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| | abu-1 | Activated in Blocked Unfolded protein response. (425 aa) |
| | pqn-2 | Prion-like-(Q/N-rich)-domain-bearing protein. (425 aa) |
| | dnj-1 | DnaJ homolog subfamily B member 1; Acts as a co-chaperone with Hsp70 required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity). Acts by determining Hsp70's ATPase and polypeptide-binding activities (By similarity). Can also act as a chaperone that promotes maturation of potassium channel unc-103 by stabilizing nascent channel subunits and assembling them into tetramers ; Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily. (401 aa) |
| | calf-1 | CAlcium channel Localization Factor. (177 aa) |
| | B0393.7 | Uncharacterized protein. (267 aa) |
| | C03A3.3 | Lactamase_B domain-containing protein. (287 aa) |
| | abu-8 | Activated in Blocked Unfolded protein response. (445 aa) |
| | abu-15 | Activated in Blocked Unfolded protein response. (388 aa) |
| | abu-6 | Activated in Blocked Unfolded protein response. (388 aa) |
| | abu-7 | Activated in Blocked Unfolded protein response. (438 aa) |
| | cdc-48.1 | Transitional endoplasmic reticulum ATPase homolog 1; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. Can also prevent aggregation of unfolded proteins also in an ATP- independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the act [...] (809 aa) |
| | hyl-1 | Ceramide synthase hyl-1; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons. (372 aa) |
| | rnf-121 | RING finger protein 121; Required for the cessation of distal tip cell migration at the end of larval morphogenesis; Belongs to the RNF121 family. (335 aa) |
| | pqn-16 | Prion-like-(Q/N-rich)-domain-bearing protein. (328 aa) |
| | C26D10.6 | Uncharacterized protein. (513 aa) |
| | tmem-131 | TMEM131_like domain-containing protein. (1831 aa) |
| | C32D5.12 | 3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (357 aa) |
| | imp-3 | IntraMembrane Protease (IMPAS) family. (530 aa) |
| | C34B2.10 | Probable signal peptidase complex subunit 1; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (105 aa) |
| | C34F6.7 | Uncharacterized protein. (411 aa) |
| | selt-1.1 | Thioredoxin reductase-like selenoprotein T homolog selt-1.1; Probably has thioredoxin reductase-like oxidoreductase activity. Plays a role in regulating the oxidative stress response, and odorant and pathogenic bacteria avoidance behavior. (247 aa) |
| | C35D10.1 | ER membrane protein complex subunit 7 homolog. (222 aa) |
| | imp-1 | IntraMembrane Protease (IMPAS) family. (662 aa) |
| | pcyt-2.2 | CTP_transf_like domain-containing protein. (361 aa) |
| | ire-1 | Serine/threonine-protein kinase/endoribonuclease ire-1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices xbp-1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes. Unfolded protein response (UPR) transcriptional activation by ire-1, as well as translational attenuation by pek-1 in a complementary pathway, maintains ER homeostasis. Regulates the transcriptional up-regulation of nucleoside-diphosphatase apy-1 upon ER str [...] (967 aa) |
| | cdc-48.2 | Transitional endoplasmic reticulum ATPase homolog 2; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. However, able to prevent aggregation of unfolded proteins also in an ATP-independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents [...] (810 aa) |
| | erl-1 | Erlin. (312 aa) |
| | C42C1.19 | MFS domain-containing protein. (403 aa) |
| | unc-36 | Voltage-dependent calcium channel unc-36; May act as an auxiliary subunit of the unc-2 voltage-gated calcium channel which appears to trigger calcium-activated signaling pathways that control the serotonin response. Inhibiting serotonin sensitivity of the vulval muscles results in egg laying defects. May act in both neurons and muscle cells to enhance motor activity as it is required for coordinated movement. Has a role in neural depolarization- induced calcium influx and pharyngeal pumping. Involved in restricting the expression of the putative olfactory receptor str-2 to only one of [...] (1249 aa) |
| | paf-2 | Platelet-activating factor acetylhydrolase homolog 2; Belongs to the AB hydrolase superfamily. Lipase family. (388 aa) |
| | C53D5.1 | PIP49_C domain-containing protein. (420 aa) |
| | rpl-27 | 60S ribosomal protein L27; Component of the large ribosomal subunit. (136 aa) |
| | tag-175 | Transmembrane protein 41 homolog. (246 aa) |
