STRINGSTRING
cdc-42 cdc-42 B0280.2 B0280.2 dpf-2 dpf-2 C31C9.6 C31C9.6 unc-115 unc-115 mig-10 mig-10 F14F7.5 F14F7.5 F41F3.3 F41F3.3 F45B8.3 F45B8.3 F54F2.7 F54F2.7 H04J21.1 H04J21.1 crml-1 crml-1 dbn-1 dbn-1 R06B10.2 R06B10.2 moa-1 moa-1 T20B6.1 T20B6.1 T20B6.2 T20B6.2 T20H9.6 T20H9.6 dpf-1 dpf-1 act-5 act-5 W02H5.19 W02H5.19 W02H5.2 W02H5.2 W03F11.4 W03F11.4 Y22D7AR.2 Y22D7AR.2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdc-42Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] (191 aa)
B0280.2Uncharacterized protein B0280.2. (627 aa)
dpf-2Dipeptidyl peptidase family member 2; Removes N-terminal dipeptides sequentially from polypeptides (By similarity). Essential for control of distal tip cell migration. Belongs to the peptidase S9B family. DPPIV subfamily. (829 aa)
C31C9.6WH1 domain-containing protein. (932 aa)
unc-115Uncharacterized protein. (639 aa)
mig-10Abnormal cell migration protein 10; Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt- 1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration. Belongs to the MRL family. (779 aa)
F14F7.5WSN domain-containing protein. (917 aa)
F41F3.3Uncharacterized protein. (156 aa)
F45B8.3Uncharacterized protein. (241 aa)
F54F2.7Uncharacterized protein F54F2.7. (157 aa)
H04J21.1Ubiquitin-like domain-containing protein. (1032 aa)
crml-1Carm_PH domain-containing protein. (1056 aa)
dbn-1Drebrin-like protein. (643 aa)
R06B10.2Protein-tyrosine-phosphatase. (1014 aa)
moa-1Modifier Of Apl-1 activity. (1238 aa)
T20B6.1Protein-tyrosine-phosphatase. (302 aa)
T20B6.2WSN domain-containing protein. (715 aa)
T20H9.6WSN domain-containing protein. (737 aa)
dpf-1Dipeptidyl peptidase family member 1; Removes N-terminal dipeptides sequentially from polypeptides (By similarity). Essential for control of distal tip cell migration. (799 aa)
act-5ACTin. (375 aa)
W02H5.19Uncharacterized protein. (169 aa)
W02H5.2Uncharacterized protein. (620 aa)
W03F11.4Protein-tyrosine-phosphatase. (1371 aa)
Y22D7AR.2F-box domain-containing protein. (1133 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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