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feh-1 feh-1 dnc-6 dnc-6 arp-1 arp-1 rho-1 rho-1 nmy-1 nmy-1 myo-6 myo-6 hum-10 hum-10 zyx-1 zyx-1 tni-1 tni-1 cal-7 cal-7 add-1 add-1 twf-2 twf-2 hum-2 hum-2 lim-8 lim-8 ehbp-1 ehbp-1 nmy-2 nmy-2 F15G9.1 F15G9.1 inft-2 inft-2 cyk-1 cyk-1 unc-54 unc-54 F10G8.8 F10G8.8 mig-10 mig-10 ifb-2 ifb-2 mlc-3 mlc-3 pkc-3 pkc-3 unc-87 unc-87 unc-15 unc-15 D2096.11 D2096.11 cap-1 cap-1 mlc-4 mlc-4 C50C3.5 C50C3.5 C50C3.2 C50C3.2 arp-11 arp-11 C46H11.3 C46H11.3 nab-1 nab-1 unc-60 unc-60 mlc-2 mlc-2 mlc-1 mlc-1 arx-6 arx-6 max-1 max-1 exc-5 exc-5 pxl-1 pxl-1 dnc-2 dnc-2 dnc-4 dnc-4 tnt-3 tnt-3 wsp-1 wsp-1 C07B5.4 C07B5.4 C07A9.5 C07A9.5 unc-94 unc-94 unc-78 unc-78 erm-1 erm-1 mlc-6 mlc-6 ani-1 ani-1 ani-3 ani-3 arx-5 arx-5 pfn-1 pfn-1 nmy-3 nmy-3 lev-11 lev-11 plst-1 plst-1 dnc-3 dnc-3 atn-1 atn-1 tni-4 tni-4 W02B8.2 W02B8.2 hic-1 hic-1 act-5 act-5 mup-2 mup-2 T22C1.1 T22C1.1 tni-3 tni-3 myo-2 myo-2 mlc-5 mlc-5 alp-1 alp-1 hum-6 hum-6 tnt-4 tnt-4 clh-4 clh-4 T05E7.3 T05E7.3 act-1 act-1 act-2 act-2 act-3 act-3 R148.5 R148.5 wip-1 wip-1 R11F4.2 R11F4.2 spe-26 spe-26 myo-1 myo-1 cap-2 cap-2 act-4 act-4 vab-8 vab-8 myo-3 myo-3 unc-70 unc-70 spc-1 spc-1 ani-2 ani-2 aipl-1 aipl-1 mlc-7 mlc-7 arx-2 arx-2 ate-1 ate-1 gsnl-1 gsnl-1 tnt-2 tnt-2 unc-60-2 unc-60-2 add-2 add-2 exc-6 exc-6 F59A6.5 F59A6.5 neto-1 neto-1 unc-27 unc-27 tnc-2 tnc-2 dnc-1 dnc-1 ZK1321.4 ZK1321.4 arx-3 arx-3 Y73B3B.1 Y73B3B.1 swsn-3 swsn-3 arx-1 arx-1 dnc-5 dnc-5 arx-4 arx-4 fln-1 fln-1 Y60A3A.9 Y60A3A.9 tag-273 tag-273 plx-1 plx-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
feh-1Protein Fe65 homolog; Modulates pharyngeal pumping activity, at least in part by regulating expression of the acetylcholinesterase genes ace-1 and ace-2. (665 aa)
dnc-6Dynactin subunit 6; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily. (180 aa)
arp-1Actin-Related Proteins; Belongs to the actin family. (374 aa)
rho-1Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] (192 aa)
nmy-1Non-muscle MYosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
myo-6Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1235 aa)
hum-10Myosin motor domain-containing protein. (853 aa)
zyx-1Zyxin; Functions as both a mechanical stabilizer (via LIM domains) of focal adhesions and as a sensor component for muscle cell damage (via N-terminus). Regulates, stabilizes and maintains posterior lateral mechanosensory (PLM) synaptic branch extension and new synapse formation and growth during larval development. (647 aa)
tni-1Troponin I 1; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (250 aa)
cal-7EF-hand domain-containing protein. (179 aa)
add-1Adducin-related protein 1; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. (732 aa)
twf-2TWinFilin actin binding protein homolog. (333 aa)
hum-2Dilute domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1811 aa)
lim-8LIM domain family. (1099 aa)
ehbp-1EH (Eps-15-homology) domain Binding Protein family. (901 aa)
nmy-2Non-muscle MYosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2003 aa)
F15G9.1Uncharacterized protein F15G9.1. (279 aa)
inft-2FH2 domain-containing protein. (1120 aa)
cyk-1CYtoKinesis defect. (1437 aa)
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
F10G8.8Uncharacterized protein. (984 aa)
mig-10Abnormal cell migration protein 10; Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt- 1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration. Belongs to the MRL family. (779 aa)
ifb-2Intermediate filament protein ifb-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413. (577 aa)
mlc-3Myosin, essential light chain. (153 aa)
pkc-3Protein kinase C-like 3; Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury. (597 aa)
unc-87Protein unc-87; Thin filament-associated protein that is implicated in actin bundling and actin filament dynamics. Exhibits F-actin cross-linking activity. Required for the maintenance of sarcomeric actin organization in striated muscles. Competes with unc-60 isoform b for actin binding and protects actin filaments from depolymerization by unc-60, thereby contributing to actin filament stability. Cooperates with myosin to form actomyosin bundles and inhibits actomyosin ATPase activity and actomyosin motility. Might protect the myofilaments from mechanical stress. (565 aa)
