Your Input: | |
| | cutl-3 | ZP domain-containing protein. (405 aa) |
| | fipr-6 | FIP (Fungus-Induced Protein) Related. (73 aa) |
| | fipr-5 | FIP (Fungus-Induced Protein) Related. (111 aa) |
| | fipr-9 | FIP (Fungus-Induced Protein) Related. (73 aa) |
| | fipr-8 | FIP (Fungus-Induced Protein) Related. (73 aa) |
| | cle-1 | CoLlagen with Endostatin domain. (1175 aa) |
| | mig-6 | Papilin; Involved in pharynx morphogenesis probably by remodeling the basement membrane. [Isoform b]: Plays a role in post embryonic distal cell tip migration. Essential extracellular matrix (ECM) protein required for hypodermal enclosure in the embryo. (2167 aa) |
| | cwp-1 | Coexpressed With Polycystins. (108 aa) |
| | cwp-2 | Coexpressed With Polycystins. (106 aa) |
| | cwp-3 | Coexpressed With Polycystins. (158 aa) |
| | ost-1 | SPARC; Has a high affinity for collagen. Affects nematode body morphology and mobility. Essential for C.elegans development and muscle function. The cysteine-rich region could have protease inhibitory activity or may provide the framework for a protein binding module. Probable role in skeletal morphogenesis; Belongs to the SPARC family. (264 aa) |
| | cut-1 | Cuticlin-1; Component of the cuticles. It forms a ribbon approximately 2 microns wide running along the lateral lines underneath the alae. Contributes to the formation of extracellular envelopes protecting the organism from the environment. (424 aa) |
| | fipr-11 | FIP (Fungus-Induced Protein) Related. (74 aa) |
| | fipr-10 | FIP (Fungus-Induced Protein) Related. (74 aa) |
| | cpg-2 | Chondroitin proteoglycan-2; Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin. (524 aa) |
| | swp-1 | Protein SWAP; It is a regulator of pre-mRNA splicing (and, possibly, of other RNA processing events). It may regulate its own expression at the level of RNA processing. (751 aa) |
| | tol-1 | TIR domain-containing protein. (1221 aa) |
| | cpg-1 | Chondroitin proteoglycan 1; Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin. (584 aa) |
| | bli-1 | Cuticle collagen bli-1; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. This collagen is required for proper strut formation within the unique medial layer of the adult cuticle. (948 aa) |
| | fipr-4 | FIP (Fungus-Induced Protein) Related. (73 aa) |
| | fipr-7 | FIP (Fungus-Induced Protein) Related. (73 aa) |
| | spe-49 | DC_STAMP domain-containing protein. (772 aa) |
| | pxn-2 | PeroXidasiN (Drosophila peroxidase) homolog. (1328 aa) |
| | epi-1 | Laminin-like protein epi-1; During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. (3715 aa) |
| | timp-1 | NTR domain-containing protein. (154 aa) |
| | cutl-16 | ZP domain-containing protein. (488 aa) |
| | lect-2 | Peptidase_M23 domain-containing protein. (335 aa) |
| | emb-9 | Collagen alpha-1(IV) chain; Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons. May play a role in axon regeneration in embryos following injury in D-type motor neurons. (1759 aa) |
| | tag-131 | Neuferricin homolog; Heme-binding protein. (326 aa) |
| | acl-1 | Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-1; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. (262 aa) |
| | bli-2 | Col_cuticle_N domain-containing protein. (311 aa) |
| | F59B2.12 | Uncharacterized protein F59B2.12. (918 aa) |
| | mig-17 | Metalloprotease mig-17; Metalloprotease. Acts in the basement membrane to control directional migration of distal tip cells (DTCs) along the body wall basement membranes, a key step that promotes gonad morphogenesis. Regulates DTC migration probably by recruiting fibulin fbl-1, type IV collagen let-2 and nidogen nid-1 to the gonad basement membrane thereby promoting the remodeling of the basement membrane. During larval development and probably upstream of basement membrane proteins fbl-1, let-2 and nid-1, regulates pharynx length, probably by regulating pharyngeal cell length. Does no [...] (509 aa) |
| | fbl-1 | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. Plays a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Important for certain developmental processes and contributes to the supramolecular organization of ECM architecture, in particular to those of basement membranes. [Isoform c]: Involved in the assembly of the flexible hemicentin-containing tracks found joining the pharynx and body-wall- muscle basement membranes; Belongs to the fibulin family. (751 aa) |
| | nid-1 | NIDogen (Basement membrane protein). (1584 aa) |
| | cutl-20 | ZP domain-containing protein. (360 aa) |
| | duox-2 | DUal OXidase. (1503 aa) |
| | cut-2 | Cuticlin-2; Component of the insoluble part of the cuticles. (215 aa) |
| | F53F1.4 | Uncharacterized protein. (105 aa) |
| | noah-2 | NOmpA Homolog (Drosophila nompA: no mechanoreceptor potential A). (741 aa) |
| | clec-78 | C-type LECtin. (3514 aa) |
| | dpy-7 | Cuticle collagen dpy-7; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-7 affects the body shape. (318 aa) |
| | elks-1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. (836 aa) |
| | agr-1 | AGRin (Synaptic protein) homolog family member. (1473 aa) |
| | unc-6 | Netrin unc-6; Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation [...] (612 aa) |
| | cox-17 | Cytochrome OXidase assembly protein. (63 aa) |
| | mam-7 | MAM domain-containing protein. (559 aa) |
| | mtx-1 | Metaxin-1 homolog; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity); Belongs to the metaxin family. (312 aa) |
| | cpz-1 | Cathepsin Z-1; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Probably, required for the degradation of the old cuticle. Belongs to the peptidase C1 family. (306 aa) |
| | dpy-13 | Cuticle collagen dpy-13; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-13 affects the body shape. (302 aa) |