| | elo-3 | Putative fatty acid elongation protein 3; Could be implicated in synthesis of very long chain fatty acids (By similarity). May be required for normally rapid growth. Belongs to the ELO family. (320 aa) |
| | piga-1 | PIGA domain-containing protein. (444 aa) |
| | maco-1 | Macoilin; Plays a role in the regulation of neuronal activity. (897 aa) |
| | sur-7 | SUppressor of activated let-60 Ras. (371 aa) |
| | F02E9.1 | Uncharacterized protein. (154 aa) |
| | fat-7 | Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa) |
| | elo-2 | Elongation of very long chain fatty acids protein. (274 aa) |
| | rtcb-1 | RNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs. Required for the ligation of mRNAs and specifically, regulates xbp-1 mRNA splicing during the endoplasmic reticulum stress- induced unfolded protein response. Has a neuroprotective role in the age-dependent degeneration of dopamine neurons, which is mediated by xbp-1. Belongs to the RtcB family. (505 aa) |
| | F17C11.7 | PhosphatidylInositol Glycan anchor biosynthesis class T. (531 aa) |
| | ufd-1 | Ubiquitin fusion degradation protein 1 homolog; Functions at a post-ubiquitination step in the ubiquitin fusion degradation (UFD) pathway (By similarity). In association with npl-4.1 and/or npl-4.2 and ATPase cdc-48.1 and/or cdc-48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with npl-4.1 and/or npl-4.2, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradati [...] (342 aa) |
| | abu-2 | Activated in Blocked Unfolded protein response. (572 aa) |
| | cup-2 | Derlin-1; Specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Belongs to the derlin family. (245 aa) |
| | hrdl-1 | E3 ubiquitin-protein ligase hrd-like protein 1; Proposed to have a role in neuroprotection. (579 aa) |
| | selt-1.2 | Thioredoxin reductase-like selenoprotein T homolog selt-1.2; Probably has thioredoxin reductase-like oxidoreductase activity; Belongs to the SelWTH family. SELT subfamily. (216 aa) |
| | F32D8.14 | Protein YIPF. (261 aa) |
| | emo-1 | Protein transport protein Sec61 subunit gamma; Required for oocyte development and ovulation. Required for the translocation of secretory and transmembrane proteins into the endoplasmic reticulum in vitro ; Belongs to the SecE/SEC61-gamma family. (68 aa) |
| | hpo-3 | GlycosylPhosphatidylinositol Anchor Attachment 1 homolog. (676 aa) |
| | itr-1 | Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...] (2892 aa) |
| | emc-6 | EMC Endoplasmic Membrane protein Complex (Yeast EMC) homolog. (111 aa) |
| | F38A1.8 | SRP54 domain-containing protein. (625 aa) |
| | rps-26 | 40S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (117 aa) |
| | csq-1 | Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (417 aa) |
| | elo-5 | Elongation of very long chain fatty acids protein 5; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) and monomethyl branched-chain fatty acids (mmBCFAs). Required for the formation of isopentadecanoate (C15iso) and isoheptadecanoate (C17iso). Belongs to the ELO family. (274 aa) |
| | sptl-2 | Serine palmitoyltransferase 2; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (586 aa) |
| | F44B9.5 | Ancient ubiquitous protein 1 homolog. (390 aa) |
| | F44E2.10 | Malectin domain-containing protein. (304 aa) |
| | F44E2.4 | Uncharacterized protein F44E2.4. (1283 aa) |
| | sel-1 | Suppressor/Enhancer of Lin-12. (685 aa) |
| | atf-6 | BZIP domain-containing protein. (589 aa) |
| | pek-1 | Eukaryotic translation initiation factor 2-alpha kinase pek-1; Phosphorylates the alpha subunit of eukaryotic translation- initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. May phosphorylate eIF2alpha during hypoxia. Proposed to have a role in alleviating endoplasmic reticulum stress ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (1077 aa) |
| | F47B8.10 | MFS domain-containing protein. (456 aa) |
| | F48B9.8 | RDD domain-containing protein. (263 aa) |
| | rps-22 | Ribosomal Protein, Small subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | sel-11 | E3 ubiquitin-protein ligase hrd-1; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Thought to play [...] (610 aa) |
| | marc-6 | RING-CH-type domain-containing protein. (1025 aa) |
| | dad-1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across th [...] (113 aa) |
| | F58E2.3 | Uncharacterized protein. (688 aa) |
| | F58E2.4 | Uncharacterized protein. (688 aa) |
| | tag-65 | SR-related CTD associated factor 6. (675 aa) |
| | dgat-2 | Acyl-CoA:DiacylGlycerol AcylTransferase. (345 aa) |
| | npl-4.1 | Nuclear protein localization protein 4 homolog 1; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...] (529 aa) |
