STRINGSTRING
F15G9.1 F15G9.1 R31.2 R31.2 R11F4.2 R11F4.2 myo-1 myo-1 act-4 act-4 vab-8 vab-8 myo-3 myo-3 unc-60-2 unc-60-2 tnt-2 tnt-2 tni-1 tni-1 act-3 act-3 unc-96 unc-96 unc-54 unc-54 mlc-3 mlc-3 unc-87 unc-87 C50C3.5 C50C3.5 unc-60 unc-60 tnt-3 tnt-3 unc-94 unc-94 C04F12.8 C04F12.8 anmt-1 anmt-1 unc-27 unc-27 tnc-2 tnc-2 lev-11 lev-11 atn-1 atn-1 tni-4 tni-4 mup-2 mup-2 tni-3 tni-3 tnt-4 tnt-4 act-1 act-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F15G9.1Uncharacterized protein F15G9.1. (279 aa)
R31.2ANK_REP_REGION domain-containing protein. (489 aa)
R11F4.2G_PROTEIN_RECEP_F1_2 domain-containing protein. (403 aa)
myo-1Myosin-1; Muscle contraction. (1938 aa)
act-4Actin-4; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
vab-8Kinesin-like protein vab-8; Required for posterior migration of cells and axon growth cones during nervous system assembly. [Isoform b]: Specifically required for CAN cell migration. (1066 aa)
myo-3Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1969 aa)
unc-60-2Actin-depolymerizing factor 1, isoforms a/b; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Competes with unc-87 for actin binding and inhibits the actin-bundling activity of unc-87. (165 aa)
tnt-2TropoNin T. (428 aa)
tni-1Troponin I 1; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (250 aa)
act-3Actin-1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
unc-96Uncharacterized protein. (418 aa)
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
mlc-3Myosin, essential light chain. (153 aa)
unc-87Protein unc-87; Thin filament-associated protein that is implicated in actin bundling and actin filament dynamics. Exhibits F-actin cross-linking activity. Required for the maintenance of sarcomeric actin organization in striated muscles. Competes with unc-60 isoform b for actin binding and protects actin filaments from depolymerization by unc-60, thereby contributing to actin filament stability. Cooperates with myosin to form actomyosin bundles and inhibits actomyosin ATPase activity and actomyosin motility. Might protect the myofilaments from mechanical stress. (565 aa)
C50C3.5Uncharacterized calcium-binding protein C50C3.5. (189 aa)
unc-60Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. (152 aa)
tnt-3TropoNin T. (1178 aa)
unc-94Tropomodulin; Acts as the pointed end capping protein which maintains the length and dynamics of the actin filament. Blocks the elongation and depolymerization of the actin filaments at the pointed end (By similarity); Belongs to the tropomodulin family. (401 aa)
C04F12.8Uncharacterized protein. (272 aa)
anmt-1Nicotinamide N-methyltransferase; Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions (By similarity). Involved in regulation of lifespan extension downstream of the sirtuin sir-2.1, probably through its role in nicotinic acid metabolism. (273 aa)
unc-27Troponin I 2; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (242 aa)
tnc-2Troponin C, isoform 2; Belongs to the troponin C family. (160 aa)
lev-11Tropomyosin isoforms a/b/d/f; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Protects actin filaments from depolymerization by unc-60 in vitro. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin. (284 aa)
atn-1AcTiniN. (920 aa)
tni-4Troponin I 4; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (194 aa)
mup-2Troponin T; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (405 aa)
tni-3Troponin I 3; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (260 aa)
tnt-4TropoNin T. (375 aa)
act-1Actin-1. (376 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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