| | sqv-4 | UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (481 aa) |
| | spe-45 | Ig-like domain-containing protein. (492 aa) |
| | dpy-5 | Cuticle collagen dpy-5; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (284 aa) |
| | gon-1 | A disintegrin and metalloproteinase with thrombospondin motifs gon-1; Secreted metalloprotease required for distal tip cell (DTC) migration along the body wall basement membranes, a key step that promotes gonad morphogenesis. Probably acts by remodeling the basement membrane during cell migration. Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons, probably by controlling collagen IV emb-9 degradation, a component of the synapse basement membrane. Also involved in the organization of adult muscle morphology. Has [...] (2165 aa) |
| | fipr-1 | FIP (Fungus-Induced Protein) Related. (75 aa) |
| | sqt-3 | Cuticle collagen 1; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (301 aa) |
| | fipr-3 | FIP (Fungus-Induced Protein) Related. (101 aa) |
| | cut-3 | ZP domain-containing protein. (389 aa) |
| | ets-4 | Transcription factor ets-4; Transcription factor which binds to 5'-GGAA/T-3' DNA consensus sequences. Both positively and negatively regulates the expression of target genes. Plays a role in the regulation of adult lifespan, which may in part be through modulation of daf-16 activity. Regulates the expression of genes such as svh-2 in response to axon injury and in addition, may function downstream of the cAMP signaling pathway to promote axon regeneration. Regulates the expression of lipid metabolism genes and may also control the expression of the RNA-binding protein rege-1 which too [...] (437 aa) |
| | him-4 | EGF-like domain-containing protein. (5213 aa) |
| | spon-1 | SPONdin (Extracellular matrix glycoprotein) family. (819 aa) |
| | adt-2 | A disintegrin and metalloproteinase with thrombospondin motifs adt-2; Regulates body size probably independently of the TGF beta- like dbl-1 pathway. However, may regulate some dbl-1-mediated transcription. Plays a role in cuticle collagen fibril organization. Required for embryonic development. (1020 aa) |
| | his-53 | Histone H2A. (127 aa) |
| | ncr-1 | NPC intracellular cholesterol transporter 1 homolog 1; Involved in the uptake or utilization of cholesterol (By similarity). Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons. Belongs to the patched family. (1383 aa) |
| | let-2 | Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. (1759 aa) |
| | eng-1 | Glyco_hydro_85 domain-containing protein. (433 aa) |
| | mec-5 | MEC-5. (327 aa) |
| | pxn-1 | Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. (1285 aa) |
| | lon-3 | Cuticle collagen lon-3; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Dose-dependent regulator of body length and shape. (324 aa) |
| | ZK813.3 | Uncharacterized protein. (157 aa) |
| | ZK813.1 | Uncharacterized protein. (145 aa) |
| | col-19 | Cuticle collagen 19; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (289 aa) |
| | cdh-3 | Cadherin-3; Cell adhesion protein involved in the control of epithelial morphogenesis. Together with metalloproteinase zmp-1 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development. (3361 aa) |
| | pat-3 | Integrin beta pat-3; Integrin alpha ina-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable). Plays a role in cell migration, morphogenesis and probably in cell-cell interactions. During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M line [...] (809 aa) |
| | unc-52 | Basement membrane proteoglycan; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable structural role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in body wall muscles and myoepithelial sheath cells. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. Involved in ovulation. (3375 aa) |
| | Y73F8A.26 | Uncharacterized protein. (476 aa) |
| | tln-1 | Talin. (2553 aa) |
| | lec-1 | 32 kDa beta-galactoside-binding lectin; Binds galactose. (285 aa) |
| | lam-1 | LAMinin related. See also lmb. (1790 aa) |
| | act-5 | ACTin. (375 aa) |
| | pir-1 | RNA/RNP complex-1-interacting phosphatase homolog; Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity (By similarity). Binds RNA (By similarity). During small-RNA-mediated gene- silencing or RNA interference (RNAi), involved in the dcr-1-mediated processing of an amplified dsRNA intermediate. (233 aa) |
| | lam-3 | LAMinin related. See also lmb. (3102 aa) |
| | T21B6.3 | Apple domain-containing protein. (821 aa) |
| | adt-3 | Peptidase M12B domain-containing protein. (940 aa) |
| | pxf-1 | Rap guanine nucleotide exchange factor; Acts as a guanine nucleotide exchange factor for small G protein GTPases like rap-1 and rap-2. Required in the hypodermis, especially in the seam cells, for proper formation of the cuticle. Belongs to the RAPGEF2 family. (1470 aa) |
| | fipr-12 | FIP (Fungus-Induced Protein) Related. (74 aa) |
| | qua-1 | Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development. (1169 aa) |
| | vap-2 | Venom-Allergen-like Protein; Belongs to the CRISP family. (507 aa) |
| | rol-6 | Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa) |
| | suro-1 | Putative carboxypeptidase suro-1; May play a role in processing or organization of cuticle collagen proteins, including rol-6 and col-19. (664 aa) |
| | R02F2.4 | Uncharacterized protein. (431 aa) |
| | R01B10.4 | Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family. (320 aa) |
| | bcc-1 | SAM domain-containing protein. (644 aa) |
| | col-135 | COLlagen. (660 aa) |
| | cut-6 | CUTiclin. (572 aa) |
| | sli-1 | Suppressor of LIneage defect. (582 aa) |
| | ave-1 | SAM domain-containing protein. (102 aa) |
| | scm-1 | Secretory carrier-associated membrane protein. (335 aa) |