| | npl-4.2 | Nuclear protein localization protein 4 homolog 2; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...] (529 aa) |
| | emc-1 | EMC1_C domain-containing protein. (946 aa) |
| | K09A9.6 | TPR_REGION domain-containing protein. (920 aa) |
| | K10B2.4 | Protein Asterix. (113 aa) |
| | emb-8 | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (662 aa) |
| | unc-68 | Uncharacterized protein. (5202 aa) |
| | sca-1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1059 aa) |
| | K12H4.4 | Probable signal peptidase complex subunit 3; Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (180 aa) |
| | ostd-1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (280 aa) |
| | algn-14 | Asparagine Linked Glycosylation (ALG) homolog, Nematode. (244 aa) |
| | mig-14 | Protein wntless homolog; Probable sorting receptor which regulates endocytosis and secretion of the wnt ligand egl-20. Recycling of mig-14 from the plasma membrane to the Golgi apparatus by the retromer complex is essential for its function. Its endosomal trafficking is regulated by its association with sorting nexin snx-3 on early endosomes and the mtm-6/mtm-9 myotubularin complex. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Functions during vulval development, [...] (549 aa) |
| | pqn-54 | Prion-like-(Q/N-rich)-domain-bearing protein. (388 aa) |
| | abu-9 | Activated in Blocked Unfolded protein response. (378 aa) |
| | pqn-57 | Activated in Blocked Unfolded protein response; Prion-like-(Q/N-rich)-domain-bearing protein. (378 aa) |
| | R11H6.2 | Uncharacterized protein. (442 aa) |
| | R151.6 | Derlin-2; May be required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Its precise function remains unclear, but its ability to complement der1 mutations in C.cerevisiae, suggests a similar function in the degradation of ER misfolded proteins. (237 aa) |
| | R186.3 | Uncharacterized protein. (240 aa) |
| | R186.8 | Uncharacterized protein. (71 aa) |
| | xbp-1 | BZIP domain-containing protein. (335 aa) |
| | uba-5 | Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates ufm-1. Required for interaction between ufm-1 and ufc-1; Belongs to the ubiquitin-activating E1 family. UBA5 subfamily. (419 aa) |
| | tag-189 | Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity); Belongs to the PGAP2 family. (263 aa) |
| | imp-2 | Intramembrane protease 2; Acts as intramembrane protease (Probable). In larvae, required for the complete shedding of the cuticle during molting, possibly by regulating cholesterol uptake via lrp-1. Involved in embryonic and larval development ; Belongs to the peptidase A22B family. (468 aa) |
| | hpo-4 | Putative GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity); Belongs to the peptidase C13 family. (319 aa) |
| | T06D8.9 | Uncharacterized protein. (316 aa) |
| | mom-1 | Protein-serine O-palmitoleoyltransferase porcupine; Key regulator of the Wnt signaling pathway that mediates lipid modification of Wnt proteins. Acts as a protein-serine O-palmitoleoyltransferase that catalyzes the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins (By similarity). Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors (By similarity). Has a role in cell specification, specifically in blastomere signaling. Involved in cytosketetal polarity. Required for the orientation of mitotic spindle [...] (442 aa) |
| | ostb-1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...] (445 aa) |
| | T11F9.12 | Uncharacterized protein. (736 aa) |
| | T11G6.2 | MFS domain-containing protein. (502 aa) |
| | T11G6.3 | MFS domain-containing protein. (475 aa) |
| | T11G6.4 | MFS domain-containing protein. (499 aa) |
| | stt-3 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt-3; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation [...] (757 aa) |
| | T13C5.6 | AcidPPc domain-containing protein. (186 aa) |
| | hpo-5 | PhosphatidylInositol Glycan anchor biosynthesis class S. (550 aa) |
| | T20D3.8 | PhosphatidylInositol Glycan anchor biosynthesis class C. (282 aa) |
| | T22C1.3 | PhosphatidylInositol Glycan anchor biosynthesis class T. (421 aa) |
| | ribo-1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (586 aa) |
| | sptl-3 | Serine palmitoyltransferase 3; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (521 aa) |
| | pqn-71 | Prion-like-(Q/N-rich)-domain-bearing protein. (330 aa) |
| | T25G12.13 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa) |
| | dhs-30 | DeHydrogenases, Short chain; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (311 aa) |
