node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ZK1321.4 | ehbp-1 | ZK1321.4b.1 | F25B3.1.1 | PDZ domain-containing protein. | EH (Eps-15-homology) domain Binding Protein family. | 0.658 |
ZK1321.4 | exc-6 | ZK1321.4b.1 | F58B6.2.1 | PDZ domain-containing protein. | Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis. | 0.584 |
ZK1321.4 | mig-10 | ZK1321.4b.1 | F10E9.6c.2 | PDZ domain-containing protein. | Abnormal cell migration protein 10; Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt- 1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration. Belongs to the MRL family. | 0.552 |
ZK1321.4 | mlc-4 | ZK1321.4b.1 | C56G7.1.1 | PDZ domain-containing protein. | Myosin regulatory light chain; Regulates myosin II activity and organization during embryo elongation. May be involved in the organization of mlc-5 into bundles. Required maternally for cytokinesis during meiosis and mitosis in the early embryo and for the establishment of embryonic anterior-posterior polarity. | 0.624 |
act-5 | ehbp-1 | T25C8.2.2 | F25B3.1.1 | ACTin. | EH (Eps-15-homology) domain Binding Protein family. | 0.565 |
act-5 | exc-6 | T25C8.2.2 | F58B6.2.1 | ACTin. | Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis. | 0.636 |
act-5 | mig-10 | T25C8.2.2 | F10E9.6c.2 | ACTin. | Abnormal cell migration protein 10; Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt- 1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration. Belongs to the MRL family. | 0.532 |
act-5 | mlc-4 | T25C8.2.2 | C56G7.1.1 | ACTin. | Myosin regulatory light chain; Regulates myosin II activity and organization during embryo elongation. May be involved in the organization of mlc-5 into bundles. Required maternally for cytokinesis during meiosis and mitosis in the early embryo and for the establishment of embryonic anterior-posterior polarity. | 0.990 |
act-5 | rho-1 | T25C8.2.2 | Y51H4A.3a.1 | ACTin. | Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] | 0.989 |
act-5 | unc-60 | T25C8.2.2 | C38C3.5.1 | ACTin. | Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. | 0.999 |
ehbp-1 | ZK1321.4 | F25B3.1.1 | ZK1321.4b.1 | EH (Eps-15-homology) domain Binding Protein family. | PDZ domain-containing protein. | 0.658 |
ehbp-1 | act-5 | F25B3.1.1 | T25C8.2.2 | EH (Eps-15-homology) domain Binding Protein family. | ACTin. | 0.565 |
ehbp-1 | exc-6 | F25B3.1.1 | F58B6.2.1 | EH (Eps-15-homology) domain Binding Protein family. | Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis. | 0.628 |
ehbp-1 | mig-10 | F25B3.1.1 | F10E9.6c.2 | EH (Eps-15-homology) domain Binding Protein family. | Abnormal cell migration protein 10; Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt- 1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration. Belongs to the MRL family. | 0.545 |
ehbp-1 | mlc-4 | F25B3.1.1 | C56G7.1.1 | EH (Eps-15-homology) domain Binding Protein family. | Myosin regulatory light chain; Regulates myosin II activity and organization during embryo elongation. May be involved in the organization of mlc-5 into bundles. Required maternally for cytokinesis during meiosis and mitosis in the early embryo and for the establishment of embryonic anterior-posterior polarity. | 0.679 |
exc-6 | ZK1321.4 | F58B6.2.1 | ZK1321.4b.1 | Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis. | PDZ domain-containing protein. | 0.584 |
exc-6 | act-5 | F58B6.2.1 | T25C8.2.2 | Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis. | ACTin. | 0.636 |
exc-6 | ehbp-1 | F58B6.2.1 | F25B3.1.1 | Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis. | EH (Eps-15-homology) domain Binding Protein family. | 0.628 |
exc-6 | mig-10 | F58B6.2.1 | F10E9.6c.2 | Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis. | Abnormal cell migration protein 10; Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt- 1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration. Belongs to the MRL family. | 0.728 |
exc-6 | mlc-4 | F58B6.2.1 | C56G7.1.1 | Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis. | Myosin regulatory light chain; Regulates myosin II activity and organization during embryo elongation. May be involved in the organization of mlc-5 into bundles. Required maternally for cytokinesis during meiosis and mitosis in the early embryo and for the establishment of embryonic anterior-posterior polarity. | 0.828 |