STRINGSTRING
skr-9 skr-9 C49H3.9 C49H3.9 C45B11.6 C45B11.6 skr-16 skr-16 fsn-1 fsn-1 skr-17 skr-17 madf-11 madf-11 ing-3 ing-3 cul-5 cul-5 cul-2 cul-2 skr-4 skr-4 skr-14 skr-14 skr-7 skr-7 skr-6 skr-6 skr-10 skr-10 T28B4.1 T28B4.1 skr-20 skr-20 skr-19 skr-19 lin-23 lin-23 skr-21 skr-21 cul-6 cul-6 K02A6.3 K02A6.3 skr-18 skr-18 skr-15 skr-15 skpt-1 skpt-1 skr-5 skr-5 skr-1 skr-1 skr-2 skr-2 skr-3 skr-3 EEED8.10 EEED8.10 mfb-1 mfb-1 cul-1 cul-1 skr-8 skr-8 skr-13 skr-13 skr-12 skr-12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
skr-9SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa)
C49H3.9C3HC-type domain-containing protein. (297 aa)
C45B11.6Epoxide hydrolase. (457 aa)
skr-16SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (181 aa)
fsn-1F-box/SPRY domain-containing protein 1; Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf- 2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM an [...] (332 aa)
skr-17SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (180 aa)
madf-11MADF domain-containing protein. (516 aa)
ing-3Inhibitor of growth protein. (490 aa)
cul-5Cullin-5; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline. (765 aa)
cul-2Cullin-2; Core component of multiple cullin-RING-based CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell [...] (791 aa)
skr-4SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (159 aa)
skr-14SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (168 aa)
skr-7SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa)
skr-6SKp1 Related (Ubiquitin ligase complex component). (106 aa)
skr-10SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (192 aa)
T28B4.1F-box domain-containing protein. (552 aa)
skr-20SKp1 Related (Ubiquitin ligase complex component). (173 aa)
skr-19Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (155 aa)
lin-23F-box/WD repeat-containing protein lin-23; Functions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation (By similarity). (667 aa)
skr-21Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (176 aa)
cul-6Cullin-6; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. (729 aa)
K02A6.3F-box domain-containing protein. (483 aa)
skr-18Skp1 domain-containing protein; Belongs to the SKP1 family. (183 aa)
skr-15SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (184 aa)
skpt-1F-box domain-containing protein. (421 aa)
skr-5SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (145 aa)
skr-1Skp1-related protein; Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. Involved in synapse elimination in early synapse development. May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress. Plays a role in sex determination. (176 aa)
skr-2SKp1 Related (Ubiquitin ligase complex component). (174 aa)
skr-3SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (167 aa)
EEED8.10Putative RNA-binding protein EEED8.10. (738 aa)
mfb-1F-box domain-containing protein. (379 aa)
cul-1Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. (780 aa)
skr-8SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa)
skr-13SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa)
skr-12SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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