STRINGSTRING
sax-7 sax-7 B0280.2 B0280.2 srtx-1 srtx-1 glr-1 glr-1 wsp-1 wsp-1 sol-1 sol-1 rol-3 rol-3 seb-3 seb-3 dpf-2 dpf-2 mps-1 mps-1 C31C9.6 C31C9.6 madd-2 madd-2 dyf-7 dyf-7 cil-1 cil-1 dex-1 dex-1 F07F6.7 F07F6.7 F07F6.8 F07F6.8 unc-115 unc-115 mig-10 mig-10 mec-2 mec-2 shw-1 shw-1 F14F7.5 F14F7.5 F17C11.22 F17C11.22 F41F3.3 F41F3.3 F45B8.3 F45B8.3 F52H2.7 F52H2.7 fig-1 fig-1 F54F2.7 F54F2.7 H04J21.1 H04J21.1 plx-2 plx-2 sol-2 sol-2 crml-1 crml-1 dbn-1 dbn-1 R06B10.2 R06B10.2 unc-7 unc-7 cdc-42 cdc-42 moa-1 moa-1 shw-3 shw-3 mec-4 mec-4 dma-1 dma-1 T20B6.1 T20B6.1 T20B6.2 T20B6.2 T20H9.6 T20H9.6 dpf-1 dpf-1 dat-1 dat-1 inpp-1 inpp-1 act-5 act-5 W02H5.19 W02H5.19 W02H5.2 W02H5.2 W03F11.4 W03F11.4 Y22D7AR.2 Y22D7AR.2 Y37A1A.4 Y37A1A.4 zig-8 zig-8 ani-1 ani-1 unc-34 unc-34 plx-1 plx-1 tag-273 tag-273 oig-5 oig-5 arx-1 arx-1 lin-17 lin-17 tln-1 tln-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sax-7Fibronectin type-III domain-containing protein. (1331 aa)
B0280.2Uncharacterized protein B0280.2. (627 aa)
srtx-1G_PROTEIN_RECEP_F1_2 domain-containing protein. (355 aa)
glr-1Glutamate receptor 1; Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. May contribute to a sensory discrimination between mechanical and chemical stimuli. Plays a role in controlling movement in response to environmental cues such as food availability and mechanosensory stimulation such as the nose touch response. In AIB interneurons, promotes om [...] (962 aa)
wsp-1WASP (Actin cytoskeleton modulator) homolog. (781 aa)
sol-1Suppressor of lurcher protein 1; Accessory protein required for glutamate-gated currents. May participate in the gating of non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptors such as glr-1. (594 aa)
rol-3Protein roller-3; Thought to have a role in developmental establishment of posterior morphology. (2481 aa)
seb-3Secretin receptor-like protein SEB-3; Belongs to the G-protein coupled receptor 2 family. (454 aa)
dpf-2Dipeptidyl peptidase family member 2; Removes N-terminal dipeptides sequentially from polypeptides (By similarity). Essential for control of distal tip cell migration. Belongs to the peptidase S9B family. DPPIV subfamily. (829 aa)
mps-1MiRP K channel accessory Subunit. (257 aa)
C31C9.6WH1 domain-containing protein. (932 aa)
madd-2Uncharacterized protein. (765 aa)
dyf-7Protein dyf-7; Required for permeability of amphid and phasmid neurons to external dyes, chemotaxis to ammonium chloride, avoidance of high osmotic stimuli, male mating and dauer formation. Along with dex-1, enables neurite growth and maintenance by anchoring amphid dendritic tips during neuron cell body migration in embryonic and larval development. (446 aa)
cil-1Inositol polyphosphate 5-phosphatase; Dephosphorylates a number of phosphatidylinositols. Controls the cellular levels and subcellular distribution of phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5- trisphosphate. Has a role in sperm activation and motility. Influences the localization of the transient receptor potential polycystin (TRPP) complex proteins lov-1 and pkd-2; Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. (398 aa)
dex-1Dendrite extension defective protein 1; Along with dyf-7, enables neurite growth and maintenance by anchoring amphid dendritic tips during neuron cell body migration in embryonic and larval development. (1137 aa)
F07F6.7Uncharacterized protein. (265 aa)
F07F6.8Uncharacterized protein. (318 aa)
unc-115Uncharacterized protein. (639 aa)
mig-10Abnormal cell migration protein 10; Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt- 1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration. Belongs to the MRL family. (779 aa)
mec-2Mechanosensory protein 2; Positively regulates the activity of the putative mechanosensory transduction channel. May link the mechanosensory channel and the microtubule cytoskeleton of the touch receptor neurons. Required for the function of a set of six touch receptor neurons. (1239 aa)
