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krr-1 krr-1 pro-2 pro-2 eif-6 eif-6 rrp-1 rrp-1 C48B6.2 C48B6.2 F10E7.5 F10E7.5 F10E7.6 F10E7.6 tag-151 tag-151 F13H8.2 F13H8.2 utp-20 utp-20 F27C1.6 F27C1.6 F30A10.9 F30A10.9 nol-10 nol-10 F53E10.6 F53E10.6 F53F4.11 F53F4.11 F55F8.3 F55F8.3 wdr-12 wdr-12 byn-1 byn-1 nol-56 nol-56 riok-1 riok-1 lpd-7 lpd-7 T01B7.5 T01B7.5 trcs-2 trcs-2 fib-1 fib-1 T02H6.1 T02H6.1 T20B12.3 T20B12.3 T23D8.3 T23D8.3 riok-2 riok-2 Y39A1A.14 Y39A1A.14 Y39F10B.1 Y39F10B.1 Y45F10D.7 Y45F10D.7 Y48B6A.1 Y48B6A.1 xrn-2 xrn-2 nol-14 nol-14 nol-6 nol-6 Y54E10BR.4 Y54E10BR.4 Y61A9LA.10 Y61A9LA.10 Y75B8A.7 Y75B8A.7 ZC434.4 ZC434.4 riok-3 riok-3 ZK792.5 ZK792.5 ZK795.3 ZK795.3 B0280.9 B0280.9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
krr-1KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (370 aa)
pro-2Nucleolar complex protein 2 homolog; Required for normal somatic gonad development and for regulation of germline development and proliferation. (715 aa)
eif-6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. Involved in miRNA-mediated gene silencing. (246 aa)
rrp-1Ribosomal RNA processing protein 1 homolog; May be involved in the generation of 28S rRNA. Belongs to the RRP1 family. (397 aa)
C48B6.2Putative 40S ribosomal protein S4-like. (183 aa)
F10E7.5Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (220 aa)
F10E7.6Uncharacterized protein. (153 aa)
tag-151Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily. (785 aa)
F13H8.2WD_REPEATS_REGION domain-containing protein. (929 aa)
utp-20DRIM domain-containing protein. (2613 aa)
F27C1.6Uncharacterized protein. (647 aa)
F30A10.9PINc domain-containing protein. (196 aa)
nol-10NUC153 domain-containing protein. (754 aa)
F53E10.6RRP15-like protein; Belongs to the RRP15 family. (191 aa)
F53F4.11Uncharacterized protein. (543 aa)
F55F8.3Periodic tryptophan protein 2 homolog; Belongs to the WD repeat PWP2 family. (910 aa)
wdr-12Ribosome biogenesis protein WDR12 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat WDR12/YTM1 family. (439 aa)
byn-1Uncharacterized protein byn-1; Belongs to the bystin family. (449 aa)
nol-56Nucleolar protein 56; Required for 60S ribosomal subunit synthesis. Belongs to the NOP5/NOP56 family. (486 aa)
riok-1Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). Plays a role in oogenesis by regulating germ cell proliferation, progression through diplotene and diakinesis stages and oocyte maturation. Regulates germline development probably by regulating the phosphorylation of mpk- 1. Involved in larval development. ECO:0 [...] (506 aa)
lpd-7Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. (531 aa)
T01B7.5Sas10 domain-containing protein. (407 aa)
trcs-2TRansport of membrane to Cell Surface. (779 aa)
fib-1rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (By similarity). Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl- L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (By similarity). Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Also acts as a protein [...] (352 aa)
T02H6.1WD_REPEATS_REGION domain-containing protein. (540 aa)
T20B12.3Uncharacterized protein T20B12.3; Belongs to the CBF/MAK21 family. (504 aa)
T23D8.3Protein LTV1 homolog; Belongs to the LTV1 family. (410 aa)
riok-2Serine/threonine-protein kinase RIO2; Required for larval development. Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (529 aa)
Y39A1A.14Ribosomal RNA small subunit methyltransferase nep-1; S-adenosyl-L-methionine-dependent pseudouridine N(1)- methyltransferase that methylates a pseudouridine in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3- carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre- ribosomes; Belongs to the class IV-like SAM-binding methyltransferase superfami [...] (231 aa)
Y39F10B.1FIP-RBD domain-containing protein. (469 aa)
Y45F10D.7Uncharacterized protein. (924 aa)
Y48B6A.1Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family. (674 aa)
xrn-25'-3' exoribonuclease 2 homolog; Possesses 5'->3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Degradation role is enhanced when in complex with paxt-1. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle. (975 aa)
nol-14NucleOLar protein. (829 aa)
nol-6Nucleolar protein 6. (1058 aa)
Y54E10BR.4RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (364 aa)
Y61A9LA.10Bms1-type G domain-containing protein. (1055 aa)
Y75B8A.7U3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family. (648 aa)
ZC434.4Ribosomal RNA-processing protein 7 homolog; Belongs to the RRP7 family. (270 aa)
riok-3Serine/threonine-protein kinase RIO3. (510 aa)
ZK792.5Uncharacterized protein. (645 aa)
ZK795.3Brix domain-containing protein ZK795.3. (292 aa)
B0280.9U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family. (429 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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