unc-15Paramyosin; Structural component of the muscle thick filaments which is involved in assembly and organization of sarcomere myofilaments. Involved in ovulation. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. Belongs to the paramyosin family. (872 aa)
D2096.11GAR domain-containing protein. (727 aa)
cap-1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (282 aa)
mlc-4Myosin regulatory light chain; Regulates myosin II activity and organization during embryo elongation. May be involved in the organization of mlc-5 into bundles. Required maternally for cytokinesis during meiosis and mitosis in the early embryo and for the establishment of embryonic anterior-posterior polarity. (172 aa)
C50C3.5Uncharacterized calcium-binding protein C50C3.5. (189 aa)
C50C3.2Uncharacterized protein C50C3.2; Belongs to the spectrin family. (2236 aa)
arp-11Actin-Related Proteins; Belongs to the actin family. (384 aa)
C46H11.3Probable actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (146 aa)
nab-1NeurABin. (721 aa)
unc-60Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. (152 aa)
mlc-2Myosin regulatory light chain 2. (170 aa)
mlc-1Myosin regulatory light chain 1. (170 aa)
arx-6Probable actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (169 aa)
max-1Motor AXon guidance. (1099 aa)
exc-5Uncharacterized protein. (861 aa)
pxl-1Paxillin homolog 1; Required for myofilament organization of the pharyngeal sarcomeres and for pharyngeal muscle contractions and hence for pharyngeal pumping. Together with lin-8, might be required for myofilament organization in the body wall muscles ; Belongs to the paxillin family. (413 aa)
dnc-2Probable dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. May play a role in synapse formation during brain development (By similarity); Belongs to the dynactin subunit 2 family. (331 aa)
dnc-4DyNactin Complex component. (413 aa)
tnt-3TropoNin T. (1178 aa)
wsp-1WASP (Actin cytoskeleton modulator) homolog. (781 aa)
C07B5.4PH domain-containing protein. (515 aa)
C07A9.5Uncharacterized calcium-binding protein C07A9.5. (358 aa)
unc-94Tropomodulin; Acts as the pointed end capping protein which maintains the length and dynamics of the actin filament. Blocks the elongation and depolymerization of the actin filaments at the pointed end (By similarity); Belongs to the tropomodulin family. (401 aa)
unc-78Actin-interacting protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Regulator of actin organization in myofibrils. (611 aa)
erm-1FERM domain-containing protein. (564 aa)
mlc-6Myosin Light Chain. (143 aa)
ani-1Anillin-like protein 1; Required for contractile events in embryos that occur prior to mitosis, such as cortical ruffling and pseudocleavage. Promotes membrane ruffling by organizing cortical patches of septins and myosin II. Not generally required for cytokinesis in mitotic cells. Required for the asymmetric cleavage events that extrude the two polar bodies during oocyte meiosis. Not required for meiotic contractile ring assembly, initiation or closure but is required for the transformation of the contractile ring from a disk above the spindle to a tube around the spindle midzone. Pro [...] (1159 aa)
ani-3Anillin-like protein 3. (709 aa)
arx-5Probable actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa)
pfn-1Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles. (132 aa)
nmy-3Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1464 aa)
lev-11Tropomyosin isoforms a/b/d/f; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Protects actin filaments from depolymerization by unc-60 in vitro. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin. (284 aa)
plst-1PLaSTin (Actin bundling protein) homolog. (370 aa)
dnc-3DyNactin Complex component. (171 aa)
atn-1AcTiniN. (920 aa)
