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unc-15 unc-15 cal-7 cal-7 hum-2 hum-2 nmy-2 nmy-2 unc-54 unc-54 mlc-3 mlc-3 unc-87 unc-87 mlc-4 mlc-4 mlc-2 mlc-2 mlc-1 mlc-1 myo-1 myo-1 spe-26 spe-26 wip-1 wip-1 R148.5 R148.5 T05E7.3 T05E7.3 hum-6 hum-6 mlc-5 mlc-5 myo-2 myo-2 act-5 act-5 nmy-3 nmy-3 Y60A3A.9 Y60A3A.9 hum-10 hum-10 myo-6 myo-6 nmy-1 nmy-1 mlc-6 mlc-6 ate-1 ate-1 mlc-7 mlc-7 myo-3 myo-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
unc-15Paramyosin; Structural component of the muscle thick filaments which is involved in assembly and organization of sarcomere myofilaments. Involved in ovulation. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. Belongs to the paramyosin family. (872 aa)
cal-7EF-hand domain-containing protein. (179 aa)
hum-2Dilute domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1811 aa)
nmy-2Non-muscle MYosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2003 aa)
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
mlc-3Myosin, essential light chain. (153 aa)
unc-87Protein unc-87; Thin filament-associated protein that is implicated in actin bundling and actin filament dynamics. Exhibits F-actin cross-linking activity. Required for the maintenance of sarcomeric actin organization in striated muscles. Competes with unc-60 isoform b for actin binding and protects actin filaments from depolymerization by unc-60, thereby contributing to actin filament stability. Cooperates with myosin to form actomyosin bundles and inhibits actomyosin ATPase activity and actomyosin motility. Might protect the myofilaments from mechanical stress. (565 aa)
mlc-4Myosin regulatory light chain; Regulates myosin II activity and organization during embryo elongation. May be involved in the organization of mlc-5 into bundles. Required maternally for cytokinesis during meiosis and mitosis in the early embryo and for the establishment of embryonic anterior-posterior polarity. (172 aa)
mlc-2Myosin regulatory light chain 2. (170 aa)
mlc-1Myosin regulatory light chain 1. (170 aa)
myo-1Myosin-1; Muscle contraction. (1938 aa)
spe-26Spermatocyte protein spe-26; May play a role in the spermatocyte cytoskeleton, possibly interacting with actin. (570 aa)
wip-1WH2 domain-containing protein. (362 aa)
R148.5PID domain-containing protein. (528 aa)
T05E7.3Uncharacterized protein. (997 aa)
hum-6Unconventional myosin heavy chain 6; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). (2098 aa)
mlc-5Myosin-2 essential light chain; Required for cytokinesis and embryo elongation. May regulate myosin II complex formation and/or the association of myosin with actin. May be involved in the organization of mlc-4 and nmy-2 into bundles. (142 aa)
myo-2Myosin-2; Muscle contraction. (1947 aa)
act-5ACTin. (375 aa)
nmy-3Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1464 aa)
Y60A3A.9GOLD domain-containing protein. (211 aa)
hum-10Myosin motor domain-containing protein. (853 aa)
myo-6Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1235 aa)
nmy-1Non-muscle MYosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
mlc-6Myosin Light Chain. (143 aa)
ate-1Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Belongs to the R-transferase family. (485 aa)
mlc-7Myosin Light Chain. (153 aa)
myo-3Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1969 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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