shw-1BTB domain-containing protein; Belongs to the potassium channel family. (619 aa)
F14F7.5WSN domain-containing protein. (917 aa)
F17C11.22DB domain-containing protein. (233 aa)
F41F3.3Uncharacterized protein. (156 aa)
F45B8.3Uncharacterized protein. (241 aa)
F52H2.7C2 domain-containing protein. (875 aa)
fig-1Uncharacterized protein. (2892 aa)
F54F2.7Uncharacterized protein F54F2.7. (157 aa)
H04J21.1Ubiquitin-like domain-containing protein. (1032 aa)
plx-2Plexin-2; Involved as a receptor for mab-20/sema-2a in the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, involved in precursor cell sorting and in the formation of distinct sensory rays. Involved in axon guidance of SDQL neurons during neurogenesis. Probably in response to stimulation by mab-20, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus axon guidance and/or fasciculation of DD/VD neurons. Bel [...] (1766 aa)
sol-2Suppressor Of Lurcher movement defect. (436 aa)
crml-1Carm_PH domain-containing protein. (1056 aa)
dbn-1Drebrin-like protein. (643 aa)
R06B10.2Protein-tyrosine-phosphatase. (1014 aa)
unc-7Innexin unc-7; Structural component of the gap junctions (By similarity). Required for coordinated locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin- 23 and phospholipase plc-3 in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. (546 aa)
cdc-42Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] (191 aa)
moa-1Modifier Of Apl-1 activity. (1238 aa)
shw-3BTB domain-containing protein; Belongs to the potassium channel family. (500 aa)
mec-4Degenerin mec-4; Probable sodium channel subunit. May be needed for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior. (768 aa)
dma-1LRRCT domain-containing protein. (603 aa)
T20B6.1Protein-tyrosine-phosphatase. (302 aa)
T20B6.2WSN domain-containing protein. (715 aa)
T20H9.6WSN domain-containing protein. (737 aa)
dpf-1Dipeptidyl peptidase family member 1; Removes N-terminal dipeptides sequentially from polypeptides (By similarity). Essential for control of distal tip cell migration. (799 aa)
dat-1Sodium-dependent dopamine transporter; Dopamine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. (615 aa)
inpp-1IPPc domain-containing protein. (432 aa)
act-5ACTin. (375 aa)
W02H5.19Uncharacterized protein. (169 aa)
W02H5.2Uncharacterized protein. (620 aa)
W03F11.4Protein-tyrosine-phosphatase. (1371 aa)
Y22D7AR.2F-box domain-containing protein. (1133 aa)
Y37A1A.4PL48 domain-containing protein. (1071 aa)
zig-8Zwei Ig domain protein zig-8; Together with zig-5, required postembryonically to maintain the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP and HSN neurons by preventing their displacement that could occur during body growth and movement. May act by reducing L1CAM-like protein sax-7 (long isoform) adhesion. (268 aa)
ani-1Anillin-like protein 1; Required for contractile events in embryos that occur prior to mitosis, such as cortical ruffling and pseudocleavage. Promotes membrane ruffling by organizing cortical patches of septins and myosin II. Not generally required for cytokinesis in mitotic cells. Required for the asymmetric cleavage events that extrude the two polar bodies during oocyte meiosis. Not required for meiotic contractile ring assembly, initiation or closure but is required for the transformation of the contractile ring from a disk above the spindle to a tube around the spindle midzone. Pro [...] (1159 aa)
unc-34WH1 domain-containing protein. (468 aa)
plx-1Sema domain-containing protein. (1956 aa)
tag-273LIM zinc-binding domain-containing protein. (891 aa)
oig-5Ig-like domain-containing protein. (164 aa)
arx-1Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (425 aa)
lin-17Transmembrane receptor LIN-17; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa)
tln-1Talin. (2553 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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