STRINGSTRING
him-8 him-8 clic-1 clic-1 epn-1 epn-1 vha-4 vha-4 dpy-23 dpy-23 R10E11.6 R10E11.6 dab-1 dab-1 unc-101 unc-101 F58D5.8 F58D5.8 htp-3 htp-3 fcho-1 fcho-1 apm-1 apm-1 rme-6 rme-6 htp-1 htp-1 syp-3 syp-3 aps-1 aps-1 tag-138 tag-138 aps-2 aps-2 D1086.9 D1086.9 rab-8 rab-8 rsd-3 rsd-3 unc-11 unc-11 unc-41 unc-41 syp-2 syp-2 ida-1 ida-1 C09B9.2 C09B9.2 lin-10 lin-10 4R79.2 4R79.2 gopc-1 gopc-1 him-3 him-3 hipr-1 hipr-1 unc-17 unc-17 agef-1 agef-1 Y45G5AM.9 Y45G5AM.9 Y18D10A.22 Y18D10A.22 apg-1 apg-1 Y105C5B.9 Y105C5B.9 W09C5.7 W09C5.7 chc-1 chc-1 apa-2 apa-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
him-8C2H2-type domain-containing protein. (361 aa)
clic-1Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (226 aa)
epn-1ENTH domain-containing protein. (469 aa)
vha-4Vacuolar H ATPase. (214 aa)
dpy-23AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles (By similarity). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). AP50 is a subunit of the plasma membrane adaptor (By similarity). Essential wnt/egl-20 signaling protein that functions in wnt/egl-20-producing cells. Required for the AP-2 complex-mediated endocytosis of membrane proteins including wntless homolog mig-14 in egl-20-producing cells. During [...] (441 aa)
R10E11.6Uncharacterized protein R10E11.6. (371 aa)
dab-1PID domain-containing protein. (492 aa)
unc-101AP-1 complex subunit mu-1-I; Component of the adaptor complexes which link clathrin to receptors in coated vesicles (Probable). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (Probable). Required for many aspects of development and behavior, including negative regulation of vulval differentiation. Required for the dendritic localization of potassium channel kvs-4 in the cholinergic motor neuron DA9. (422 aa)
F58D5.8Uncharacterized protein. (328 aa)
htp-3HORMA domain-containing protein. (739 aa)
fcho-1FCH domain Only (FCH stands for Fes/CIP4 homology domain). (968 aa)
apm-1MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (426 aa)
rme-6Receptor-mediated endocytosis protein 6; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis. Acts by regulating the activation of rab-5 by exchanging bound GDP for free GTP at clathrin coated pits. (1093 aa)
htp-1HORMA domain-containing protein. (352 aa)
syp-3Uncharacterized protein. (224 aa)
aps-1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (157 aa)
tag-138ENTH domain-containing protein. (362 aa)
aps-2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
D1086.9Uncharacterized protein. (686 aa)
rab-8RAB family. (211 aa)
rsd-3ENTH domain-containing protein. (483 aa)
unc-11Phosphatidylinositol-binding clathrin assembly protein unc-11; Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Required for the efficient targeting of the synaptic vesicle protein synaptobrevin. Belongs to the PICALM/SNAP91 family. (657 aa)
unc-41Putative stoned B-like protein; Potential adapter protein, which may be involved in endocytic vesicle recycling of synaptic vesicles; Belongs to the Stoned B family. (1693 aa)
syp-2Uncharacterized protein. (213 aa)
ida-1Receptor-type tyrosine-protein phosphatase-like ida-1; Regulates dense-core vesicle (DCV) trafficking and/or secretion. Probably by controlling DCV trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Involved in locomotion by regulating acetylcholine release. Probably by controlling the secretion of FLP neuropeptides, regulates the turning step of male mating behavior. Plays a role in preventing dauer formation. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. (767 aa)
C09B9.2Uncharacterized protein. (328 aa)
lin-10Protein lin-10; Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glutamate receptor glr-1 in the ventral nerve cord. (982 aa)
4R79.2Uncharacterized protein. (395 aa)
gopc-1PDZ domain-containing protein. (414 aa)
him-3HORMA domain-containing protein. (291 aa)
hipr-1Huntington interacting protein related 1; Regulates pre-synaptic vesicle recycling at neuromuscular junctions of mechanosensory neurons. Plays a role in maintaining a normal defecation cycle; Belongs to the SLA2 family. (927 aa)
unc-17Vesicular acetylcholine transporter unc-17; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. (532 aa)
agef-1SEC7 domain-containing protein. (1594 aa)
Y45G5AM.9Uncharacterized protein. (499 aa)
Y18D10A.22ENTH domain-containing protein. (333 aa)
apg-1AP-1 complex subunit gamma. (829 aa)
Y105C5B.9Phytanoyl-CoA dioxygenase domain-containing protein 1 homolog; Has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is not expected to be active with phytanoyl CoA (By similarity). Belongs to the PhyH family. PHYHD1 subfamily. (288 aa)
W09C5.7SAC domain-containing protein. (783 aa)
chc-1Probable clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (By similarity). May play a role in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis ; Belongs to the clathrin heavy chain family. (1681 aa)
apa-2AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (925 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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