| | plpp-1.2 | Phospholipid phosphatase homolog 1.2 homolog. (358 aa) |
| | fat-6 | Delta(9)-fatty-acid desaturase fat-6; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA and heptadecanyol-CoA. Belongs to the fatty acid desaturase type 1 family. (339 aa) |
| | paf-1 | 1-alkyl-2-acetylglycerophosphocholine esterase. (384 aa) |
| | ret-1 | Reticulon-like protein. (3303 aa) |
| | pod-2 | Uncharacterized protein. (2165 aa) |
| | W09G3.8 | Uncharacterized protein. (80 aa) |
| | pqn-76 | Prion-like-(Q/N-rich)-domain-bearing protein. (335 aa) |
| | abu-5 | Activated in Blocked Unfolded protein response. (335 aa) |
| | pqn-78 | Prion-like-(Q/N-rich)-domain-bearing protein. (335 aa) |
| | pqn-79 | Prion-like-(Q/N-rich)-domain-bearing protein. (335 aa) |
| | ero-1 | Endoplasmic reticulum oxidoreductin-1; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity). (513 aa) |
| | rnf-145 | RING-type domain-containing protein. (742 aa) |
| | fkb-2 | Peptidylprolyl isomerase. (108 aa) |
| | fkb-8 | Peptidylprolyl isomerase. (290 aa) |
| | hpo-21 | Probable signal peptidase complex subunit 2; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (180 aa) |
| | npp-25 | Transmembrane protein 33 homolog. (271 aa) |
| | pcyt-2.1 | CTP_transf_like domain-containing protein. (391 aa) |
| | crt-1 | Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle (By similarity). This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). Probably by controlling the folding of extracellular matrix protein unc-52/Perlecan, may play a role in the formation of fibrous organelles, a hemidesmosome-like structure attaching muscles to the epidermis. Protects dopaminergic neurons against oxidative stress-induced neurodegen [...] (395 aa) |
| | Y38E10A.8 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (289 aa) |
| | trap-3 | TRanslocon-Associated Protein. (178 aa) |
| | Y38F2AR.9 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (81 aa) |
| | dnj-26 | J domain-containing protein. (365 aa) |
| | rps-28 | 40S ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. (65 aa) |
| | Y43F8C.7 | Uncharacterized protein. (236 aa) |
| | Y45F10B.13 | Uncharacterized protein. (633 aa) |
| | wrb-1 | WRB (Human W(Tryptophan)-Rich Basic nuclear protein) homolog. (196 aa) |
| | Y53C10A.5 | TMEM189_B_dmain domain-containing protein. (319 aa) |
| | Y53G8B.2 | Uncharacterized protein. (340 aa) |
| | pign-1 | PigN domain-containing protein. (912 aa) |
| | Y54E10BR.5 | Signal peptidase complex catalytic subunit SEC11. (183 aa) |
| | trap-4 | TRanslocon-Associated Protein. (159 aa) |
| | Y56A3A.36 | DOLichol Kinase. (299 aa) |
| | Y57E12AL.1 | Uncharacterized protein. (459 aa) |
| | Y57E12AM.1 | Transmembrane protein 258; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are requ [...] (79 aa) |
| | sec-61 | Plug_translocon domain-containing protein. (473 aa) |
| | hhat-2 | Homolog of Hedgehog AcylTransferase; Belongs to the membrane-bound acyltransferase family. (524 aa) |
| | emc-2 | TPR_REGION domain-containing protein. (294 aa) |
| | tcc-1 | Transmembrane and Coiled-Coil protein. (676 aa) |
| | abu-4 | Activated in Blocked Unfolded protein response. (339 aa) |
| | Y5H2A.4 | Uncharacterized protein. (539 aa) |
| | algn-7 | Asparagine Linked Glycosylation (ALG) homolog, Nematode. (414 aa) |
| | emc-3 | ER membrane protein complex subunit 3. (234 aa) |
| | dnj-29 | J domain-containing protein. (752 aa) |
| | hsd-1 | 3Beta_HSD domain-containing protein. (462 aa) |
| | Y70C5A.3 | Uncharacterized protein. (716 aa) |
| | pqn-90 | Prion-like-(Q/N-rich)-domain-bearing protein. (420 aa) |
| | pqn-91 | Prion-like-(Q/N-rich)-domain-bearing protein. (419 aa) |
| | Y92H12A.5 | DUF2428 domain-containing protein. (1378 aa) |
| | abhd-12 | Hydrolase_4 domain-containing protein. (345 aa) |
| | hsd-3 | 3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (359 aa) |
| | hsd-2 | 3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (374 aa) |
| | ccdc-47 | CCDC (Human Coiled Coil Domain Containing) homolog. (442 aa) |
| | fitm-2 | FIT family protein fitm-2. (283 aa) |
| | perm-3 | ER membrane protein complex subunit 4; Belongs to the EMC4 family. (174 aa) |
| | pmt-1 | Methyltransf_11 domain-containing protein. (484 aa) |
| | cnx-1 | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity). Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death. (619 aa) |
| | ZK686.3 | Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation acro [...] (331 aa) |
| | ZK973.11 | Thioredoxin domain-containing protein. (447 aa) |