tni-4Troponin I 4; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (194 aa)
W02B8.2Uncharacterized protein. (1256 aa)
hic-1Uncharacterized protein. (167 aa)
act-5ACTin. (375 aa)
mup-2Troponin T; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (405 aa)
T22C1.1UBR-type domain-containing protein. (356 aa)
tni-3Troponin I 3; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (260 aa)
myo-2Myosin-2; Muscle contraction. (1947 aa)
mlc-5Myosin-2 essential light chain; Required for cytokinesis and embryo elongation. May regulate myosin II complex formation and/or the association of myosin with actin. May be involved in the organization of mlc-4 and nmy-2 into bundles. (142 aa)
alp-1ALP/Enigma encoding. (1424 aa)
hum-6Unconventional myosin heavy chain 6; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). (2098 aa)
tnt-4TropoNin T. (375 aa)
clh-4Chloride channel protein. (1085 aa)
T05E7.3Uncharacterized protein. (997 aa)
act-1Actin-1. (376 aa)
act-2Actin-2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
act-3Actin-1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
R148.5PID domain-containing protein. (528 aa)
wip-1WH2 domain-containing protein. (362 aa)
R11F4.2G_PROTEIN_RECEP_F1_2 domain-containing protein. (403 aa)
spe-26Spermatocyte protein spe-26; May play a role in the spermatocyte cytoskeleton, possibly interacting with actin. (570 aa)
myo-1Myosin-1; Muscle contraction. (1938 aa)
cap-2F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (270 aa)
act-4Actin-4; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
vab-8Kinesin-like protein vab-8; Required for posterior migration of cells and axon growth cones during nervous system assembly. [Isoform b]: Specifically required for CAN cell migration. (1066 aa)
myo-3Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1969 aa)
unc-70Spectrin beta chain; Belongs to the spectrin family. (2326 aa)
spc-1SPeCtrin. (2432 aa)
ani-2Anillin-like protein 2; Required to maintain the structure of the rachis, the central cytoplasmic core of the syncytial adult gonad. Failure to maintain the rachis leads to premature dissociation of oocytes and thereby impedes oogenesis. (1009 aa)
aipl-1WD_REPEATS_REGION domain-containing protein. (600 aa)
mlc-7Myosin Light Chain. (153 aa)
arx-2Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (395 aa)
ate-1Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Belongs to the R-transferase family. (485 aa)
gsnl-1Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. Belongs to the villin/gelsolin family. (475 aa)
tnt-2TropoNin T. (428 aa)
unc-60-2Actin-depolymerizing factor 1, isoforms a/b; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Competes with unc-87 for actin binding and inhibits the actin-bundling activity of unc-87. (165 aa)
add-2Adducin-related protein 2; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network; Belongs to the aldolase class II family. Adducin subfamily. (611 aa)
exc-6Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis. (843 aa)
F59A6.5Uncharacterized protein. (1286 aa)
neto-1NETO (NEuropilin and TOlloid-like) homolog. (368 aa)
unc-27Troponin I 2; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (242 aa)
tnc-2Troponin C, isoform 2; Belongs to the troponin C family. (160 aa)
dnc-1CAP-Gly domain-containing protein. (1351 aa)
ZK1321.4PDZ domain-containing protein. (429 aa)
arx-3Actin-related protein 2/3 complex subunit. (375 aa)
Y73B3B.1Calponin-homology (CH) domain-containing protein. (376 aa)
swsn-3HMG box domain-containing protein. (338 aa)
arx-1Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (425 aa)
dnc-5DyNactin Complex component. (184 aa)
arx-4Probable actin-related protein 2/3 complex subunit 2; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (301 aa)
fln-1Calponin-homology (CH) domain-containing protein. (2259 aa)
Y60A3A.9GOLD domain-containing protein. (211 aa)
tag-273LIM zinc-binding domain-containing protein. (891 aa)
plx-1Sema domain-containing protein. (1956 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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