EGFR) signaling; Belongs to the lst-2 family. (661 aa)
rab-21RAB family. (207 aa)
eea-1FYVE-type domain-containing protein. (1205 aa)
rab-10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for basolateral endocytic recycling, the return of macromolecules and fluid from endosomes to the plasma membrane, in polarized epithelial cells of the intestine upstream of rm [...] (201 aa)
snx-3PX domain-containing protein. (162 aa)
rme-1Receptor Mediated Endocytosis; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (791 aa)
hmt-1Heavy metal tolerance factor 1. (801 aa)
snx-13Sorting NeXin. (940 aa)
cnt-1Arf-GAP with ANK repeat and PH domain-containing protein cnt-1; GTPase-activating protein for the ADP ribosylation factor family (Probable). Regulates endosome recycling downstream of rab-10 and upstream of arf-6. (826 aa)
rabx-5RAB eXchange factor. (517 aa)
rab-35RAB family. (209 aa)
plr-1Probable E3 ubiquitin-protein ligase plr-1; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled (By similarity). Acts on both canonical and non- canonical Wnt signaling pathway (By similarity). Plays a role in the migration and axon guidance of different neuronal cell types including CAN, HSN, AVK and AVG. Promotes the differentiation and regulates the anteroposterior polarity of AVG unpaired interneurons by sequestering the [...] (487 aa)
tat-1Phospholipid-transporting ATPase tat-1; Transports phosphatidylserine from the outer to the inner leaflet of the plasma membrane, thereby maintaining the enrichment of this phospholipid in the inner leaflet. Ectopic exposure of phosphatidylserine on the cell surface may result in removal of living cells by neighboring phagocytes. Regulation of the phosphatidylserine distribution in plasma membranes is likely to help in the maintainence and control of the membrane surface charge. Plays a role in the formation of the tubular membrane structure and in membrane trafficking and is specifica [...] (1192 aa)
marc-5RING-CH-type domain-containing protein. (470 aa)
Y57G11C.22Uncharacterized protein. (444 aa)
sorf-1Suppressor of organelle fusion 1; Together with sorf-2 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-2 and the sorf-1-sorf- 2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels. Belongs to the WD repeat WDR91 family. (239 aa)
emc-5EMC Endoplasmic Membrane protein Complex (Yeast EMC) homolog. (144 aa)
B0334.4PRELI/MSF1 domain-containing protein. (210 aa)
B0334.5Uncharacterized protein. (420 aa)
snx-1PX domain-containing protein. (472 aa)
C07A12.7GAT domain-containing protein. (437 aa)
hgrs-1Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. (729 aa)
ocrl-1Rho-GAP domain-containing protein. (768 aa)
stam-1Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. (457 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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