STRINGSTRING
cyk-1 cyk-1 mig-10 mig-10 mlc-4 mlc-4 unc-60 unc-60 erm-1 erm-1 ZK1321.4 ZK1321.4 Y73B3B.1 Y73B3B.1 fln-1 fln-1 plx-1 plx-1 feh-1 feh-1 rho-1 rho-1 lev-11 lev-11 plst-1 plst-1 act-5 act-5 act-2 act-2 exc-6 exc-6 twf-2 twf-2 ehbp-1 ehbp-1 inft-2 inft-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cyk-1CYtoKinesis defect. (1437 aa)
mig-10Abnormal cell migration protein 10; Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt- 1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration. Belongs to the MRL family. (779 aa)
mlc-4Myosin regulatory light chain; Regulates myosin II activity and organization during embryo elongation. May be involved in the organization of mlc-5 into bundles. Required maternally for cytokinesis during meiosis and mitosis in the early embryo and for the establishment of embryonic anterior-posterior polarity. (172 aa)
unc-60Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. (152 aa)
erm-1FERM domain-containing protein. (564 aa)
ZK1321.4PDZ domain-containing protein. (429 aa)
Y73B3B.1Calponin-homology (CH) domain-containing protein. (376 aa)
fln-1Calponin-homology (CH) domain-containing protein. (2259 aa)
plx-1Sema domain-containing protein. (1956 aa)
feh-1Protein Fe65 homolog; Modulates pharyngeal pumping activity, at least in part by regulating expression of the acetylcholinesterase genes ace-1 and ace-2. (665 aa)
rho-1Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] (192 aa)
lev-11Tropomyosin isoforms a/b/d/f; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Protects actin filaments from depolymerization by unc-60 in vitro. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin. (284 aa)
plst-1PLaSTin (Actin bundling protein) homolog. (370 aa)
act-5ACTin. (375 aa)
act-2Actin-2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
exc-6Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis. (843 aa)
twf-2TWinFilin actin binding protein homolog. (333 aa)
ehbp-1EH (Eps-15-homology) domain Binding Protein family. (901 aa)
inft-2FH2 domain-containing protein. (1120 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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